The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Gevorkian Es - One of the best experts on this subject based on the ideXlab platform.
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Shifts in phospholipid composition of the nuclear matrix in rat liver cells exposed to insulin
Ukraïnsʹkyĭ biokhimichnyĭ z︠h︡urnal, 2020Co-Authors: Gevorkian Es, Artsruni Ig, Demirkhanian Lo, Derziian NgAbstract:It was shown that the total content of phospholipids of rat liver nuclear matrix increased after in vivo action of insulin (2 units per 100 g of animal weight). At the same time the sphyngomyelin content was increased and the content of phosphatydilcholine and phoshpatydilinositol was decreased significantly under the hormone action. The decreasing of monophosphoinositides amount was accompanied by the increasing of Triphosphoinositides content which indicates the redistribution among the phosphoinositides fractions under the hormone action and may be the result of insulin initiation of phosphoinositide pathway in nuclear membrances.
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Effect of hydrocortisone on composition of polyphosphoinositides in liver cell nuclear membrane and rat brain
Ukraïnsʹkyĭ biokhimichnyĭ z︠h︡urnal, 1999Co-Authors: Gevorkian Es, Artsruni Ig, Demirkhanian Lo, Akopian NrAbstract:The action of hydrocortisone in vivo was shown to cause changes both in the total amount of phospholipids and polyphosphoinositides of rat liver and brain nuclear membranes. The hormone increased the content of five from seven phospholipid fractions including the fraction of monophosphoinositide when acting in concentration and exposition leading to activation of biosynthetic processes. The increasing of monophosphoinositides amount was accompanied by the decreasing of Triphosphoinositides content which indicated the redistribution among the phosphoinositides fractions under the steroid hormone action in both cell types.
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Effect of estradiol on phosphoinositide composition of nuclear membranes of rat brain cells
Ukrainskiĭ biokhimicheskiĭ zhurnal, 1998Co-Authors: Gevorkian Es, Artsruni Ig, Akopian Nr, Demirkhanian LoAbstract:The effect of estradiol on phospholipids and particularly on phosphoinositides of nuclear membranes of rat brain cells at different stages of hormone action was investigated. It was shown that hormone leads to the elevation of phospholipids total amount at the primary and early stages of its action (1 and 4 h after estradiol injection, correspondingly). The increase of content of almost all individual fractions of phospholipids as well as phosphatidylinositol (i.e. monophosphoinositide) was detected. It is remarkable that the monophosphoinositides elevation takes place mainly due to the decrease of di- and especially of Triphosphoinositide. The ratio of Triphosphoinositide/monophosphoinositide decreases more than twice. It was concluded that the ratio of Triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of nuclear membranes for the functioning of Triphosphoinositide regulatory system.
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Effect of estradiol on the rat brain synaptosomal phosphoinositide composition
Voprosy medit︠s︡inskoĭ khimii, 1995Co-Authors: Gevorkian Es, Artsruni Ig, Akopian NrAbstract:The in vivo action of estradiol was shown to cause changes both in the total amount of phosphoinsitides and their individual fractions of rat synaptosomes. The maximum elevated levels of phosphoinositides was revealed on 1-hour exposure to the hormone. It is suggested the redistribution of phosphoinositides at the primary stage (1 hour postinjection) of exposure may rely on the initiation and functioning of the phosphoinositide mechanism, the ratio of Triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of synaptosomal membranes for the functioning of this regulatory system.
Akopian Nr - One of the best experts on this subject based on the ideXlab platform.
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Effect of hydrocortisone on composition of polyphosphoinositides in liver cell nuclear membrane and rat brain
Ukraïnsʹkyĭ biokhimichnyĭ z︠h︡urnal, 1999Co-Authors: Gevorkian Es, Artsruni Ig, Demirkhanian Lo, Akopian NrAbstract:The action of hydrocortisone in vivo was shown to cause changes both in the total amount of phospholipids and polyphosphoinositides of rat liver and brain nuclear membranes. The hormone increased the content of five from seven phospholipid fractions including the fraction of monophosphoinositide when acting in concentration and exposition leading to activation of biosynthetic processes. The increasing of monophosphoinositides amount was accompanied by the decreasing of Triphosphoinositides content which indicated the redistribution among the phosphoinositides fractions under the steroid hormone action in both cell types.
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Effect of estradiol on phosphoinositide composition of nuclear membranes of rat brain cells
Ukrainskiĭ biokhimicheskiĭ zhurnal, 1998Co-Authors: Gevorkian Es, Artsruni Ig, Akopian Nr, Demirkhanian LoAbstract:The effect of estradiol on phospholipids and particularly on phosphoinositides of nuclear membranes of rat brain cells at different stages of hormone action was investigated. It was shown that hormone leads to the elevation of phospholipids total amount at the primary and early stages of its action (1 and 4 h after estradiol injection, correspondingly). The increase of content of almost all individual fractions of phospholipids as well as phosphatidylinositol (i.e. monophosphoinositide) was detected. It is remarkable that the monophosphoinositides elevation takes place mainly due to the decrease of di- and especially of Triphosphoinositide. The ratio of Triphosphoinositide/monophosphoinositide decreases more than twice. It was concluded that the ratio of Triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of nuclear membranes for the functioning of Triphosphoinositide regulatory system.
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Effect of estradiol on the rat brain synaptosomal phosphoinositide composition
Voprosy medit︠s︡inskoĭ khimii, 1995Co-Authors: Gevorkian Es, Artsruni Ig, Akopian NrAbstract:The in vivo action of estradiol was shown to cause changes both in the total amount of phosphoinsitides and their individual fractions of rat synaptosomes. The maximum elevated levels of phosphoinositides was revealed on 1-hour exposure to the hormone. It is suggested the redistribution of phosphoinositides at the primary stage (1 hour postinjection) of exposure may rely on the initiation and functioning of the phosphoinositide mechanism, the ratio of Triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of synaptosomal membranes for the functioning of this regulatory system.
Demirkhanian Lo - One of the best experts on this subject based on the ideXlab platform.
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Shifts in phospholipid composition of the nuclear matrix in rat liver cells exposed to insulin
Ukraïnsʹkyĭ biokhimichnyĭ z︠h︡urnal, 2020Co-Authors: Gevorkian Es, Artsruni Ig, Demirkhanian Lo, Derziian NgAbstract:It was shown that the total content of phospholipids of rat liver nuclear matrix increased after in vivo action of insulin (2 units per 100 g of animal weight). At the same time the sphyngomyelin content was increased and the content of phosphatydilcholine and phoshpatydilinositol was decreased significantly under the hormone action. The decreasing of monophosphoinositides amount was accompanied by the increasing of Triphosphoinositides content which indicates the redistribution among the phosphoinositides fractions under the hormone action and may be the result of insulin initiation of phosphoinositide pathway in nuclear membrances.
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Effect of hydrocortisone on composition of polyphosphoinositides in liver cell nuclear membrane and rat brain
Ukraïnsʹkyĭ biokhimichnyĭ z︠h︡urnal, 1999Co-Authors: Gevorkian Es, Artsruni Ig, Demirkhanian Lo, Akopian NrAbstract:The action of hydrocortisone in vivo was shown to cause changes both in the total amount of phospholipids and polyphosphoinositides of rat liver and brain nuclear membranes. The hormone increased the content of five from seven phospholipid fractions including the fraction of monophosphoinositide when acting in concentration and exposition leading to activation of biosynthetic processes. The increasing of monophosphoinositides amount was accompanied by the decreasing of Triphosphoinositides content which indicated the redistribution among the phosphoinositides fractions under the steroid hormone action in both cell types.
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Effect of estradiol on phosphoinositide composition of nuclear membranes of rat brain cells
Ukrainskiĭ biokhimicheskiĭ zhurnal, 1998Co-Authors: Gevorkian Es, Artsruni Ig, Akopian Nr, Demirkhanian LoAbstract:The effect of estradiol on phospholipids and particularly on phosphoinositides of nuclear membranes of rat brain cells at different stages of hormone action was investigated. It was shown that hormone leads to the elevation of phospholipids total amount at the primary and early stages of its action (1 and 4 h after estradiol injection, correspondingly). The increase of content of almost all individual fractions of phospholipids as well as phosphatidylinositol (i.e. monophosphoinositide) was detected. It is remarkable that the monophosphoinositides elevation takes place mainly due to the decrease of di- and especially of Triphosphoinositide. The ratio of Triphosphoinositide/monophosphoinositide decreases more than twice. It was concluded that the ratio of Triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of nuclear membranes for the functioning of Triphosphoinositide regulatory system.
Artsruni Ig - One of the best experts on this subject based on the ideXlab platform.
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Shifts in phospholipid composition of the nuclear matrix in rat liver cells exposed to insulin
Ukraïnsʹkyĭ biokhimichnyĭ z︠h︡urnal, 2020Co-Authors: Gevorkian Es, Artsruni Ig, Demirkhanian Lo, Derziian NgAbstract:It was shown that the total content of phospholipids of rat liver nuclear matrix increased after in vivo action of insulin (2 units per 100 g of animal weight). At the same time the sphyngomyelin content was increased and the content of phosphatydilcholine and phoshpatydilinositol was decreased significantly under the hormone action. The decreasing of monophosphoinositides amount was accompanied by the increasing of Triphosphoinositides content which indicates the redistribution among the phosphoinositides fractions under the hormone action and may be the result of insulin initiation of phosphoinositide pathway in nuclear membrances.
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Effect of hydrocortisone on composition of polyphosphoinositides in liver cell nuclear membrane and rat brain
Ukraïnsʹkyĭ biokhimichnyĭ z︠h︡urnal, 1999Co-Authors: Gevorkian Es, Artsruni Ig, Demirkhanian Lo, Akopian NrAbstract:The action of hydrocortisone in vivo was shown to cause changes both in the total amount of phospholipids and polyphosphoinositides of rat liver and brain nuclear membranes. The hormone increased the content of five from seven phospholipid fractions including the fraction of monophosphoinositide when acting in concentration and exposition leading to activation of biosynthetic processes. The increasing of monophosphoinositides amount was accompanied by the decreasing of Triphosphoinositides content which indicated the redistribution among the phosphoinositides fractions under the steroid hormone action in both cell types.
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Effect of estradiol on phosphoinositide composition of nuclear membranes of rat brain cells
Ukrainskiĭ biokhimicheskiĭ zhurnal, 1998Co-Authors: Gevorkian Es, Artsruni Ig, Akopian Nr, Demirkhanian LoAbstract:The effect of estradiol on phospholipids and particularly on phosphoinositides of nuclear membranes of rat brain cells at different stages of hormone action was investigated. It was shown that hormone leads to the elevation of phospholipids total amount at the primary and early stages of its action (1 and 4 h after estradiol injection, correspondingly). The increase of content of almost all individual fractions of phospholipids as well as phosphatidylinositol (i.e. monophosphoinositide) was detected. It is remarkable that the monophosphoinositides elevation takes place mainly due to the decrease of di- and especially of Triphosphoinositide. The ratio of Triphosphoinositide/monophosphoinositide decreases more than twice. It was concluded that the ratio of Triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of nuclear membranes for the functioning of Triphosphoinositide regulatory system.
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Effect of estradiol on the rat brain synaptosomal phosphoinositide composition
Voprosy medit︠s︡inskoĭ khimii, 1995Co-Authors: Gevorkian Es, Artsruni Ig, Akopian NrAbstract:The in vivo action of estradiol was shown to cause changes both in the total amount of phosphoinsitides and their individual fractions of rat synaptosomes. The maximum elevated levels of phosphoinositides was revealed on 1-hour exposure to the hormone. It is suggested the redistribution of phosphoinositides at the primary stage (1 hour postinjection) of exposure may rely on the initiation and functioning of the phosphoinositide mechanism, the ratio of Triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of synaptosomal membranes for the functioning of this regulatory system.
M. O. Samoilov - One of the best experts on this subject based on the ideXlab platform.
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Levels and metabolism of phosphoinositides in the cerebral cortex of rats during anoxia and in the early period of reoxygenation
Bulletin of Experimental Biology and Medicine, 1994Co-Authors: T. E. Raize, M. O. SamoilovAbstract:During anoxia lasting for 50 sec, the levels of Triphosphoinositide and diphosphoinositide in the rat cerebral cortex declined while the metabolic rate of their phosphate groups sharply increased. Thirty minutes after the resumption of oxygen supply their levels rose above the control values, while by the 60th min of the postanoxic period a tendency toward normalization of their metabolism was observed. No significant changes were noted either in levels or metabolism of monophosphoinositide and total phospholipids under the experimental conditions used.
