Ulmaceae

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Cheorl-ho Kim - One of the best experts on this subject based on the ideXlab platform.

  • Stimulative effects of Ulmus davidiana Planch (Ulmaceae) on osteoblastic MC3T3-E1 cells
    Journal of ethnopharmacology, 2006
    Co-Authors: Seok-jong Suh, Woo-sik Yun, Kap-sung Kim, Un-ho Jin, June-ki Kim, Myung-sunny Kim, Dae Young Kwon, Cheorl-ho Kim
    Abstract:

    Abstract Ulmus davidiana Planch (Ulmaceae) has long been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone among other functions. To treat rheumatoid arthritis (RA), a herbal medicine, Ulmus davidiana Planch (Ulmaceae) extract (UD) is being used in traditional oriental medicine. The effect of UD on the proliferation and osteoblastic differentiation in non-transformed osteoblastic cells (MC3T3-E1) was studied. UD dose-dependently increased DNA synthesis (significant at 5–20 μg/ml). UD increased alkaline phosphatase (ALP) activity and prolyl hydroxylase activity of MC3T3-E1 cells (5–20 μg/ml). Antiestrogen tamoxifen eliminated the stimulation of proliferation and ALP activity of MC3T3-E1, which was induced by UD. UD at concentrations ranged from 30 to 100 μg/ml inhibited prostaglandin E2 production in MC3T3-E1. These results indicate that UD directly stimulates cell proliferation and differentiation of osteoblasts. These results also suggest and UD is effective for bone anti-resorptive action in bone cells.

  • Suppressive effects of a water extract of Ulmus davidiana Planch (Ulmaceae) on collagen-induced arthritis in mice.
    Journal of ethnopharmacology, 2004
    Co-Authors: Kap-sung Kim, Seung-duk Lee, Kyung-ho Kim, Sang-yong Kil, Kang-hyun Chung, Cheorl-ho Kim
    Abstract:

    Abstract Ulmus davidiana Planch (Ulmaceae) has long been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone resorption. Therefore, this study was undertaken to address (1) whether the water extract of the bark of Ulmus davidiana Planch (Ulmaceae) (UD) can modulate the expression of inducible inflammatory cytokines in mice; (2) in order to assess the therapeutic effects of UD in collagen-induced arthritis (CIA) in mice. DBA/1 mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with UD orally at 100 mg/kg once a day for 3 weeks. Paws were evaluated macroscopically for redness, swelling and deformities. The levels of TNF-α and IL-1β in the ankle were examined. The severity of arthritis within the knee joints was evaluated by histological assessment of cartilage destruction and pannus formation. Administration of UD significantly suppressed the progression of CIA and inhibited the production of TNF-α and IL-1β in the paws. The erosion of cartilage was dramatically reduced in mouse knees after treatment with UD. In the serum of UD-treated mice, the levels of IL-4 and IL-10, anti-inflammatory cytokines, were increased. From the results, it was concluded that administration of UD has therapeutic effects on CIA including protection of cartilage and RA for a potential therapy.

Kap-sung Kim - One of the best experts on this subject based on the ideXlab platform.

  • Stimulative effects of Ulmus davidiana Planch (Ulmaceae) on osteoblastic MC3T3-E1 cells
    Journal of ethnopharmacology, 2006
    Co-Authors: Seok-jong Suh, Woo-sik Yun, Kap-sung Kim, Un-ho Jin, June-ki Kim, Myung-sunny Kim, Dae Young Kwon, Cheorl-ho Kim
    Abstract:

    Abstract Ulmus davidiana Planch (Ulmaceae) has long been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone among other functions. To treat rheumatoid arthritis (RA), a herbal medicine, Ulmus davidiana Planch (Ulmaceae) extract (UD) is being used in traditional oriental medicine. The effect of UD on the proliferation and osteoblastic differentiation in non-transformed osteoblastic cells (MC3T3-E1) was studied. UD dose-dependently increased DNA synthesis (significant at 5–20 μg/ml). UD increased alkaline phosphatase (ALP) activity and prolyl hydroxylase activity of MC3T3-E1 cells (5–20 μg/ml). Antiestrogen tamoxifen eliminated the stimulation of proliferation and ALP activity of MC3T3-E1, which was induced by UD. UD at concentrations ranged from 30 to 100 μg/ml inhibited prostaglandin E2 production in MC3T3-E1. These results indicate that UD directly stimulates cell proliferation and differentiation of osteoblasts. These results also suggest and UD is effective for bone anti-resorptive action in bone cells.

  • Suppressive effects of a water extract of Ulmus davidiana Planch (Ulmaceae) on collagen-induced arthritis in mice.
    Journal of ethnopharmacology, 2004
    Co-Authors: Kap-sung Kim, Seung-duk Lee, Kyung-ho Kim, Sang-yong Kil, Kang-hyun Chung, Cheorl-ho Kim
    Abstract:

    Abstract Ulmus davidiana Planch (Ulmaceae) has long been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone resorption. Therefore, this study was undertaken to address (1) whether the water extract of the bark of Ulmus davidiana Planch (Ulmaceae) (UD) can modulate the expression of inducible inflammatory cytokines in mice; (2) in order to assess the therapeutic effects of UD in collagen-induced arthritis (CIA) in mice. DBA/1 mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with UD orally at 100 mg/kg once a day for 3 weeks. Paws were evaluated macroscopically for redness, swelling and deformities. The levels of TNF-α and IL-1β in the ankle were examined. The severity of arthritis within the knee joints was evaluated by histological assessment of cartilage destruction and pannus formation. Administration of UD significantly suppressed the progression of CIA and inhibited the production of TNF-α and IL-1β in the paws. The erosion of cartilage was dramatically reduced in mouse knees after treatment with UD. In the serum of UD-treated mice, the levels of IL-4 and IL-10, anti-inflammatory cytokines, were increased. From the results, it was concluded that administration of UD has therapeutic effects on CIA including protection of cartilage and RA for a potential therapy.

Giuseppe Garfì - One of the best experts on this subject based on the ideXlab platform.

  • leaf architecture and epidermal characters in zelkova Ulmaceae
    Botanical Journal of the Linnean Society, 2001
    Co-Authors: Yufei Wang, David K Ferguson, Reinhard Zetter, Thomas Denk, Giuseppe Garfì
    Abstract:

    Abstract Zelkova , with six extant species in Eurasia – three in East Asia ( Z. schneideriana , Z. serrata , Z. sinica ), one in south-western Asia ( Z. carpinifolia ) and two in southern Europe ( Z. abelicea , Z. sicula ) – was investigated with respect to leaf architecture and epidermal characters by LM and SEM. The leaf venation of Zelkova is relatively uniform, while leaf size and shape are highly variable. Characters such as teeth and epidermal cells, trichomes and stomata provide useful specific distinctions. Beginning in the Miocene, increasing aridity in Central Asia would appear to have been responsible for isolating the eastern Asiatic species from their European/western Asiatic counterparts. The European range underwent further changes in response to Quaternary climatic oscillations.

  • Pollen morphology of Zelkova sicula (Ulmaceae), a recently discovered relic species of the European Tertiary flora: description, chromosomal relevance, and palaeobotanical significance
    Review of Palaeobotany and Palynology, 1998
    Co-Authors: Takeshi Nakagawa, Giuseppe Garfì, M. Reille, Régine Verlaque
    Abstract:

    Pollen morphological characteristics of Zelkova sicula Di Pasquale, Garfi et Quezel and Z. carpinifolia (Pallas) Koch (Ulmaceae) are described. Z. sicula is a shrub species which was recently discovered on southeastern Sicily. Z. carpinifolia is the Zelkova species to which some European Tertiary to Quaternary leaf fossils have been attributed in recent studies. The new results were compared with the pollen morphological characteristics of some other Ulmaceae species such as Z. abelicea (Lamark) Boissier, Z. serrata (Thunberg) Makino, Ulmus glabra Hudson, U. laevis Pallas, U. minor Miller, and U. procera Salisbury. It was observed that Z. sicula usually possesses 5 to 6 pores, whereas the other Zelkova species normally have fewer than 5 pores. Higher frequencies of tetrads, a Y-mark on the proximal face, and a smoother exine sculpture (compared with other Zelkova species) were noted for pollen of Z. sicula. The equatorial diameter of Z. sicula was larger than every other Ulmaceae species, with a smaller PE ratio. Some of these differences can be explained by the triploid nature of Z. sicula, which is quite exceptional for Ulmaceae. Given these remarkable characteristics, it should be possible to recognise Z. sicula pollen grains in fossil pollen assemblages. It is thus anticipated that a more comprehensive pollen analytical study will lead to a revision of the Mediterranean phytogeographical history of the genus Zelkova.

Seok-jong Suh - One of the best experts on this subject based on the ideXlab platform.

  • Stimulative effects of Ulmus davidiana Planch (Ulmaceae) on osteoblastic MC3T3-E1 cells
    Journal of ethnopharmacology, 2006
    Co-Authors: Seok-jong Suh, Woo-sik Yun, Kap-sung Kim, Un-ho Jin, June-ki Kim, Myung-sunny Kim, Dae Young Kwon, Cheorl-ho Kim
    Abstract:

    Abstract Ulmus davidiana Planch (Ulmaceae) has long been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone among other functions. To treat rheumatoid arthritis (RA), a herbal medicine, Ulmus davidiana Planch (Ulmaceae) extract (UD) is being used in traditional oriental medicine. The effect of UD on the proliferation and osteoblastic differentiation in non-transformed osteoblastic cells (MC3T3-E1) was studied. UD dose-dependently increased DNA synthesis (significant at 5–20 μg/ml). UD increased alkaline phosphatase (ALP) activity and prolyl hydroxylase activity of MC3T3-E1 cells (5–20 μg/ml). Antiestrogen tamoxifen eliminated the stimulation of proliferation and ALP activity of MC3T3-E1, which was induced by UD. UD at concentrations ranged from 30 to 100 μg/ml inhibited prostaglandin E2 production in MC3T3-E1. These results indicate that UD directly stimulates cell proliferation and differentiation of osteoblasts. These results also suggest and UD is effective for bone anti-resorptive action in bone cells.

José L. Linares - One of the best experts on this subject based on the ideXlab platform.