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Mal-soon Shin - One of the best experts on this subject based on the ideXlab platform.
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Treadmill Exercise improves memory function by inhibiting hippocampal apoptosis in pilocarpine-induced epileptic rats
Journal of Exercise Rehabilitation, 2018Co-Authors: Jae-min Lee, Tae-woon Kim, Chang-ju Kim, Mal-soon Shin, Baek-vin Lim, Yong-rak Chung, Young Sam ChoAbstract:Epilepsy is characterized by recurrent seizures and loss of neurons with abnormal rhythmic firing in the brains. In the present study, we investigated the effect of Treadmill Exercise on memory function in relation with cell proliferation and apoptosis in the hippocampus using pilocarpine-induced seizure rats. Epilepsy was initiated by intraperitoneal injection of pilocarpine hydrochloride. The rats in the Exercise group were forced to run on a motorized Treadmill for 30 min once a day for 2 weeks. In the present results, Treadmill Exercise alleviated short-term and spatial learning memory impairments in the epileptic rats. Treadmill Exercise suppressed neuronal degeneration and enhanced neuronal maturation in the epileptic rats. Treadmill Exercise suppressed cell proliferation and apoptosis in the epileptic rats. Treadmill Exercise alleviated pilocarpine-induced memory impairments and suppressed neuronal loss in the hippocampus through down-regulation of apoptosis. These findings offer a possibility that Treadmill Exercise may provide a preventive or therapeutic value to the epilepsy-induced learning and memory impairments.
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Treadmill Exercise prevents GABAergic neuronal loss with suppression of neuronal activation in the pilocarpine-induced epileptic rats
Journal of Exercise Rehabilitation, 2015Co-Authors: Baek-vin Lim, Jae-min Lee, Mal-soon Shin, Jin-hee SeoAbstract:Epilepsy is a common neurological disorder characterized by seizure and loss of neuronal cells by abnormal rhythmic firing of neurons in the brain. In the present study, we investigated the effect of Treadmill Exercise on gamma-aminobutyric acid (GABA)ergic neuronal loss in relation with neuronal activation using pilocarpine-induced epileptic rats. The rats were divided into four groups: control group, control and Treadmill Exercise group, pilocarpine-induced epilepsy group, and pilocarpine-induced epilepsy and Treadmill Exercise group. Epilepsy was induced by intraperitoneal injection of 320 mg/kg pilocarpine hydrochloride. The rats in the Exercise groups were forced to run on a motorized Treadmill for 30 min once a day for 2 weeks. In the present results, neuronal loss in the hippocampal CA1 region was increased after pilocarpine-induced seizure. Treadmill Exercise inhibited hippocampal neuronal loss in the epileptic rats. Glutamic acid decarboxylase (GAD67) expression in the hippocampal CA1 region was reduced by pilocarpine-induced seizure. Treadmill Exercise increased GAD67 expression in the epileptic rats. c-Fos expression in the hippocampal CA1 region was increased in response to epileptic seizure. Treadmill Exercise inhibited c-Fos expression in the epileptic rats. Epileptic seizure increased brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) expressions in the hippocampus. Treadmill Exercise suppressed BDNF and TrkB expressions in the epileptic rats. In the present study, Treadmill Exercise prevented GABAergic neuronal loss and inhibited neuronal activation in the hippocampal CA1 region through the down-regulation of BDNF-TrkB signaling pathway.
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The impact of duration of one bout Treadmill Exercise on cell proliferation and central fatigue in rats.
Journal of Exercise Rehabilitation, 2013Co-Authors: Sang-won Lee, Mal-soon Shin, Jin-hee Seo, Yeon Soo Kim, Tae-won Jun, Kijeong Kim, Chang-ju KimAbstract:The purpose of this study was to investigate the impact of the duration-dependence of the one bout Treadmill Exercise on cell proliferation, stress, and central fatigue in rats. The animals were randomly divided into five groups: the non-Exercise group, 1-h Exercise group, 2-h Exercise group, 4-h Exercise group, and 6-h Exercise group. The Exercise load consisted of running at speed of 13 meters/min with the 0° inclination. Cell proliferation in the hippocampal dentate gyrus was increased in response to one bout moderate Treadmill Exercise in all Exercise groups. But there was no statistical significance between the Exercise duration and cell proliferation. The optical density of glucocorticoid (GR)-positive cells in the hippocampal dentate gyrus was not changed by Treadmill Exercise at any Exercise duration. Expressions of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hyroxylase (TPH) were increased by Treadmill Exercise only at 6 h duration. It seemed like that there was no additional benefits on cell proliferation over 2 h Exercise due to stressful factors with over Exercise dose, and there was no change of GR expression due to early assessment point of time. It can be suggested that the one-bout of moderate Treadmill Exercise increased cell proliferation, but Treadmill Exercise prolonged to 6 h induced central fatigue in rats.
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Short-Term Repeated Treadmill Exercise More Potently Increases Cell Proliferation and Brain-Derived Neurotrophic Factor Expression in the Hippocampus of Rats
THE KOREAN JOURNAL OF STRESS RESEARCH, 2010Co-Authors: Ji-heon Jung, Tae-woon Kim, Mal-soon Shin, Bokyun Kim, Jin-hee Seo, Hyung-hwan Baik, Dong-hee Kim, Seung-soo BaekAbstract:Physical Exercise enhances cell proliferation and/or neurogenesis in the hippocampal dentate gyrus. Brain-derived neurotrophic factor (BDNF) is implicated in the modulation of neurotransmitters turnover, neurite genesis, and neuronal survival. BDNF binds to the tyrosine kinas B (TrK). In this study, we compared the effects of the one bout of long-duration Treadmill Exercise and the repeated short-duration Treadmill Exercise on cell proliferation and expressions of BDNF and TrKB in the hippocampus. Adult male Sprague-Dawley rats, weighing 200±5 g, were randomly divided into three groups (n=8 in each group): control group, one hour-one bout-Treadmill Exercise group, and ten minutes-six bouts-Treadmill Exercise group. The rats in the one hour-one bout-Treadmill Exercise group were forced to run on a motorized Treadmill for 60 min once a day (at 16:00). The rats in the ten minutes-six bouts-Treadmill Exercise group were forced to run on a Treadmill once 10 minutes per six times for a day (at 10:00, 11:00, 14:00, 15:00, 19:00, 20:00). Treadmill Exercise was continued for 7 consecutive days. The rats in the control group were left without running. Both types of Treadmill Exercise increased cell proliferation and enhanced expressions of BDNF and TrkB in the hippocampus. Cell proliferation and BDNF expression was more potently increased by the ten minutes-six bouts Treadmill Exercise than the one hour-one bout Treadmill Exercise. These results showed that repeated bouts of short-duration Treadmill Exercise may achieve more useful results for the brain functions than one-bout long-duration Treadmill Exercise. (Korean J Str Res 2010;18:295∼303)
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Treadmill Exercise inhibits traumatic brain injury induced hippocampal apoptosis
Physiology & Behavior, 2010Co-Authors: Donghyun Kim, Sung Eun Kim, Tae-woon Kim, Chang-ju Kim, Mal-soon Shin, Bokyun Kim, Hong Kim, Kyeongmi Kim, Seung-soo BaekAbstract:Abstract Traumatic brain injury (TBI) occurs when an outside force impacts the brain. The main problem associated with TBI is neuronal cell death of the brain, and the outcome of TBI ranges from complete recovery to permanent disability, and sometimes death. Physical Exercise is known to ameliorate neurologic impairment induced by various brain insults. In the present study, we investigated the effects of Treadmill Exercise on short-term memory and apoptosis in the hippocampus following TBI in rats. TBI was induced by an electromagnetic-controlled cortical impact. The rats in the Exercise group were forced to run on a Treadmill for 30 min once daily for 10 consecutive days, beginning 2 days after induction of TBI. For the current study, a step-down avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, Western blot for Bcl-2 and Bax, and immunohistochemistry for caspase-3 were conducted. The present results revealed that TBI impaired short-term memory, and increased DNA fragmentation and caspase-3 expression in the hippocampus. Induction of TBI also enhanced expression of pro-apoptotic factor Bax protein and suppressed expression of anti-apoptotic factor Bcl-2 protein in the hippocampus. Treadmill Exercise alleviated short-term memory impairment, and decreased DNA fragmentation and caspase-3 expression in the hippocampus. In addition, Treadmill Exercise remarkably suppressed expression of Bax protein and slightly increased expression of Bcl-2 protein in TBI-induced rats. The present study showed that Treadmill Exercise might overcome TBI-induced apoptotic neuronal cell death, thus facilitating recovery following TBI.
Cheryl C. H. Yang - One of the best experts on this subject based on the ideXlab platform.
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Effect of aging on Treadmill Exercise induced theta power in the rat
AGE, 2010Co-Authors: Jia-yi Li, Sandy Shen-yu Hsieh, Jin-jong Chen, Ching-yao Tsai, Cheryl C. H. YangAbstract:The effects of aging on the electroencephalogram (EEG) power spectra of 8- and 60-week-old Wistar–Kyoto rats were examined during the waking baseline and Treadmill Exercise. Using continuous and simultaneous recordings of EEG and electromyogram signals, this study demonstrated that the alpha (10–13 Hz), theta (6–10 Hz), and delta (0.5–4 Hz) powers of the EEG were significantly lower in older rats as compared with young rats during the waking baseline. In the young rats, Treadmill Exercise resulted promptly in a higher alpha power, higher theta power, and higher theta power percentage as compared with the waking baseline. In the aged rats, Treadmill Exercise only resulted in a higher theta power and higher theta power percentage. During the Treadmill Exercise, however, the aged rats still showed a significantly lower Exercise-evoked theta power change than the young rats. These results suggested that aging is accompanied by lower EEG activities during waking and this also is accompanied by an attenuated response of the brain to Exercise in the rat.
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Changes in electroencephalogram and heart rate during Treadmill Exercise in the rat.
Neuroscience Letters, 2008Co-Authors: Terry B.j. Kuo, Sandy S. Hsieh, Cheryl C. H. YangAbstract:To explore whether Exercise is related to electroencephalogram (EEG) and heart rate changes, continuous EEG power spectral analysis was performed on rats during Treadmill Exercise. Compared with before Exercise, Treadmill Exercise resulted promptly in a higher mean power frequency and theta (6-10 Hz) power of the EEG, but lower delta (0.5-4 Hz) power of the EEG together with a lower R-R interval of electrocardiogram. Such changes quickly reversed when the Treadmill Exercise was stopped. We conclude that the cerebral cortex activates along with the autonomic system during running. Our methodology offers an efficient way to study the interaction of cerebral and brain stem functions with Exercise in the rat.
Chang-ju Kim - One of the best experts on this subject based on the ideXlab platform.
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Treadmill Exercise improves memory function by inhibiting hippocampal apoptosis in pilocarpine-induced epileptic rats
Journal of Exercise Rehabilitation, 2018Co-Authors: Jae-min Lee, Tae-woon Kim, Chang-ju Kim, Mal-soon Shin, Baek-vin Lim, Yong-rak Chung, Young Sam ChoAbstract:Epilepsy is characterized by recurrent seizures and loss of neurons with abnormal rhythmic firing in the brains. In the present study, we investigated the effect of Treadmill Exercise on memory function in relation with cell proliferation and apoptosis in the hippocampus using pilocarpine-induced seizure rats. Epilepsy was initiated by intraperitoneal injection of pilocarpine hydrochloride. The rats in the Exercise group were forced to run on a motorized Treadmill for 30 min once a day for 2 weeks. In the present results, Treadmill Exercise alleviated short-term and spatial learning memory impairments in the epileptic rats. Treadmill Exercise suppressed neuronal degeneration and enhanced neuronal maturation in the epileptic rats. Treadmill Exercise suppressed cell proliferation and apoptosis in the epileptic rats. Treadmill Exercise alleviated pilocarpine-induced memory impairments and suppressed neuronal loss in the hippocampus through down-regulation of apoptosis. These findings offer a possibility that Treadmill Exercise may provide a preventive or therapeutic value to the epilepsy-induced learning and memory impairments.
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Duration-dependence of the effect of Treadmill Exercise on hyperactivity in attention deficit hyperactivity disorder rats.
Journal of Exercise Rehabilitation, 2014Co-Authors: Chang-ju Kim, Jun Heon Park, Geon Ho BahnAbstract:Attention-deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder, and its symptoms are hyperactivity and deficits in learning and memory. Physical Exercise increases dopamine synthesis and neuronal activity in various brain regions. In the present study, we investigate the duration-dependence of the Treadmill Exercise on hyperactivity in relation with dopamine expression in ADHD. Spontaneously hypertensive rats were used for the ADHD rats and Wistar-Kyoto rats were used for the control rats. The rats in the Exercise groups were forced to run on a Treadmill for 10 min, 30 min, and 60 min once daily for 28 consecutive days. For this experiment, open field test and immunohistochemistry for tyrosine hydroxylase were conducted. The present results revealed that ADHD rats showed hyperactivity, and tyrosine hydroxylase expression in the striatum and substantia nigra were decreased in ADHD rats. Treadmill Exercise alleviated hyperactivity and also increased TH expression in ADHD rats. Treadmill Exercise for 30 min per day showed most potent suppressing effect on hyperactivity, and this dose of Treadmill Exercise also most potently inhibited tyrosine hydroxylase expression. The present study suggests that Treadmill Exercise for 30 min once a day is the most effective therapeutic intervention for ADHD patients.
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The impact of duration of one bout Treadmill Exercise on cell proliferation and central fatigue in rats.
Journal of Exercise Rehabilitation, 2013Co-Authors: Sang-won Lee, Mal-soon Shin, Jin-hee Seo, Yeon Soo Kim, Tae-won Jun, Kijeong Kim, Chang-ju KimAbstract:The purpose of this study was to investigate the impact of the duration-dependence of the one bout Treadmill Exercise on cell proliferation, stress, and central fatigue in rats. The animals were randomly divided into five groups: the non-Exercise group, 1-h Exercise group, 2-h Exercise group, 4-h Exercise group, and 6-h Exercise group. The Exercise load consisted of running at speed of 13 meters/min with the 0° inclination. Cell proliferation in the hippocampal dentate gyrus was increased in response to one bout moderate Treadmill Exercise in all Exercise groups. But there was no statistical significance between the Exercise duration and cell proliferation. The optical density of glucocorticoid (GR)-positive cells in the hippocampal dentate gyrus was not changed by Treadmill Exercise at any Exercise duration. Expressions of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hyroxylase (TPH) were increased by Treadmill Exercise only at 6 h duration. It seemed like that there was no additional benefits on cell proliferation over 2 h Exercise due to stressful factors with over Exercise dose, and there was no change of GR expression due to early assessment point of time. It can be suggested that the one-bout of moderate Treadmill Exercise increased cell proliferation, but Treadmill Exercise prolonged to 6 h induced central fatigue in rats.
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Treadmill Exercise ameliorates apoptotic cell death in the retinas of diabetic rats
Molecular Medicine Reports, 2013Co-Authors: Dae-young Kim, Chang-ju Kim, Sun‑young Jung, Yun Hee Sung, Jae‑deung KimAbstract:Apoptotic neuronal cell death in the retina is a hallmark of diabetic retinopathy. Exercise has been recommended for the alleviation of symptoms in patients with diabetes. In the present study, the effect of Treadmill Exercise on apoptosis in the retinas of diabetic rats was investigated. Diabetes was induced by intraperitoneal injection of streptozotocin. The rats in the Exercise groups ran on a Treadmill for 30 min/day, 5 times a week, over the course of 6 weeks. In this study, the terminal deoxynucleotidyl transferase‑mediated dUTP nick‑end labeling (TUNEL) assay, immunohistochemistry staining of caspase‑3 and western blot analysis for Bax, Bcl‑2 and phosphorylated protein kinase B (p‑Akt) in the retinas of diabetic rats were performed. The results demonstrated that the number of TUNEL‑ and caspase‑3‑positive cells was increased in the retinas of diabetic rats, whereas Treadmill Exercise decreased these numbers. In addition, the expression of the pro‑apoptotic protein Bax and the anti‑apoptotic protein Bcl‑2 was enhanced in the retinas of diabetic rats. Treadmill Exercise suppressed Bax and enhanced Bcl‑2 levels. The expression of the cell survival factor, p‑Akt, was decreased in the retinas of diabetic rats and Treadmill Exercise increased the expression of p‑Akt. The results of the present study demonstrated that Treadmill Exercise ameliorated diabetes‑induced apoptosis in retinal cells by enhancing p‑Akt levels in the retina. Treadmill Exercise represents an effective strategy to delay or prevent the onset of ocular complications in diabetic patients.
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Treadmill Exercise inhibits traumatic brain injury induced hippocampal apoptosis
Physiology & Behavior, 2010Co-Authors: Donghyun Kim, Sung Eun Kim, Tae-woon Kim, Chang-ju Kim, Mal-soon Shin, Bokyun Kim, Hong Kim, Kyeongmi Kim, Seung-soo BaekAbstract:Abstract Traumatic brain injury (TBI) occurs when an outside force impacts the brain. The main problem associated with TBI is neuronal cell death of the brain, and the outcome of TBI ranges from complete recovery to permanent disability, and sometimes death. Physical Exercise is known to ameliorate neurologic impairment induced by various brain insults. In the present study, we investigated the effects of Treadmill Exercise on short-term memory and apoptosis in the hippocampus following TBI in rats. TBI was induced by an electromagnetic-controlled cortical impact. The rats in the Exercise group were forced to run on a Treadmill for 30 min once daily for 10 consecutive days, beginning 2 days after induction of TBI. For the current study, a step-down avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, Western blot for Bcl-2 and Bax, and immunohistochemistry for caspase-3 were conducted. The present results revealed that TBI impaired short-term memory, and increased DNA fragmentation and caspase-3 expression in the hippocampus. Induction of TBI also enhanced expression of pro-apoptotic factor Bax protein and suppressed expression of anti-apoptotic factor Bcl-2 protein in the hippocampus. Treadmill Exercise alleviated short-term memory impairment, and decreased DNA fragmentation and caspase-3 expression in the hippocampus. In addition, Treadmill Exercise remarkably suppressed expression of Bax protein and slightly increased expression of Bcl-2 protein in TBI-induced rats. The present study showed that Treadmill Exercise might overcome TBI-induced apoptotic neuronal cell death, thus facilitating recovery following TBI.
Bokyun Kim - One of the best experts on this subject based on the ideXlab platform.
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Short-Term Repeated Treadmill Exercise More Potently Increases Cell Proliferation and Brain-Derived Neurotrophic Factor Expression in the Hippocampus of Rats
THE KOREAN JOURNAL OF STRESS RESEARCH, 2010Co-Authors: Ji-heon Jung, Tae-woon Kim, Mal-soon Shin, Bokyun Kim, Jin-hee Seo, Hyung-hwan Baik, Dong-hee Kim, Seung-soo BaekAbstract:Physical Exercise enhances cell proliferation and/or neurogenesis in the hippocampal dentate gyrus. Brain-derived neurotrophic factor (BDNF) is implicated in the modulation of neurotransmitters turnover, neurite genesis, and neuronal survival. BDNF binds to the tyrosine kinas B (TrK). In this study, we compared the effects of the one bout of long-duration Treadmill Exercise and the repeated short-duration Treadmill Exercise on cell proliferation and expressions of BDNF and TrKB in the hippocampus. Adult male Sprague-Dawley rats, weighing 200±5 g, were randomly divided into three groups (n=8 in each group): control group, one hour-one bout-Treadmill Exercise group, and ten minutes-six bouts-Treadmill Exercise group. The rats in the one hour-one bout-Treadmill Exercise group were forced to run on a motorized Treadmill for 60 min once a day (at 16:00). The rats in the ten minutes-six bouts-Treadmill Exercise group were forced to run on a Treadmill once 10 minutes per six times for a day (at 10:00, 11:00, 14:00, 15:00, 19:00, 20:00). Treadmill Exercise was continued for 7 consecutive days. The rats in the control group were left without running. Both types of Treadmill Exercise increased cell proliferation and enhanced expressions of BDNF and TrkB in the hippocampus. Cell proliferation and BDNF expression was more potently increased by the ten minutes-six bouts Treadmill Exercise than the one hour-one bout Treadmill Exercise. These results showed that repeated bouts of short-duration Treadmill Exercise may achieve more useful results for the brain functions than one-bout long-duration Treadmill Exercise. (Korean J Str Res 2010;18:295∼303)
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Treadmill Exercise inhibits traumatic brain injury induced hippocampal apoptosis
Physiology & Behavior, 2010Co-Authors: Donghyun Kim, Sung Eun Kim, Tae-woon Kim, Chang-ju Kim, Mal-soon Shin, Bokyun Kim, Hong Kim, Kyeongmi Kim, Seung-soo BaekAbstract:Abstract Traumatic brain injury (TBI) occurs when an outside force impacts the brain. The main problem associated with TBI is neuronal cell death of the brain, and the outcome of TBI ranges from complete recovery to permanent disability, and sometimes death. Physical Exercise is known to ameliorate neurologic impairment induced by various brain insults. In the present study, we investigated the effects of Treadmill Exercise on short-term memory and apoptosis in the hippocampus following TBI in rats. TBI was induced by an electromagnetic-controlled cortical impact. The rats in the Exercise group were forced to run on a Treadmill for 30 min once daily for 10 consecutive days, beginning 2 days after induction of TBI. For the current study, a step-down avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, Western blot for Bcl-2 and Bax, and immunohistochemistry for caspase-3 were conducted. The present results revealed that TBI impaired short-term memory, and increased DNA fragmentation and caspase-3 expression in the hippocampus. Induction of TBI also enhanced expression of pro-apoptotic factor Bax protein and suppressed expression of anti-apoptotic factor Bcl-2 protein in the hippocampus. Treadmill Exercise alleviated short-term memory impairment, and decreased DNA fragmentation and caspase-3 expression in the hippocampus. In addition, Treadmill Exercise remarkably suppressed expression of Bax protein and slightly increased expression of Bcl-2 protein in TBI-induced rats. The present study showed that Treadmill Exercise might overcome TBI-induced apoptotic neuronal cell death, thus facilitating recovery following TBI.
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Treadmill Exercise suppresses nigrostriatal dopaminergic neuronal loss in 6 hydroxydopamine induced parkinson s rats
Neuroscience Letters, 2007Co-Authors: Myoungchul Yoon, Sung Eun Kim, Mal-soon Shin, Yun Hee Sung, Bokyun Kim, Hee Hyuk Lee, T Kim, Young Pyo KimAbstract:In Parkinson's disease, the progressive loss of dopaminergic neurons in the pars compacta of the substantia nigra leads to debilitating motor dysfunction. In the present study, we investigated the effects of Treadmill Exercise on the dopaminergic neuronal cell death in the substantia nigra and on the dopaminergic fiber loss in the striatum of Parkinson's rats. Parkinson's rats were made by injecting 6-hydroxydopamine into the striatum with using a stereotaxic instrument. The rats in the Exercise groups were put on the Treadmill to run for 30 min once a day for 14 consecutive days after 6-hydroxydopamine administration into the striatum. Two weeks after the intrastriatal injection of 6-hydroxydopamine, the rats without Treadmill Exercise displayed rotational asymmetry following injection of apomorphine (0.5 mg/kg, s.c.). In contrast, the rats undergoing Treadmill Exercise showed a significant reduction of rotational asymmetry. Analysis via immunohistochemistry for the tyrosine hydroxylase expression revealed a substantial loss of cell bodies in the substantia nigra and their projected fibers in the striatum ipsilateral to the lesion following 6-hydroxydapamine injection into the striatum. However, Treadmill running enhanced the survival of dopaminergic neurons in the substantia nigra and also their fibers projecting into the striatum. The results of the present study show that Treadmill Exercise may provide therapeutic value for the treatment of Parkinson's disease patients.
Young Pyo Kim - One of the best experts on this subject based on the ideXlab platform.
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Treadmill Exercise suppresses nigrostriatal dopaminergic neuronal loss in 6 hydroxydopamine induced parkinson s rats
Neuroscience Letters, 2007Co-Authors: Myoungchul Yoon, Sung Eun Kim, Mal-soon Shin, Yun Hee Sung, Bokyun Kim, Hee Hyuk Lee, T Kim, Young Pyo KimAbstract:In Parkinson's disease, the progressive loss of dopaminergic neurons in the pars compacta of the substantia nigra leads to debilitating motor dysfunction. In the present study, we investigated the effects of Treadmill Exercise on the dopaminergic neuronal cell death in the substantia nigra and on the dopaminergic fiber loss in the striatum of Parkinson's rats. Parkinson's rats were made by injecting 6-hydroxydopamine into the striatum with using a stereotaxic instrument. The rats in the Exercise groups were put on the Treadmill to run for 30 min once a day for 14 consecutive days after 6-hydroxydopamine administration into the striatum. Two weeks after the intrastriatal injection of 6-hydroxydopamine, the rats without Treadmill Exercise displayed rotational asymmetry following injection of apomorphine (0.5 mg/kg, s.c.). In contrast, the rats undergoing Treadmill Exercise showed a significant reduction of rotational asymmetry. Analysis via immunohistochemistry for the tyrosine hydroxylase expression revealed a substantial loss of cell bodies in the substantia nigra and their projected fibers in the striatum ipsilateral to the lesion following 6-hydroxydapamine injection into the striatum. However, Treadmill running enhanced the survival of dopaminergic neurons in the substantia nigra and also their fibers projecting into the striatum. The results of the present study show that Treadmill Exercise may provide therapeutic value for the treatment of Parkinson's disease patients.
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The influence of age on the Treadmill Exercise‐induced c‐Fos expression in the hippocampus of rats
Neuroscience Research Communications, 2004Co-Authors: Sangho Kim, Hyun-kyung Chang, Mal-soon Shin, Hong Kim, Sung-soo Kim, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Hee Hyuk Lee, Young Pyo KimAbstract:c-Fos has been used as a neuronal activity marker. Here, we examined the influence of age on the Treadmill running-induced c-Fos expression in rat hippocampus. Rats of Exercise groups were forces to run on Treadmill for 30 min. once a day for 5 consecutive days. Without Exercise, c-Fos expression was highest in 8-week old rats. Treadmill Exercise significantly enhanced the c-Fos expression in the hippocampus of rats in all ages. In the CA region, the increase of the c-Fos expression by Treadmill Exercise was highest in 4-week old rats. In the dentate gyrus, the increase of the c-Fos expression by Treadmill Exercise was highest in 62-week old rats. The data show that age is an important factor for the regulation of the c-Fos expression in the hippocampus and that the ability of the Treadmill Exercise enhancing the c-Fos expression is dependent on age status.
