The Experts below are selected from a list of 870 Experts worldwide ranked by ideXlab platform
Maria Nolano - One of the best experts on this subject based on the ideXlab platform.
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Differential myelinated and Unmyelinated sensory and autonomic skin Nerve Fiber involvement in patients with ophthalmic postherpetic neuralgia.
Frontiers in neuroanatomy, 2015Co-Authors: Andrea Truini, Maija Haanpää, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, G. Caporaso, Lucio Santoro, Giorgio Cruccu, Maria NolanoAbstract:Postherpetic neuralgia (PHN) is a common and exceptionally drug-resistant neuropathic pain condition. In this cross-sectional skin biopsy study, seeking information on the responsible pathophysiological mechanisms we assessed how ophthalmic PHN affects sensory and autonomic skin innervation. We took 2-mm supraorbital punch skin biopsies from the affected and unaffected sides in 10 patients with ophthalmic PHN. Using indirect immunofluorescence and a large panel of antibodies including protein gene product (PGP) 9.5 we quantified epidermal Unmyelinated, dermal myelinated and autonomic Nerve Fibers. Although skin biopsy showed reduced epidermal and dermal myelinated Fiber density in specimens from the affected side, the epidermal/dermal myelinated Nerve Fiber ratio was lower in the affected than in the unaffected side (p < 0.001), thus suggesting a predominant epidermal Unmyelinated Nerve Fiber loss. Conversely, autonomic skin innervation was spared. Our study showing that ophthalmic PHN predominantly affects Unmyelinated Nerve Fiber and spares autonomic Nerve Fiber might help to understand the pathophysiological mechanisms underlying this difficult-to-treat condition.
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differential trigeminal myelinated and Unmyelinated Nerve Fiber involvement in fosmn syndrome
Neurology, 2015Co-Authors: Andrea Truini, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, Lucio Santoro, Giorgio Cruccu, Giovanni Antonini, Maria NolanoAbstract:Facial-onset sensory-motor neuronopathy (FOSMN) first manifests with trigeminal sensory loss and pain, then spreads to bulbopontine and spinal motoneurons, sometimes with a fatal outcome.1,2
Andrea Truini - One of the best experts on this subject based on the ideXlab platform.
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Differential myelinated and Unmyelinated sensory and autonomic skin Nerve Fiber involvement in patients with ophthalmic postherpetic neuralgia.
Frontiers in neuroanatomy, 2015Co-Authors: Andrea Truini, Maija Haanpää, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, G. Caporaso, Lucio Santoro, Giorgio Cruccu, Maria NolanoAbstract:Postherpetic neuralgia (PHN) is a common and exceptionally drug-resistant neuropathic pain condition. In this cross-sectional skin biopsy study, seeking information on the responsible pathophysiological mechanisms we assessed how ophthalmic PHN affects sensory and autonomic skin innervation. We took 2-mm supraorbital punch skin biopsies from the affected and unaffected sides in 10 patients with ophthalmic PHN. Using indirect immunofluorescence and a large panel of antibodies including protein gene product (PGP) 9.5 we quantified epidermal Unmyelinated, dermal myelinated and autonomic Nerve Fibers. Although skin biopsy showed reduced epidermal and dermal myelinated Fiber density in specimens from the affected side, the epidermal/dermal myelinated Nerve Fiber ratio was lower in the affected than in the unaffected side (p < 0.001), thus suggesting a predominant epidermal Unmyelinated Nerve Fiber loss. Conversely, autonomic skin innervation was spared. Our study showing that ophthalmic PHN predominantly affects Unmyelinated Nerve Fiber and spares autonomic Nerve Fiber might help to understand the pathophysiological mechanisms underlying this difficult-to-treat condition.
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differential trigeminal myelinated and Unmyelinated Nerve Fiber involvement in fosmn syndrome
Neurology, 2015Co-Authors: Andrea Truini, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, Lucio Santoro, Giorgio Cruccu, Giovanni Antonini, Maria NolanoAbstract:Facial-onset sensory-motor neuronopathy (FOSMN) first manifests with trigeminal sensory loss and pain, then spreads to bulbopontine and spinal motoneurons, sometimes with a fatal outcome.1,2
Vincenzo Provitera - One of the best experts on this subject based on the ideXlab platform.
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Differential myelinated and Unmyelinated sensory and autonomic skin Nerve Fiber involvement in patients with ophthalmic postherpetic neuralgia.
Frontiers in neuroanatomy, 2015Co-Authors: Andrea Truini, Maija Haanpää, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, G. Caporaso, Lucio Santoro, Giorgio Cruccu, Maria NolanoAbstract:Postherpetic neuralgia (PHN) is a common and exceptionally drug-resistant neuropathic pain condition. In this cross-sectional skin biopsy study, seeking information on the responsible pathophysiological mechanisms we assessed how ophthalmic PHN affects sensory and autonomic skin innervation. We took 2-mm supraorbital punch skin biopsies from the affected and unaffected sides in 10 patients with ophthalmic PHN. Using indirect immunofluorescence and a large panel of antibodies including protein gene product (PGP) 9.5 we quantified epidermal Unmyelinated, dermal myelinated and autonomic Nerve Fibers. Although skin biopsy showed reduced epidermal and dermal myelinated Fiber density in specimens from the affected side, the epidermal/dermal myelinated Nerve Fiber ratio was lower in the affected than in the unaffected side (p < 0.001), thus suggesting a predominant epidermal Unmyelinated Nerve Fiber loss. Conversely, autonomic skin innervation was spared. Our study showing that ophthalmic PHN predominantly affects Unmyelinated Nerve Fiber and spares autonomic Nerve Fiber might help to understand the pathophysiological mechanisms underlying this difficult-to-treat condition.
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differential trigeminal myelinated and Unmyelinated Nerve Fiber involvement in fosmn syndrome
Neurology, 2015Co-Authors: Andrea Truini, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, Lucio Santoro, Giorgio Cruccu, Giovanni Antonini, Maria NolanoAbstract:Facial-onset sensory-motor neuronopathy (FOSMN) first manifests with trigeminal sensory loss and pain, then spreads to bulbopontine and spinal motoneurons, sometimes with a fatal outcome.1,2
Giorgio Cruccu - One of the best experts on this subject based on the ideXlab platform.
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Differential myelinated and Unmyelinated sensory and autonomic skin Nerve Fiber involvement in patients with ophthalmic postherpetic neuralgia.
Frontiers in neuroanatomy, 2015Co-Authors: Andrea Truini, Maija Haanpää, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, G. Caporaso, Lucio Santoro, Giorgio Cruccu, Maria NolanoAbstract:Postherpetic neuralgia (PHN) is a common and exceptionally drug-resistant neuropathic pain condition. In this cross-sectional skin biopsy study, seeking information on the responsible pathophysiological mechanisms we assessed how ophthalmic PHN affects sensory and autonomic skin innervation. We took 2-mm supraorbital punch skin biopsies from the affected and unaffected sides in 10 patients with ophthalmic PHN. Using indirect immunofluorescence and a large panel of antibodies including protein gene product (PGP) 9.5 we quantified epidermal Unmyelinated, dermal myelinated and autonomic Nerve Fibers. Although skin biopsy showed reduced epidermal and dermal myelinated Fiber density in specimens from the affected side, the epidermal/dermal myelinated Nerve Fiber ratio was lower in the affected than in the unaffected side (p < 0.001), thus suggesting a predominant epidermal Unmyelinated Nerve Fiber loss. Conversely, autonomic skin innervation was spared. Our study showing that ophthalmic PHN predominantly affects Unmyelinated Nerve Fiber and spares autonomic Nerve Fiber might help to understand the pathophysiological mechanisms underlying this difficult-to-treat condition.
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differential trigeminal myelinated and Unmyelinated Nerve Fiber involvement in fosmn syndrome
Neurology, 2015Co-Authors: Andrea Truini, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, Lucio Santoro, Giorgio Cruccu, Giovanni Antonini, Maria NolanoAbstract:Facial-onset sensory-motor neuronopathy (FOSMN) first manifests with trigeminal sensory loss and pain, then spreads to bulbopontine and spinal motoneurons, sometimes with a fatal outcome.1,2
Lucio Santoro - One of the best experts on this subject based on the ideXlab platform.
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Differential myelinated and Unmyelinated sensory and autonomic skin Nerve Fiber involvement in patients with ophthalmic postherpetic neuralgia.
Frontiers in neuroanatomy, 2015Co-Authors: Andrea Truini, Maija Haanpää, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, G. Caporaso, Lucio Santoro, Giorgio Cruccu, Maria NolanoAbstract:Postherpetic neuralgia (PHN) is a common and exceptionally drug-resistant neuropathic pain condition. In this cross-sectional skin biopsy study, seeking information on the responsible pathophysiological mechanisms we assessed how ophthalmic PHN affects sensory and autonomic skin innervation. We took 2-mm supraorbital punch skin biopsies from the affected and unaffected sides in 10 patients with ophthalmic PHN. Using indirect immunofluorescence and a large panel of antibodies including protein gene product (PGP) 9.5 we quantified epidermal Unmyelinated, dermal myelinated and autonomic Nerve Fibers. Although skin biopsy showed reduced epidermal and dermal myelinated Fiber density in specimens from the affected side, the epidermal/dermal myelinated Nerve Fiber ratio was lower in the affected than in the unaffected side (p < 0.001), thus suggesting a predominant epidermal Unmyelinated Nerve Fiber loss. Conversely, autonomic skin innervation was spared. Our study showing that ophthalmic PHN predominantly affects Unmyelinated Nerve Fiber and spares autonomic Nerve Fiber might help to understand the pathophysiological mechanisms underlying this difficult-to-treat condition.
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differential trigeminal myelinated and Unmyelinated Nerve Fiber involvement in fosmn syndrome
Neurology, 2015Co-Authors: Andrea Truini, Vincenzo Provitera, Antonella Biasiotta, A. Stancanelli, Lucio Santoro, Giorgio Cruccu, Giovanni Antonini, Maria NolanoAbstract:Facial-onset sensory-motor neuronopathy (FOSMN) first manifests with trigeminal sensory loss and pain, then spreads to bulbopontine and spinal motoneurons, sometimes with a fatal outcome.1,2
