The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Herman S. Overkleeft - One of the best experts on this subject based on the ideXlab platform.
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synthesis of l altro 1 deoxynojirimycin d allo 1 deoxynojirimycin and d galacto 1 deoxynojirimycin from a single chiral cyanohydrin
Organic Letters, 2010Co-Authors: Adrianus M C H Van Den Nieuwendijk, Johannes Brussee, Richard J B H N Van Den Berg, Mark Ruben, Gijsbert A Van Der Marel, Rene G A Boot, Sander E Engelsma, Martijn D P Risseeuw, Johannes M F G Aerts, Herman S. OverkleeftAbstract:The chemoenzymatic synthesis of three 1-deoxynojirimycin-type iminosugars is reported. Key steps in the synthetic scheme include a Dibal reduction−transimination−sodium borohydride reduction cascade of reactions on an enantiomerically pure cyanohydrin, itself prepared employing almond hydroxynitrile lyase (paHNL) as the common precursor. Ensuing ring-closing metathesis and Upjohn Dihydroxylation afford the target compounds.
Adrianus M C H Van Den Nieuwendijk - One of the best experts on this subject based on the ideXlab platform.
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synthesis of l altro 1 deoxynojirimycin d allo 1 deoxynojirimycin and d galacto 1 deoxynojirimycin from a single chiral cyanohydrin
Organic Letters, 2010Co-Authors: Adrianus M C H Van Den Nieuwendijk, Johannes Brussee, Richard J B H N Van Den Berg, Mark Ruben, Gijsbert A Van Der Marel, Rene G A Boot, Sander E Engelsma, Martijn D P Risseeuw, Johannes M F G Aerts, Herman S. OverkleeftAbstract:The chemoenzymatic synthesis of three 1-deoxynojirimycin-type iminosugars is reported. Key steps in the synthetic scheme include a Dibal reduction−transimination−sodium borohydride reduction cascade of reactions on an enantiomerically pure cyanohydrin, itself prepared employing almond hydroxynitrile lyase (paHNL) as the common precursor. Ensuing ring-closing metathesis and Upjohn Dihydroxylation afford the target compounds.
David S. Nirschl - One of the best experts on this subject based on the ideXlab platform.
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Dihydroxylation of Polyenes Using Narasaka's Modification of the Upjohn Procedure.
The Journal of organic chemistry, 1998Co-Authors: Andreas Gypser, Michel D, David S. NirschlAbstract:Dihydroxylation of a variety of commercially available polyenes has been investigated using phenylboronic acid, N-methylmorpholine N-oxide (NMO), and osmium tetroxide in anhydrous solvent. The diastereoselectivity of multiple oxidation steps is in some cases affected by the in situ protection of the intermediate ene−diols as phenyboronic esters, affording polyols not available from the standard Upjohn Dihydroxylation procedure. A convenient oxidative deprotection of the phenylboronic esters is also described.
Martijn D P Risseeuw - One of the best experts on this subject based on the ideXlab platform.
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synthesis of l altro 1 deoxynojirimycin d allo 1 deoxynojirimycin and d galacto 1 deoxynojirimycin from a single chiral cyanohydrin
Organic Letters, 2010Co-Authors: Adrianus M C H Van Den Nieuwendijk, Johannes Brussee, Richard J B H N Van Den Berg, Mark Ruben, Gijsbert A Van Der Marel, Rene G A Boot, Sander E Engelsma, Martijn D P Risseeuw, Johannes M F G Aerts, Herman S. OverkleeftAbstract:The chemoenzymatic synthesis of three 1-deoxynojirimycin-type iminosugars is reported. Key steps in the synthetic scheme include a Dibal reduction−transimination−sodium borohydride reduction cascade of reactions on an enantiomerically pure cyanohydrin, itself prepared employing almond hydroxynitrile lyase (paHNL) as the common precursor. Ensuing ring-closing metathesis and Upjohn Dihydroxylation afford the target compounds.
Sander E Engelsma - One of the best experts on this subject based on the ideXlab platform.
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synthesis of l altro 1 deoxynojirimycin d allo 1 deoxynojirimycin and d galacto 1 deoxynojirimycin from a single chiral cyanohydrin
Organic Letters, 2010Co-Authors: Adrianus M C H Van Den Nieuwendijk, Johannes Brussee, Richard J B H N Van Den Berg, Mark Ruben, Gijsbert A Van Der Marel, Rene G A Boot, Sander E Engelsma, Martijn D P Risseeuw, Johannes M F G Aerts, Herman S. OverkleeftAbstract:The chemoenzymatic synthesis of three 1-deoxynojirimycin-type iminosugars is reported. Key steps in the synthetic scheme include a Dibal reduction−transimination−sodium borohydride reduction cascade of reactions on an enantiomerically pure cyanohydrin, itself prepared employing almond hydroxynitrile lyase (paHNL) as the common precursor. Ensuing ring-closing metathesis and Upjohn Dihydroxylation afford the target compounds.
