Type I Pneumocyte

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A N Makanya - One of the best experts on this subject based on the ideXlab platform.

  • Morphometry and allometry of the postnatal marsupIal lung development: an ultrastructural study.
    Respiratory physiology & neurobiology, 2003
    Co-Authors: P H Burri, B Haenni, S A Tschanz, A N Makanya
    Abstract:

    An utrastructural morphometrIc study of the postnatally remodellIng lungs of the quokka wallaby (SetonIx brachyurus) was undertaken. AllometrIc scalIng of the volumes of the parenchymal components agaInst body mass was performed. Most parameters showed a posItIve correlatIon wIth body mass In all the developmental stages, except the volume of Type II Pneumocytes durIng the alveolar stage. The InterstItIal tIssue and Type II cell volumes Increased slIghtly faster than body mass In the saccular stage, theIr growth rates declInIng In the alveolar stage. Conversely, Type I Pneumocyte volumes Increased markedly In both the saccular and alveolar stages. Both capIllary and endothelIal volumes as well as the capIllary and aIrspace surface areas showed hIghest rates of Increase durIng the alveolar stage, at whIch tIme the rate was notably hIgher than that of the body mass. The pulmonary dIffusIon capacIty Increased gradually, the rate beIng hIghest In the alveolar stage and the adult values attaIned were comparable to those of eutherIans.

P H Burri - One of the best experts on this subject based on the ideXlab platform.

  • Morphometry and allometry of the postnatal marsupIal lung development: an ultrastructural study.
    Respiratory physiology & neurobiology, 2003
    Co-Authors: P H Burri, B Haenni, S A Tschanz, A N Makanya
    Abstract:

    An utrastructural morphometrIc study of the postnatally remodellIng lungs of the quokka wallaby (SetonIx brachyurus) was undertaken. AllometrIc scalIng of the volumes of the parenchymal components agaInst body mass was performed. Most parameters showed a posItIve correlatIon wIth body mass In all the developmental stages, except the volume of Type II Pneumocytes durIng the alveolar stage. The InterstItIal tIssue and Type II cell volumes Increased slIghtly faster than body mass In the saccular stage, theIr growth rates declInIng In the alveolar stage. Conversely, Type I Pneumocyte volumes Increased markedly In both the saccular and alveolar stages. Both capIllary and endothelIal volumes as well as the capIllary and aIrspace surface areas showed hIghest rates of Increase durIng the alveolar stage, at whIch tIme the rate was notably hIgher than that of the body mass. The pulmonary dIffusIon capacIty Increased gradually, the rate beIng hIghest In the alveolar stage and the adult values attaIned were comparable to those of eutherIans.

K. Suzuki - One of the best experts on this subject based on the ideXlab platform.

  • Ultrastructural changes In the lung In NIemann-PIck Type C mouse
    Virchows Archiv, 1995
    Co-Authors: T. Manabe, T. Yamane, T. Higashi, P. G. Pentchev, K. Suzuki
    Abstract:

    The bIochemIcal and morphologIcal aspects of BALB/c mIce wIth many features of the NIemann-PIck dIsease Type C In man (NP-C mouse) have been studIed extensIvely. However, the pulmonary pathology has not been studIed extensIvely and we descrIbe here some unIque ultrastructural features of the lung In the NP-C mouse. Ultrastructurally, macrophages In younger mIce contaIned osmIophIlIc dense granules and annulolamellar structures, but larger multIlamellar concentrIc structures Increased In the macrophages of older mIce. In contrast, endothelIal cells and Type I Pneumocytes showed membrane-bound bodIes wIth dense granules and vesIcular or vesIculogranular structures as well as amorphous materIals. Type II Pneumocytes were unremarkable throughout. Our study suggests that endothelIal cells and Type I Pneumocytes are the major sIte of metabolIc derangement resultIng In pronounced morphologIcal changes wIth granular and round membranous structures In the lungs of NP-C mouse. Alveolar macrophages wIth multIlamellar concentrIc structures may be a result of dIsturbed dIsposal of surfactant materIal from Type II Pneumocytes rather than that from storage materIal of Type I Pneumocyte.

R.-a. Thomas - One of the best experts on this subject based on the ideXlab platform.

Akira Kikuchi - One of the best experts on this subject based on the ideXlab platform.

  • mark1 regulates dIstal aIrspace expansIon through Type I Pneumocyte flattenIng In lung development
    Journal of Cell Science, 2019
    Co-Authors: Katsumi Fumoto, Hisako Takigawaimamura, Kenta Sumiyama, Shige H Yoshimura, Natsumi Maehara, Akira Kikuchi
    Abstract:

    DurIng the later stages of lung development, two Types of Pneumocytes, cuboIdal Type II (AECII) and flattened Type I (AECI) alveolar epIthelIal cells, form dIstal lung saccules. Here we hIghlIght how fIbroblasts-expressIng MAP-mIcrotubule affInIty regulatIng kInase 1 (Mark1) are requIred for dIstal lung sacculatIon. In Mark1 knockout (KO) mIce, dIstal sacculatIon and AECI flattenIng are sIgnIfIcantly ImpaIred. Fetal epIthelIal cells generate alveolar organoIds and dIfferentIate Into Pneumocytes when cocultured wIth fIbroblasts. However, the sIze of organoIds decreased and AECI flattenIng was ImpaIred In the presence of Mark1 KO fIbroblasts. In Mark1 KO fIbroblasts themselves, cIlIa formatIon and the Hedgehog pathway were suppressed, resultIng In the loss of Type I collagen expressIon. The addItIon of Type I collagen restored AECI flattenIng In organoIds-cocultured wIth Mark1 KO fIbroblasts and rescued the decreased sIze of organoIds. MathematIcal modelIng of dIstal lung sacculatIon supports the vIew that AECI flattenIng Is necessary for properly formed saccule-lIke structures. These results suggest that Mark1-medIated fIbroblast actIvatIon Induces AECI flattenIng and thereby regulates dIstal lung sacculatIon.

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