The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Samad Khaksar - One of the best experts on this subject based on the ideXlab platform.
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lewis acid catalyst free synthesis of substituted imidazoles in 2 2 2 Trifluoroethanol
ChemInform, 2013Co-Authors: Samad Khaksar, Mandana AlipourAbstract:Trifluoroethanol is used as solvent for the synthesis of tri- and tetrasubstituted imidazoles (III) and (V), respectively.
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a concise and versatile synthesis of 2 amino 3 cyanopyridine derivatives in 2 2 2 Trifluoroethanol
ChemInform, 2013Co-Authors: Samad Khaksar, Mandana YaghoobiAbstract:Trifluoroethanol is found to be an efficient and easily recoverable solvent for the synthesis of pyridine derivatives (IV)/(VI) via one-pot four-component condensation of aldehydes, ketones, malononitrile and NH4OAc.
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a concise and versatile synthesis of 2 amino 3 cyanopyridine derivatives in 2 2 2 Trifluoroethanol
Journal of Fluorine Chemistry, 2012Co-Authors: Samad Khaksar, Mandana YaghoobiAbstract:Abstract Trifluoroethanol (TFE) is found to be an efficient and recyclable medium in promoting one-pot, four-component coupling reactions of aldehydes, ketones, malononitrile, and ammonium acetate to afford the corresponding 2-amino-3-cyanopyridine derivatives in high yields. The solvent (TFE) can be readily separated from reaction products and recovered in excellent purity for direct reuse.
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a facile and efficient synthesis of 2 amino 3 cyano 4h chromenes and tetrahydrobenzo b pyrans using 2 2 2 Trifluoroethanol as a metal free and reusable medium
Journal of Fluorine Chemistry, 2012Co-Authors: Samad Khaksar, Ahmad Rouhollahpour, Saeed Mohammadzadeh TaleshAbstract:Abstract A highly efficient one-pot three-component regioselective synthesis of 2-amino-3-cyano-4 H -chromene and tetrahydrobenzo[ b ]pyran derivatives has been developed by annulation of aldehydes, malononitrile, and resorcinol or dimedone under reflux conditions in 2,2,2-Trifluoroethanol without the use of a catalyst or any other additive.
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catalyst free one pot reductivealkylation of primary and secondary amines and n n dimethylationof amino acids using sodium borohydride in 2 2 2 Trifluoroethanol
Synthesis, 2011Co-Authors: Mahmood Tajbakhsh, Akbar Heydari, Heshmatollah Alinezhad, Rahman Hosseinzadeh, Somayeh Ghahari, Samad KhaksarAbstract:A simple and convenient procedure for the reductive alkylation of primary and secondary amines and N,N-dimethylation of amino acids is described using sodium borohydride as a reducing agent in 2,2,2- Trifluoroethanol without use of a catalyst or any other additive. The solvent can be readily recovered from reaction products in excellent purity for direct reuse.
Hamid Reza Bijanzadeh - One of the best experts on this subject based on the ideXlab platform.
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a facile and efficient synthesis of 2 2 2 trifluoroethyl 2 e n phenylcinnamamido 2 phenylacetates in Trifluoroethanol via sequential ugi four component reaction esterification
Tetrahedron Letters, 2012Co-Authors: Saeed Balalaie, Hassan Motaghedi, Daryoush Tahmassebi, Morteza Bararjanian, Hamid Reza BijanzadehAbstract:Abstract We describe an efficient approach for the synthesis of N-substituted 2-alkenylamides in Trifluoroethanol via an Ugi 4-component reaction in short reaction times. The use of a catalytic amount of sulfuric acid in Trifluoroethanol gave the desired trifluoroethyl derivatives in good to high yields.
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a facile and efficient synthesis of β amino alcohols using 2 2 2 Trifluoroethanol as a metal free and reusable medium
Journal of Fluorine Chemistry, 2010Co-Authors: Samad Khaksar, Akbar Heydari, Mahmood Tajbakhsh, Hamid Reza BijanzadehAbstract:Trifluoroethanol was used as a reusable catalyst and medium for the ring opening of epoxides using aliphatic and aromatic amines as nucleophile under mild conditions to give the corresponding β-amino alcohols in high yields and regioselectivity.
Allan J B Watson - One of the best experts on this subject based on the ideXlab platform.
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amidation of unactivated ester derivatives mediated by Trifluoroethanol
Organic and Biomolecular Chemistry, 2017Co-Authors: Christopher G Mcpherson, Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J B WatsonAbstract:A catalytic amidation protocol mediated by 2,2,2-Trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.
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catalytic amidation of unactivated ester derivatives mediated by Trifluoroethanol
ChemInform, 2015Co-Authors: Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J B WatsonAbstract:A novel and versatile organocatalytic amidation method facilitated by inexpensive 2,2,2-Trifluoroethanol is presented.
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catalytic amidation of unactivated ester derivatives mediated by Trifluoroethanol
Chemical Communications, 2015Co-Authors: Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J B WatsonAbstract:A catalytic amidation method has been developed, employing 2,2,2-Trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a Trifluoroethanol-derived active ester intermediate.
Mahmood Tajbakhsh - One of the best experts on this subject based on the ideXlab platform.
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catalyst free one pot synthesis of 1 4 5 trisubstituted pyrazoles in 2 2 2 Trifluoroethanol
ChemInform, 2012Co-Authors: Heshmatollah Alinezhad, Mahmood Tajbakhsh, Mahboobeh ZareAbstract:Abstract A simple, efficient and three component one-pot synthesis of 1,4,5-trisubstituted pyrazoles by condensation of β-dicarbonyls, N,N-dimethylformamide dimethyl acetal (DMFDMA) and hydrazine derivatives in 2,2,2-Trifluoroethanol without using any catalyst and activation, is described.
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catalyst free one pot reductivealkylation of primary and secondary amines and n n dimethylationof amino acids using sodium borohydride in 2 2 2 Trifluoroethanol
Synthesis, 2011Co-Authors: Mahmood Tajbakhsh, Akbar Heydari, Heshmatollah Alinezhad, Rahman Hosseinzadeh, Somayeh Ghahari, Samad KhaksarAbstract:A simple and convenient procedure for the reductive alkylation of primary and secondary amines and N,N-dimethylation of amino acids is described using sodium borohydride as a reducing agent in 2,2,2- Trifluoroethanol without use of a catalyst or any other additive. The solvent can be readily recovered from reaction products in excellent purity for direct reuse.
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a facile and efficient synthesis of β amino alcohols using 2 2 2 Trifluoroethanol as a metal free and reusable medium
Journal of Fluorine Chemistry, 2010Co-Authors: Samad Khaksar, Akbar Heydari, Mahmood Tajbakhsh, Hamid Reza BijanzadehAbstract:Trifluoroethanol was used as a reusable catalyst and medium for the ring opening of epoxides using aliphatic and aromatic amines as nucleophile under mild conditions to give the corresponding β-amino alcohols in high yields and regioselectivity.
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Trifluoroethanol as a metal free homogeneous and recyclable medium for the efficient one pot synthesis of α amino nitriles and α amino phosphonates
Tetrahedron Letters, 2009Co-Authors: Akbar Heydari, Samad Khaksar, Mahmood TajbakhshAbstract:Abstract Trifluoroethanol is found to be an efficient and recyclable medium in promoting one-pot, three-component coupling reactions of aldehydes or ketones, amines and trimethylsilyl cyanide or trimethyl phosphite to afford the corresponding α-amino nitriles or α-amino phosphonates in high yields. This protocol does not require the use of an acid or base catalyst.
Akbar Heydari - One of the best experts on this subject based on the ideXlab platform.
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catalyst free one pot reductivealkylation of primary and secondary amines and n n dimethylationof amino acids using sodium borohydride in 2 2 2 Trifluoroethanol
Synthesis, 2011Co-Authors: Mahmood Tajbakhsh, Akbar Heydari, Heshmatollah Alinezhad, Rahman Hosseinzadeh, Somayeh Ghahari, Samad KhaksarAbstract:A simple and convenient procedure for the reductive alkylation of primary and secondary amines and N,N-dimethylation of amino acids is described using sodium borohydride as a reducing agent in 2,2,2- Trifluoroethanol without use of a catalyst or any other additive. The solvent can be readily recovered from reaction products in excellent purity for direct reuse.
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a facile and efficient synthesis of β amino alcohols using 2 2 2 Trifluoroethanol as a metal free and reusable medium
Journal of Fluorine Chemistry, 2010Co-Authors: Samad Khaksar, Akbar Heydari, Mahmood Tajbakhsh, Hamid Reza BijanzadehAbstract:Trifluoroethanol was used as a reusable catalyst and medium for the ring opening of epoxides using aliphatic and aromatic amines as nucleophile under mild conditions to give the corresponding β-amino alcohols in high yields and regioselectivity.
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Trifluoroethanol as a metal free homogeneous and recyclable medium for the efficient one pot synthesis of α amino nitriles and α amino phosphonates
Tetrahedron Letters, 2009Co-Authors: Akbar Heydari, Samad Khaksar, Mahmood TajbakhshAbstract:Abstract Trifluoroethanol is found to be an efficient and recyclable medium in promoting one-pot, three-component coupling reactions of aldehydes or ketones, amines and trimethylsilyl cyanide or trimethyl phosphite to afford the corresponding α-amino nitriles or α-amino phosphonates in high yields. This protocol does not require the use of an acid or base catalyst.