The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform
Kevin G Rice - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of Uridine 5′‐[2‐S‐Pyridyl‐3‐thio‐α‐d‐galactopyranosyl Diphosphate]: Precursors of UDP‐Thiogal Sugar Nucleotide Donor Substrate for β‐1,4‐Galactosyltransferase
Nucleosides nucleotides & nucleic acids, 2004Co-Authors: Jordan Elhalabi, Kevin G RiceAbstract:The syntheses of a novel Uridine Diphosphate Galactose (UDP‐Gal) analog, (UDP‐2,4,6‐tri‐O‐acetyl‐3‐S‐acetyl‐3‐thio‐α‐d‐galactopyranose) (11) and the thiolpyridine protected (Uridine 5′‐[3‐S‐(2‐S‐pyridyl)‐3‐thio‐α‐d‐galactopyranosyl Diphosphate) analog (12) are described. The reported synthesis relies on the novel use of thiolpyridine to generate 12 which is a suitably protected intermediate for generating a UDP‐thioGal derivative by reduction prior to enzyme transfer via β‐1,4‐galactosyltransferase. †In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
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Thiosugar nucleotide analogs: synthesis of 5'-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-alpha-D-galactopyranosyl Diphosphate).
Carbohydrate research, 2002Co-Authors: Jordan Elhalabi, Kevin G RiceAbstract:The synthesis of a novel analog of Uridine Diphosphate Galactose (UDP-Gal) is described. A sulfur atom was inserted into the 6-position of Galactose to give Uridine 5'-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-alpha-D-galactopyranosyl Diphosphate). This peracetylated thiol analogue of UDP-Gal has been synthesized in nine steps starting from methyl alpha-D-galactopyranoside in an overall yield of 3%.
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Thiosugar nucleotide analogs: Synthesis of 5′-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-α-d-galactopyranosyl Diphosphate)
Carbohydrate Research, 2002Co-Authors: Jordan Elhalabi, Kevin G RiceAbstract:The synthesis of a novel analog of Uridine Diphosphate Galactose (UDP-Gal) is described. A sulfur atom was inserted into the 6-position of Galactose to give Uridine 5'-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-alpha-D-galactopyranosyl Diphosphate). This peracetylated thiol analogue of UDP-Gal has been synthesized in nine steps starting from methyl alpha-D-galactopyranoside in an overall yield of 3%.
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Thiosugar nucleotide analogues: synthesis of Uridine 5′-(2,3,6-tri-O-acetyl-4-S-acetyl-4-thio-α-d-galactopyranosyl Diphosphate)
Carbohydrate research, 2001Co-Authors: Jordan Elhalabi, Kevin G RiceAbstract:Abstract The synthesis of a novel Uridine Diphosphate Galactose (UDP-Gal) analog, (UDP-2,3,6-tri- O -acetyl-4- S -acetyl-4-thio-α- d -galactopyranose) ( 10 ) is described. Compound 10 contains a sulfur in the place of oxygen at the 4-position of the Galactose moiety. Compound 10 represents a protected form of a novel sugar nucleotide analog that can potentially be used during chemoenzymatic synthesis to modify complex oligosaccharides.
H. N. Kirkman - One of the best experts on this subject based on the ideXlab platform.
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Measurements of Uridine Diphosphate glucose and Uridine Diphosphate Galactose ― an appraisal
European Journal of Pediatrics, 1995Co-Authors: H. N. KirkmanAbstract:The recent disproof of a major deficiency of Uridine Diphosphate Galactose in Galactosemia should not lead investigators to assume either that enzymatic methods are unreliable for Uridine sugar assays or that a defect in galactosylation in Galactosemia has been excluded.
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Erythrocytic Uridine Diphosphate Galactose in galactosaemia
Journal of Inherited Metabolic Disease, 1992Co-Authors: H. N. KirkmanAbstract:An earlier claim of a deficiency of Uridine Diphosphate Galactose in erythrocytes of galactosaemia patients was not confirmed. Enzymic techniques similar to those of the earlier investigators were used to determine not only the concentration of Uridine Diphosphate Galactose but also the ratio of this concentration to the sum of the Uridine sugar Diphosphates (Uridine Diphosphate Galactose and Uridine Diphosphate glucose). The values in erythrocytes of galactosaemic subjects were similar to those of non-galactosaemic children on a Galactose-restricted diet and to those of normal adults. These results cast doubt on the claim of a major deficiency of Uridine Diphosphate Galactose in galactosaemia and on the need for treating galactosaemic children with Uridine.
Ying Liu - One of the best experts on this subject based on the ideXlab platform.
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A systematic review of the Uridine Diphosphate-Galactose/Glucose-4-epimerase (UGE) in plants
Plant Growth Regulation, 2021Co-Authors: Jiaming Hou, Shaokai Tian, Lin Yang, Zhixin Zhang, Ying LiuAbstract:Uridine Diphosphate (UDP)-Galactose/Glucose-4-epimerase (UGE) is the third enzyme involved in the Leloir pathway. It catalyzes the conversion of UDP-Galactose to UDP-Glucose, which is a rate-limiting step for polysaccharides biosynthesis. As the main cell wall materials, polysaccharides play an irreplaceable role throughout the whole life history of plant. In this review, 1243 UGE mRNA sequences registered in NCBI were obtained and their evolutionary relationship was analyzed by constructing a neighbor-joining tree based on representative sequences. The physicochemical properties of 15 specific UGEs were analyzed, and four UGE sequences of Setaria italica, Zea mays, Ricinus Communis, and Oryza sativa were selected for further secondary structure, three-dimensional protein modeling, transmembrane structure, and signal peptide prediction analyses. The results demonstrate that UGEs are mostly conservative without signal peptides and exert activities in cytoplasm. Then, studies related to the catalytic reaction, characteristic structure, function, and regulation of UGE were summarized, which provide strong evidence that UGE plays a crucial role in cell growth, cell differentiation, cell-to-cell communication, primary metabolism, secondary metabolism, and defense responses. However, the molecular mechanisms whereby UGE regulates the plant stress resistance and useful secondary metabolites accumulation are far from clear. This paper will lay a foundation for further studies and applications of UGE.
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a systematic review of the Uridine Diphosphate Galactose glucose 4 epimerase uge in plants
Plant Growth Regulation, 2021Co-Authors: Jiaming Hou, Shaokai Tian, Lin Yang, Zhixin Zhang, Ying LiuAbstract:Uridine Diphosphate (UDP)-Galactose/Glucose-4-epimerase (UGE) is the third enzyme involved in the Leloir pathway. It catalyzes the conversion of UDP-Galactose to UDP-Glucose, which is a rate-limiting step for polysaccharides biosynthesis. As the main cell wall materials, polysaccharides play an irreplaceable role throughout the whole life history of plant. In this review, 1243 UGE mRNA sequences registered in NCBI were obtained and their evolutionary relationship was analyzed by constructing a neighbor-joining tree based on representative sequences. The physicochemical properties of 15 specific UGEs were analyzed, and four UGE sequences of Setaria italica, Zea mays, Ricinus Communis, and Oryza sativa were selected for further secondary structure, three-dimensional protein modeling, transmembrane structure, and signal peptide prediction analyses. The results demonstrate that UGEs are mostly conservative without signal peptides and exert activities in cytoplasm. Then, studies related to the catalytic reaction, characteristic structure, function, and regulation of UGE were summarized, which provide strong evidence that UGE plays a crucial role in cell growth, cell differentiation, cell-to-cell communication, primary metabolism, secondary metabolism, and defense responses. However, the molecular mechanisms whereby UGE regulates the plant stress resistance and useful secondary metabolites accumulation are far from clear. This paper will lay a foundation for further studies and applications of UGE.
Jordan Elhalabi - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of Uridine 5′‐[2‐S‐Pyridyl‐3‐thio‐α‐d‐galactopyranosyl Diphosphate]: Precursors of UDP‐Thiogal Sugar Nucleotide Donor Substrate for β‐1,4‐Galactosyltransferase
Nucleosides nucleotides & nucleic acids, 2004Co-Authors: Jordan Elhalabi, Kevin G RiceAbstract:The syntheses of a novel Uridine Diphosphate Galactose (UDP‐Gal) analog, (UDP‐2,4,6‐tri‐O‐acetyl‐3‐S‐acetyl‐3‐thio‐α‐d‐galactopyranose) (11) and the thiolpyridine protected (Uridine 5′‐[3‐S‐(2‐S‐pyridyl)‐3‐thio‐α‐d‐galactopyranosyl Diphosphate) analog (12) are described. The reported synthesis relies on the novel use of thiolpyridine to generate 12 which is a suitably protected intermediate for generating a UDP‐thioGal derivative by reduction prior to enzyme transfer via β‐1,4‐galactosyltransferase. †In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
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Thiosugar nucleotide analogs: synthesis of 5'-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-alpha-D-galactopyranosyl Diphosphate).
Carbohydrate research, 2002Co-Authors: Jordan Elhalabi, Kevin G RiceAbstract:The synthesis of a novel analog of Uridine Diphosphate Galactose (UDP-Gal) is described. A sulfur atom was inserted into the 6-position of Galactose to give Uridine 5'-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-alpha-D-galactopyranosyl Diphosphate). This peracetylated thiol analogue of UDP-Gal has been synthesized in nine steps starting from methyl alpha-D-galactopyranoside in an overall yield of 3%.
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Thiosugar nucleotide analogs: Synthesis of 5′-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-α-d-galactopyranosyl Diphosphate)
Carbohydrate Research, 2002Co-Authors: Jordan Elhalabi, Kevin G RiceAbstract:The synthesis of a novel analog of Uridine Diphosphate Galactose (UDP-Gal) is described. A sulfur atom was inserted into the 6-position of Galactose to give Uridine 5'-(2,3,4-tri-O-acetyl-6-S-acetyl-6-thio-alpha-D-galactopyranosyl Diphosphate). This peracetylated thiol analogue of UDP-Gal has been synthesized in nine steps starting from methyl alpha-D-galactopyranoside in an overall yield of 3%.
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Thiosugar nucleotide analogues: synthesis of Uridine 5′-(2,3,6-tri-O-acetyl-4-S-acetyl-4-thio-α-d-galactopyranosyl Diphosphate)
Carbohydrate research, 2001Co-Authors: Jordan Elhalabi, Kevin G RiceAbstract:Abstract The synthesis of a novel Uridine Diphosphate Galactose (UDP-Gal) analog, (UDP-2,3,6-tri- O -acetyl-4- S -acetyl-4-thio-α- d -galactopyranose) ( 10 ) is described. Compound 10 contains a sulfur in the place of oxygen at the 4-position of the Galactose moiety. Compound 10 represents a protected form of a novel sugar nucleotide analog that can potentially be used during chemoenzymatic synthesis to modify complex oligosaccharides.
Philip M. Rosoff - One of the best experts on this subject based on the ideXlab platform.
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myelodysplasia and deficiency of Uridine Diphosphate Galactose 4 epimerase
The Journal of Pediatrics, 1995Co-Authors: Philip M. RosoffAbstract:A 4-year-old girl known to have peripheral Uridine Diphosphate-Galactose 4-epimerase deficiency was examined for bruising and thrombocytopenia. She had dysplastic peripheral blood and bone marrow changes, with a global platelet function defect. Uridine Diphosphate-Galactose-4-epimerase participates in a metabolic pathway that provides substrates for posttranslational glycosylation of secreted and membrane glycoproteins, including hematopoietic growth factors and their receptors; there may be a causal relationship between the two disorders.
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Myelodysplasia and deficiency of Uridine Diphosphate–Galactose 4-epimerase
The Journal of pediatrics, 1995Co-Authors: Philip M. RosoffAbstract:A 4-year-old girl known to have peripheral Uridine Diphosphate-Galactose 4-epimerase deficiency was examined for bruising and thrombocytopenia. She had dysplastic peripheral blood and bone marrow changes, with a global platelet function defect. Uridine Diphosphate-Galactose-4-epimerase participates in a metabolic pathway that provides substrates for posttranslational glycosylation of secreted and membrane glycoproteins, including hematopoietic growth factors and their receptors; there may be a causal relationship between the two disorders.
