The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
Mauro Panunzio - One of the best experts on this subject based on the ideXlab platform.
-
α alkyl α aryl Trimethyltin nitriles versatile nucleophilic intermediates in aldol like reactions
ChemInform, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:Trimethyltin nitriles either generated in situ or introduced directly readily react with carbonyl compounds to yield β-hydroxynitriles.
-
α alkyl α aryl Trimethyltin nitriles versatile nucleophilic intermediates in aldol like reactions
European Journal of Organic Chemistry, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:α-Alkyl-α-aryl (Trimethyltin) nitriles react spontaneously with aldehydes and ketones in THF/toluene to give β-hydroxy nitriles with satisfactory to good yields and diastereoselectivity. No extra catalyst is required in this aldol-like reaction. A possible Trimethyltin-substituted ketene imine intermediate is invoked as reactive species. DFT calculations offer good support for this hypothesis.
-
α‐Alkyl‐α‐aryl (Trimethyltin) Nitriles: Versatile Nucleophilic Intermediates in Aldol‐Like Reactions
European Journal of Organic Chemistry, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:α-Alkyl-α-aryl (Trimethyltin) nitriles react spontaneously with aldehydes and ketones in THF/toluene to give β-hydroxy nitriles with satisfactory to good yields and diastereoselectivity. No extra catalyst is required in this aldol-like reaction. A possible Trimethyltin-substituted ketene imine intermediate is invoked as reactive species. DFT calculations offer good support for this hypothesis.
Sha Long - One of the best experts on this subject based on the ideXlab platform.
-
α alkyl α aryl Trimethyltin nitriles versatile nucleophilic intermediates in aldol like reactions
ChemInform, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:Trimethyltin nitriles either generated in situ or introduced directly readily react with carbonyl compounds to yield β-hydroxynitriles.
-
α alkyl α aryl Trimethyltin nitriles versatile nucleophilic intermediates in aldol like reactions
European Journal of Organic Chemistry, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:α-Alkyl-α-aryl (Trimethyltin) nitriles react spontaneously with aldehydes and ketones in THF/toluene to give β-hydroxy nitriles with satisfactory to good yields and diastereoselectivity. No extra catalyst is required in this aldol-like reaction. A possible Trimethyltin-substituted ketene imine intermediate is invoked as reactive species. DFT calculations offer good support for this hypothesis.
-
α‐Alkyl‐α‐aryl (Trimethyltin) Nitriles: Versatile Nucleophilic Intermediates in Aldol‐Like Reactions
European Journal of Organic Chemistry, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:α-Alkyl-α-aryl (Trimethyltin) nitriles react spontaneously with aldehydes and ketones in THF/toluene to give β-hydroxy nitriles with satisfactory to good yields and diastereoselectivity. No extra catalyst is required in this aldol-like reaction. A possible Trimethyltin-substituted ketene imine intermediate is invoked as reactive species. DFT calculations offer good support for this hypothesis.
Alessandro Bongini - One of the best experts on this subject based on the ideXlab platform.
-
α alkyl α aryl Trimethyltin nitriles versatile nucleophilic intermediates in aldol like reactions
ChemInform, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:Trimethyltin nitriles either generated in situ or introduced directly readily react with carbonyl compounds to yield β-hydroxynitriles.
-
α alkyl α aryl Trimethyltin nitriles versatile nucleophilic intermediates in aldol like reactions
European Journal of Organic Chemistry, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:α-Alkyl-α-aryl (Trimethyltin) nitriles react spontaneously with aldehydes and ketones in THF/toluene to give β-hydroxy nitriles with satisfactory to good yields and diastereoselectivity. No extra catalyst is required in this aldol-like reaction. A possible Trimethyltin-substituted ketene imine intermediate is invoked as reactive species. DFT calculations offer good support for this hypothesis.
-
α‐Alkyl‐α‐aryl (Trimethyltin) Nitriles: Versatile Nucleophilic Intermediates in Aldol‐Like Reactions
European Journal of Organic Chemistry, 2015Co-Authors: Sha Long, Alessandro Bongini, Mauro PanunzioAbstract:α-Alkyl-α-aryl (Trimethyltin) nitriles react spontaneously with aldehydes and ketones in THF/toluene to give β-hydroxy nitriles with satisfactory to good yields and diastereoselectivity. No extra catalyst is required in this aldol-like reaction. A possible Trimethyltin-substituted ketene imine intermediate is invoked as reactive species. DFT calculations offer good support for this hypothesis.
Fabrizio Michetti - One of the best experts on this subject based on the ideXlab platform.
-
expression of astrocytic nestin in the rat hippocampus during Trimethyltin induced neurodegeneration
Neuroscience Letters, 2004Co-Authors: Maria Concetta Geloso, Valentina Corvino, Valentina Cavallo, Amelia Toesca, Enrico Guadagni, Roberto Passalacqua, Fabrizio MichettiAbstract:In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during Trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.
Jonathan W Steed - One of the best experts on this subject based on the ideXlab platform.
-
Trimethyltin Hydroxide: A Crystallographic and High Z′ Curiosity
Crystal Growth & Design, 2011Co-Authors: Kirsty M Anderson, Sarah E Tallentire, Michael R Probert, Andres E Goeta, B G Mendis, Jonathan W SteedAbstract:The remarkable room temperature structure of Trimethyltin hydroxide comprises a total of 32 crystallographically independent SnMe3OH units arranged in four independent coordination polymer strands. We suggest that a Z′ = 4 value is more appropriate than Z′ = 32, reflecting the polymeric structure of the compound. DSC, single crystal and XRPD studies show that on cooling below ca.160 K the structure undergoes a first order phase change to a symmetric Z′ = 1 structure with just one crystallographically unique SnMe3OH unit. The phase change is reversible, and on warming past 176 K the high Z′ structure is regenerated, in an endothermic transition. The Z′ = 1 and 4 structures are an enantiotropic pair, and Trimethyltin hydroxide represents a case where the higher Z′ structure is the most stable form at high temperature with the high Z′ value possibly arising from a consideration of the dynamics of the crystal as a whole.
-
Trimethyltin hydroxide a crystallographic and high z curiosity
Crystal Growth & Design, 2011Co-Authors: Kirsty M Anderson, Sarah E Tallentire, Michael R Probert, Andres E Goeta, B G Mendis, Jonathan W SteedAbstract:The remarkable room temperature structure of Trimethyltin hydroxide comprises a total of 32 crystallographically independent SnMe3OH units arranged in four independent coordination polymer strands. We suggest that a Z′ = 4 value is more appropriate than Z′ = 32, reflecting the polymeric structure of the compound. DSC, single crystal and XRPD studies show that on cooling below ca.160 K the structure undergoes a first order phase change to a symmetric Z′ = 1 structure with just one crystallographically unique SnMe3OH unit. The phase change is reversible, and on warming past 176 K the high Z′ structure is regenerated, in an endothermic transition. The Z′ = 1 and 4 structures are an enantiotropic pair, and Trimethyltin hydroxide represents a case where the higher Z′ structure is the most stable form at high temperature with the high Z′ value possibly arising from a consideration of the dynamics of the crystal as a whole.
