The Experts below are selected from a list of 60 Experts worldwide ranked by ideXlab platform
G Tudorwilliams - One of the best experts on this subject based on the ideXlab platform.
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mmr Vaccine in hiv infected children potential hazards
Vaccine, 2001Co-Authors: P Goon, B Cohen, L Jin, R Watkins, G TudorwilliamsAbstract:Although given routinely as prophylaxis against wild-type measles to HIV-infected children, the live attenuated measles component of the MMR Triple Vaccine also possesses potential for disease. We document a case of measles proven to be caused by Vaccine strain in a HIV-infected child here in the UK and discuss the clinical and immunological aspects. We also consider the new guidelines for MMR vaccination in HIV-infected children adopted last year in the USA.
Bernard Dixon - One of the best experts on this subject based on the ideXlab platform.
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Triple Vaccine fears mask media efforts at balance
Current Biology, 2002Co-Authors: Bernard DixonAbstract:“It's all a result of scaremongering by the media,” said a general practitioner, speaking on a British breakfast TV station on 8 February. She was referring to public concern in Britain over the alleged risks of MMR (measles, mumps, rubella) Vaccine. This has meant that uptake of the Vaccine has declined steeply in some parts of the country, leading to significant increases in the numbers of children developing measles in London and elsewhere.As a GP constantly trying but failing to reassure parents that the overwhelming weight of evidence supports the safety of MMR Vaccine, her irritation was understandable. Many people have been more convinced by a single claim, publicised in the media, linking MMR immunisation with autism and inflammatory bowel disease (Current Biology, 16 October 2001, R807).They have remained unimpressed by warnings of the very real dangers associated with all three diseases. And the confident ignorance of certain journalists has not helped. “My mother had measles. I had measles. My daughter had measles…So why, all of a sudden, do we speak of ‘outbreaks’, as if it were typhoid or cholera?” wrote Carol Sarler in the Daily Express.The situation has also been exacerbated by the steadfast refusal of the Prime Minister to say whether his baby son has received the Vaccine. “Tony Blair's secrecy has alarmed parents, which is why the number of children having the jabs has fallen dramatically,” wrote Lynda Lee-Potter in the Daily Mail. “If there is a measles epidemic, it will be his fault.” A further complication, as highlighted by the Patients Association, is that some GPs have begun to strike off their lists the names of parents who decline MMR Vaccine for their offspring.But have journalists really been responsible for the hysteria and the dangerous situation which the UK Department of Health has now been trying so hard to address?A dispassionate examination of media coverage across the board reveals a rather different picture. Journalists did, of course, report Andrew Wakefield's original claim in 1998 linking MMR Vaccine with autism. Yet textual analysis shows that most newspapers have at least tried to produce rational and balanced coverage, and that most have succeeded rather well. The Guardian, for example, assembled a dossier headed “The facts” which emphasised the results of extensive studies in the UK and elsewhere that have contradicted Wakefield's claim, which was based on a very small sample. The dossier also showed that there was no scientific evidence that the Triple Vaccine was less safe than monovalent ones — whose use would leave children alarmingly exposed.Other broadsheet newspapers published similar evidence — as too did most of the mass market tabloids. The Daily ExpressDaily Express, for example, ran a double-page spread headed “Vaccinate — or risk your child's life”. This was accompanied by an editorial suggesting that parents be given the choice of single Vaccines, simply because so many of them were rejecting the MMR shot. However, the main article stated prominently that the WHO and other authorities throughout the world believe MMR to be safe.Fig. 1Tabloid worries: One of the British newspapers concerned about the MMR Vaccine and lower uptake leading to new measles outbreaks.View Large Image | View Hi-Res Image | Download PowerPoint SlideAnother tabloid, The Mirror, went even further and attacked two of its competitors. “Who backs combined MMR jab?” the paper asked in bold type. The answer was a list of organisations, from the British Medical Association to the Royal College of Nursing. “And who doesn't?… Answer: The Sun and Daily Mail”.The Mirror's dossier was backed by an editorial beginning “Consider the facts. In 90 countries MMR is used to inoculate children. The UK is the only one in which there is any suggestion it is not safe.” Reminding readers that a similar scare over pertussis inoculation 20 years ago led to the deaths of more than 100 children, the editorial concluded: “The real threat today is not from giving children MMR but from not giving it to them”.Likewise, The Times pointed out that children receiving MMR immunisation do not face an increased risk of autism; that autism victims are not more likely than anyone else to have had the Vaccine; and that, although diagnosed autism has been increasing, there has been no correlation with vaccination. “These are the conclusions of studies from around the world by independent and reputable researchers…The rest is unsupported allegation, tragic but unrepresentative anecdote and scaremongering.”The second of these three factors may well have been the most significant in shaping public opinion. That, linked with blows to public confidence in fields such as BSE and GM food, could have had a more far-reaching influence than the machinations of the media.There is at least one reassuring feature of the MMR furore in the media. This is the repeated request — even by commentators opposed to the Vaccine — for “more research”. There have been few if any calls for MMR immunisation to be abandoned in favour of crystal therapy, homeopathy or tender loving care. What is advocated, whether by parents or journalists, is more extensive research — real, scientific research. That hardly accords with the fears of some scientists that the public is rejecting medical science and espousing irrationality.
P Goon - One of the best experts on this subject based on the ideXlab platform.
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mmr Vaccine in hiv infected children potential hazards
Vaccine, 2001Co-Authors: P Goon, B Cohen, L Jin, R Watkins, G TudorwilliamsAbstract:Although given routinely as prophylaxis against wild-type measles to HIV-infected children, the live attenuated measles component of the MMR Triple Vaccine also possesses potential for disease. We document a case of measles proven to be caused by Vaccine strain in a HIV-infected child here in the UK and discuss the clinical and immunological aspects. We also consider the new guidelines for MMR vaccination in HIV-infected children adopted last year in the USA.
Alberto Juan Dorta Contreras - One of the best experts on this subject based on the ideXlab platform.
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neuroimmunological approach for evaluation of viral measles mumps and rubella Triple Vaccine
Revista Cubana de Investigaciones Biomédicas, 2019Co-Authors: William Castillo Gonzalez, Mileydis Cruz Quevedo, Jose Alejandro Rodriguez Perez, Eneida Barrios Lamoth, Cristobal Gonzalez Losada, Alberto Juan Dorta ContrerasAbstract:Introduction: During the neuroinflammatory processes there are a poly-specific and polyclonal activation in the cerebrospinal fluid. It means that there can be quantified antibodies against all the components of the Vaccines may have received. Objective: To evaluate the immune response against measles, mumps and rubella in vaccinated pediatric patients. Methods: All the serum and cerebrospinal fluid (CSF) paired samples from pediatric patients with neurological symptoms, that were submitted to hospitals from Havana City and were performed a lumbar puncture, were collected. Serum and CSF IgG, albumin were measured by immune-diffusion techniques using NOR and LC Partigen Immunoplates (Siemens, Marburg) and specific antibodies against measles, mumps and rubella were quantified by ELISA kits (Enzygnost, Siemens, Marburg). Reibergrams were employed in order to determine if there was IgG intrathecal synthesis. Later on, antibody index against the specific virus were calculated. Results: In all the neuroimmune inflammation process were found antibody index against measles, mumps and rubella in a different ample confidence variation among the different virus. Antibodies against mumps are significantly different from the other ones. It could be due to a natural different immune response or due to a deficient Vaccine quality lot. Also it was possible to identify six pediatric patients that had no immune antibody index at all. It coincides with a transient hypogammaglobulinemia of infancy in such patients. Conclusions: This neuroimmunological approach can be used to evaluate the immune status in pediatric population.
Correa Werneck - One of the best experts on this subject based on the ideXlab platform.
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estudo colaborativo nacional para o estabelecimento do material de referencia de trabalho da vacina contra sarampo caxumba e rubeola evolucao para a autossuficencia na producao nacional da vacina triplice viral national collaborative study for establ
2015Co-Authors: Danielle Da Silva Almeida, Paulo Cesar Dick, Carlos Jose Da Silva, Ingrid Pinheiro De Medeiros, Carina Cantelli, Pacheco De Oliveira, Darcy Akemi Hokama, Jarbas Emilio, Lucia Maria, Correa WerneckAbstract:The pharmacopoeia monograph for the measles/mumps and rubella (MMR) Triple Vaccine demands to perform the validation of the potency assay by using the suitable reference material (MR). Aiming at establishing the first work MR (MRT) for the MMR Triple Vaccine, a national collaborative study was performed with the participation of the two unique national institutions working on the Vaccine potency evaluation test, the Imunobiological Technology Institute (Bio-Manguinhos, national manufacturer) and the National Institute for Quality Control in Health. The candidate product (cMRT Bio) prepared by the manufacturer was evaluated by the participant laboratories by employing the respective in-house methodologies for determining the potency. The cMRTBio was considered suitable as in-house MR, according to the specifications based on the normative compendia, being the intra-assay (< 5 %), inter-assay (< 10 %) and between laboratories variations (< 10 %) below the acceptable limits, and the estimate potency (log 10 CCID50/DH) in 3.72 for measles, 4.80 for mumps and 3.70 for rubella. This study reflects the commitment of the unique national MMR Vaccine producer to the public health, describing the expansion of technology, the compliance with international guidelines and the careful quality control, leading to the national self-sufficiency in the Vaccine production.
