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Anja R. Heckeroth - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of fluralaner (Bravecto™ chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs.
Parasites & vectors, 2017Co-Authors: Heike Kohler-aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R. HeckerothAbstract:The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to Two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded. Percentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (Two-sided Two-Sample t-Test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (Two-sided Two-Sample t-Test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, Two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups. Single oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although Two animals required unscheduled re-treatment.
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Efficacy of fluralaner (Bravecto™ chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs
Parasites & Vectors, 2017Co-Authors: Heike Kohler-aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R. HeckerothAbstract:Background The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. Methods Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to Two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded. Results Percentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (Two-sided Two-Sample t -test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (Two-sided Two-Sample t -test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, Two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups. Conclusions Single oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although Two animals required unscheduled re-treatment.
Riko Kelter - One of the best experts on this subject based on the ideXlab platform.
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analysis of bayesian posterior significance and effect size indices for the Two Sample t test to support reproducible medical research
BMC Medical Research Methodology, 2020Co-Authors: Riko KelterAbstract:The replication crisis hit the medical sciences about a decade ago, but today still most of the flaws inherent in null hypothesis significance testing (NHST) have not been solved. While the drawbacks of p-values have been detailed in endless venues, for clinical research, only a few attractive alternatives have been proposed to replace p-values and NHST. Bayesian methods are one of them, and they are gaining increasing attention in medical research, as some of their advantages include the description of model parameters in terms of probability, as well as the incorporation of prior information in contrast to the frequentist framework. While Bayesian methods are not the only remedy to the situation, there is an increasing agreement that they are an essential way to avoid common misconceptions and false interpretation of study results. The requirements necessary for applying Bayesian statistics have transitioned from detailed programming knowledge into simple point-and-click programs like JASP. Still, the multitude of Bayesian significance and effect measures which contrast the gold standard of significance in medical research, the p-value, causes a lack of agreement on which measure to report. Therefore, in this paper, we conduct an extensive simulation study to compare common Bayesian significance and effect measures which can be obtained from a posterior distribution. In it, we analyse the behaviour of these measures for one of the most important statistical procedures in medical research and in particular clinical trials, the Two-Sample Student’s (and Welch’s) t-Test. The results show that some measures cannot state evidence for both the null and the alternative. While the different indices behave similarly regarding increasing Sample size and noise, the prior modelling influences the obtained results and extreme priors allow for cherry-picking similar to p-hacking in the frequentist paradigm. The indices behave quite differently regarding their ability to control the type I error rates and regarding their ability to detect an existing effect. Based on the results, Two of the commonly used indices can be recommended for more widespread use in clinical and biomedical research, as they improve the type I error control compared to the classic Two-Sample t-Test and enjoy multiple other desirable properties.
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simulation data for the analysis of bayesian posterior significance and effect size indices for the Two Sample t test to support reproducible medical research
BMC Research Notes, 2020Co-Authors: Riko KelterAbstract:The data presented herein represents the simulated datasets of a recently conducted larger study which investigated the behaviour of Bayesian indices of significance and effect size as alternatives to traditional p-values. The study considered the setting of Student’s and Welch’s Two-Sample t-Test often used in medical research. It investigated the influence of the Sample size, noise, the selected prior hyperparameters and the sensitivity to type I errors. The posterior indices used included the Bayes factor, the region of practical equivalence, the probability of direction, the MAP-based p-value and the e-value in the Full Bayesian Significance Test. The simulation study was conducted in the statistical programming language R. The R script files for simulation of the datasets used in the study are presented in this article. These script files can both simulate the raw datasets and run the analyses. As researchers may be faced with different effect sizes, noise levels or priors in their domain than the ones studied in the original paper, the scripts extend the original results by allowing to recreate all analyses of interest in different contexts. Therefore, they should be relevant to other researchers.
Heike Kohler-aanesen - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of fluralaner (Bravecto™ chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs.
Parasites & vectors, 2017Co-Authors: Heike Kohler-aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R. HeckerothAbstract:The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to Two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded. Percentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (Two-sided Two-Sample t-Test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (Two-sided Two-Sample t-Test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, Two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups. Single oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although Two animals required unscheduled re-treatment.
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Efficacy of fluralaner (Bravecto™ chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs
Parasites & Vectors, 2017Co-Authors: Heike Kohler-aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R. HeckerothAbstract:Background The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. Methods Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to Two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded. Results Percentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (Two-sided Two-Sample t -test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (Two-sided Two-Sample t -test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, Two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups. Conclusions Single oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although Two animals required unscheduled re-treatment.
Seppo Saari - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of fluralaner (Bravecto™ chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs.
Parasites & vectors, 2017Co-Authors: Heike Kohler-aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R. HeckerothAbstract:The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to Two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded. Percentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (Two-sided Two-Sample t-Test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (Two-sided Two-Sample t-Test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, Two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups. Single oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although Two animals required unscheduled re-treatment.
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Efficacy of fluralaner (Bravecto™ chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs
Parasites & Vectors, 2017Co-Authors: Heike Kohler-aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R. HeckerothAbstract:Background The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. Methods Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to Two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded. Results Percentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (Two-sided Two-Sample t -test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (Two-sided Two-Sample t -test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, Two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups. Conclusions Single oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although Two animals required unscheduled re-treatment.
Rob Armstrong - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of fluralaner (Bravecto™ chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs.
Parasites & vectors, 2017Co-Authors: Heike Kohler-aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R. HeckerothAbstract:The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to Two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded. Percentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (Two-sided Two-Sample t-Test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (Two-sided Two-Sample t-Test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, Two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups. Single oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although Two animals required unscheduled re-treatment.
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Efficacy of fluralaner (Bravecto™ chewable tablets) for the treatment of naturally acquired Linognathus setosus infestations on dogs
Parasites & Vectors, 2017Co-Authors: Heike Kohler-aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche, Anja R. HeckerothAbstract:Background The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal Health) treatment. Methods Privately-owned dogs naturally infested with L. setosus from 21 different households were randomly allocated to Two treatment groups. Fourteen dogs were treated once orally with fluralaner and ten dogs were treated once topically with permethrin, at the recommended label dose. Live L. setosus on all dogs were counted before treatment and 1, 7, 28 (both groups) and 84 (fluralaner group) days post-treatment according to a coat parting technique at pre-specified locations and lice species were confirmed microscopically. At the same time points, a veterinary dermatology severity score and an owner’s perceived pruritus score were recorded. Results Percentage reduction in geometric mean L. setosus counts, comparing post- with pre-treatment counts within each group, were 85.7% (day 1), 96.8% (day 7) and 100% (days 28 and 84) for the fluralaner (Two-sided Two-Sample t -test, P ≤ 0.0088 for days 1–84) and 67.5% (day 1), 90.3% (day 7) 99.1% (day 28) for the permethrin group (Two-sided Two-Sample t -test, P ≤ 0.0014 for days 7–28). No lice were seen on fluralaner-treated dogs 28 and 84 days post-treatment. In contrast, Two permethrin-treated dogs were re-treated at 7 and 28 days after initial treatment because of observed lice. Owner’s perceived pruritus scores were reduced compared to pre-treatment levels by 23.8% (day 1), 31.1% (day 7), 70.4% (day 28) and 99.5% (day 84) after fluralaner treatment and 21.3% (day 1), 45.8% (day 7), and 78.1% (day 28) after permethrin treatment. Dermatological signs were improved compared to pre-treatment levels in both treatment groups. Conclusions Single oral fluralaner treatment eliminated natural L. setosus infestation on dogs within 28 days and led to complete dermatological recovery that was maintained until the study end on day 84. Single topical permethrin treatment reduced the number of L. setosus by 99.1% at day 28 although Two animals required unscheduled re-treatment.
