The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
Ami S. Bhatt - One of the best experts on this subject based on the ideXlab platform.
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Microbiota Manipulation With Prebiotics and Probiotics in Patients Undergoing Stem Cell Transplantation
Current Hematologic Malignancy Reports, 2016Co-Authors: Tessa M. Andermann, Andrew Rezvani, Ami S. BhattAbstract:Hematopoietic stem cell Transplantation (HSCT) is a potentially life-saving therapy that often comes at the cost of complications such as graft-versus-host disease and post-Transplant Infections. With improved technology to understand the ecosystem of microorganisms (viruses, bacteria, fungi, and microeukaryotes) that make up the gut microbiota, there is increasing evidence of the microbiota’s contribution to the development of post-Transplant complications. Antibiotics have traditionally been the mainstay of microbiota-altering therapies available to physicians. Recently, interest is increasing in the use of prebiotics and probiotics to support the development and sustainability of a healthier microbiota. In this review, we will describe the evidence for the use of prebiotics and probiotics in combating microbiota dysbiosis and explore the ways in which they may be used in future research to potentially improve clinical outcomes and decrease rates of graft-versus-host disease (GVHD) and post-Transplant Infection.
A G Habib - One of the best experts on this subject based on the ideXlab platform.
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Post-renal Transplant Infections: single-center experience from Nigeria.
Transplant infectious disease : an official journal of the Transplantation Society, 2016Co-Authors: G Iliyasu, A Abdu, F M Dayyab, A B Tiamiyu, Z G Habib, B Adamu, A G HabibAbstract:Infections are the leading cause of hospitalization and mortality in Transplant recipients. Nigeria has a growing number of renal Transplant recipients. The aim of this study was to determine the pattern of Infections in renal allograft recipients in one of the major renal Transplant centers in Nigeria. All case records of renal allograft recipients on follow-up were retrieved. Those that had Infection at any time after Transplantation were selected. Demographic and clinical information was collected and analyzed. Thirty-three case records were analyzed, out of which 24/33 (72.7%) were males, with a mean age of 42.3 years (± 7.38). The median duration of developing Infection post Transplant was 270 days (range 2-2190). Most of the Infections occurred after 6 months in 15/33 (45.5%). Urinary tract Infection was the most common Infection, noted in 13/33 (39.4%), followed by pneumonia, which was seen in 12 (33.3%), 9/12 (75%) of which were culture-positive. There were 2 cases (5.6%) of tuberculosis and 1 case (2.8%) of cytomegalovirus colitis. Out of the 9 culture-positive pneumonia cases, 6 (66.7%) were caused by gram-negative pathogens, with Pseudomonas aeruginosa being the most common isolate seen in 3/9 (33.3%) of the patients. Among those with urinary tract Infection, Escherichia coli and Klebsiella species were isolated with equal proportion in 3/13 (23.1%), while Enterococcus faecalis was the most common isolate in 4/13 (30.8%). Overall Infection-related mortality was 10/33 (30.3%), out of which 5/10 (50%) of deaths were from pneumonia. Post-Transplant Infection surveillance must be strengthened. The role of multidrug-resistant gram-negative bacteria in post-renal Transplant Infection in Nigeria needs to be evaluated. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Post-renal Transplant Infections: single-center experience from Nigeria.
International Journal of Infectious Diseases, 2016Co-Authors: G Iliyasu, A Abdu, F M Dayyab, A B Tiamiyu, Z G Habib, B Adamu, A G HabibAbstract:BACKGROUND Infections are the leading cause of hospitalization and mortality in Transplant recipients. Nigeria has a growing number of renal Transplant recipients. The aim of this study was to determine the pattern of Infections in renal allograft recipients in one of the major renal Transplant centers in Nigeria. METHODS All case records of renal allograft recipients on follow-up were retrieved. Those that had Infection at any time after Transplantation were selected. Demographic and clinical information was collected and analyzed. RESULTS Thirty-three case records were analyzed, out of which 24/33 (72.7%) were males, with a mean age of 42.3 years (± 7.38). The median duration of developing Infection post Transplant was 270 days (range 2-2190). Most of the Infections occurred after 6 months in 15/33 (45.5%). Urinary tract Infection was the most common Infection, noted in 13/33 (39.4%), followed by pneumonia, which was seen in 12 (33.3%), 9/12 (75%) of which were culture-positive. There were 2 cases (5.6%) of tuberculosis and 1 case (2.8%) of cytomegalovirus colitis. Out of the 9 culture-positive pneumonia cases, 6 (66.7%) were caused by gram-negative pathogens, with Pseudomonas aeruginosa being the most common isolate seen in 3/9 (33.3%) of the patients. Among those with urinary tract Infection, Escherichia coli and Klebsiella species were isolated with equal proportion in 3/13 (23.1%), while Enterococcus faecalis was the most common isolate in 4/13 (30.8%). Overall Infection-related mortality was 10/33 (30.3%), out of which 5/10 (50%) of deaths were from pneumonia. CONCLUSION Post-Transplant Infection surveillance must be strengthened. The role of multidrug-resistant gram-negative bacteria in post-renal Transplant Infection in Nigeria needs to be evaluated.
On Koç - One of the best experts on this subject based on the ideXlab platform.
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Autologous CD34^+ enriched peripheral blood progenitor cell (PBPC) Transplantation is associated with higher morbidity in patients with lymphoma when compared to unmanipulated PBPC Transplantation
Bone Marrow Transplantation, 2000Co-Authors: J Friedman, Hm Lazarus, On KoçAbstract:High-dose chemotherapy followed by CD34^+ enriched peripheral blood progenitor cell (PBPC) Transplantation is used for the treatment of primary refractory or relapsed Hodgkin’s and non-Hodgkin’s lymphomas. The CD34^+ enrichment procedure, while reducing tumor burden, may compromise immunological reconstitution in the Transplanted patient and result in increased rates of post-Transplant Infection. We compared infectious complications in patients with lymphoma who were treated with high-dose chemotherapy and supported either with CD34^+ enriched PBPC ( n = 19) or unmanipulated PBPCs ( n = 24). Analysis was limited to patients discharged from initial hospitalization for Transplantation with a minimum of 1 year follow-up and free of lymphoma recurrence. We found a statistically significant increase in the number of patients with one or more infectious events in the CD34^+Transplant group (14/19) compared with the unmanipulated PBPC group (9/24, P < 0.01). Greater numbers of patients with two or more infectious events were observed in the CD34^+ group (7/19 vs 2/24, P < 0.03) and an increased incidence of bacterial Infections was observed in the CD34^+ group (10/19 vs 5/24, P < 0.05). Two deaths due to infectious complications were observed in the CD34^+ group. There was no significant difference in blood lymphocyte or monocyte recovery between the groups. These data demonstrate a significant increase in the long-term incidence of infectious events in lymphoma patients Transplanted with autologous CD34^+ enriched PBPCs compared to unmanipulated PBPCs. Thus, patients who undergo CD34^+ enriched PBPC Transplantation should be followed closely for infectious complications and prolonged infectious prophylaxis should be considered. Bone Marrow Transplantation (2000) 26, 831–836.
Tessa M. Andermann - One of the best experts on this subject based on the ideXlab platform.
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Microbiota Manipulation With Prebiotics and Probiotics in Patients Undergoing Stem Cell Transplantation
Current Hematologic Malignancy Reports, 2016Co-Authors: Tessa M. Andermann, Andrew Rezvani, Ami S. BhattAbstract:Hematopoietic stem cell Transplantation (HSCT) is a potentially life-saving therapy that often comes at the cost of complications such as graft-versus-host disease and post-Transplant Infections. With improved technology to understand the ecosystem of microorganisms (viruses, bacteria, fungi, and microeukaryotes) that make up the gut microbiota, there is increasing evidence of the microbiota’s contribution to the development of post-Transplant complications. Antibiotics have traditionally been the mainstay of microbiota-altering therapies available to physicians. Recently, interest is increasing in the use of prebiotics and probiotics to support the development and sustainability of a healthier microbiota. In this review, we will describe the evidence for the use of prebiotics and probiotics in combating microbiota dysbiosis and explore the ways in which they may be used in future research to potentially improve clinical outcomes and decrease rates of graft-versus-host disease (GVHD) and post-Transplant Infection.
G Iliyasu - One of the best experts on this subject based on the ideXlab platform.
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Post-renal Transplant Infections: single-center experience from Nigeria.
Transplant infectious disease : an official journal of the Transplantation Society, 2016Co-Authors: G Iliyasu, A Abdu, F M Dayyab, A B Tiamiyu, Z G Habib, B Adamu, A G HabibAbstract:Infections are the leading cause of hospitalization and mortality in Transplant recipients. Nigeria has a growing number of renal Transplant recipients. The aim of this study was to determine the pattern of Infections in renal allograft recipients in one of the major renal Transplant centers in Nigeria. All case records of renal allograft recipients on follow-up were retrieved. Those that had Infection at any time after Transplantation were selected. Demographic and clinical information was collected and analyzed. Thirty-three case records were analyzed, out of which 24/33 (72.7%) were males, with a mean age of 42.3 years (± 7.38). The median duration of developing Infection post Transplant was 270 days (range 2-2190). Most of the Infections occurred after 6 months in 15/33 (45.5%). Urinary tract Infection was the most common Infection, noted in 13/33 (39.4%), followed by pneumonia, which was seen in 12 (33.3%), 9/12 (75%) of which were culture-positive. There were 2 cases (5.6%) of tuberculosis and 1 case (2.8%) of cytomegalovirus colitis. Out of the 9 culture-positive pneumonia cases, 6 (66.7%) were caused by gram-negative pathogens, with Pseudomonas aeruginosa being the most common isolate seen in 3/9 (33.3%) of the patients. Among those with urinary tract Infection, Escherichia coli and Klebsiella species were isolated with equal proportion in 3/13 (23.1%), while Enterococcus faecalis was the most common isolate in 4/13 (30.8%). Overall Infection-related mortality was 10/33 (30.3%), out of which 5/10 (50%) of deaths were from pneumonia. Post-Transplant Infection surveillance must be strengthened. The role of multidrug-resistant gram-negative bacteria in post-renal Transplant Infection in Nigeria needs to be evaluated. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Post-renal Transplant Infections: single-center experience from Nigeria.
International Journal of Infectious Diseases, 2016Co-Authors: G Iliyasu, A Abdu, F M Dayyab, A B Tiamiyu, Z G Habib, B Adamu, A G HabibAbstract:BACKGROUND Infections are the leading cause of hospitalization and mortality in Transplant recipients. Nigeria has a growing number of renal Transplant recipients. The aim of this study was to determine the pattern of Infections in renal allograft recipients in one of the major renal Transplant centers in Nigeria. METHODS All case records of renal allograft recipients on follow-up were retrieved. Those that had Infection at any time after Transplantation were selected. Demographic and clinical information was collected and analyzed. RESULTS Thirty-three case records were analyzed, out of which 24/33 (72.7%) were males, with a mean age of 42.3 years (± 7.38). The median duration of developing Infection post Transplant was 270 days (range 2-2190). Most of the Infections occurred after 6 months in 15/33 (45.5%). Urinary tract Infection was the most common Infection, noted in 13/33 (39.4%), followed by pneumonia, which was seen in 12 (33.3%), 9/12 (75%) of which were culture-positive. There were 2 cases (5.6%) of tuberculosis and 1 case (2.8%) of cytomegalovirus colitis. Out of the 9 culture-positive pneumonia cases, 6 (66.7%) were caused by gram-negative pathogens, with Pseudomonas aeruginosa being the most common isolate seen in 3/9 (33.3%) of the patients. Among those with urinary tract Infection, Escherichia coli and Klebsiella species were isolated with equal proportion in 3/13 (23.1%), while Enterococcus faecalis was the most common isolate in 4/13 (30.8%). Overall Infection-related mortality was 10/33 (30.3%), out of which 5/10 (50%) of deaths were from pneumonia. CONCLUSION Post-Transplant Infection surveillance must be strengthened. The role of multidrug-resistant gram-negative bacteria in post-renal Transplant Infection in Nigeria needs to be evaluated.
