The Experts below are selected from a list of 1158 Experts worldwide ranked by ideXlab platform
Guang-hui Wei - One of the best experts on this subject based on the ideXlab platform.
-
Trans-uretero-cystic external Urethral Stent for urinary diversion in pediatric laparoscopic pyeloplasty: A novel approach.
Medicine, 2020Co-Authors: Jun-jun Dong, Sheng Wen, Xing Liu, Tao Lin, Feng Liu, Guang-hui WeiAbstract:We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-uretero-cystic external Urethral Stent (TEUS). We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J Stent) or group B (TEUS). In group A, the double-J Stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external Stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of Stent-related complications including urinary leakage, Stent dislocation, Stent occlusion, and urinary tract infection. The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding Stent-related complications. In group A, 4 patients need auxiliary Stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had Stent occlusion. In group B, none needed auxiliary Stent re-insertion for complications and avoided re-operation. In children, the outcome of external Stent implantation was similar to that using double-J Stent, and the use of the former approach may be beneficial for younger children.
-
trans uretero cystic external Urethral Stent for urinary diversion in pediatric laparoscopic pyeloplasty a novel approach
Medicine, 2020Co-Authors: Jun-jun Dong, Sheng Wen, Xing Liu, Tao Lin, Feng Liu, Guang-hui WeiAbstract:Purpose We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-uretero-cystic external Urethral Stent (TEUS). Methods We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J Stent) or group B (TEUS). In group A, the double-J Stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external Stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of Stent-related complications including urinary leakage, Stent dislocation, Stent occlusion, and urinary tract infection. Results The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding Stent-related complications. In group A, 4 patients need auxiliary Stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had Stent occlusion. In group B, none needed auxiliary Stent re-insertion for complications and avoided re-operation. Conclusions In children, the outcome of external Stent implantation was similar to that using double-J Stent, and the use of the former approach may be beneficial for younger children.
Jun-jun Dong - One of the best experts on this subject based on the ideXlab platform.
-
Trans-uretero-cystic external Urethral Stent for urinary diversion in pediatric laparoscopic pyeloplasty: A novel approach.
Medicine, 2020Co-Authors: Jun-jun Dong, Sheng Wen, Xing Liu, Tao Lin, Feng Liu, Guang-hui WeiAbstract:We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-uretero-cystic external Urethral Stent (TEUS). We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J Stent) or group B (TEUS). In group A, the double-J Stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external Stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of Stent-related complications including urinary leakage, Stent dislocation, Stent occlusion, and urinary tract infection. The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding Stent-related complications. In group A, 4 patients need auxiliary Stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had Stent occlusion. In group B, none needed auxiliary Stent re-insertion for complications and avoided re-operation. In children, the outcome of external Stent implantation was similar to that using double-J Stent, and the use of the former approach may be beneficial for younger children.
-
trans uretero cystic external Urethral Stent for urinary diversion in pediatric laparoscopic pyeloplasty a novel approach
Medicine, 2020Co-Authors: Jun-jun Dong, Sheng Wen, Xing Liu, Tao Lin, Feng Liu, Guang-hui WeiAbstract:Purpose We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-uretero-cystic external Urethral Stent (TEUS). Methods We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J Stent) or group B (TEUS). In group A, the double-J Stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external Stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of Stent-related complications including urinary leakage, Stent dislocation, Stent occlusion, and urinary tract infection. Results The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding Stent-related complications. In group A, 4 patients need auxiliary Stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had Stent occlusion. In group B, none needed auxiliary Stent re-insertion for complications and avoided re-operation. Conclusions In children, the outcome of external Stent implantation was similar to that using double-J Stent, and the use of the former approach may be beneficial for younger children.
Teuvo L. J. Tammela - One of the best experts on this subject based on the ideXlab platform.
-
preclinical evaluation of new indomethacin eluting biodegradable Urethral Stent
Journal of Endourology, 2012Co-Authors: Andres Kotsar, M. Talja, Taina Isotalo, Riina Nieminen, Joonas Mikkonen, Ilkka Uurto, Minna Kellomaki, Eeva Moilanen, Teuvo L. J. TammelaAbstract:Abstract Purpose: To evaluate the effect of an indomethacin-eluting biodegradable Urethral Stent on the production of inflammatory cytokines in vitro and the degradation and biocompatibility of the new Stent in vivo. Materials and Methods: The effects of an indomethacin and indomethacin-eluting biodegradable Stent on monocyte chemoattractant protein (MCP)-1, RANTES (regulated on activation, normal T-cell expressed and secreted), and transforming growth factor-s were measured in THP-1 cells by enzyme-linked immunosorbent assay. Stents (copolymer of L-lactide and glycolide acid) that were coated with 50L/50D polylactic acid and two different concentrations of indomethacin were inserted into the rabbit urethra. Stents without the drug were used as controls. Scanning electron microscopy (SEM) was used to assess the degradation of the Stents. Biocompatibility was evaluated using histologic analyses of the Urethral specimen. The measurements were performed at 3 weeks and 3 months. Results: Indomethacin and indo...
-
Preclinical Evaluation of New Indomethacin-Eluting Biodegradable Urethral Stent
Journal of endourology, 2012Co-Authors: Andres Kotsar, M. Talja, Taina Isotalo, Riina Nieminen, Joonas Mikkonen, Ilkka Uurto, Minna Kellomaki, Eeva Moilanen, Teuvo L. J. TammelaAbstract:To evaluate the effect of an indomethacin-eluting biodegradable Urethral Stent on the production of inflammatory cytokines in vitro and the degradation and biocompatibility of the new Stent in vivo. The effects of an indomethacin and indomethacin-eluting biodegradable Stent on monocyte chemoattractant protein (MCP)-1, RANTES (regulated on activation, normal T-cell expressed and secreted), and transforming growth factor-ß were measured in THP-1 cells by enzyme-linked immunosorbent assay. Stents (copolymer of L-lactide and glycolide acid) that were coated with 50L/50D polylactic acid and two different concentrations of indomethacin were inserted into the rabbit urethra. Stents without the drug were used as controls. Scanning electron microscopy (SEM) was used to assess the degradation of the Stents. Biocompatibility was evaluated using histologic analyses of the Urethral specimen. The measurements were performed at 3 weeks and 3 months. Indomethacin and indomethacin-releasing Stent material inhibited MCP-1 and RANTES production in activated THP-1 macrophages. SEM analysis revealed that indomethacin coating had no effect on the degradation process of the Stents and less epithelial polyposis had developed in the indomethacin Stent group. In histologic analyses at 3 weeks, indomethacin-eluting Stents caused more calcification but no significant differences in other tissue reactions. At 3 months, the indomethacin-eluting Stents caused less inflammatory reaction and calcification compared with the control Stents. Indomethacin-eluting property can be safely added to biodegradable Stents without major influence on the degradation time. The development of epithelial polyposis in the urethra can be potentially reduced by the new indomethacin-eluting Urethral Stents.
-
biocompatibility of new drug eluting biodegradable Urethral Stent materials
Urology, 2010Co-Authors: Andres Kotsar, M. Talja, Taina Isotalo, Riina Nieminen, Joonas Mikkonen, Ilkka Uurto, Minna Kellomaki, Eeva Moilanen, Teuvo L. J. TammelaAbstract:Objectives To investigate the effects of biodegradable Stent material (poly-96L/4D-lactic acid [PLA]) on the production of cytokines and other inflammatory mediators in vitro and the biocompatibility of new drug-eluting biodegradable Urethral Stent materials in vivo. Indomethacin, dexamethasone, and simvastatin were used in the materials. Methods The effects of the biodegradable Stent material on cytokines and other inflammatory mediators were measured using the Human Cytokine Antibody Array and enzyme-linked immunosorbent assay in THP-1 cells, with bacterial lipopolysaccharide as a positive control. To assess the biocompatibility of the Stent materials, we used muscle implantation. Biodegradable Stent materials without drug-eluting properties and silicone and latex were used as controls. The measurements were done at 3 weeks and 3 months. Results The PLA Stent material induced production of inflammatory mediators, especially interleukin-8, tumor necrosis factor-α, and transforming growth factor-β, in vitro. The increase in the production of these mediators with the PLA Stent material was smaller than in the cells treated with lipopolysaccharide. In vivo, the effects of the biodegradable materials did not differ at 3 weeks, although, at 3 months, dexamethasone had induced more tissue reactions than had the other materials. At 3 months, fibrosis and chronic inflammatory changes were decreased in the biodegradable material groups compared with the positive control. Conclusions PLA Stent material increased the production of cytokines and other inflammatory mediators less than did positive controls in vitro. The in vivo biocompatibility of the drug-eluting biodegradable materials was better than that of the positive controls. Drug-eluting biodegradable Urethral Stents could potentially offer a new treatment modality in the future.
-
Biocompatibility of new drug-eluting biodegradable Urethral Stent materials.
Urology, 2009Co-Authors: Andres Kotsar, M. Talja, Taina Isotalo, Riina Nieminen, Joonas Mikkonen, Ilkka Uurto, Minna Kellomaki, Eeva Moilanen, Teuvo L. J. TammelaAbstract:To investigate the effects of biodegradable Stent material (poly-96L/4D-lactic acid [PLA]) on the production of cytokines and other inflammatory mediators in vitro and the biocompatibility of new drug-eluting biodegradable Urethral Stent materials in vivo. Indomethacin, dexamethasone, and simvastatin were used in the materials. The effects of the biodegradable Stent material on cytokines and other inflammatory mediators were measured using the Human Cytokine Antibody Array and enzyme-linked immunosorbent assay in THP-1 cells, with bacterial lipopolysaccharide as a positive control. To assess the biocompatibility of the Stent materials, we used muscle implantation. Biodegradable Stent materials without drug-eluting properties and silicone and latex were used as controls. The measurements were done at 3 weeks and 3 months. The PLA Stent material induced production of inflammatory mediators, especially interleukin-8, tumor necrosis factor-alpha, and transforming growth factor-beta, in vitro. The increase in the production of these mediators with the PLA Stent material was smaller than in the cells treated with lipopolysaccharide. In vivo, the effects of the biodegradable materials did not differ at 3 weeks, although, at 3 months, dexamethasone had induced more tissue reactions than had the other materials. At 3 months, fibrosis and chronic inflammatory changes were decreased in the biodegradable material groups compared with the positive control. PLA Stent material increased the production of cytokines and other inflammatory mediators less than did positive controls in vitro. The in vivo biocompatibility of the drug-eluting biodegradable materials was better than that of the positive controls. Drug-eluting biodegradable Urethral Stents could potentially offer a new treatment modality in the future. 2010 Elsevier Inc. All rights reserved.
-
biodegradable braided poly lactic co glycolic acid Urethral Stent combined with dutasteride in the treatment of acute urinary retention due to benign prostatic enlargement a pilot study
BJUI, 2009Co-Authors: Andres Kotsar, M. Talja, Taina Isotalo, Joonas Mikkonen, Minna Kellomaki, Hanne Juuti, Jenni Leppiniemi, Venla Hänninen, Teuvo L. J. TammelaAbstract:OBJECTIVE To evaluate, in a pilot study, the efficacy and safety of combining a braided poly(lactic-co-glycolic acid) (PLGA, a copolymer of l-lactide and glycolide) Urethral Stent and dutasteride in the treatment of acute urinary retention (AUR) due to benign prostatic enlargement (BPE). PATIENTS AND METHODS Ten men with AUR due to BPE were treated as outpatients. A biodegradable braided PLGA Urethral Stent was inserted into the prostatic urethra, using a specially designed insertion device under visual control. Dutasteride treatment was started and the patients were followed up for 3 months after insertion of the Stents. RESULTS In all patients the Stents were placed successfully with the new insertion device. All men were able to void after inserting the Stent. At 1 month five patients voided freely with a low residual urine volume (<150 mL), two voided but had a high residual urine volume and a suprapubic catheter was placed, and three needed a suprapubic or an indwelling catheter before 1 month, due to AUR or comorbidities. At 3 months five patients were voiding with no problems. CONCLUSIONS We have developed a new and effective insertion device for biodegradable braided prostatic Stents. The new braided-pattern Stent overcomes the earlier problems of migration and sudden breakage into large particles associated with biodegradable spiral Stents. However, the mechanical properties of the new Stent need to be improved and tested in a longer follow-up. We consider that this new biodegradable braided-pattern Urethral Stent could provide a new option in the future treatment of AUR.
Sheng Wen - One of the best experts on this subject based on the ideXlab platform.
-
Trans-uretero-cystic external Urethral Stent for urinary diversion in pediatric laparoscopic pyeloplasty: A novel approach.
Medicine, 2020Co-Authors: Jun-jun Dong, Sheng Wen, Xing Liu, Tao Lin, Feng Liu, Guang-hui WeiAbstract:We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-uretero-cystic external Urethral Stent (TEUS). We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J Stent) or group B (TEUS). In group A, the double-J Stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external Stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of Stent-related complications including urinary leakage, Stent dislocation, Stent occlusion, and urinary tract infection. The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding Stent-related complications. In group A, 4 patients need auxiliary Stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had Stent occlusion. In group B, none needed auxiliary Stent re-insertion for complications and avoided re-operation. In children, the outcome of external Stent implantation was similar to that using double-J Stent, and the use of the former approach may be beneficial for younger children.
-
trans uretero cystic external Urethral Stent for urinary diversion in pediatric laparoscopic pyeloplasty a novel approach
Medicine, 2020Co-Authors: Jun-jun Dong, Sheng Wen, Xing Liu, Tao Lin, Feng Liu, Guang-hui WeiAbstract:Purpose We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-uretero-cystic external Urethral Stent (TEUS). Methods We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J Stent) or group B (TEUS). In group A, the double-J Stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external Stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of Stent-related complications including urinary leakage, Stent dislocation, Stent occlusion, and urinary tract infection. Results The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding Stent-related complications. In group A, 4 patients need auxiliary Stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had Stent occlusion. In group B, none needed auxiliary Stent re-insertion for complications and avoided re-operation. Conclusions In children, the outcome of external Stent implantation was similar to that using double-J Stent, and the use of the former approach may be beneficial for younger children.
Feng Liu - One of the best experts on this subject based on the ideXlab platform.
-
Trans-uretero-cystic external Urethral Stent for urinary diversion in pediatric laparoscopic pyeloplasty: A novel approach.
Medicine, 2020Co-Authors: Jun-jun Dong, Sheng Wen, Xing Liu, Tao Lin, Feng Liu, Guang-hui WeiAbstract:We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-uretero-cystic external Urethral Stent (TEUS). We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J Stent) or group B (TEUS). In group A, the double-J Stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external Stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of Stent-related complications including urinary leakage, Stent dislocation, Stent occlusion, and urinary tract infection. The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding Stent-related complications. In group A, 4 patients need auxiliary Stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had Stent occlusion. In group B, none needed auxiliary Stent re-insertion for complications and avoided re-operation. In children, the outcome of external Stent implantation was similar to that using double-J Stent, and the use of the former approach may be beneficial for younger children.
-
trans uretero cystic external Urethral Stent for urinary diversion in pediatric laparoscopic pyeloplasty a novel approach
Medicine, 2020Co-Authors: Jun-jun Dong, Sheng Wen, Xing Liu, Tao Lin, Feng Liu, Guang-hui WeiAbstract:Purpose We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-uretero-cystic external Urethral Stent (TEUS). Methods We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J Stent) or group B (TEUS). In group A, the double-J Stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external Stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of Stent-related complications including urinary leakage, Stent dislocation, Stent occlusion, and urinary tract infection. Results The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding Stent-related complications. In group A, 4 patients need auxiliary Stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had Stent occlusion. In group B, none needed auxiliary Stent re-insertion for complications and avoided re-operation. Conclusions In children, the outcome of external Stent implantation was similar to that using double-J Stent, and the use of the former approach may be beneficial for younger children.
