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Renato Zenobi - One of the best experts on this subject based on the ideXlab platform.
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a modified traveling wave ion mobility mass spectrometer as a versatile platform for gas phase ion molecule reactions
Analytical Chemistry, 2019Co-Authors: Martin F Czar, Adrien Marchand, Renato ZenobiAbstract:Taken individually, chemical labeling and mass spectrometry are two well-established tools for the structural characterization of biomolecular complexes. A way to combine their respective advantages is to perform gas-phase ion-molecule reactions (IMRs) inside the mass spectrometer. This is, however, not so well developed because of the limited range of usable chemicals and the lack of commercially available IMR devices. Here, we modified a traveling wave ion mobility mass spectrometer to enable IMRs in the trapping region of the instrument. Only one minor hardware modification is needed to allow vapors of a variety of liquid reagents to be leaked into the trap traveling wave ion guide of the instrument. A diverse set of IMRs can then readily be performed without any loss in instrument performance. We demonstrate the advantages of implementing IMR capabilities in general, and to this quadrupole-ion mobility-time-of-flight (Q-IM-TOF) mass spectrometer in particular, by exploiting the full functionality of the instrument, including mass selection, ion mobility separation, and post-mobility fragmentation. The potential to carry out gas-phase IMR kinetics experiments is also illustrated. We demonstrate the versatility of the setup using gas-phase IMRs of established utility for biological mass spectrometry, including hydrogen-deuterium exchange, ion-molecule proton transfer reactions, and covalent modification of DNA anions using Trimethylsilyl Chloride.
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A Modified Traveling Wave Ion Mobility Mass Spectrometer as a Versatile Platform for Gas-Phase Ion–Molecule Reactions
2019Co-Authors: Martin F Czar, Adrien Marchand, Renato ZenobiAbstract:Taken individually, chemical labeling and mass spectrometry are two well-established tools for the structural characterization of biomolecular complexes. A way to combine their respective advantages is to perform gas-phase ion–molecule reactions (IMRs) inside the mass spectrometer. This is, however, not so well developed because of the limited range of usable chemicals and the lack of commercially available IMR devices. Here, we modified a traveling wave ion mobility mass spectrometer to enable IMRs in the trapping region of the instrument. Only one minor hardware modification is needed to allow vapors of a variety of liquid reagents to be leaked into the trap traveling wave ion guide of the instrument. A diverse set of IMRs can then readily be performed without any loss in instrument performance. We demonstrate the advantages of implementing IMR capabilities in general, and to this quadrupole–ion mobility–time-of-flight (Q-IM-TOF) mass spectrometer in particular, by exploiting the full functionality of the instrument, including mass selection, ion mobility separation, and post-mobility fragmentation. The potential to carry out gas-phase IMR kinetics experiments is also illustrated. We demonstrate the versatility of the setup using gas-phase IMRs of established utility for biological mass spectrometry, including hydrogen–deuterium exchange, ion–molecule proton transfer reactions, and covalent modification of DNA anions using Trimethylsilyl Chloride
Martin F Czar - One of the best experts on this subject based on the ideXlab platform.
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a modified traveling wave ion mobility mass spectrometer as a versatile platform for gas phase ion molecule reactions
Analytical Chemistry, 2019Co-Authors: Martin F Czar, Adrien Marchand, Renato ZenobiAbstract:Taken individually, chemical labeling and mass spectrometry are two well-established tools for the structural characterization of biomolecular complexes. A way to combine their respective advantages is to perform gas-phase ion-molecule reactions (IMRs) inside the mass spectrometer. This is, however, not so well developed because of the limited range of usable chemicals and the lack of commercially available IMR devices. Here, we modified a traveling wave ion mobility mass spectrometer to enable IMRs in the trapping region of the instrument. Only one minor hardware modification is needed to allow vapors of a variety of liquid reagents to be leaked into the trap traveling wave ion guide of the instrument. A diverse set of IMRs can then readily be performed without any loss in instrument performance. We demonstrate the advantages of implementing IMR capabilities in general, and to this quadrupole-ion mobility-time-of-flight (Q-IM-TOF) mass spectrometer in particular, by exploiting the full functionality of the instrument, including mass selection, ion mobility separation, and post-mobility fragmentation. The potential to carry out gas-phase IMR kinetics experiments is also illustrated. We demonstrate the versatility of the setup using gas-phase IMRs of established utility for biological mass spectrometry, including hydrogen-deuterium exchange, ion-molecule proton transfer reactions, and covalent modification of DNA anions using Trimethylsilyl Chloride.
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A Modified Traveling Wave Ion Mobility Mass Spectrometer as a Versatile Platform for Gas-Phase Ion–Molecule Reactions
2019Co-Authors: Martin F Czar, Adrien Marchand, Renato ZenobiAbstract:Taken individually, chemical labeling and mass spectrometry are two well-established tools for the structural characterization of biomolecular complexes. A way to combine their respective advantages is to perform gas-phase ion–molecule reactions (IMRs) inside the mass spectrometer. This is, however, not so well developed because of the limited range of usable chemicals and the lack of commercially available IMR devices. Here, we modified a traveling wave ion mobility mass spectrometer to enable IMRs in the trapping region of the instrument. Only one minor hardware modification is needed to allow vapors of a variety of liquid reagents to be leaked into the trap traveling wave ion guide of the instrument. A diverse set of IMRs can then readily be performed without any loss in instrument performance. We demonstrate the advantages of implementing IMR capabilities in general, and to this quadrupole–ion mobility–time-of-flight (Q-IM-TOF) mass spectrometer in particular, by exploiting the full functionality of the instrument, including mass selection, ion mobility separation, and post-mobility fragmentation. The potential to carry out gas-phase IMR kinetics experiments is also illustrated. We demonstrate the versatility of the setup using gas-phase IMRs of established utility for biological mass spectrometry, including hydrogen–deuterium exchange, ion–molecule proton transfer reactions, and covalent modification of DNA anions using Trimethylsilyl Chloride
Adrien Marchand - One of the best experts on this subject based on the ideXlab platform.
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a modified traveling wave ion mobility mass spectrometer as a versatile platform for gas phase ion molecule reactions
Analytical Chemistry, 2019Co-Authors: Martin F Czar, Adrien Marchand, Renato ZenobiAbstract:Taken individually, chemical labeling and mass spectrometry are two well-established tools for the structural characterization of biomolecular complexes. A way to combine their respective advantages is to perform gas-phase ion-molecule reactions (IMRs) inside the mass spectrometer. This is, however, not so well developed because of the limited range of usable chemicals and the lack of commercially available IMR devices. Here, we modified a traveling wave ion mobility mass spectrometer to enable IMRs in the trapping region of the instrument. Only one minor hardware modification is needed to allow vapors of a variety of liquid reagents to be leaked into the trap traveling wave ion guide of the instrument. A diverse set of IMRs can then readily be performed without any loss in instrument performance. We demonstrate the advantages of implementing IMR capabilities in general, and to this quadrupole-ion mobility-time-of-flight (Q-IM-TOF) mass spectrometer in particular, by exploiting the full functionality of the instrument, including mass selection, ion mobility separation, and post-mobility fragmentation. The potential to carry out gas-phase IMR kinetics experiments is also illustrated. We demonstrate the versatility of the setup using gas-phase IMRs of established utility for biological mass spectrometry, including hydrogen-deuterium exchange, ion-molecule proton transfer reactions, and covalent modification of DNA anions using Trimethylsilyl Chloride.
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A Modified Traveling Wave Ion Mobility Mass Spectrometer as a Versatile Platform for Gas-Phase Ion–Molecule Reactions
2019Co-Authors: Martin F Czar, Adrien Marchand, Renato ZenobiAbstract:Taken individually, chemical labeling and mass spectrometry are two well-established tools for the structural characterization of biomolecular complexes. A way to combine their respective advantages is to perform gas-phase ion–molecule reactions (IMRs) inside the mass spectrometer. This is, however, not so well developed because of the limited range of usable chemicals and the lack of commercially available IMR devices. Here, we modified a traveling wave ion mobility mass spectrometer to enable IMRs in the trapping region of the instrument. Only one minor hardware modification is needed to allow vapors of a variety of liquid reagents to be leaked into the trap traveling wave ion guide of the instrument. A diverse set of IMRs can then readily be performed without any loss in instrument performance. We demonstrate the advantages of implementing IMR capabilities in general, and to this quadrupole–ion mobility–time-of-flight (Q-IM-TOF) mass spectrometer in particular, by exploiting the full functionality of the instrument, including mass selection, ion mobility separation, and post-mobility fragmentation. The potential to carry out gas-phase IMR kinetics experiments is also illustrated. We demonstrate the versatility of the setup using gas-phase IMRs of established utility for biological mass spectrometry, including hydrogen–deuterium exchange, ion–molecule proton transfer reactions, and covalent modification of DNA anions using Trimethylsilyl Chloride
Hajime Matsushita - One of the best experts on this subject based on the ideXlab platform.
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Lactonization of Hydroxy Ester over Hydrous Zirconium(IV) Oxide Modified by Trimethylsilyl Chloride
Bulletin of the Chemical Society of Japan, 1993Co-Authors: Hideyuki Kuno, Makoto Shibagaki, Kyoko Takahashi, Hajime MatsushitaAbstract:The lactonization of hydroxy esters was performed over hydrous zirconium(IV) oxide modified by Trimethylsilyl Chloride. In the case of both primary and secondary hydroxy esters, lactones were obtained in high yield. In addition, it was elucidated that modified-hydrous zirconium(IV) oxide is superior to hydrous zirconium(IV) oxide regarding selectivity in lactonization.
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Oxidation of Alcohols to Aldehydes and Ketones over Hydrous Zirconium(IV) Oxide Modified by Trimethylsilyl Chloride
Bulletin of the Chemical Society of Japan, 1993Co-Authors: Hideyuki Kuno, Makoto Shibagaki, Kyoko Takahashi, Hajime MatsushitaAbstract:A modified catalyst was prepared by the reaction of Trimethylsilyl Chloride and hydrous zirconium(IV) oxide. It was then applied to the oxidation of alcohols by using carbonyl compounds as hydrogen acceptors. In the case of cycloalkanols, the oxidation proceeded efficiently to give the corresponding ketones. Further, primary aliphatic alcohols were converted to the corresponding aldehydes in high yields in a batch reaction system. In addition, it was investigated that the oxidation was influenced by a variety of solvents and hydrogen acceptors.
Avinash Desai - One of the best experts on this subject based on the ideXlab platform.
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zinc and Trimethylsilyl Chloride mediated synthesis of 2 3 5 trisubstituted pyrrole diesters from nitriles and ethyl bromoacetate
ChemInform, 2015Co-Authors: Surya Prakash H Rao, Avinash DesaiAbstract:An efficient synthesis of pyrrole diesters from readily available aromatic, benzylic, and aliphatic nitriles with ethyl bromoacetate takes place if the amount of the catalyst is 50 mol%.
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zinc and Trimethylsilyl Chloride mediated synthesis of 2 3 5 trisubstituted pyrrole diesters from nitriles and ethyl bromoacetate
Synlett, 2015Co-Authors: Surya Prakash H Rao, Avinash DesaiAbstract:An efficient, zinc-mediated, single-pot and CN+3C type pseudo-four-component synthesis of 2,3,5-trisubstituted pyrrole diesters was achieved from readily available aromatic/benzylic/aliphatic nitriles and ethyl bromoacetate under Trimethylsilyl Chloride catalysis.
