The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
C D Fletcher - One of the best experts on this subject based on the ideXlab platform.
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The clinical role of molecular genetics in soft tissue Tumor Pathology.
Cancer metastasis reviews, 1997Co-Authors: K J Busam, C D FletcherAbstract:Cytogenetic and molecular analysis of soft tissue Tumors has yielded a wealth of information over the past decade. Some of the genetic aberrations that have been identified appear to be fairly specific for individual Tumor types. It is because of this specificity that these findings harbor the promise to become useful as diagnostic and/or prognostic markers. Technical advances that allow the application of cytogenetic and molecular techniques to archival material have been crucial in this respect. Molecular genetics has already become an integral part of the work-up of some Tumors, e.g., small cell sarcomas of childhood, which demonstrate fairly characteristic translocations, often involving the Ewing's sarcoma gene. Some genetic abnormalities have become established as prognostic markers, such as the deletion of the short arm of chromosome 1 for neuroblastomas. Soft tissue Tumor Pathology has also benefitted from major advances in identifying genes that are critical in mesenchymal differentiation or cell cycle control. MyoD is a good example of a such a gene, that has become useful as a diagnostic tool in rhabdomyosarcomas. Beyond potential practical applications of cytogenetic and molecular analyses in the diagnosis of these Tumors, we also review their impact on several philosophical concepts concerning soft tissue neoplasia.
Angelo Paolo Dei Tos - One of the best experts on this subject based on the ideXlab platform.
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a current perspective on the role for molecular studies in soft tissue Tumor Pathology
Seminars in Diagnostic Pathology, 2013Co-Authors: Angelo Paolo Dei TosAbstract:Soft tissue sarcomas represent an heterogenous group of malignancies. They represent a diagnostic challenge, and their accurate classification impact over treatment options. Sarcomas, similarly to hematologic neoplasm, often harbor relatively specific genetic aberrations, the recognition of which can be used to improved diagnostic accuracy. This review will focus on the clinical relevance of molecular analysis in soft tissue sarcomas, trying to elucidate its role as a diagnostic tool as well as a potential prognostic/predictive marker.
Leona A. Doyle - One of the best experts on this subject based on the ideXlab platform.
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Soft tissue Tumor Pathology: New diagnostic immunohistochemical markers
Seminars in diagnostic pathology, 2015Co-Authors: Leona A. DoyleAbstract:Recent insights into the pathogenesis of various soft tissue Tumors, along with the identification of recurrent molecular alterations characteristic of specific Tumor types, have resulted in the development of many diagnostically useful immunohistochemical markers. In some cases, expression of these markers is significantly associated with distinctive clinical and histologic features, which may impart prognostic or predictive information. This review outlines new diagnostic immunohistochemical markers in soft tissue Tumor Pathology, emphasizing their utility in clinical practice and potential pitfalls, molecular correlates and clinical associations.
J. Woodruff - One of the best experts on this subject based on the ideXlab platform.
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Tumors Of The Peripheral Nervous System. Afip Atlas Of Tumor Pathology Series 4, Vol. 19
2013Co-Authors: C. Antonescu, B. Scheithauer, J. WoodruffAbstract:Tumors Of The Peripheral Nervous System. Afip Atlas Of Tumor Pathology Series 4, Vol. 19 - Libros de Medicina - Anatomia - 158,65
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Comprar Tumors Of The Peripheral Nervous System. Afip Atlas Of Tumor Pathology Series 4, Vol. 19 | Antonescu, C. | 9781933477305 | AFIP
2013Co-Authors: C. Antonescu, B. Scheithauer, J. WoodruffAbstract:Tienda online donde Comprar Tumors Of The Peripheral Nervous System. Afip Atlas Of Tumor Pathology Series 4, Vol. 19 al precio 166,58 € de Antonescu, C. | Scheithauer, B. | Woodruff, J., tienda de Libros de Medicina, Libros de Anatomia - Anatomia
Jason L Hornick - One of the best experts on this subject based on the ideXlab platform.
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the 2020 who classification what s new in soft tissue Tumor Pathology
The American Journal of Surgical Pathology, 2021Co-Authors: Michael E Kallen, Jason L HornickAbstract:The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and Bone was published in early 2020. The revisions reflect a consensus among an international expert editorial board composed of soft tissue and bone pathologists, geneticists, a medical oncologist, surgeon, and radiologist. The changes in the soft tissue Tumor chapter notably include diverse, recently described Tumor types (eg, atypical spindle cell/pleomorphic lipomatous Tumor, angiofibroma of soft tissue, and CIC-rearranged sarcoma), new clinically significant prognostic information for a variety of existing entities (eg, dedifferentiated liposarcoma and solitary fibrous Tumor), and a plethora of novel genetic alterations, some of practical diagnostic relevance (eg, NAB2-STAT6 in solitary fibrous Tumor, FOSB rearrangements in epithelioid hemangioma and pseudomyogenic hemangioendothelioma, and SUZ12 or EED mutations in malignant peripheral nerve sheath Tumor, leading to loss of H3K27 trimethylation). In this review, we highlight the major changes to the soft tissue chapter in the 2020 World Health Organization Classification, as well as the new chapter on undifferentiated small round cell sarcomas, with a focus on updates in diagnostic categories, prognostication, and novel markers. Recent discoveries in molecular genetics are also discussed, particularly those of immediate utility in differential diagnosis, including protein correlates detectable using immunohistochemistry.
