The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Georgios Gakis - One of the best experts on this subject based on the ideXlab platform.
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Prognostic factors and outcomes in primary Urethral Cancer: results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2016Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir Ali-el-deinAbstract:Purpose To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). Methods A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan–Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. Results Median age at definitive treatment was 66 years (IQR 58–76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p
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prognostic factors and outcomes in primary Urethral Cancer results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2016Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir AlieldeinAbstract:PURPOSE To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). METHODS A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. RESULTS Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026). CONCLUSIONS These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
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impact of salvage surgery and radiotherapy on overall survival in patients with recurrent primary Urethral Cancer
Journal of Clinical Oncology, 2015Co-Authors: Georgios Gakis, Todd M. Morgan, Kirk A. Keegan, Johannes Mischinger, Harras B. Zaid, Jan Hrbacek, Siamak Daneshmand, R H Clayman, Bedeir Alieldein, Sigolene GallandAbstract:4568 Background: To evaluate the impact of salvage therapy (ST) on overall survival (OS) in recurrent primary Urethral Cancer (PUC). Methods: A series of 154 patients (109 men, 45 women; median age: 66, IQR: 58-76) were diagnosed with PUC at ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank was used to estimate the impact of ST on OS. The median follow-up was 21 months (mean: 32 months; IQR: 4-48). Results: The modality of primary treatment was cystectomy+urethrectomy in 43 (27.9%), total/partial urethrectomy in 39/6 (25.3/3.9%), transUrethral resection in 39 (25.3%), chemoradiotherapy (CRT), radiotherapy (RT), chemotherapy (CT) and other in 9 (5.8%), 4 (2.6%), 3 (1.9%) and 9 (5.8%) patients, respectively. Neoadjuvant CT/CRT and adjuvant CT were administered to 16/9 (10.4/5.8%) and 23 (14.9%) patients, respectively. The locations of recurrences were: Urethral in 28 (18.2%), lymph nodes (LN) in 18 (11.7%), LN+distant in 12 (7.8%), LN+distant+Urethral in 9 (5.8%), LN+Urethral i...
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Prognostic factors and outcomes in primary Urethral Cancer: results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2015Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir Ali-el-deinAbstract:PURPOSE To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). METHODS A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. RESULTS Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p
Tetsuro Matsumoto - One of the best experts on this subject based on the ideXlab platform.
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bladder sparing surgery and continent urinary diversion using the appendix mitrofanoff procedure for Urethral Cancer
International Journal of Urology, 2005Co-Authors: Mizuki Kobayashi, Masayoshi Nomura, Yoji Yamada, Naohiro Fujimoto, Tetsuro MatsumotoAbstract:Abstract We performed bladder-sparing surgery and continent urinary diversion in two patients with Urethral Cancer. The first patient was a 58-year-old man with bulbomembranous Urethral Cancer (squamous cell carcinoma, cT2N0M0). The second patient was a 77-year-old woman with Urethral Cancer invading the vaginal wall (transitional cell carcinoma with squamous cell carcinoma, cT3N0M0). After bladder-sparing urethrectomy, continent urinary diversion with appendicovesicostomy (Mitrofanoff procedure) was performed in the both patients. More than 4 years after the surgery, both patients were continent, had no trouble with catheterization, and experienced no recurrence of Cancer. Bladder-sparing surgery and urinary diversion based on the Mitrofanoff procedure can be considered for appropriately selected patients with Urethral Cancer.
L Donahue - One of the best experts on this subject based on the ideXlab platform.
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su gg t 73 high dose rate hdr brachytherapy using foley and catheter technique for treatment of Urethral Cancer
Medical Physics, 2010Co-Authors: S Deore, M Atanas, X Xu, J Haynes, L DonahueAbstract:Purpose: To present an innovative treatment technique using Foley Catheter and high dose rate (HDR) brachytherapy for localized Urethral Cancer. Introduction: Urethral Cancer that is localized between bladder neck and penile area presents a significant challenge for external beam irradiation treatment. Irregular surface plus large depth variations often lead to severe skinreactions in scrotal and penile area. This limits the total dose a patient can receive. To overcome this limitation, we developed a technique using High Dose Rate (HDR) brachytherapy delivered through a Foley Catheter. Methods and Materials: A 61 year old gentleman with Cancer of penile urethra was treated with external beam using 10 MV photons to the dose of 39.6 Gy. Patient had considerable acute skinreactions in the scrotal and penile area, resulting treatment break. An alternative technique using HDR system was developed. The biggest challenge for HDR treatment was holding the catheter in place, reproducibility, and high mucosal dose. The patient was catheterized with largest Foley catheter and through this Foley; a 6 French endobronchial catheter was inserted. The inflated Foley helped us to secure and reproduce the HDR catheter for multiple fractions. Patient was CT‐Simmed using Foley and Catheter with X‐ray localizer for HDR planning. Based on Linear Quadratic model, HDR fractionation of 4.5 Gy/F times 5F, was planned to take total dose equivalent to 74 Gy with 2Gy/F. Results: Patient received five fractions of HDR treatment delivered bi‐weekly. The catheter placement was confirmed using CTimaging before each HDR treatment. At the end of each fraction, the HDR catheter was removed. Patient tolerated all treatments very well. The early results for this technique appear very promising. Conclusions: This alternative delivery technique allowed adequate dose to the Cancer, while sparing morbidity to the soft tissues of his penus, scrotum and rectum.
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SU‐GG‐T‐73: High Dose Rate (HDR) Brachytherapy Using Foley and Catheter Technique for Treatment of Urethral Cancer
Medical Physics, 2010Co-Authors: S Deore, M Atanas, X Xu, J Haynes, L DonahueAbstract:Purpose: To present an innovative treatment technique using Foley Catheter and high dose rate (HDR) brachytherapy for localized Urethral Cancer. Introduction: Urethral Cancer that is localized between bladder neck and penile area presents a significant challenge for external beam irradiation treatment. Irregular surface plus large depth variations often lead to severe skinreactions in scrotal and penile area. This limits the total dose a patient can receive. To overcome this limitation, we developed a technique using High Dose Rate (HDR) brachytherapy delivered through a Foley Catheter. Methods and Materials: A 61 year old gentleman with Cancer of penile urethra was treated with external beam using 10 MV photons to the dose of 39.6 Gy. Patient had considerable acute skinreactions in the scrotal and penile area, resulting treatment break. An alternative technique using HDR system was developed. The biggest challenge for HDR treatment was holding the catheter in place, reproducibility, and high mucosal dose. The patient was catheterized with largest Foley catheter and through this Foley; a 6 French endobronchial catheter was inserted. The inflated Foley helped us to secure and reproduce the HDR catheter for multiple fractions. Patient was CT‐Simmed using Foley and Catheter with X‐ray localizer for HDR planning. Based on Linear Quadratic model, HDR fractionation of 4.5 Gy/F times 5F, was planned to take total dose equivalent to 74 Gy with 2Gy/F. Results: Patient received five fractions of HDR treatment delivered bi‐weekly. The catheter placement was confirmed using CTimaging before each HDR treatment. At the end of each fraction, the HDR catheter was removed. Patient tolerated all treatments very well. The early results for this technique appear very promising. Conclusions: This alternative delivery technique allowed adequate dose to the Cancer, while sparing morbidity to the soft tissues of his penus, scrotum and rectum.
Harras B. Zaid - One of the best experts on this subject based on the ideXlab platform.
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Prognostic factors and outcomes in primary Urethral Cancer: results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2016Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir Ali-el-deinAbstract:Purpose To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). Methods A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan–Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. Results Median age at definitive treatment was 66 years (IQR 58–76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p
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prognostic factors and outcomes in primary Urethral Cancer results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2016Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir AlieldeinAbstract:PURPOSE To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). METHODS A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. RESULTS Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026). CONCLUSIONS These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
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impact of salvage surgery and radiotherapy on overall survival in patients with recurrent primary Urethral Cancer
Journal of Clinical Oncology, 2015Co-Authors: Georgios Gakis, Todd M. Morgan, Kirk A. Keegan, Johannes Mischinger, Harras B. Zaid, Jan Hrbacek, Siamak Daneshmand, R H Clayman, Bedeir Alieldein, Sigolene GallandAbstract:4568 Background: To evaluate the impact of salvage therapy (ST) on overall survival (OS) in recurrent primary Urethral Cancer (PUC). Methods: A series of 154 patients (109 men, 45 women; median age: 66, IQR: 58-76) were diagnosed with PUC at ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank was used to estimate the impact of ST on OS. The median follow-up was 21 months (mean: 32 months; IQR: 4-48). Results: The modality of primary treatment was cystectomy+urethrectomy in 43 (27.9%), total/partial urethrectomy in 39/6 (25.3/3.9%), transUrethral resection in 39 (25.3%), chemoradiotherapy (CRT), radiotherapy (RT), chemotherapy (CT) and other in 9 (5.8%), 4 (2.6%), 3 (1.9%) and 9 (5.8%) patients, respectively. Neoadjuvant CT/CRT and adjuvant CT were administered to 16/9 (10.4/5.8%) and 23 (14.9%) patients, respectively. The locations of recurrences were: Urethral in 28 (18.2%), lymph nodes (LN) in 18 (11.7%), LN+distant in 12 (7.8%), LN+distant+Urethral in 9 (5.8%), LN+Urethral i...
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Prognostic factors and outcomes in primary Urethral Cancer: results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2015Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir Ali-el-deinAbstract:PURPOSE To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). METHODS A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. RESULTS Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p
Todd M. Morgan - One of the best experts on this subject based on the ideXlab platform.
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Prognostic factors and outcomes in primary Urethral Cancer: results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2016Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir Ali-el-deinAbstract:Purpose To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). Methods A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan–Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. Results Median age at definitive treatment was 66 years (IQR 58–76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p
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prognostic factors and outcomes in primary Urethral Cancer results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2016Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir AlieldeinAbstract:PURPOSE To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). METHODS A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. RESULTS Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026). CONCLUSIONS These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
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impact of salvage surgery and radiotherapy on overall survival in patients with recurrent primary Urethral Cancer
Journal of Clinical Oncology, 2015Co-Authors: Georgios Gakis, Todd M. Morgan, Kirk A. Keegan, Johannes Mischinger, Harras B. Zaid, Jan Hrbacek, Siamak Daneshmand, R H Clayman, Bedeir Alieldein, Sigolene GallandAbstract:4568 Background: To evaluate the impact of salvage therapy (ST) on overall survival (OS) in recurrent primary Urethral Cancer (PUC). Methods: A series of 154 patients (109 men, 45 women; median age: 66, IQR: 58-76) were diagnosed with PUC at ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank was used to estimate the impact of ST on OS. The median follow-up was 21 months (mean: 32 months; IQR: 4-48). Results: The modality of primary treatment was cystectomy+urethrectomy in 43 (27.9%), total/partial urethrectomy in 39/6 (25.3/3.9%), transUrethral resection in 39 (25.3%), chemoradiotherapy (CRT), radiotherapy (RT), chemotherapy (CT) and other in 9 (5.8%), 4 (2.6%), 3 (1.9%) and 9 (5.8%) patients, respectively. Neoadjuvant CT/CRT and adjuvant CT were administered to 16/9 (10.4/5.8%) and 23 (14.9%) patients, respectively. The locations of recurrences were: Urethral in 28 (18.2%), lymph nodes (LN) in 18 (11.7%), LN+distant in 12 (7.8%), LN+distant+Urethral in 9 (5.8%), LN+Urethral i...
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Prognostic factors and outcomes in primary Urethral Cancer: results from the international collaboration on primary Urethral carcinoma
World Journal of Urology, 2015Co-Authors: Georgios Gakis, Todd M. Morgan, Jason A. Efstathiou, Kirk A. Keegan, Johannes Mischinger, Tilman Todenhoefer, Tina Schubert, Harras B. Zaid, Jan Hrbacek, Bedeir Ali-el-deinAbstract:PURPOSE To evaluate risk factors for survival in a large international cohort of patients with primary Urethral Cancer (PUC). METHODS A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. RESULTS Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p
