Triterpene Derivative

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Augustin Ephrem Nkengfack - One of the best experts on this subject based on the ideXlab platform.

  • Chemical constituents from leaves and trunk bark of Rinorea oblongifolia (Violaceae).
    Natural product research, 2019
    Co-Authors: Aristide Mfifen Munvera, Blandine Marlyse Wache Ouahouo, Pierre Mkounga, Michelle Ines Kanko Mbekou, Shehla Nuzhat, Muhammad Iqbal Choudhary, Augustin Ephrem Nkengfack
    Abstract:

    Two new coruleoellagic acid Derivatives, 3,4′,5,5′,-tetramethylcoruleoellagic acid (1); 3′,4,4′,5,5′-pentamethylcoruleoellagic acid (2) and a new friedelane-type Triterpene Derivative rinol (5), we...

  • Chemical constituents from leaves and trunk bark of Rinorea oblongifolia (Violaceae)
    2019
    Co-Authors: Aristide Mfifen Munvera, Blandine Marlyse Wache Ouahouo, Pierre Mkounga, Michelle Ines Kanko Mbekou, Shehla Nuzhat, Muhammad Iqbal Choudhary, Augustin Ephrem Nkengfack
    Abstract:

    Two new coruleoellagic acid Derivatives, 3,4′,5,5′,-tetramethylcoruleoellagic acid (1); 3′,4,4′,5,5′-pentamethylcoruleoellagic acid (2) and a new friedelane-type Triterpene Derivative rinol (5), were isolated from leaves and trunk bark of Rinorea oblongifolia (Violaceae) along with seven known compounds including 3,3′,4,4′,5′-pentamethylcoruleoellagic acid (3), hexamethylcoruleoellagic acid (4), 28-hydroxyfriedelin (6), friedelin (7), friedelan-3-ol (8), scopoletin (9) and β-sitosterol-3-O-β-D-glucopyranoside (10). Their structures were elucidated by means of spectroscopic methods including IR, 1D and 2D NMR in conjunction with mass spectrometry. Crude extracts of leaves and trunk bark as well as compounds 1–4 were evaluated for their antibacterial activities against 7 pathogenic bacterial strains (Streptococcus pneumoniae ATCC49619, Staphylococcus aureus ATCC 43300, Klepsiella pneumoniae ATCC 700603, Haemophilus influenza ATCC 49247, Escherichia coli ATCC 25922, Pseudomonas aeruginosa HM601, Staphylococcus aureus BAA 977). Compound (3) displayed noteworthy activity against Haemophilus influenza with MIC value of 9.38 µg/mL.

Douglas A Kinghorn - One of the best experts on this subject based on the ideXlab platform.

  • activity guided fractionation of the seeds of ziziphus jujuba using a cyclooxygenase 2 inhibitory assay
    Planta Medica, 2002
    Co-Authors: Muriel Cuendet, Norman R Farnsworth, Harry H S Fong, John M Pezzuto, Douglas A Kinghorn
    Abstract:

    Bioactivity-guided fractionation of petroleum ether- and EtOAc-soluble extracts of the seeds of Ziziphus jujuba using a cyclooxygenase-2 assay as a monitor indicated that the triglyceride, 1,3-di-O-[9(Z)-octadecenoyl]-2-O-[9(Z),12(Z)-octadecadienoyl]glycerol (3), and a fatty acid mixture of linoleic, oleic and stearic acids, were the major active components. A new pentacyclic lupane-type Triterpene Derivative, 3-O-[9(Z)-octadecenoyl]betulinic acid (1), and betulinic acid (2) were also isolated and identified. All isolates as well as pure linoleic, oleic and stearic acids were evaluated for their inhibitory effects against both cyclooxygenases-1 (COX-1) and -2 (COX-2).

  • activity guided fractionation of the seeds of ziziphus jujuba using a cyclooxygenase 2 inhibitory assay
    Planta Medica, 2002
    Co-Authors: Baoning Su, Muriel Cuendet, Norman R Farnsworth, Harry H S Fong, John M Pezzuto, Douglas A Kinghorn
    Abstract:

    : Bioactivity-guided fractionation of petroleum ether- and EtOAc-soluble extracts of the seeds of Ziziphus jujuba using a cyclooxygenase-2 assay as a monitor indicated that the triglyceride, 1,3-di-O-[9(Z)-octadecenoyl]-2-O-[9(Z),12(Z)-octadecadienoyl]glycerol (3), and a fatty acid mixture of linoleic, oleic and stearic acids, were the major active components. A new pentacyclic lupane-type Triterpene Derivative, 3-O-[9(Z)-octadecenoyl]betulinic acid (1), and betulinic acid (2) were also isolated and identified. All isolates as well as pure linoleic, oleic and stearic acids were evaluated for their inhibitory effects against both cyclooxygenases-1 (COX-1) and -2 (COX-2).

Aristide Mfifen Munvera - One of the best experts on this subject based on the ideXlab platform.

  • Chemical constituents from leaves and trunk bark of Rinorea oblongifolia (Violaceae).
    Natural product research, 2019
    Co-Authors: Aristide Mfifen Munvera, Blandine Marlyse Wache Ouahouo, Pierre Mkounga, Michelle Ines Kanko Mbekou, Shehla Nuzhat, Muhammad Iqbal Choudhary, Augustin Ephrem Nkengfack
    Abstract:

    Two new coruleoellagic acid Derivatives, 3,4′,5,5′,-tetramethylcoruleoellagic acid (1); 3′,4,4′,5,5′-pentamethylcoruleoellagic acid (2) and a new friedelane-type Triterpene Derivative rinol (5), we...

  • Chemical constituents from leaves and trunk bark of Rinorea oblongifolia (Violaceae)
    2019
    Co-Authors: Aristide Mfifen Munvera, Blandine Marlyse Wache Ouahouo, Pierre Mkounga, Michelle Ines Kanko Mbekou, Shehla Nuzhat, Muhammad Iqbal Choudhary, Augustin Ephrem Nkengfack
    Abstract:

    Two new coruleoellagic acid Derivatives, 3,4′,5,5′,-tetramethylcoruleoellagic acid (1); 3′,4,4′,5,5′-pentamethylcoruleoellagic acid (2) and a new friedelane-type Triterpene Derivative rinol (5), were isolated from leaves and trunk bark of Rinorea oblongifolia (Violaceae) along with seven known compounds including 3,3′,4,4′,5′-pentamethylcoruleoellagic acid (3), hexamethylcoruleoellagic acid (4), 28-hydroxyfriedelin (6), friedelin (7), friedelan-3-ol (8), scopoletin (9) and β-sitosterol-3-O-β-D-glucopyranoside (10). Their structures were elucidated by means of spectroscopic methods including IR, 1D and 2D NMR in conjunction with mass spectrometry. Crude extracts of leaves and trunk bark as well as compounds 1–4 were evaluated for their antibacterial activities against 7 pathogenic bacterial strains (Streptococcus pneumoniae ATCC49619, Staphylococcus aureus ATCC 43300, Klepsiella pneumoniae ATCC 700603, Haemophilus influenza ATCC 49247, Escherichia coli ATCC 25922, Pseudomonas aeruginosa HM601, Staphylococcus aureus BAA 977). Compound (3) displayed noteworthy activity against Haemophilus influenza with MIC value of 9.38 µg/mL.

M M Cabo - One of the best experts on this subject based on the ideXlab platform.

  • antioxidant activity of maslinic acid a Triterpene Derivative obtained from olea europaea
    Planta Medica, 2003
    Co-Authors: M P Montilla, Ahmad Agil, M C Navarro, M I Jimenez, Andres Garciagranados, Andres Parra, M M Cabo
    Abstract:

    We investigated the effect of maslinic acid (a Triterpene Derivative obtained from olive pomace), on the susceptibility of plasma or hepatocyte membranes to lipid peroxidation (LPO), induced respectively by the hydroxyl radical (OH-) generated by Fe 2+ / H 2 O 2 ex vivo and by the system Fe 3+ /ascorbate in vitro; moreover, three groups of animals used in the plasma study were pretreated with CCl 4 (to generate CCl 3 -.). Endogenous plasma lipoperoxide levels and susceptibility to LPO were decreased in rats treated with maslinic acid, after exposure to OH by Fe 2+ /H 2 O 2 (Fenton reaction). Co-incubation with maslinic acid prevented hepatocyte membrane LPO as shown by the reduction of TBARS. In conclusion, maslinic acid may offer some advantages in the resistance of oxidative stress in the animals.

Muriel Cuendet - One of the best experts on this subject based on the ideXlab platform.

  • activity guided fractionation of the seeds of ziziphus jujuba using a cyclooxygenase 2 inhibitory assay
    Planta Medica, 2002
    Co-Authors: Muriel Cuendet, Norman R Farnsworth, Harry H S Fong, John M Pezzuto, Douglas A Kinghorn
    Abstract:

    Bioactivity-guided fractionation of petroleum ether- and EtOAc-soluble extracts of the seeds of Ziziphus jujuba using a cyclooxygenase-2 assay as a monitor indicated that the triglyceride, 1,3-di-O-[9(Z)-octadecenoyl]-2-O-[9(Z),12(Z)-octadecadienoyl]glycerol (3), and a fatty acid mixture of linoleic, oleic and stearic acids, were the major active components. A new pentacyclic lupane-type Triterpene Derivative, 3-O-[9(Z)-octadecenoyl]betulinic acid (1), and betulinic acid (2) were also isolated and identified. All isolates as well as pure linoleic, oleic and stearic acids were evaluated for their inhibitory effects against both cyclooxygenases-1 (COX-1) and -2 (COX-2).

  • activity guided fractionation of the seeds of ziziphus jujuba using a cyclooxygenase 2 inhibitory assay
    Planta Medica, 2002
    Co-Authors: Baoning Su, Muriel Cuendet, Norman R Farnsworth, Harry H S Fong, John M Pezzuto, Douglas A Kinghorn
    Abstract:

    : Bioactivity-guided fractionation of petroleum ether- and EtOAc-soluble extracts of the seeds of Ziziphus jujuba using a cyclooxygenase-2 assay as a monitor indicated that the triglyceride, 1,3-di-O-[9(Z)-octadecenoyl]-2-O-[9(Z),12(Z)-octadecadienoyl]glycerol (3), and a fatty acid mixture of linoleic, oleic and stearic acids, were the major active components. A new pentacyclic lupane-type Triterpene Derivative, 3-O-[9(Z)-octadecenoyl]betulinic acid (1), and betulinic acid (2) were also isolated and identified. All isolates as well as pure linoleic, oleic and stearic acids were evaluated for their inhibitory effects against both cyclooxygenases-1 (COX-1) and -2 (COX-2).

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