The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Linda Brubaker - One of the best experts on this subject based on the ideXlab platform.
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development and psychometric evaluation of the Urgency questionnaire for evaluating severity and health related quality of life impact of Urinary Urgency in overactive bladder
International Urogynecology Journal, 2015Co-Authors: Karin S Coyne, Chris C Sexton, Christine Thompson, Tamara Bavendam, Linda BrubakerAbstract:Urinary Urgency is the cardinal symptom of overactive bladder (OAB). However, there is no single instrument that assesses the context, severity, intensity, and daily life impact of Urinary Urgency. The purpose of this manuscript is to describe the methods and results of the qualitative and quantitative research conducted to develop a new tool for this purpose, the Urgency Questionnaire (UQ). Qualitative data from interviews with patients with Urinary Urgency were used to develop and refine the items and response options of the UQ. Three studies were used to evaluate psychometric properties: a clinical trial of tolterodine (Detrol; n = 974); a psychometric validation study (n = 163); and a test–retest validation study (n = 47). Item and exploratory factor analysis (EFA) were performed to assess the subscale structure, and the psychometric performance of the resulting scales was evaluated. Fifteen Likert-scale items and four VAS questions were retained. A four-factor solution was shown to best fit the data, with the subscales: Impact on Daily Activities, Time to Control Urgency, Nocturia, and Fear of Incontinence. All subscales and VAS items demonstrated good reliability (Cronbach’s α 0.79–0.94), convergent and discriminant validity, and responsiveness to change. The UQ differentiated between OAB patients and controls. The results provide quantitative evidence that Urinary Urgency, as assessed by the UQ, is a pathological sensation distinctive from the normal urge to void and suggest that the UQ might be a reliable, valid, and responsive instrument for evaluating the severity and HRQL impact of Urinary Urgency in OAB.
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Urinary bacteria in adult women with Urgency Urinary incontinence
International Urogynecology Journal, 2014Co-Authors: Linda Brubaker, Charles W Nager, Holly E Richter, Anthony G Visco, Ingrid Nygaard, Matthew D Barber, Joseph I Schaffer, Susan Meikle, Dennis Wallace, Noriko ShibataAbstract:Introduction and hypothesis This study’s aims were to detect and quantify bacterial DNA in the urine of randomized trial participants about to undergo treatment for Urinary Urgency incontinence (UUI) without clinical evidence of Urinary tract infection (UTI) and to determine if the presence of bacterial DNA in baseline urine relates to either baseline Urinary symptoms or UTI risk after Urinary tract instrumentation.
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risk factors for an elevated postvoid residual urine volume in women with symptoms of Urinary Urgency frequency and urge incontience
International Urogynecology Journal, 2001Co-Authors: M P Fitzgerald, J Jaffar, Linda BrubakerAbstract:The aim of this study was to identify factors in patients with symptoms of Urgency/frequency or urge incontinence that predict that the postvoid residual urine volume (PVR) will be elevated. A restrospective chart review was carried out of all patients new to our urogynecology practice between June 1998 and May 1999, with symptoms of Urgency, frequency and/or urge incontinence. Demographic variables, symptoms and physical findings were correlated with the presence of an elevated PVR (>100 ml) using logistic regression analysis. An elevated PVR was found in 10% (33/336) of patients with urge incontinence (UI), and in 5% (3/57) of patients with Urgency/frequency without UI. In patients with UI the presence of pelvic organ prolapse (POP) ≥stage II, symptoms of voiding difficulty and the absence of the symptom of stress incontinence, predicted 82% of patients with an elevated PVR.
Jacob Bornstein - One of the best experts on this subject based on the ideXlab platform.
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comparison of two inside out transobturator suburethral sling techniques for stress incontinence early postoperative thigh pain and 3 year outcomes
International Journal of Urology, 2012Co-Authors: Menahem Neuman, Vladimir Sosnovski, Svetlana Goralnik, Benjamin Diker, Jacob BornsteinAbstract:Objectives: Inside-out tension-free vaginal tape obturators for the cure of female stress incontinence can cause postoperative thigh pain. The aim of the present study was to analyze and compare the mid-term outcomes of two tension-free vaginal tape obturator procedures. Methods: Patients diagnosed with Urinary stress incontinence were enrolled to undergo a tension-free vaginal tape obturator sub-mid urethral tape operation either by de-Leval's method or by Flam's modification. Peri- and postoperative data were collected by uninvolved researchers and analyzed. Follow up was 36 months. Results: Overall, 161 patients were included in the study. Cure and complication rates were similar between the two treatment groups. Postoperative thigh pain was significantly more frequent and lasted longer in the de-Leval group compared with the Flam group (31.9% vs 10.0%, respectively). Urinary Urgency was more frequent in the de-Leval patients (20.3% vs 2.8%). Conclusion: Our findings suggest that both tension-free vaginal tape obturator procedures are effective with few adverse effects. The Flam method provides shorter and decreased levels of postoperative thigh pain, as well as reduced long-term postoperative Urinary Urgency.
Norman Zinner - One of the best experts on this subject based on the ideXlab platform.
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trospium chloride an anticholinergic quaternary ammonium compound for the treatment of overactive bladder
Expert Opinion on Pharmacotherapy, 2005Co-Authors: Norman ZinnerAbstract:: The International Continence Society has defined overactive bladder (OAB) as Urinary Urgency, with or without urge Urinary incontinence, usually with Urinary frequency and nocturia. Approximately 17% of men and women in the US report OAB symptoms, which can affect quality of life. Trospium chloride, which has recently been introduced in the US as Sanctura, has been prescribed for > 10 years in Europe as, for example, Spasmo-lyt, Regurin and Spasmex. Trospium chloride has been shown to be effective in relieving OAB symptoms, and has a favourable safety profile, showing < 1% difference for all adverse events compared with placebo, except for dry mouth, constipation and headache. Metabolic drug-drug interactions are unlikely, given that trospium chloride is not metabolised by cytochrome P450 isozymes. The fast-acting efficacy of trospium chloride, coupled with its good safety profile and tolerability, make it an important new option for treatment of OAB.
John Heesakkers - One of the best experts on this subject based on the ideXlab platform.
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a new implanted posterior tibial nerve stimulator for the treatment of overactive bladder syndrome 3 month results of a novel therapy at a single center
The Journal of Urology, 2017Co-Authors: Hendrikje M K Van Breda, Frank Martens, Johnny Tromp, John HeesakkersAbstract:Purpose: This study was designed to investigate the safety and performance of a new implantable system for tibial nerve stimulation for overactive bladder symptoms.Materials and Methods: A battery-free stimulation device for tibial nerve stimulation (BlueWind Medical, Herzliya, Israel) was implanted in 15 patients. Safety and efficacy assessments were done at 3 months after activation with a 3-day bladder diary, a 24-hour pad test and 2 quality of life questionnaires.Results: Two males and 13 females were enrolled in the study. Mean age was 54 years (range 19 to 72). Five of 15 patients were previously treated with percutaneous tibial nerve stimulation and 12 experienced Urgency Urinary incontinence. Median operative time was 34 minutes. At 3 months of followup a significant change was seen in 24-hour frequency from a mean ± SD of 11.8 ± 3.5 to 8.1 ± 2.0 times per day (p = 0.002), the number of severe Urinary Urgency episodes from 6.5 ± 5.1 to 2.0 ± 2.1 times per day (p = 0.002), the number of severe inco...
Mahreen Pakzad - One of the best experts on this subject based on the ideXlab platform.
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one year outcomes of the artisan snm study with the axonics system for the treatment of Urinary Urgency incontinence
Neurourology and Urodynamics, 2020Co-Authors: Kevin Benson, Rebecca Mccrery, Chris Taylor, Osvaldo Padron, Bertil F M Blok, Stefan De Wachter, Andrea Pezzella, Jennifer Gruenenfelder, Mahreen Pakzad, Marie Aimee PerrouinverbeAbstract:Author(s): Benson, Kevin; McCrery, Rebecca; Taylor, Chris; Padron, Osvaldo; Blok, Bertil; de Wachter, Stefan; Pezzella, Andrea; Gruenenfelder, Jennifer; Pakzad, Mahreen; Perrouin-Verbe, Marie-Aimee; Van Kerrebroeck, Philip; Mangel, Jeffrey; Peters, Kenneth; Kennelly, Michael; Shapiro, Andrew; Lee, Una; Comiter, Craig; Mueller, Margaret; Goldman, Howard; Lane, Felicia | Abstract: AimsSacral neuromodulation (SNM) is a guideline-recommended treatment for voiding dysfunction including Urgency, urge incontinence, and nonobstructive retention as well as fecal incontinence. The Axonics® System is a miniaturized, rechargeable SNM system designed to provide therapy for at least 15 years, which is expected to significantly reduce revision surgeries as it will not require replacement as frequently as the non-rechargeable SNM system. The ARTISAN-SNM study is a pivotal study designed to treat patients with Urinary Urgency incontinence (UUI). Clinical results at 1-year are presented.MethodsA total of 129 eligible UUI patients were treated. All participants were implanted with a quadripolar tined lead and neurostimulator in a single procedure. Efficacy data were collected using a 3-day bladder diary, a validated quality of life questionnaire (ICIQ-OABqol), and a participant satisfaction questionnaire. Therapy responders were defined as participants with ≥50% reduction in UUI episodes compared to baseline. Data were analyzed on all 129 participants.ResultsAt 1 year, 89% of the participants were therapy responders. The average UUI episodes per day reduced from 5.6 ± 0.3 at baseline to 1.4 ± 0.2. Participants experienced an overall clinically meaningful improvement of 34 points on the ICIQ-OABqol questionnaire. All study participants (100%) were able to recharge their device at 1 year, and 96% of participants reported that the frequency and duration of recharging was acceptable. There were no serious device-related adverse events.ConclusionsThe Axonics System is safe and effective at 1 year, with 89% of participants experiencing clinically and statistically significant improvements in UUI symptoms.
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treatment of Urinary Urgency incontinence using a rechargeable snm system 6 month results of the artisan snm study
The Journal of Urology, 2020Co-Authors: Rebecca Mccrery, Kevin Benson, Chris Taylor, Osvaldo Padron, Bertil F M Blok, Stefan De Wachter, Andrea Pezzella, Jennifer Gruenenfelder, Felicia Lane, Mahreen PakzadAbstract:Purpose:Sacral neuromodulation is a guideline recommended treatment of Urinary dysfunction and fecal incontinence in patients in whom conservative treatments have failed. Historically sacral neurom...
