The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
N. R. Gall - One of the best experts on this subject based on the ideXlab platform.
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Application of high-performance liquid chromatography/high-resolution mass spectrometry to the investigation of sodium 2,3-disulfanyl-1-propanesulfonate (Unithiol) and products of its oxidation with hydrogen peroxide
Journal of Analytical Chemistry, 2016Co-Authors: D. O. Kuleshov, T. E. Berezkina, Y. V. Russkikh, E. N. Chernova, Z. A. Zhakovskaya, S. V. Masyukevich, L. N. Gall, N. R. GallAbstract:High-performance liquid chromatography combined with high-resolution mass spectrometry has been used to study the mild oxidation of sodium 2,3-disulfanyl-1-propanesulfonate (Unithiol) with hydrogen peroxide. Reference peaks have been identified for the initial substance and reaction products. A possibility of using high-performance liquid chromatography with high-resolution mass spectrometry for the Sokolovskii thiol–disulphide test has been shown.
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application of high performance liquid chromatography high resolution mass spectrometry to the investigation of sodium 2 3 disulfanyl 1 propanesulfonate Unithiol and products of its oxidation with hydrogen peroxide
Journal of Analytical Chemistry, 2016Co-Authors: D. O. Kuleshov, T. E. Berezkina, Y. V. Russkikh, Z. A. Zhakovskaya, S. V. Masyukevich, L. N. Gall, Ekaterina Chernova, N. R. GallAbstract:High-performance liquid chromatography combined with high-resolution mass spectrometry has been used to study the mild oxidation of sodium 2,3-disulfanyl-1-propanesulfonate (Unithiol) with hydrogen peroxide. Reference peaks have been identified for the initial substance and reaction products. A possibility of using high-performance liquid chromatography with high-resolution mass spectrometry for the Sokolovskii thiol–disulphide test has been shown.
D. O. Kuleshov - One of the best experts on this subject based on the ideXlab platform.
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Application of high-performance liquid chromatography/high-resolution mass spectrometry to the investigation of sodium 2,3-disulfanyl-1-propanesulfonate (Unithiol) and products of its oxidation with hydrogen peroxide
Journal of Analytical Chemistry, 2016Co-Authors: D. O. Kuleshov, T. E. Berezkina, Y. V. Russkikh, E. N. Chernova, Z. A. Zhakovskaya, S. V. Masyukevich, L. N. Gall, N. R. GallAbstract:High-performance liquid chromatography combined with high-resolution mass spectrometry has been used to study the mild oxidation of sodium 2,3-disulfanyl-1-propanesulfonate (Unithiol) with hydrogen peroxide. Reference peaks have been identified for the initial substance and reaction products. A possibility of using high-performance liquid chromatography with high-resolution mass spectrometry for the Sokolovskii thiol–disulphide test has been shown.
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application of high performance liquid chromatography high resolution mass spectrometry to the investigation of sodium 2 3 disulfanyl 1 propanesulfonate Unithiol and products of its oxidation with hydrogen peroxide
Journal of Analytical Chemistry, 2016Co-Authors: D. O. Kuleshov, T. E. Berezkina, Y. V. Russkikh, Z. A. Zhakovskaya, S. V. Masyukevich, L. N. Gall, Ekaterina Chernova, N. R. GallAbstract:High-performance liquid chromatography combined with high-resolution mass spectrometry has been used to study the mild oxidation of sodium 2,3-disulfanyl-1-propanesulfonate (Unithiol) with hydrogen peroxide. Reference peaks have been identified for the initial substance and reaction products. A possibility of using high-performance liquid chromatography with high-resolution mass spectrometry for the Sokolovskii thiol–disulphide test has been shown.
Krista Kostial - One of the best experts on this subject based on the ideXlab platform.
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Chelators as antidotes of metal toxicity: therapeutic and experimental aspects.
Current medicinal chemistry, 2005Co-Authors: Maja Blanuša, Veda Marija Varnai, Martina Piasek, Krista KostialAbstract:The effects of chelating drugs used clinically as antidotes to metal toxicity are reviewed. Human exposure to a number of metals such as lead, cadmium, mercury, manganese, aluminum, iron, copper, thallium, arsenic, chromium, nickel and platinum may lead to toxic effects, which are different for each metal. Similarly the pharmacokinetic data, clinical use and adverse effects of most of the chelating drugs used in human metal poisoning are also different for each chelating drug. The chelating drugs with worldwide application are dimercaprol (BAL), succimer (meso-DMSA), Unithiol (DMPS), D-penicillamine (DPA), N-acetyl-D-penicillamine (NAPA), calcium disodium ethylenediaminetetraacetate (CaNa(2)EDTA), calcium trisodium or zinc trisodium diethylenetriaminepentaacetate (CaNa(3)DTPA, ZnNa(3)DTPA), deferoxamine (DFO), deferiprone (L1), triethylenetetraamine (trientine), N-acetylcysteine (NAC), and Prussian blue (PB). Several new synthetic homologues and experimental chelating agents have been designed and tested in vivo for their metal binding effects. These include three groups of synthetic chelators, namely the polyaminopolycarboxylic acids (EDTA and DTPA), the derivatives of BAL (DMPS, DMSA and mono- and dialkylesters of DMSA) and the carbodithioates. Many factors have been shown to affect the efficacy of the chelation treatment in metal poisoning. Within this context it has been shown in experiments using young and adult animals that metal toxicity and chelation effects could be influenced by age. These findings may have a bearing in the design of new therapeutic chelation protocols for metal toxicity.
S. A. Grachev - One of the best experts on this subject based on the ideXlab platform.
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Study of the Antitoxic Effect of Unithiol on Cystamine in Dogs
2008Co-Authors: S. A. Grachev, A G SverdlovAbstract:Abstract : It was shown in experiments using a canine model that intramuscular administration of Unithiol (monohydrate sodium salt of 2,3-dimercapto-1-propansulfonic acid, 50 mg/kg) before cystamine (cystamine dihydrochloride, 100 mg/kg, calculation on the salt, intragastric administration) decreases the toxic effect of this radioprotector. The frequency of manifestations of the toxic effects of cystamine (change of behavior, vomiting reaction, decrease of body temperature and so on) is not decreased, but the severity of expression and duration are decreased. The period of agitation induced by cystamine is shortened, and the period and expression of vomiting induced by this preparation are decreased. Respiratory frequency and condition of the heart are less changed (according to EKG data).
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effect of Unithiol on cystamine toxicity in dogs
Radiatsionnaia biologiia radioecologiia Rossiĭskaia akademiia nauk, 1999Co-Authors: S. A. Grachev, A G Sverdlov, N G Nikanorova, S I TimoshenkoAbstract:In experiments with dogs it was shown that administration of Unithiol before administration of cystamine decreases toxic effect of the last: period of excitation induced by cystamine is shortened, the time of emetic reaction decreases and expression of the emetic reaction to this preparation is diminished, the recorded EKG changes of conditions of heart decrease.
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increased efficacy of radiation protection against fission neutrons using Unithiol
Radiatsionnaia biologiia radioecologiia Rossiĭskaia akademiia nauk, 1999Co-Authors: S. A. Grachev, A G Sverdlov, N G Nikanorova, S I TimoshenkoAbstract:It was found that the combination of Unithiol (Sodium salt of 2,3-dimercapto-1-propansulfonic acid) with cystamine and AET diminished their toxicity. The optimum ratio for the antitoxic effect is 0.5 molar equivalent of Unithiol per radioprotective 1.0 equivalent of thiol. Animals withstand big doses of protectors well, that gives an opportunity to use increased amounts of cystamine and AET. In the experiments with circular irradiation of male (CBA x C57B1)F1 mice weighing 18-22 g with fission neutrons (the neutron mean energy was 0.85 MeV, the contribution of gamma-quanta to the total was 25%, dose rate was 14 cGy/min) it was shown that the combination of Unithiol with cystamine and AET enhances their radioprotective effect: the DRF of cystamine (150 mg/kg)--1.1, and the DRF of the combination of cystamine (300 mg/kg) with Unithiol (152 mg/kg)--1.2; the DRF of AET (150 mg/kg)--1.2, the DRF of the combination of AET (300 mg/kg) with Unithiol--1.4. Thus, the enhancement of dose of the radioprotectors, which was made possible as a result of their combination with Unithiol, leads to enhancement of efficacy of chemical protection against fission neutron irradiation as much as 10-20%. Efficacy of AET is found to be comparable to efficacy of this protector in conditions of X-rays irradiation.
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decrease of toxic effects of aminothiol radiation protective agents and increase of chemical protection action against ionizing radiation by the use of Unithiol
Radiatsionnaia biologiia radioecologiia Rossiĭskaia akademiia nauk, 1994Co-Authors: S. A. Grachev, A G Sverdlov, N G Nikanorova, O I Bolshakova, I K KorolvaAbstract:It has been shown that Unithiol diminishes toxic action of cysteamine, AET, and disulfide of WR-1065 on mice. This permits to enhance protection of animals against X-rays by increasing of protector doses. The effect of Unithiol on cysteamine action in rats was the same. Antitoxic effect of Unithiol on cysteamine was shown both at i.p. and p.o. protector administration. The effect was also revealed in Chinese hamster V-79 cell culture. Combined disulfide of cysteamine and Unithiol was synthetized, which ensures effective prolonged protection against ionizing radiation.
Xueji Zhang - One of the best experts on this subject based on the ideXlab platform.
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Chronopotentiometric synthesis of quantum dots with efficient surface-derived near-infrared electrochemiluminescence for ultrasensitive microchip-based ion-selective sensing
RSC Advances, 2014Co-Authors: Shengyuan Deng, Zhang Tingting, Zhang Yuan, Dan Shan, Xueji ZhangAbstract:A novel QD with near-infrared (NIR) electrochemiluminescence (ECL) emission was prepared electrolytically by hydrodynamic chronopotentiometry, using Unithiol, a clinically-known metalantidote, as the capping agent for the fabrication of an ultrasensitive ion-selective microchip. The proposed synthetic route as well as the optical properties of QD was clarified with both morphological and spectroscopic characterization. In air-saturated pH 8.0 phosphate buffer with dissolved oxygen as the endogenous coreactant, an intensive NIR-ECL emission at 692 nm arose which was ascribed to the unique surface states of multidentate-chelated QDs. By tuning electrolytes, a low-potential ECL peaking at −0.79 V (vs. Ag/AgCl) could further be achieved. Based on the validated competition of heavy metallic cations with the stabilizer Unithiol as it stabilizes the aqueous dispersion of QDs, the ECL emission could be significantly quenched and a home-made ECL ion-selective chip was manufactured. It was further found that capping with a cation exchange membrane enabled accelerated adsorption of metal ions and sensitized the ECL signal. Using cupric cations as a model analyte, the devised sensor showed a linear range from 10.0 pM to 1.0 mM with a detection limit down to 6.7 pM, and was successfully used in the direct detection of a Bordeaux mixture with an inorganic pesticide residue on the grape skin with high accuracy and selectivity. The proposed strategy could also be extended to quantify Hg2+ and Pb2+ with stronger thiol-bonding capability than Cd2+. The developed microsensing system with replicable one-step synthesis should facilitate portable and integrated QD-based NIR-ECL applications for food hygiene inspection and environmental monitoring.
