The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Motoi Kawatsura - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of Trifluoromethyl-Group-containing cyclopentadienones by the palladium-catalyzed [2 + 2 + 1] cycloaddition of aryl- and Trifluoromethyl-Group substituted internal alkynes and carbon monoxide
Tetrahedron Letters, 2019Co-Authors: Shogo Murakami, Taro Sonehara, Kousuke Iwakami, Hiroaki Tsuji, Motoi KawatsuraAbstract:Abstract We investigated the palladium-catalyzed [2 + 2 + 1] cycloaddition of aryl- and Trifluoromethyl-Group-substituted internal alkynes and carbon monoxide, and revealed that the PdBr2 effectively catalyzed the intended reaction. The PdBr2-catalyzed reaction smoothly proceeded and provided aryl- and Trifluoromethyl-Group-containing cyclopentadienone derivatives in up to 92% yield.
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Intramolecular construction of Trifluoromethyl Group by the palladium-catalyzed reaction of 2,3,3-trifluoroallylic carbonates with O-nucleophiles
Tetrahedron, 2018Co-Authors: Yuji Hoshino, Taisyun Hanakawa, Hiroaki Tsuji, Kazuki Isa, Motoi KawatsuraAbstract:Abstract The synthesis of the Trifluoromethyl Group containing enol ethers by the palladium-catalyzed intermolecular reaction of 2,3,3-trifluoroallylic carbonates with oxygen nucleophiles was accomplished. The reaction proceeds through the intermolecular attack of oxygen nucleophiles on the C-2 carbon atom of the allylic unit, and the intramolecular fluorine atom shift from the C-2 position to the C-3 position. The reactions with several types of alcohols and phenols proceeded smoothly, and afforded the corresponding Trifluoromethyl Group containing enol ethers in good to high yields.
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Intramolecular Construction of Trifluoromethyl Group by the Palladium-Catalyzed Alkylation of 2,3,3-Trifluoroallylic Carbonates with Indoles
The Journal of organic chemistry, 2017Co-Authors: Taisyun Hanakawa, Biao Zhou, Kazuki Isa, Shin-ichi Isobe, Yuji Hoshino, Motoi KawatsuraAbstract:The palladium-catalyzed alkylation reaction of 2,3,3-trifluoroallylic carbonates with indoles afforded a Trifluoromethyl Group possessing 3-substituted indole derivatives. The reaction proceeded via attack of the C-3 carbon of the indoles onto the C-2 position of the allylic moiety and intramolecular construction of the Trifluoromethyl Group by the intramolecular fluorine atom shift from the C-2 position to the C-3 position of the allyl unit.
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palladium catalyzed enantioselective allylic alkylation of Trifluoromethyl Group substituted racemic and acyclic unsymmetrical 1 3 disubstituted allylic esters with malonate anions
Organic and Biomolecular Chemistry, 2016Co-Authors: Kazunori Ikeda, Maki Minakawa, Taisyun Hanakawa, Takashi Futamura, Motoi KawatsuraAbstract:We examined the palladium-catalyzed allylic alkylation of Trifluoromethyl Group-substituted racemic and acyclic unsymmetrical 1,3-disubstituted allylic benzoate with a malonate anion, and succeeded in obtaining an enantiomerically enriched product in high yields with high ee values through the dynamic kinetic asymmetric transformation (DYKAT). The best result was attained by the [Pd(C3H5)(cod)]BF4/(S)-tol-BINAP in the presence of BSA or DMAP as a base.
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Iron‐Catalyzed [2 + 2 + 2] Cycloaddition of Trifluoromethyl Group Substituted Unsymmetrical Internal Alkynes.
ChemInform, 2015Co-Authors: Maki Minakawa, Tomoki Ishikawa, Junya Namioka, Souichirou Hirooka, Biao Zhou, Motoi KawatsuraAbstract:The title reaction affords the corresponding Trifluoromethyl Group substituted benzene derivatives in high yield with excellent selectivity.
Toshiyuki Itoh - One of the best experts on this subject based on the ideXlab platform.
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Enantioselective Allylic Amination of Trifluoromethyl Group Substituted Racemic and Unsymmetrical 1,3-Disubstituted Allylic Esters by Palladium Catalysts
Organic letters, 2014Co-Authors: Motoi Kawatsura, Shou Terasaki, Maki Minakawa, Takuya Hirakawa, Kazunori Ikeda, Toshiyuki ItohAbstract:The palladium-catalyzed regio- and enantioselective allylic amination of Trifluoromethyl Group substituted racemic and unsymmetrical 1,3-disubstituted allylic esters has been accomplished. The enantioselective formation of the α-type allylic amines was attained by the dynamic kinetic asymmetric transformation (DYKAT).
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regioselective synthesis of Trifluoromethyl Group containing allylic amines by palladium catalyzed allylic amination and sequential isomerization
Tetrahedron, 2011Co-Authors: Takuya Hirakawa, Motoi Kawatsura, Kazunori Ikeda, Hiroshi Ogasa, Daiji Ikeda, Tomoko Tanaka, Toshiyuki ItohAbstract:Abstract The palladium-catalyzed regioselective allylic amination of the α-Trifluoromethyl Group-substituted allyl acetate has been accomplished using Pd(OAc)2/DPPE and [Pd(π-allyl)(cod)]BF4/DPPF as catalysts. The selective formation of the γ-product was attained in the presence of Pd(OAc)2/DPPE, while the α-product was obtained using [Pd(π-allyl)(cod)]BF4/DPPF. We also succeeded in the regioselective synthesis of the enantiomerically enriched aminated product from chiral allyl acetate using Pd(OAc)2/DPPE and [Pd(π-allyl)(cod)]BF4/(S)-BINAP. Furthermore, we found that kinetic resolution had occurred during the isomerization step from the γ-type product to the α-type product by the [Pd(π-allyl)(cod)]BF4/(S)-BINAP catalyst.
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ruthenium catalyzed regio and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes
Organic Letters, 2011Co-Authors: Motoi Kawatsura, Hiroaki Tsuji, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Toshiyuki ItohAbstract:The regio- and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes has been accomplished: the Ru3(CO)12/3PPh3 catalyst system has effectively catalyzed the reaction to afford the Trifluoromethyl Group substituted (E)-enol esters with high regio- and stereoselectivities.
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Ruthenium-catalyzed regio- and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes.
Organic letters, 2011Co-Authors: Motoi Kawatsura, Hiroaki Tsuji, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Toshiyuki ItohAbstract:The regio- and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes has been accomplished: the Ru3(CO)12/3PPh3 catalyst system has effectively catalyzed the reaction to afford the Trifluoromethyl Group substituted (E)-enol esters with high regio- and stereoselectivities.
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Ruthenium-catalyzed regioselective [2 + 2 + 2] cyclotrimerization of Trifluoromethyl Group substituted internal alkynes.
Organic letters, 2011Co-Authors: Motoi Kawatsura, Takuya Hirakawa, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Toshiyuki ItohAbstract:It found that the Ru3(CO)12 coordinated with 2-(diphenylphosphino)benzonitrile (2-DPPBN) to effectively catalyze the [2 + 2 + 2] cyclotrimerization of the Trifluoromethyl Group substituted internal alkynes in high yields with up to >98% regioselectivity. Isolation of a ruthenacyclopentadiene was successful and confirmed that the complex is a reaction intermediate.
Junya Namioka - One of the best experts on this subject based on the ideXlab platform.
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Iron‐Catalyzed [2 + 2 + 2] Cycloaddition of Trifluoromethyl Group Substituted Unsymmetrical Internal Alkynes.
ChemInform, 2015Co-Authors: Maki Minakawa, Tomoki Ishikawa, Junya Namioka, Souichirou Hirooka, Biao Zhou, Motoi KawatsuraAbstract:The title reaction affords the corresponding Trifluoromethyl Group substituted benzene derivatives in high yield with excellent selectivity.
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iron catalyzed 2 2 2 cycloaddition of Trifluoromethyl Group substituted unsymmetrical internal alkynes
ChemInform, 2015Co-Authors: Maki Minakawa, Tomoki Ishikawa, Junya Namioka, Souichirou Hirooka, Biao Zhou, Motoi KawatsuraAbstract:The title reaction affords the corresponding Trifluoromethyl Group substituted benzene derivatives in high yield with excellent selectivity.
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iron catalyzed 2 2 2 cycloaddition of Trifluoromethyl Group substituted unsymmetrical internal alkynes
RSC Advances, 2014Co-Authors: Maki Minakawa, Tomoki Ishikawa, Junya Namioka, Souichirou Hirooka, Biao Zhou, Motoi KawatsuraAbstract:Iron-catalyzed [2 + 2 + 2] intermolecular cycloaddition of Trifluoromethyl Group substituted unsymmetrical internal alkynes afforded the corresponding Trifluoromethyl Group substituted benzene derivatives in high yield with excellent selectivity.
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Iron-catalyzed [2 + 2 + 2] cycloaddition of Trifluoromethyl Group substituted unsymmetrical internal alkynes
RSC Adv., 2014Co-Authors: Maki Minakawa, Tomoki Ishikawa, Junya Namioka, Souichirou Hirooka, Biao Zhou, Motoi KawatsuraAbstract:Iron-catalyzed [2 + 2 + 2] intermolecular cycloaddition of Trifluoromethyl Group substituted unsymmetrical internal alkynes afforded the corresponding Trifluoromethyl Group substituted benzene derivatives in high yield with excellent selectivity.
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ruthenium catalyzed regio and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes
Organic Letters, 2011Co-Authors: Motoi Kawatsura, Hiroaki Tsuji, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Toshiyuki ItohAbstract:The regio- and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes has been accomplished: the Ru3(CO)12/3PPh3 catalyst system has effectively catalyzed the reaction to afford the Trifluoromethyl Group substituted (E)-enol esters with high regio- and stereoselectivities.
Maki Minakawa - One of the best experts on this subject based on the ideXlab platform.
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palladium catalyzed enantioselective allylic alkylation of Trifluoromethyl Group substituted racemic and acyclic unsymmetrical 1 3 disubstituted allylic esters with malonate anions
Organic and Biomolecular Chemistry, 2016Co-Authors: Kazunori Ikeda, Maki Minakawa, Taisyun Hanakawa, Takashi Futamura, Motoi KawatsuraAbstract:We examined the palladium-catalyzed allylic alkylation of Trifluoromethyl Group-substituted racemic and acyclic unsymmetrical 1,3-disubstituted allylic benzoate with a malonate anion, and succeeded in obtaining an enantiomerically enriched product in high yields with high ee values through the dynamic kinetic asymmetric transformation (DYKAT). The best result was attained by the [Pd(C3H5)(cod)]BF4/(S)-tol-BINAP in the presence of BSA or DMAP as a base.
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Iron‐Catalyzed [2 + 2 + 2] Cycloaddition of Trifluoromethyl Group Substituted Unsymmetrical Internal Alkynes.
ChemInform, 2015Co-Authors: Maki Minakawa, Tomoki Ishikawa, Junya Namioka, Souichirou Hirooka, Biao Zhou, Motoi KawatsuraAbstract:The title reaction affords the corresponding Trifluoromethyl Group substituted benzene derivatives in high yield with excellent selectivity.
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iron catalyzed 2 2 2 cycloaddition of Trifluoromethyl Group substituted unsymmetrical internal alkynes
ChemInform, 2015Co-Authors: Maki Minakawa, Tomoki Ishikawa, Junya Namioka, Souichirou Hirooka, Biao Zhou, Motoi KawatsuraAbstract:The title reaction affords the corresponding Trifluoromethyl Group substituted benzene derivatives in high yield with excellent selectivity.
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iron catalyzed 2 2 2 cycloaddition of Trifluoromethyl Group substituted unsymmetrical internal alkynes
RSC Advances, 2014Co-Authors: Maki Minakawa, Tomoki Ishikawa, Junya Namioka, Souichirou Hirooka, Biao Zhou, Motoi KawatsuraAbstract:Iron-catalyzed [2 + 2 + 2] intermolecular cycloaddition of Trifluoromethyl Group substituted unsymmetrical internal alkynes afforded the corresponding Trifluoromethyl Group substituted benzene derivatives in high yield with excellent selectivity.
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Enantioselective Allylic Amination of Trifluoromethyl Group Substituted Racemic and Unsymmetrical 1,3-Disubstituted Allylic Esters by Palladium Catalysts
Organic letters, 2014Co-Authors: Motoi Kawatsura, Shou Terasaki, Maki Minakawa, Takuya Hirakawa, Kazunori Ikeda, Toshiyuki ItohAbstract:The palladium-catalyzed regio- and enantioselective allylic amination of Trifluoromethyl Group substituted racemic and unsymmetrical 1,3-disubstituted allylic esters has been accomplished. The enantioselective formation of the α-type allylic amines was attained by the dynamic kinetic asymmetric transformation (DYKAT).
Mitsuaki Yamamoto - One of the best experts on this subject based on the ideXlab platform.
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ruthenium catalyzed regio and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes
Organic Letters, 2011Co-Authors: Motoi Kawatsura, Hiroaki Tsuji, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Toshiyuki ItohAbstract:The regio- and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes has been accomplished: the Ru3(CO)12/3PPh3 catalyst system has effectively catalyzed the reaction to afford the Trifluoromethyl Group substituted (E)-enol esters with high regio- and stereoselectivities.
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Ruthenium-catalyzed regio- and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes.
Organic letters, 2011Co-Authors: Motoi Kawatsura, Hiroaki Tsuji, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Toshiyuki ItohAbstract:The regio- and stereoselective addition of carboxylic acids to aryl and Trifluoromethyl Group substituted unsymmetrical internal alkynes has been accomplished: the Ru3(CO)12/3PPh3 catalyst system has effectively catalyzed the reaction to afford the Trifluoromethyl Group substituted (E)-enol esters with high regio- and stereoselectivities.
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Ruthenium-catalyzed regioselective [2 + 2 + 2] cyclotrimerization of Trifluoromethyl Group substituted internal alkynes.
Organic letters, 2011Co-Authors: Motoi Kawatsura, Takuya Hirakawa, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Toshiyuki ItohAbstract:It found that the Ru3(CO)12 coordinated with 2-(diphenylphosphino)benzonitrile (2-DPPBN) to effectively catalyze the [2 + 2 + 2] cyclotrimerization of the Trifluoromethyl Group substituted internal alkynes in high yields with up to >98% regioselectivity. Isolation of a ruthenacyclopentadiene was successful and confirmed that the complex is a reaction intermediate.
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ruthenium catalyzed regioselective 2 2 2 cyclotrimerization of Trifluoromethyl Group substituted internal alkynes
Organic Letters, 2011Co-Authors: Motoi Kawatsura, Takuya Hirakawa, Junya Namioka, Koji Kajita, Mitsuaki Yamamoto, Toshiyuki ItohAbstract:It found that the Ru3(CO)12 coordinated with 2-(diphenylphosphino)benzonitrile (2-DPPBN) to effectively catalyze the [2 + 2 + 2] cyclotrimerization of the Trifluoromethyl Group substituted internal alkynes in high yields with up to >98% regioselectivity. Isolation of a ruthenacyclopentadiene was successful and confirmed that the complex is a reaction intermediate.
