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Sofia Enhörning - One of the best experts on this subject based on the ideXlab platform.
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High water intake and low Urine Osmolality are associated with favorable metabolic profile at a population level: low vasopressin secretion as a possible explanation
European Journal of Nutrition, 2020Co-Authors: Louise Brunkwall, Ulrika Ericson, Peter M. Nilsson, Sofia EnhörningAbstract:Purpose Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low Urine volume and high Urine Osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water intake or high u-Osm correlated with high fp-copeptin and components of the metabolic syndrome at the population level. Methods In the population-based Malmö Offspring Study (MOS, n = 2599), fp-copeptin and u-Osm from morning Urine samples were measured, and diet and total water intake (from beverages and food moisture) was assessed by a 4-day web-based record. Results Increasing water intake by tertile was after adjustment for age and sex associated with low fp-triglycerides ( p = 0.002) and high fp-HDL ( p = 0.004), whereas there was no association with the other investigated metabolic traits (HbA1c, fp-glucose, BMI or waist circumference). Increasing u-Osm by tertile was, after adjustment for age and sex, associated with high fp-glucose ( p = 0.007), and borderline significantly associated with high HbA1c ( p = 0.053), but no association was observed with fp-HDL, fp-triglycerides, BMI or waist circumference. Fp-copeptin concentration correlated significantly with water intake ( r = − 0.13, p
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high water intake and low Urine Osmolality are associated with favorable metabolic profile at a population level low vasopressin secretion as a possible explanation
European Journal of Nutrition, 2020Co-Authors: Louise Brunkwall, Ulrika Ericson, Peter M. Nilsson, Sofia EnhörningAbstract:Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low Urine volume and high Urine Osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water intake or high u-Osm correlated with high fp-copeptin and components of the metabolic syndrome at the population level. In the population-based Malmo Offspring Study (MOS, n = 2599), fp-copeptin and u-Osm from morning Urine samples were measured, and diet and total water intake (from beverages and food moisture) was assessed by a 4-day web-based record. Increasing water intake by tertile was after adjustment for age and sex associated with low fp-triglycerides (p = 0.002) and high fp-HDL (p = 0.004), whereas there was no association with the other investigated metabolic traits (HbA1c, fp-glucose, BMI or waist circumference). Increasing u-Osm by tertile was, after adjustment for age and sex, associated with high fp-glucose (p = 0.007), and borderline significantly associated with high HbA1c (p = 0.053), but no association was observed with fp-HDL, fp-triglycerides, BMI or waist circumference. Fp-copeptin concentration correlated significantly with water intake (r = − 0.13, p < 0.001) and u-Osm (r = 0.27, p < 0.001). High copeptin was associated with all investigated metabolic traits (p < 0.001 for all). Low concentrations of the vasopressin marker copeptin is linked to high water intake, low u-Osm, and a favorable metabolic profile, suggesting that vasopressin lowering lifestyle interventions, such as increased water intake, may promote metabolic health.
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high water intake and low Urine Osmolality are associated with favorable metabolic profile at a population level low vasopressin secretion as a possible explanation
European Journal of Nutrition, 2020Co-Authors: Louise Brunkwall, Ulrika Ericson, Peter M. Nilsson, Sofia EnhörningAbstract:Purpose: Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low Urine volume and high Urine Osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water intake or high u-Osm correlated with high fp-copeptin and components of the metabolic syndrome at the population level. Methods: In the population-based Malmo Offspring Study (MOS, n = 2599), fp-copeptin and u-Osm from morning Urine samples were measured, and diet and total water intake (from beverages and food moisture) was assessed by a 4-day web-based record. Results: Increasing water intake by tertile was after adjustment for age and sex associated with low fp-triglycerides (p = 0.002) and high fp-HDL (p = 0.004), whereas there was no association with the other investigated metabolic traits (HbA1c, fp-glucose, BMI or waist circumference). Increasing u-Osm by tertile was, after adjustment for age and sex, associated with high fp-glucose (p = 0.007), and borderline significantly associated with high HbA1c (p = 0.053), but no association was observed with fp-HDL, fp-triglycerides, BMI or waist circumference. Fp-copeptin concentration correlated significantly with water intake (r = − 0.13, p < 0.001) and u-Osm (r = 0.27, p < 0.001). High copeptin was associated with all investigated metabolic traits (p < 0.001 for all). Conclusion: Low concentrations of the vasopressin marker copeptin is linked to high water intake, low u-Osm, and a favorable metabolic profile, suggesting that vasopressin lowering lifestyle interventions, such as increased water intake, may promote metabolic health.
Antoine C G Egberts - One of the best experts on this subject based on the ideXlab platform.
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Urine Osmolality cyclic amp and aquaporin 2 in Urine of patients under lithium treatment in response to water loading followed by vasopressin administration
European Journal of Pharmacology, 2007Co-Authors: Ingeborg Wilting, Ruben Baumgarten, Kris L L Movig, Jan Van Laarhoven, Alfred J Apperloo, Willem A Nolen, Eibert R Heerdink, Nine V A M Knoers, Antoine C G EgbertsAbstract:Lithium is the drug that is most frequently associated with acquired nephrogenic diabetes insipidus (NDI). The exact mechanism of lithium-induced NDI in man is unknown. The aim of the present study was to investigate the kidney response to minimal and maximal stimulation of the kidney Urine concentrating mechanism by measuring Urine Osmolality, and Urine levels of cAMP and AQP-2 in Urine of patients under long-term lithium treatment. Twenty patients under long-term lithium treatment were included. The kidney urinary 3',5'-cyclic adenosine monophosphate (cyclic AMP), aquaporin-2 levels and Urine Osmolality were determined during a situation of minimal kidney Urine concentrating activity (induced by water loading) and during a situation following maximal stimulation of kidney Urine concentrating activity (induced by 1-desamino-8-D-arginine-vasopressin). Patients were classified as NDI, partial NDI and non-NDI based on maximal reached Urine Osmolality. The partial correlation (r) between urinary cyclic AMP levels (mol/l) and Urine Osmolality was 0.94 (P<0.001). No significant correlation was observed between urinary aquaporin-2 levels (mol/mol creatinine) and Osmolality nor between urinary cyclic AMP and aquaporin-2 levels. The rise in urinary cyclic AMP but not aquaporin-2 levels upon 1-desamino-8-D-arginine-vasopressin administration after water loading significantly differed between the three categories, decreasing with increasing NDI category. In conclusion we found that in lithium-induced kidney Urine concentrating deficit in man, the cyclic AMP generation in response to 1-desamino-8-D-arginine-vasopressin administration after water loading, is impaired. It remains to be elucidated whether principal cells, G-proteins or adenylate cyclase e.g. are the major targets for the mechanism underlying lithium-induced NDI in man.
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Urine Osmolality, cyclic AMP and aquaporin-2 in Urine of patients under lithium treatment in response to water loading followed by vasopressin administration.
European Journal of Pharmacology, 2007Co-Authors: Ingeborg Wilting, Ruben Baumgarten, Kris L L Movig, Jan Van Laarhoven, Alfred J Apperloo, Willem A Nolen, Eibert R Heerdink, Nine V A M Knoers, Antoine C G EgbertsAbstract:Lithium is the drug that is most frequently associated with acquired nephrogenic diabetes insipidus (NDI). The exact mechanism of lithium-induced NDI in man is unknown. The aim of the present study was to investigate the kidney response to minimal and maximal stimulation of the kidney Urine concentrating mechanism by measuring Urine Osmolality, and Urine levels of cAMP and AQP-2 in Urine of patients under long-term lithium treatment. Twenty patients under long-term lithium treatment were included. The kidney urinary 3',5'-cyclic adenosine monophosphate (cyclic AMP), aquaporin-2 levels and Urine Osmolality were determined during a situation of minimal kidney Urine concentrating activity (induced by water loading) and during a situation following maximal stimulation of kidney Urine concentrating activity (induced by 1-desamino-8-D-arginine-vasopressin). Patients were classified as NDI, partial NDI and non-NDI based on maximal reached Urine Osmolality. The partial correlation (r) between urinary cyclic AMP levels (mol/l) and Urine Osmolality was 0.94 (P
Atsushi Yao - One of the best experts on this subject based on the ideXlab platform.
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Urine Osmolality estimated using Urine urea nitrogen sodium and creatinine can effectively predict response to tolvaptan in decompensated heart failure patients
Circulation, 2013Co-Authors: Teruhiko Imamura, Koichiro Kinugawa, Shun Minatsuki, Hironori Muraoka, Naoko Kato, Toshiro Inaba, Hisataka Maki, Taro Shiga, Masaru Hatano, Atsushi YaoAbstract:Background: Urine Osmolality (U-OSM) is valuable to predict response to tolvaptan (TLV) in decompensated heart failure patients, but measurement of U-OSM is not always available on site. Methods and Results: Data were collected from 66 hospitalized patients with decompensated heart failure who had received TLV at 3.75–15mg/day. U-OSM, which was estimated using the following formula: 1.07×{2×[(Urine sodium (mEq/L)]+[Urine urea nitrogen (mg/dl)]/2.8+[Urine creatinine (mg/dl)]×2/3}+16, was well correlated with the actual measurement (r=0.938, P 358mOsm/L) and C2 (%decrease in estimated U-OSM >24% at 4–6h after the first TLV dose) significantly discriminated responders from non-responders (P<0.05). Conclusions: Response to TLV can be predicted using U-OSM, which can be estimated using Urine urea nitrogen, sodium, and creatinine concentration data. (Circ J 2013; 77: 1208–1213)
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Urine Osmolality Estimated Using Urine Urea Nitrogen, Sodium and Creatinine Can Effectively Predict Response to Tolvaptan in Decompensated Heart Failure Patients
Circulation Journal, 2013Co-Authors: Teruhiko Imamura, Koichiro Kinugawa, Shun Minatsuki, Hironori Muraoka, Naoko Kato, Toshiro Inaba, Hisataka Maki, Taro Shiga, Masaru Hatano, Atsushi YaoAbstract:Background: Urine Osmolality (U-OSM) is valuable to predict response to tolvaptan (TLV) in decompensated heart failure patients, but measurement of U-OSM is not always available on site. Methods and Results: Data were collected from 66 hospitalized patients with decompensated heart failure who had received TLV at 3.75–15mg/day. U-OSM, which was estimated using the following formula: 1.07×{2×[(Urine sodium (mEq/L)]+[Urine urea nitrogen (mg/dl)]/2.8+[Urine creatinine (mg/dl)]×2/3}+16, was well correlated with the actual measurement (r=0.938, P 358mOsm/L) and C2 (%decrease in estimated U-OSM >24% at 4–6h after the first TLV dose) significantly discriminated responders from non-responders (P
Teruhiko Imamura - One of the best experts on this subject based on the ideXlab platform.
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Urine Osmolality estimated using Urine urea nitrogen sodium and creatinine can effectively predict response to tolvaptan in decompensated heart failure patients
Circulation, 2013Co-Authors: Teruhiko Imamura, Koichiro Kinugawa, Shun Minatsuki, Hironori Muraoka, Naoko Kato, Toshiro Inaba, Hisataka Maki, Taro Shiga, Masaru Hatano, Atsushi YaoAbstract:Background: Urine Osmolality (U-OSM) is valuable to predict response to tolvaptan (TLV) in decompensated heart failure patients, but measurement of U-OSM is not always available on site. Methods and Results: Data were collected from 66 hospitalized patients with decompensated heart failure who had received TLV at 3.75–15mg/day. U-OSM, which was estimated using the following formula: 1.07×{2×[(Urine sodium (mEq/L)]+[Urine urea nitrogen (mg/dl)]/2.8+[Urine creatinine (mg/dl)]×2/3}+16, was well correlated with the actual measurement (r=0.938, P 358mOsm/L) and C2 (%decrease in estimated U-OSM >24% at 4–6h after the first TLV dose) significantly discriminated responders from non-responders (P<0.05). Conclusions: Response to TLV can be predicted using U-OSM, which can be estimated using Urine urea nitrogen, sodium, and creatinine concentration data. (Circ J 2013; 77: 1208–1213)
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novel criteria of Urine Osmolality effectively predict response to tolvaptan in decompensated heart failure patients association between non responders and chronic kidney disease
Circulation, 2013Co-Authors: Teruhiko Imamura, Koichiro Kinugawa, Shun Minatsuki, Hironori Muraoka, Naoko Kato, Toshiro Inaba, Hisataka Maki, Taro Shiga, Masaru Hatano, Ryozo NagaiAbstract:Background: A newly-developed vasopressin type 2 receptor antagonist, tolvaptan (TLV), has a unique feature of diuresis, but the response to this drug can be unpredictable. Methods and Results: Data were collected from hospitalized patients with decompensated congestive heart failure who were administered TLV at 3.75–15 mg/day (n=61). A responder/non-responder to TLV was determined as having any increase/decrease in Urine volume (UV) during the next 24 h after TLV treatment on the first day. Logistic regression analyses for increases in UV were performed, and independent predictors of the responder were the following: C1, baseline Urine Osmolality (U-OSM) >352 mOsm/L; and C2, %decrease in U-OSM >26% at 4–6 h after TLV administration. Criteria consisting of C1 and C2 had a good predictability for responders by receiver-operating characteristic analysis (area under the curve=0.960). Kidneys of the non-responders no longer had diluting ability (%decrease of U-OSM at 4–6 h=2.7±14.6%*), but also barely kept concentrating ability (baseline U-OSM= 296.4±68.7* mOsm/L) with markedly reduced estimated glomerular filtration ratio (35.5±29.4 ml · min –1 · 1.73 m −2 *) (*P 352 mOsm/L for the first 4–6 h predicts responders to TLV. Unresponsiveness to TLV is attributable to nephrogenic diabetes insipidus complicated by chronic renal disease. (Circ J 2013; 77: 397 – 404)
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Urine Osmolality Estimated Using Urine Urea Nitrogen, Sodium and Creatinine Can Effectively Predict Response to Tolvaptan in Decompensated Heart Failure Patients
Circulation Journal, 2013Co-Authors: Teruhiko Imamura, Koichiro Kinugawa, Shun Minatsuki, Hironori Muraoka, Naoko Kato, Toshiro Inaba, Hisataka Maki, Taro Shiga, Masaru Hatano, Atsushi YaoAbstract:Background: Urine Osmolality (U-OSM) is valuable to predict response to tolvaptan (TLV) in decompensated heart failure patients, but measurement of U-OSM is not always available on site. Methods and Results: Data were collected from 66 hospitalized patients with decompensated heart failure who had received TLV at 3.75–15mg/day. U-OSM, which was estimated using the following formula: 1.07×{2×[(Urine sodium (mEq/L)]+[Urine urea nitrogen (mg/dl)]/2.8+[Urine creatinine (mg/dl)]×2/3}+16, was well correlated with the actual measurement (r=0.938, P 358mOsm/L) and C2 (%decrease in estimated U-OSM >24% at 4–6h after the first TLV dose) significantly discriminated responders from non-responders (P
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A case with recovery of response to tolvaptan associated with remission of acute kidney injury and increased Urine Osmolality.
International Heart Journal, 2013Co-Authors: Teruhiko Imamura, Koichiro Kinugawa, Shun Minatsuki, Hironori Muraoka, Naoko Kato, Toshiro Inaba, Hisataka Maki, Taro Shiga, Masaru Hatano, Yumiko HosoyaAbstract:Tolvaptan (TLV), a vasopressin type 2 receptor antagonist, has been demonstrated to be effective in patients with decompensated heart failure (HF) refractory to incremental doses of diuretics, but the responsiveness has not always been predictable. We have recently proposed that Urine Osmolality (U-OSM) is a valuable parameter for the prediction of responses to TLV, because U-OSM reflects the activity of the collecting ducts, where TLV plays its unique role. Acute kidney injury (AKI) is often associated with severe tubular dysfunction, including the collecting ducts, and in such cases a response to TLV may not be expected. We here experienced a patient with HF and AKI in whom TLV was not effective during AKI. We also observed recovery of responsiveness to TLV along with remission of AKI as well as increased U-OSM later on. We believe that this is the first report on the reversibility of the TLV response in relation to U-OSM.
L. A. Moreno - One of the best experts on this subject based on the ideXlab platform.
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Fluid consumption, total water intake and first morning Urine Osmolality in Spanish adolescents from Zaragoza: data from the HELENA study
European Journal of Clinical Nutrition, 2016Co-Authors: Iris Iglesia, A. M. Santaliestra-pasias, T Sadalla-collese, María L Miguel-berges, S Bel-serrat, L. A. MorenoAbstract:Background/Objectives: The objective of the study is to describe the hydration status and to assess the main food- and/or fluid intake-associated factors in healthy adolescents. Subjects/Methods: A total of 194 adolescents from the city of Zaragoza aged 12.5–17.5 years (99 males) participating in the 'Healthy Lifestyle in Europe by Nutrition in Adolescence' (HELENA) cross-sectional study were included. First morning Urine was collected, and Osmolality was determined by freezing point depression osmometer. A self-reported computer-based 24-h dietary recall was applied the same day of the Urine collection. Analysis of variance, Kruskal–Wallis procedure or Pearson’s χ ^2 analyses was used to examine the group associations. Results: Seventy-one percent of adolescents did not meet the European Food Safety Agency (EFSA) recommendations for average total water intake (TWI), and 68% had high first morning Urine Osmolality values. TWI and the proportion of those meeting EFSA reference values significantly ( P
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Fluid consumption, total water intake and first morning Urine Osmolality in Spanish adolescents from Zaragoza: data from the HELENA study.
European Journal of Clinical Nutrition, 2015Co-Authors: Iris Iglesia, A. M. Santaliestra-pasias, Silvia Bel-serrat, T Sadalla-collese, María L Miguel-berges, L. A. MorenoAbstract:Fluid consumption, total water intake and first morning Urine Osmolality in Spanish adolescents from Zaragoza: data from the HELENA study
