Tropical Diseases

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Peter J. Hotez - One of the best experts on this subject based on the ideXlab platform.

  • world neglected Tropical Diseases day
    PLOS Neglected Tropical Diseases, 2020
    Co-Authors: Peter J. Hotez, Serap Aksoy, Paul J Brindley, Shaden Kamhawi
    Abstract:

    January 30, 2020 is the first-ever World Neglected Tropical Diseases Day (World NTD Day), a day when we celebrate the achievements made towards control of the world’s NTDs, yet recognize the daunting challenges we face in the control and elimination of these conditions.

  • Whatever happened to China’s neglected Tropical Diseases?
    Infectious Diseases of Poverty, 2019
    Co-Authors: Peter J. Hotez
    Abstract:

    Before the founding of the People’s Republic of China 70 years ago, both extreme poverty and parasitic infections and other neglected Tropical Diseases were highly prevalent. Owing to social development, particularly economic reforms since the 1980s, poverty has since been dramatically reduced, and China became increasingly urbanized and industrialized. In parallel, China’s economic transformation translated into similar and remarkable reductions in neglected Tropical Diseases. Qian and colleagues report in their review published in Infectious Diseases of Poverty, the elimination or near elimination as a public health problem of lymphatic filariasis, trachoma, soil-transmitted helminth infections, schistosomiasis and other neglected Tropical Diseases. Of note, neglected Tropical disease control and poverty reduction each appear to reinforce the other. China’s formula for success in parasitic and neglected Tropical disease control might translate to other parts of the world, such as in sub-Saharan Africa through China’s new Belt and Road Initiative.

  • southern europe s coming plagues vector borne neglected Tropical Diseases
    PLOS Neglected Tropical Diseases, 2016
    Co-Authors: Peter J. Hotez
    Abstract:

    New social and environmental forces, including economic downturns, climate change, and human migrations from the Middle East and North Africa, are merging into a “perfect storm” to promote the widespread emergence of neglected Tropical Diseases (NTDs) in Southern Europe.

  • ten global hotspots for the neglected Tropical Diseases
    PLOS Neglected Tropical Diseases, 2014
    Co-Authors: Peter J. Hotez
    Abstract:

    Since the founding of PLOS Neglected Tropical Diseases more than six years ago, I have written about the interface between disease and geopolitics. The neglected Tropical Diseases (NTDs) are the world's most common infections of people living in poverty [1]. Where they are widespread in affected communities and nations, NTDs can be highly destabilizing and ultimately may promote conflict and affect international and foreign policy [2]. Many of the published papers in this area were recently re-organized in a PLOS “Geopolitics of Neglected Tropical Diseases” collection that was posted on our website in the fall of 2012, coinciding with the start of our sixth anniversary [3]. From this information, a number of new and interesting findings emerged about the populations who are most vulnerable to the NTDs, including the extreme poor who live in the large, middle-income countries and even some wealthy countries (such as the United States) that comprise the Group of Twenty (G20) countries [4], as well as selected Aboriginal populations [5]. Together, the PLOS “Geopolitics of Neglected Tropical Diseases” collection and the G20 analyses identified more than a dozen areas of the world that repeatedly show up as ones where NTDs disproportionately affect the poorest people living at the margins. Here, I summarize what I view as ten of the worst global “hotspots” where NTDs predominate (Figure 1). They represent regions of the world that will require special emphasis for NTD control and elimination if we still aspire to meet Millennium Development Goals (MDGs) and targets by 2015; they are regions that may need to be highlighted again as we consider post-MDG aspirations and new Sustainable Development Goals (SDGs). Figure 1 Ten neglected Tropical disease “hotspots” around the globe.

  • elimination and eradication of neglected Tropical Diseases with mass drug administrations a survey of experts
    PLOS Neglected Tropical Diseases, 2013
    Co-Authors: Jeremy D Keenan, Peter J. Hotez, Abdou Amza, Nicole E Stoller, Bruce D Gaynor, Travis C Porco, Thomas M Lietman
    Abstract:

    Background Lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths, and trachoma are the five most prevalent neglected Tropical Diseases in the world, and each is frequently treated with mass drug administrations. We performed a survey of neglected Tropical Diseases experts to elicit their opinions on the role of mass drug administrations for the elimination of these infections.

David H. Molyneux - One of the best experts on this subject based on the ideXlab platform.

  • Neglected Tropical Diseases 4. Socioeconomic aspects of neglected Tropical Diseases.
    The Lancet, 2010
    Co-Authors: Lesong Conteh, Thomas Engels, David H. Molyneux
    Abstract:

    Although many examples of highly cost-eff ective interventions to control neglected Tropical Diseases exist, our understanding of the full economic eff ect that these Diseases have on individuals, households, and nations needs to be improved to target interventions more eff ectively and equitably. We review data for the eff ect of neglected Tropical Diseases on a population’s health and economy. We also present evidence on the costs, cost-eff ectiveness, and fi nancing of strategies to monitor, control, or reduce morbidity and mortality associated with these Diseases. We explore the potential for economies of scale and scope in terms of the costs and benefi ts of successfully delivering large-scale and integrated interventions. The low cost of neglected Tropical disease control is driven by four factors: the commitment of pharmaceutical companies to provide free drugs; the scale of programmes; the opportunities for synergising delivery modes; and the often non-remunerated volunteer contribution of communities and teachers in drug distribution. Finally, we make suggestions for future economic research.

  • socioeconomic aspects of neglected Tropical Diseases
    The Lancet, 2010
    Co-Authors: Lesong Conteh, Thomas Engels, David H. Molyneux
    Abstract:

    Although many examples of highly cost-effective interventions to control neglected Tropical Diseases exist, our understanding of the full economic effect that these Diseases have on individuals, households, and nations needs to be improved to target interventions more effectively and equitably. We review data for the effect of neglected Tropical Diseases on a population's health and economy. We also present evidence on the costs, cost-effectiveness, and financing of strategies to monitor, control, or reduce morbidity and mortality associated with these Diseases. We explore the potential for economies of scale and scope in terms of the costs and benefits of successfully delivering large-scale and integrated interventions. The low cost of neglected Tropical disease control is driven by four factors: the commitment of pharmaceutical companies to provide free drugs; the scale of programmes; the opportunities for synergising delivery modes; and the often non-remunerated volunteer contribution of communities and teachers in drug distribution. Finally, we make suggestions for future economic research.

  • rescuing the bottom billion through control of neglected Tropical Diseases
    The Lancet, 2009
    Co-Authors: Peter J. Hotez, Lorenzo Savioli, Alan Fenwick, David H. Molyneux
    Abstract:

    Here we outline low-cost opportunities to control the neglected Tropical Diseases through preventive chemotherapy, and propose fi nancial innovations to provide poor individuals with essential drugs.13 parasitic (helminthic and protozoan) and bacterial Tropical infections, and dengue are the highest-burden neglected Tropical Diseases; another 20 include fungal, viral, and ectoparasitic infections (panel 2).

  • control of neglected Tropical Diseases
    The New England Journal of Medicine, 2007
    Co-Authors: Peter J. Hotez, Jeffrey D. Sachs, David H. Molyneux, Alan Fenwick, Jacob Kumaresan, Sonia Ehrlich Sachs, Lorenzo Savioli
    Abstract:

    In addition to malaria, tuberculosis, and human immunodeficiency virus infection, several other infectious Diseases are associated with substantial morbidity and mortality. In particular, 13 Tropical Diseases infect billions of people and cause disabilities such as blindness and heart failure, especially in persons who live in impoverished conditions. This review article describes approaches to the global control of these Diseases.

Janis K Lazdins - One of the best experts on this subject based on the ideXlab platform.

  • strategic emphases for Tropical Diseases research a tdr perspective
    Trends in Microbiology, 2002
    Co-Authors: J Remme, Erik Blas, Lester Chitsulo, Philippe M P Desjeux, Howard Engers, Thomas P Kanyok, Jane Kengeya F Kayondo, Deborah W Kioy, Vasanthapuram Kumaraswami, Janis K Lazdins
    Abstract:

    Abstract Setting priorities for health research is a difficult task, especially for the neglected Diseases of the poor. A new approach to priority setting for Tropical Diseases research has been adopted by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (known as the TDR). Priorities are defined on the basis of a comprehensive analysis of research needs and research opportunities for each of the ten major Tropical Diseases in the TDR portfolio. The resulting strategic emphases matrix reflects the priorities for Tropical Diseases research from the perspective of the TDR. Its purpose is not to impose global research priorities, but we believe the results could be useful to other organizations.

Alessandro Bartoloni - One of the best experts on this subject based on the ideXlab platform.

  • Spectrum and burden of neglected Tropical Diseases observed in an infectious and Tropical Diseases unit in Florence, Italy (2000–2015)
    Internal and Emergency Medicine, 2017
    Co-Authors: Lorenzo Zammarchi, Iacopo Vellere, Leonardo Stella, Filippo Bartalesi, Marianne Strohmeyer, Alessandro Bartoloni
    Abstract:

    Neglected Tropical Diseases (NTDs) are a diverse group of acute and chronic conditions with distinct characteristics that thrive mainly among the poorest populations, almost exclusively in Tropical countries. To evaluate the relevance and impact of NTDs in a temperate area, the number and features of patients diagnosed with NTDs at the Infectious and Tropical Diseases Unit (ITDU), Azienda Ospedaliero-Universitaria Careggi, Florence, Italy between 2000 and 2015 were retrospectively reviewed. Overall 289 NTD cases were diagnosed in 283 subjects accounting for 2.4% of all patients accessing the center: 96 dengue, 62 schistosomiasis, 36 strongyloidiasis, 22 cystic echinococcosis, 19 Chagas disease, 14 leishmaniasis, 11 chikungunya, 10 cysticercosis, 6 soil-transmitted helminthiasis, 6 lymphatic filariasis, 3 trachoma, 2 onchocerciasis, and 2 leprosy. There was one fatal case of disseminated strongyloidiasis. According to the type of exposure, 145 (50.2%) NTDs were diagnosed in immigrants, 121 (41.9%) in travelers, 18 (6.3%) were autochthonous infections, while in 5 cases (1.7%), the type of exposure was unknown. The number of patients seen at the ITDU with a diagnosis of NTD increased over time (from 29 in 2000–2005 to 81 in 2006–2010, to 173 in 2011–2015). Late diagnosis and mismanagement before coming to the center were common features in several cases. Considering the increasing incidence and possible misdiagnosis of NTDs in non-endemic countries, to raise awareness about NTDs among health care providers seems to be of primary concern.

Anthony W Solomon - One of the best experts on this subject based on the ideXlab platform.

  • a diagnostics platform for the integrated mapping monitoring and surveillance of neglected Tropical Diseases rationale and target product profiles
    PLOS Neglected Tropical Diseases, 2012
    Co-Authors: Anthony W Solomon, Dirk Engels, Junhu Chen, Robin L Bailey, Isobel M Blake, Simon Brooker, Jiaxu Chen, Thomas S Churcher, Chris Drakeley, Tansy Edwards
    Abstract:

    JX; Chen, JH; Churcher, TS; Drakeley, CJ; Edwards, T; Fenwick, A; French, M; Gabrielli, AF; Grassly, NC; Harding-Esch, EM; Holland, MJ; Koukounari, A; Lammie, PJ; Leslie, J; Mabey, DC; Rhajaoui, M; Secor, WE; Stothard, JR; Wei, H; Willingham, AL; Zhou, XN; Peeling, RW (2012) A diagnostics platform for the integrated mapping, monitoring, and surveillance of neglected Tropical Diseases: rationale and target product profiles. PLoS neglected Tropical Diseases, 6 (7). e1746. ISSN 1935-2727

  • neglected Tropical Diseases
    British Medical Bulletin, 2010
    Co-Authors: Nicholas A Feasey, Mark Wansbroughjones, David Mabey, Anthony W Solomon
    Abstract:

    Introduction: The neglected Tropical Diseases (NTDs) are infectious Diseases that principally impact the world’s poorest people. They have been neglected for decades, initially as part of a general disregard for the developing world, and more recently due to the intensity of focus on HIV/AIDS, tuberculosis and malaria. Sources of data: Primary research and review articles were selected for inclusion using searches of PubMed and our existing collections. Results: There have been recent notable successes in NTD control. Dracunculiasis is approaching eradication. Leprosy and onchocerciasis are in decline. There are ambitious plans to eliminate trachoma and lymphatic filariasis. Investment in NTD control has high rates of economic return. Conclusion: Although there are proven strategies to control several NTDs, these Diseases continue to cause a massive burden of morbidity. There is urgent need for more basic and operational research, drug and vaccine development, and greater prioritization by governments and international agencies.