The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Antonio Lopezbeltran - One of the best experts on this subject based on the ideXlab platform.
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pathology and genetics tumours of the Urinary System and male genital System clinical implications of the 4th edition of the who classification and beyond
European Urology, 2016Co-Authors: Rodolfo Montironi, Marina Scarpelli, Antonio LopezbeltranAbstract:This issue of European Urology contains two extensive reviews of the 4th edition of the WHO classification of tumours of the Urinary System and male genital organs [1], covering renal, penile, and testicular tumours [2] and prostate and bladder tumours [3]. We read these two reviews with great interest because the authors have summarised the 4th edition in a clinically oriented manner. All readers of European Urology, including urologists, uropathologists, medical oncologists, radiologists, surgeons, and radiotherapists, are kept abreast of recent contributions to thepathologyandgenetics of these tumours. This is sure to lead to further improvements in the diagnosis and treatment of tumours of the Urinary System and male genital System.
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pathology and genetics tumours of the Urinary System and male genital System clinical implications of the 4th edition of the who classification and beyond
European Urology, 2016Co-Authors: Rodolfo Montironi, Marina Scarpelli, Liang Cheng, Antonio LopezbeltranAbstract:This issue of European Urology contains two extensive reviews of the 4th edition of the WHO classification of tumours of the Urinary System and male genital organs [1], covering renal, penile, and testicular tumours [2] and prostate and bladder tumours [3]. We read these two reviews with great interest because the authors have summarised the 4th edition in a clinically oriented manner. All readers of European Urology, including urologists, uropathologists, medical oncologists, radiologists, surgeons, and radiotherapists, are kept abreast of recent contributions to thepathologyandgenetics of these tumours. This is sure to lead to further improvements in the diagnosis and treatment of tumours of the Urinary System and male genital System.
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secondary neoplasms of the Urinary System and male genital organs
BJUI, 2009Co-Authors: Doriana Morichetti, Antonio Lopezbeltran, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Ziya Kirkali, Francesco Montorsi, Rodolfo MontironiAbstract:BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the Urinary System and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the Urinary System (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitoUrinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitoUrinary site primary tumour to another genitoUrinary organ occurs most frequently between the prostate and Urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The Urinary System and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.
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secondary neoplasms of the Urinary System and male genital organs
BJUI, 2009Co-Authors: Doriana Morichetti, Antonio Lopezbeltran, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Ziya Kirkali, Francesco Montorsi, Rodolfo MontironiAbstract:BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the Urinary System and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the Urinary System (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitoUrinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitoUrinary site primary tumour to another genitoUrinary organ occurs most frequently between the prostate and Urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The Urinary System and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.
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neuroendocrine tumours of the Urinary System and male genital organs clinical significance
BJUI, 2009Co-Authors: Roberta Mazzucchelli, Antonio Lopezbeltran, Marina Scarpelli, Doriana Morichetti, Liang Cheng, Ziya Kirkali, Rodolfo MontironiAbstract:Two basic types of neuroendocrine (NE) tumours with diverse clinicopathological features and outcome are identified in the Urinary System and male genital organs: carcinoid tumour and neuroendocrine carcinoma. Carcinoid, a rare tumour, occurs in the kidney, bladder, prostate and testis. It is morphologically, histochemically, immunohistochemically and ultrastructurally similar to its counterpart in other organs, such as lung or gastrointestinal tract. Metastases can be detected at the initial evaluation, although they have been reported up to several years after removal, emphasizing the need for a long-term follow-up. NE carcinoma occurs in the kidney, bladder and prostate, and includes small cell carcinoma (SCC) and large cell NE carcinoma (LCNEC), the latter being exceedingly rare. Both show the morphology and immunophenotype of NE carcinoma originating in other organs. Although the occurrence is rare, it is highly aggressive.
Rodolfo Montironi - One of the best experts on this subject based on the ideXlab platform.
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pathology and genetics tumours of the Urinary System and male genital System clinical implications of the 4th edition of the who classification and beyond
European Urology, 2016Co-Authors: Rodolfo Montironi, Marina Scarpelli, Antonio LopezbeltranAbstract:This issue of European Urology contains two extensive reviews of the 4th edition of the WHO classification of tumours of the Urinary System and male genital organs [1], covering renal, penile, and testicular tumours [2] and prostate and bladder tumours [3]. We read these two reviews with great interest because the authors have summarised the 4th edition in a clinically oriented manner. All readers of European Urology, including urologists, uropathologists, medical oncologists, radiologists, surgeons, and radiotherapists, are kept abreast of recent contributions to thepathologyandgenetics of these tumours. This is sure to lead to further improvements in the diagnosis and treatment of tumours of the Urinary System and male genital System.
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pathology and genetics tumours of the Urinary System and male genital System clinical implications of the 4th edition of the who classification and beyond
European Urology, 2016Co-Authors: Rodolfo Montironi, Marina Scarpelli, Liang Cheng, Antonio LopezbeltranAbstract:This issue of European Urology contains two extensive reviews of the 4th edition of the WHO classification of tumours of the Urinary System and male genital organs [1], covering renal, penile, and testicular tumours [2] and prostate and bladder tumours [3]. We read these two reviews with great interest because the authors have summarised the 4th edition in a clinically oriented manner. All readers of European Urology, including urologists, uropathologists, medical oncologists, radiologists, surgeons, and radiotherapists, are kept abreast of recent contributions to thepathologyandgenetics of these tumours. This is sure to lead to further improvements in the diagnosis and treatment of tumours of the Urinary System and male genital System.
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secondary neoplasms of the Urinary System and male genital organs
BJUI, 2009Co-Authors: Doriana Morichetti, Antonio Lopezbeltran, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Ziya Kirkali, Francesco Montorsi, Rodolfo MontironiAbstract:BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the Urinary System and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the Urinary System (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitoUrinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitoUrinary site primary tumour to another genitoUrinary organ occurs most frequently between the prostate and Urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The Urinary System and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.
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secondary neoplasms of the Urinary System and male genital organs
BJUI, 2009Co-Authors: Doriana Morichetti, Antonio Lopezbeltran, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Ziya Kirkali, Francesco Montorsi, Rodolfo MontironiAbstract:BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the Urinary System and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the Urinary System (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitoUrinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitoUrinary site primary tumour to another genitoUrinary organ occurs most frequently between the prostate and Urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The Urinary System and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.
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neuroendocrine tumours of the Urinary System and male genital organs clinical significance
BJUI, 2009Co-Authors: Roberta Mazzucchelli, Antonio Lopezbeltran, Marina Scarpelli, Doriana Morichetti, Liang Cheng, Ziya Kirkali, Rodolfo MontironiAbstract:Two basic types of neuroendocrine (NE) tumours with diverse clinicopathological features and outcome are identified in the Urinary System and male genital organs: carcinoid tumour and neuroendocrine carcinoma. Carcinoid, a rare tumour, occurs in the kidney, bladder, prostate and testis. It is morphologically, histochemically, immunohistochemically and ultrastructurally similar to its counterpart in other organs, such as lung or gastrointestinal tract. Metastases can be detected at the initial evaluation, although they have been reported up to several years after removal, emphasizing the need for a long-term follow-up. NE carcinoma occurs in the kidney, bladder and prostate, and includes small cell carcinoma (SCC) and large cell NE carcinoma (LCNEC), the latter being exceedingly rare. Both show the morphology and immunophenotype of NE carcinoma originating in other organs. Although the occurrence is rare, it is highly aggressive.
Marina Scarpelli - One of the best experts on this subject based on the ideXlab platform.
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pathology and genetics tumours of the Urinary System and male genital System clinical implications of the 4th edition of the who classification and beyond
European Urology, 2016Co-Authors: Rodolfo Montironi, Marina Scarpelli, Antonio LopezbeltranAbstract:This issue of European Urology contains two extensive reviews of the 4th edition of the WHO classification of tumours of the Urinary System and male genital organs [1], covering renal, penile, and testicular tumours [2] and prostate and bladder tumours [3]. We read these two reviews with great interest because the authors have summarised the 4th edition in a clinically oriented manner. All readers of European Urology, including urologists, uropathologists, medical oncologists, radiologists, surgeons, and radiotherapists, are kept abreast of recent contributions to thepathologyandgenetics of these tumours. This is sure to lead to further improvements in the diagnosis and treatment of tumours of the Urinary System and male genital System.
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pathology and genetics tumours of the Urinary System and male genital System clinical implications of the 4th edition of the who classification and beyond
European Urology, 2016Co-Authors: Rodolfo Montironi, Marina Scarpelli, Liang Cheng, Antonio LopezbeltranAbstract:This issue of European Urology contains two extensive reviews of the 4th edition of the WHO classification of tumours of the Urinary System and male genital organs [1], covering renal, penile, and testicular tumours [2] and prostate and bladder tumours [3]. We read these two reviews with great interest because the authors have summarised the 4th edition in a clinically oriented manner. All readers of European Urology, including urologists, uropathologists, medical oncologists, radiologists, surgeons, and radiotherapists, are kept abreast of recent contributions to thepathologyandgenetics of these tumours. This is sure to lead to further improvements in the diagnosis and treatment of tumours of the Urinary System and male genital System.
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secondary neoplasms of the Urinary System and male genital organs
BJUI, 2009Co-Authors: Doriana Morichetti, Antonio Lopezbeltran, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Ziya Kirkali, Francesco Montorsi, Rodolfo MontironiAbstract:BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the Urinary System and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the Urinary System (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitoUrinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitoUrinary site primary tumour to another genitoUrinary organ occurs most frequently between the prostate and Urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The Urinary System and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.
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secondary neoplasms of the Urinary System and male genital organs
BJUI, 2009Co-Authors: Doriana Morichetti, Antonio Lopezbeltran, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Ziya Kirkali, Francesco Montorsi, Rodolfo MontironiAbstract:BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the Urinary System and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the Urinary System (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitoUrinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitoUrinary site primary tumour to another genitoUrinary organ occurs most frequently between the prostate and Urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The Urinary System and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.
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neuroendocrine tumours of the Urinary System and male genital organs clinical significance
BJUI, 2009Co-Authors: Roberta Mazzucchelli, Antonio Lopezbeltran, Marina Scarpelli, Doriana Morichetti, Liang Cheng, Ziya Kirkali, Rodolfo MontironiAbstract:Two basic types of neuroendocrine (NE) tumours with diverse clinicopathological features and outcome are identified in the Urinary System and male genital organs: carcinoid tumour and neuroendocrine carcinoma. Carcinoid, a rare tumour, occurs in the kidney, bladder, prostate and testis. It is morphologically, histochemically, immunohistochemically and ultrastructurally similar to its counterpart in other organs, such as lung or gastrointestinal tract. Metastases can be detected at the initial evaluation, although they have been reported up to several years after removal, emphasizing the need for a long-term follow-up. NE carcinoma occurs in the kidney, bladder and prostate, and includes small cell carcinoma (SCC) and large cell NE carcinoma (LCNEC), the latter being exceedingly rare. Both show the morphology and immunophenotype of NE carcinoma originating in other organs. Although the occurrence is rare, it is highly aggressive.
Liang Cheng - One of the best experts on this subject based on the ideXlab platform.
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pathology and genetics tumours of the Urinary System and male genital System clinical implications of the 4th edition of the who classification and beyond
European Urology, 2016Co-Authors: Rodolfo Montironi, Marina Scarpelli, Liang Cheng, Antonio LopezbeltranAbstract:This issue of European Urology contains two extensive reviews of the 4th edition of the WHO classification of tumours of the Urinary System and male genital organs [1], covering renal, penile, and testicular tumours [2] and prostate and bladder tumours [3]. We read these two reviews with great interest because the authors have summarised the 4th edition in a clinically oriented manner. All readers of European Urology, including urologists, uropathologists, medical oncologists, radiologists, surgeons, and radiotherapists, are kept abreast of recent contributions to thepathologyandgenetics of these tumours. This is sure to lead to further improvements in the diagnosis and treatment of tumours of the Urinary System and male genital System.
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secondary neoplasms of the Urinary System and male genital organs
BJUI, 2009Co-Authors: Doriana Morichetti, Antonio Lopezbeltran, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Ziya Kirkali, Francesco Montorsi, Rodolfo MontironiAbstract:BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the Urinary System and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the Urinary System (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitoUrinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitoUrinary site primary tumour to another genitoUrinary organ occurs most frequently between the prostate and Urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The Urinary System and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.
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secondary neoplasms of the Urinary System and male genital organs
BJUI, 2009Co-Authors: Doriana Morichetti, Antonio Lopezbeltran, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Ziya Kirkali, Francesco Montorsi, Rodolfo MontironiAbstract:BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the Urinary System and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the Urinary System (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non-genitoUrinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitoUrinary site primary tumour to another genitoUrinary organ occurs most frequently between the prostate and Urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The Urinary System and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow-up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.
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neuroendocrine tumours of the Urinary System and male genital organs clinical significance
BJUI, 2009Co-Authors: Roberta Mazzucchelli, Antonio Lopezbeltran, Marina Scarpelli, Doriana Morichetti, Liang Cheng, Ziya Kirkali, Rodolfo MontironiAbstract:Two basic types of neuroendocrine (NE) tumours with diverse clinicopathological features and outcome are identified in the Urinary System and male genital organs: carcinoid tumour and neuroendocrine carcinoma. Carcinoid, a rare tumour, occurs in the kidney, bladder, prostate and testis. It is morphologically, histochemically, immunohistochemically and ultrastructurally similar to its counterpart in other organs, such as lung or gastrointestinal tract. Metastases can be detected at the initial evaluation, although they have been reported up to several years after removal, emphasizing the need for a long-term follow-up. NE carcinoma occurs in the kidney, bladder and prostate, and includes small cell carcinoma (SCC) and large cell NE carcinoma (LCNEC), the latter being exceedingly rare. Both show the morphology and immunophenotype of NE carcinoma originating in other organs. Although the occurrence is rare, it is highly aggressive.
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neuroendocrine tumours of the Urinary System and male genital organs clinical significance
BJUI, 2009Co-Authors: Roberta Mazzucchelli, Antonio Lopezbeltran, Marina Scarpelli, Doriana Morichetti, Liang Cheng, Ziya Kirkali, Rodolfo MontironiAbstract:Two basic types of neuroendocrine (NE) tumours with diverse clinicopathological features and outcome are identified in the Urinary System and male genital organs: carcinoid tumour and neuroendocrine carcinoma. Carcinoid, a rare tumour, occurs in the kidney, bladder, prostate and testis. It is morphologically, histochemically, immunohistochemically and ultrastructurally similar to its counterpart in other organs, such as lung or gastrointestinal tract. Metastases can be detected at the initial evaluation, although they have been reported up to several years after removal, emphasizing the need for a long-term follow-up. NE carcinoma occurs in the kidney, bladder and prostate, and includes small cell carcinoma (SCC) and large cell NE carcinoma (LCNEC), the latter being exceedingly rare. Both show the morphology and immunophenotype of NE carcinoma originating in other organs. Although the occurrence is rare, it is highly aggressive.
Yang Yuxi - One of the best experts on this subject based on the ideXlab platform.
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the clinical significance of multiple tumor marker protein chip in diagnosis of Urinary System tumor and male genital System tumor
Chinese clinical oncology, 2008Co-Authors: Yang YuxiAbstract:Objective:To evaluate the diagnosis value of multiple tumor marker protein chip in diagnosis for Urinary System tumor and male genital System tumor,and set up the diagnostic function of Urinary System tumor and male genital System tumor with 12 tumor markers.Methods:The serum levels of 12 tumor makers were measured in 57 Urinary System tumor patients,38 male genital System tumor patients,11 Urinary System benign diseases patients,25 male genital System benign diseases patients and 1203 health examinations.All the patients were definitely diagnosed by pathological,imaging and clinical diagnosis.Results:In Urinary System tumor,specificity was 81.81%,sensitivity was 49.12%,positive predict value was 93.33% and negative predict value was 23.68%;in male genital System tumor,specificity was 48%,sensitivity was 62.16%,positive predict value was 64.86% and negative predict value was 46.15%.Except for prostatic carcinoma,the combining diagnosis of multiple serum tumor markers using C-12 protein chip had a great significance with diagnosis of the single serum tumor marker in both Urinary System tumor and male genital System tumor(P0.05).We also established the diagnostic function of Urinary System tumor and male genital System tumor with 12 tumor markers.The accuracy rate of the diagnostic functions,which had a great significance with diagnosis of the single serum tumor marker(P0.01),was 81.3% in renal carcinoma,94.5% in bladder and renal duct tumor,94% in prostatic carcinoma and 91% in carcinoma of testis.Conclusion:The combining diagnosis of multiple serum tumor markers using multiple tumor marker protein chip detection System,which is significantly better than the single serum tumor marker,can increase the diagnostic sensitivity for Urinary System tumor and male genital System tumor except for prostatic carcinoma.And the diagnostic functions which can notably increase the accuracy rate for Urinary System tumor and male genital System tumor are helpful in clinic.
