The Experts below are selected from a list of 87 Experts worldwide ranked by ideXlab platform
Artur Cavacopaulo - One of the best experts on this subject based on the ideXlab platform.
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effect of ultrasound parameters for Unilamellar Liposome preparation
Ultrasonics Sonochemistry, 2010Co-Authors: Raquel Silva, Helena Ferreira, Collin Little, Artur CavacopauloAbstract:In this study, it was investigated the effects of ultrasound, namely power input, distance from ultrasound tip to base of reactor and treatment time, in the formation of Liposomes. Results indicate a dependence on cavitation events that are a function of power input, and consequently dependent on the position of the probe within the reaction vessel and the wave behaviour. Short treatment times are required to achieve nanosized vesicles in anti-nodal (lambda/4; 19mm) reactor geometries. In this wave point the cavitation phenomenon is more pronounced when compared with the nodal point (lambda/2; 38mm). Therefore, the consideration of the above parameters is vital if dependable and repeatable results are to be achieved.
Raquel Silva - One of the best experts on this subject based on the ideXlab platform.
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effect of ultrasound parameters for Unilamellar Liposome preparation
Ultrasonics Sonochemistry, 2010Co-Authors: Raquel Silva, Helena Ferreira, Collin Little, Artur CavacopauloAbstract:In this study, it was investigated the effects of ultrasound, namely power input, distance from ultrasound tip to base of reactor and treatment time, in the formation of Liposomes. Results indicate a dependence on cavitation events that are a function of power input, and consequently dependent on the position of the probe within the reaction vessel and the wave behaviour. Short treatment times are required to achieve nanosized vesicles in anti-nodal (lambda/4; 19mm) reactor geometries. In this wave point the cavitation phenomenon is more pronounced when compared with the nodal point (lambda/2; 38mm). Therefore, the consideration of the above parameters is vital if dependable and repeatable results are to be achieved.
Guangzhao Mao - One of the best experts on this subject based on the ideXlab platform.
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effect of chain lengths of peo ppo peo on small Unilamellar Liposome morphology and stability an afm investigation
Journal of Colloid and Interface Science, 2005Co-Authors: Xuemei Liang, Guangzhao MaoAbstract:Abstract The morphology and stability of small Unilamellar egg yolk phosphatidylcholine (EggPC) Liposomes modified with the Pluronic® copolymer (poly (oxyethylene)–poly (oxypropylene)–poly (oxyethylene) (PEO–PPO–PEO)) with different compositions on mica surface have been investigated using atomic force microscopy. Morphology studies reveal significant morphological changes of Liposomes upon incorporating the Pluronic® copolymer. Bilayers are observed for Pluronic® with small hydrophilic (PEO) chain lengths such as L81 [(PEO)2(PPO)40(PEO)2] and L121 [(PEO)4(PPO)60(PEO)4]; bilayer and vesicle coexistence is observed for P85 [(PEO)26(PPO)39.5(PEO)26] and F87 [(PEO)61.1(PPO)39.7(PEO)61.1]; and stable vesicles are observed for F88 [(PEO)103.5(PPO)39.2(PEO)103.5], F127 [(PEO)100(PPO)65(PEO)100], and F108 [(PEO)132.6(PPO)50.3(PEO)132.6]. The micromechanical properties of Pluronic®-modified EggPC vesicles were studied by analyzing AFM approaching force curve. The bending modulus ( k c ) of the Pluronic®-modified EggPC vesicles increased several-fold compared with that of the pure EggPC vesicles. The significant difference is due to the enhanced rigidity of the EggPC vesicles as a result of the incorporation of PPO molecules and PEO chains. Based on the analysis of onset point by AFM and diameters of vesicles by light scattering, it was concluded that the favorable model to describe the polymer–bilayer interaction is the membrane-spanning model.
Olle Ringdén - One of the best experts on this subject based on the ideXlab platform.
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Early Pharmacokinetic and Clinical Results from a Noncomparative Multicentre Trial of Amphotericin B Encapsulated in a Small Unilamellar Liposome (AmBisome®)
Drug Investigation, 1992Co-Authors: Jan Tollemar, Olle RingdénAbstract:AmBisome® 0.5 to 4 mg/kg/day, a small Unilamellar Liposome encapsulating amphotericin B, was administered to 59 patients with ideologically confirmed infections (36 had candidiasis, 18 had aspergillosis and 5 had other infections). Of the treated patients, 37 (63%) were considered cured, 9 (15%) improved, and 13 (22%) failed to respond. The response rate in patients with candidiasis was 83% (30/36) compared with 61% (11/18) for aspergillosis (not significant). All other mycoses were cured or improved. 80% (16) of 20 evaluable patients were cured or improved when AmBisome® was used because of the prior failure of conventional amphotericin B in a compassionate basis trial. AmBisome® at dose levels ranging between 2 and 4 mg/kg produced peak plasma levels ranging from 16.0 ± 6.7 to 46.0 ± 10.2 mg/L. Tissue levels were highest in liver and spleen and were low in kidney and lung. Side effects associated with AmBisome® included increases in serum Creatinine (n = 9) and alkaline Phosphatase (2), hypokalaemia (3) and pancreatitis (1).
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Early Pharmacokinetic and Clinical Results from a Noncomparative Multicentre Trial of Amphotericin B Encapsulated in a Small Unilamellar Liposome (AmBisome
Drug Investigation, 1992Co-Authors: Jan Tollemar, Olle RingdénAbstract:AmBisome® 0.5 to 4 mg/kg/day, a small Unilamellar Liposome encapsulating amphotericin B, was administered to 59 patients with ideologically confirmed infections (36 had candidiasis, 18 had aspergillosis and 5 had other infections). Of the treated patients, 37 (63%) were considered cured, 9 (15%) improved, and 13 (22%) failed to respond. The response rate in patients with candidiasis was 83% (30/36) compared with 61% (11/18) for aspergillosis (not significant). All other mycoses were cured or improved. 80% (16) of 20 evaluable patients were cured or improved when AmBisome® was used because of the prior failure of conventional amphotericin B in a compassionate basis trial. AmBisome® at dose levels ranging between 2 and 4 mg/kg produced peak plasma levels ranging from 16.0 ± 6.7 to 46.0 ± 10.2 mg/L. Tissue levels were highest in liver and spleen and were low in kidney and lung.
Collin Little - One of the best experts on this subject based on the ideXlab platform.
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effect of ultrasound parameters for Unilamellar Liposome preparation
Ultrasonics Sonochemistry, 2010Co-Authors: Raquel Silva, Helena Ferreira, Collin Little, Artur CavacopauloAbstract:In this study, it was investigated the effects of ultrasound, namely power input, distance from ultrasound tip to base of reactor and treatment time, in the formation of Liposomes. Results indicate a dependence on cavitation events that are a function of power input, and consequently dependent on the position of the probe within the reaction vessel and the wave behaviour. Short treatment times are required to achieve nanosized vesicles in anti-nodal (lambda/4; 19mm) reactor geometries. In this wave point the cavitation phenomenon is more pronounced when compared with the nodal point (lambda/2; 38mm). Therefore, the consideration of the above parameters is vital if dependable and repeatable results are to be achieved.
