The Experts below are selected from a list of 1140 Experts worldwide ranked by ideXlab platform
Takashi Harayama - One of the best experts on this subject based on the ideXlab platform.
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Triflic Anhydride mediated tandem formylation cyclization of cyanoacetanilides a concise synthesis of glycocitlone alkaloids
Tetrahedron Letters, 2009Co-Authors: Yusuke Kobayashi, Takashi HarayamaAbstract:A method is presented for the concise synthesis of 3-formyl-4-hydroxyquinolin-2(1H)-ones through Triflic Anhydride-mediated tandem formylation/cyclization of cyanoacetanilides. This tandem process was successfully used for the rapid syntheses of glycocitlones A and C.
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Triflic Anhydride-mediated tandem formylation/cyclization of cyanoacetanilides: a concise synthesis of glycocitlone alkaloids
Tetrahedron Letters, 2009Co-Authors: Yusuke Kobayashi, Takashi HarayamaAbstract:A method is presented for the concise synthesis of 3-formyl-4-hydroxyquinolin-2(1H)-ones through Triflic Anhydride-mediated tandem formylation/cyclization of cyanoacetanilides. This tandem process was successfully used for the rapid syntheses of glycocitlones A and C.
Dewen Dong - One of the best experts on this subject based on the ideXlab platform.
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Tf2O-Mediated Cyclization of α-Acyl-β-(2-aminopyridinyl)acrylamides: Access to N-Substituted 4H-Pyrido[1,2-a]pyrimidin-4-imines.
The Journal of Organic Chemistry, 2020Co-Authors: Chitturi Bhujanga Rao, Rui Zhang, Jingwen Yuan, Yongjiu Liang, Ning Zhang, Yu Wang, Dewen DongAbstract:A facile and efficient direct synthesis of N-substituted 4H-pyrido[1,2-a]pyrimidin-4-imines is developed from α-acyl-β-(2-aminopyridinyl)acrylamides mediated by Triflic Anhydride (Tf2O) in the pres...
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Triflic Anhydride Promoted Intramolecular Cyclization of N-Aryl Cinnamides: Access to Polysubstituted Quinolin-2(1H)-ones
Synthesis, 2017Co-Authors: Qian Bo-zhang, Peng Huang, Rui Zhang, Jingwen Yuan, Yongjiu Liang, Dewen DongAbstract:A facile and efficient synthesis of polysubstituted quinolin-2(1 H )-ones is developed via intramolecular cyclization of readily available N -aryl cinnamides promoted by Triflic Anhydride in N , N -dimethyl trifluoroacetamide (DTA) under mild conditions.
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Triflic Anhydride mediated beckmann rearrangement reaction of β oximyl amides access to 5 iminooxazolines
Journal of Chemical Sciences, 2016Co-Authors: Mangfei Yu, Jia Wang, Peng Huang, Qian Bo-zhang, Rui Zhang, Dewen DongAbstract:Facile and efficient synthesis of 5-iminooxazolines from α,α-disubstituted β-oximyl amides mediated by Triflic Anhydride (Tf2O) in the presence of 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU) in dichloromethane at room temperature is developed, and a mechanism involving tandem Beckmann rearrangement and intramolecular cyclization reaction is proposed.
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Triflic Anhydride mediated ring opening recyclization reaction of α carbamoyl α oximyl cyclopropanes with dmf synthetic route to 5 aminoisoxazoles
Synthesis, 2016Co-Authors: Mangfei Yu, Jia Wang, Peng Huang, Qian Bo-zhang, Rui Zhang, Dewen DongAbstract:A facile and efficient synthesis of fully substituted 5-aminoisoxazoles was developed from α-cyclopropyl β-oximyl amides in the presence of Triflic Anhydride (Tf2O) in DMF under very mild conditions. The process involves sequential ring-opening and intramolecular cyclization reactions.
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Triflic Anhydride Mediated Ring-Opening/Recyclization Reaction of α-Carbamoyl α-Oximyl Cyclopropanes with DMF: Synthetic Route to 5-Aminoisoxazoles
Synthesis, 2016Co-Authors: Qian Bo-zhang, Jia Wang, Peng Huang, Rui Zhang, Pengfei Yan, Dewen DongAbstract:A facile and efficient synthesis of fully substituted 5-aminoisoxazoles was developed from α-cyclopropyl β-oximyl amides in the presence of Triflic Anhydride (Tf2O) in DMF under very mild conditions. The process involves sequential ring-opening and intramolecular cyclization reactions.
Bruce W Turnbull - One of the best experts on this subject based on the ideXlab platform.
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mechanistic studies on a sulfoxide transfer reaction mediated by diphenyl sulfoxide Triflic Anhydride
Chemistry: A European Journal, 2012Co-Authors: Martin A. Fascione, Sophie J. Adshead, Pintu K. Mandal, Colin A. Kilner, Andrew G. Leach, Bruce W TurnbullAbstract:Sulfoxides are frequently used in organic synthesis as chiral auxiliaries and reagents to mediate a wide variety of chemical transformations. For example, diphenyl sulfoxide and Triflic Anhydride can be used to activate a wide range of glycosyl donors including hemiacetals, glycals and thioglycosides. In this way, an alcohol, enol or sulfide is converted into a good leaving group for subsequent reaction with an acceptor alcohol. However, reaction of diphenyl sulfoxide and Triflic Anhydride with oxathiane-based thioglycosides, and other oxathianes, leads to a different process in which the thioglycoside is oxidised to a sulfoxide. This unexpected oxidation reaction is very stereoselective and proceeds under anhydrous conditions in which the diphenyl sulfoxide acts both as oxidant and as the source of the oxygen atom. Isotopic labelling experiments support a reaction mechanism that involves the formation of oxodisulfonium (S-O-S) dication intermediates. These intermediates undergo oxygen-exchange reactions with other sulfoxides and also allow interconversion of axial and equatorial sulfoxides in oxathiane rings. The reversibility of the oxygen-exchange reaction suggests that the stereochemical outcome of the oxidation reaction may be under thermodynamic control, which potentially presents a novel strategy for the stereoselective synthesis of sulfoxides.
Yusuke Kobayashi - One of the best experts on this subject based on the ideXlab platform.
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Triflic Anhydride mediated tandem formylation cyclization of cyanoacetanilides a concise synthesis of glycocitlone alkaloids
Tetrahedron Letters, 2009Co-Authors: Yusuke Kobayashi, Takashi HarayamaAbstract:A method is presented for the concise synthesis of 3-formyl-4-hydroxyquinolin-2(1H)-ones through Triflic Anhydride-mediated tandem formylation/cyclization of cyanoacetanilides. This tandem process was successfully used for the rapid syntheses of glycocitlones A and C.
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Triflic Anhydride-mediated tandem formylation/cyclization of cyanoacetanilides: a concise synthesis of glycocitlone alkaloids
Tetrahedron Letters, 2009Co-Authors: Yusuke Kobayashi, Takashi HarayamaAbstract:A method is presented for the concise synthesis of 3-formyl-4-hydroxyquinolin-2(1H)-ones through Triflic Anhydride-mediated tandem formylation/cyclization of cyanoacetanilides. This tandem process was successfully used for the rapid syntheses of glycocitlones A and C.
Mangfei Yu - One of the best experts on this subject based on the ideXlab platform.
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Triflic Anhydride mediated beckmann rearrangement reaction of β oximyl amides access to 5 iminooxazolines
Journal of Chemical Sciences, 2016Co-Authors: Mangfei Yu, Jia Wang, Peng Huang, Qian Bo-zhang, Rui Zhang, Dewen DongAbstract:Facile and efficient synthesis of 5-iminooxazolines from α,α-disubstituted β-oximyl amides mediated by Triflic Anhydride (Tf2O) in the presence of 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU) in dichloromethane at room temperature is developed, and a mechanism involving tandem Beckmann rearrangement and intramolecular cyclization reaction is proposed.
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Triflic Anhydride mediated ring opening recyclization reaction of α carbamoyl α oximyl cyclopropanes with dmf synthetic route to 5 aminoisoxazoles
Synthesis, 2016Co-Authors: Mangfei Yu, Jia Wang, Peng Huang, Qian Bo-zhang, Rui Zhang, Dewen DongAbstract:A facile and efficient synthesis of fully substituted 5-aminoisoxazoles was developed from α-cyclopropyl β-oximyl amides in the presence of Triflic Anhydride (Tf2O) in DMF under very mild conditions. The process involves sequential ring-opening and intramolecular cyclization reactions.
