The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
Patrick Dubach - One of the best experts on this subject based on the ideXlab platform.
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binaural Tympanic Membrane perforations after blast injury
The New England Journal of Medicine, 2017Co-Authors: Jeroen B Van Rijswijk, Patrick DubachAbstract:A 30-year-old man was found to have Tympanic-Membrane perforation in both ears after a blast injury.
Reza Ghassemifar - One of the best experts on this subject based on the ideXlab platform.
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chronic Tympanic Membrane perforation a better animal model is needed
Wound Repair and Regeneration, 2007Co-Authors: Peter Santa L Maria, Marcus D Atlas, Reza GhassemifarAbstract:Developments in the treatment of chronic Tympanic Membrane perforation have been hindered by the lack of an ideal animal model. It is not appropriate to test such treatments on acute perforations as the majority of these heal spontaneously. An ideal animal model would be one that most closely resembles the human clinical situation. It should be inexpensive, readily available, and easy to create. There have been a number of attempts to create a chronic Tympanic Membrane perforation model with limited success. All published attempts at chronic Tympanic Membrane perforations have been reviewed and the limitations of each model are discussed. A number of areas for research exist for further developing a chronic Tympanic Membrane perforation model. These areas include a perforation model in the presence of bacteria and eustachian tube dysfunction. Understanding the molecular and genetic mechanisms of chronic otitis media and potential treatments will also be useful.
Rodney J. Dilley - One of the best experts on this subject based on the ideXlab platform.
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Tympanic Membrane organ culture using cell culture well inserts engrafted with Tympanic Membrane tissue explants
BioTechniques, 2017Co-Authors: Lawrence J Liew, Richard M. Day, Rodney J. DilleyAbstract:© 2017, Eaton Publishing Company. All rights reserved. Tissue engineering approaches using growth factors and various materials for repairing chronic perforations of the Tympanic Membrane are being developed, but there are surprisingly few relevant tissue culture models available to test new treatments. Here, we present a simple three-dimensional model system based on micro-dissecting the rat Tympanic Membrane umbo and grafting it into the Membrane of a cell culture well insert. Cell outgrowth from the graft produced sufficient cells to populate a Membrane of similar surface area to the human Tympanic Membrane within 2 weeks. Tissue grafts from the annulus region also showed cell outgrowth but were not as productive. The umbo organoid supported substantial cell proliferation and migration under the influence of keratinocyte growth medium. Cells from umbo grafts were enzymatically harvested from the polyethylene terephthalate (PET) Membrane for expansion in routine culture and cells could be harvested consecutively from the same graft over multiple cycles. We used harvested cells to test cell migration properties and to engraft a porous silk scaffold material as proof-of-principle for tissue engineering applications. This model is simple enough to be widely adopted for Tympanic Membrane regeneration studies and has promise as a tissue-equivalent model alternative to animal testing.
Jeroen B Van Rijswijk - One of the best experts on this subject based on the ideXlab platform.
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binaural Tympanic Membrane perforations after blast injury
The New England Journal of Medicine, 2017Co-Authors: Jeroen B Van Rijswijk, Patrick DubachAbstract:A 30-year-old man was found to have Tympanic-Membrane perforation in both ears after a blast injury.
Karen Nicolas - One of the best experts on this subject based on the ideXlab platform.
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Tympanic Membrane Retraction Pocket - Tympanic Membrane retraction pocket
Tympanic Membrane Retraction Pocket, 2014Co-Authors: Salah Mansour, Jacques Magnan, Hassan Haidar, Karen NicolasAbstract:Epidemiologic studies already done on the frequency of Tympanic Membrane retractions have been rare and almost exclusively exploring pediatric populations. Numerous studies agreed on the fact that in the presence of otitis media, the frequency of Tympanic Membrane pathologies is significantly higher.
