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Ramazan Geyik - One of the best experts on this subject based on the ideXlab platform.

  • the value of Urine Specific Gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus Urine Specific Gravity in differential diagnosis
    Journal of General Internal Medicine, 2006
    Co-Authors: Ersin Akarsu, Hakan Buyukhatipoglu, Sebnem Aktaran, Ramazan Geyik
    Abstract:

    When a patient with diabetes mellitus presents with worsening polyuria and polydipsia, what is a sensible, cost-effective approach? We report the unique coincidence of type 2 diabetes mellitus and diabetes insipidus. A 46-year-old woman with poorly controlled type 2 diabetes complained of polyuria with a daily output of 5 L. Although urinalysis demonstrated significant glucosuria, diabetes insipidus was suspected owing to a low Urine Specific Gravity (1.008). The low Specific Gravity persisted during a water deprivation test. Ultimately, diabetes insipidus was confirmed when Urine Specific Gravity and Urine osmolality normalized following desmopressin administration. This case emphasizes the importance of accurately interpreting the Urine Specific Gravity in patients with polyuria and diabetes mellitus to detect diabetes insipidus.

  • the value of Urine Specific Gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus
    Journal of General Internal Medicine, 2006
    Co-Authors: Ersin Akarsu, Hakan Buyukhatipoglu, Sebnem Aktaran, Ramazan Geyik
    Abstract:

    When a patient with diabetes mellitus presents with worsening polyuria and polydipsia, what is a sensible, cost-effective approach? We report the unique coincidence of type 2 diabetes mellitus and diabetes insipidus. A 46-year-old woman with poorly controlled type 2 diabetes complained of polyuria with a daily output of 5 L. Although urinalysis demonstrated significant glucosuria, diabetes insipidus was suspected owing to a low Urine Specific Gravity (1.008). The low Specific Gravity persisted during a water deprivation test. Ultimately, diabetes insipidus was confirmed when Urine Specific Gravity and Urine osmolaity normalized following desmopressin administration. This case emphasizes the importance of accurately interpreting the Urine Specific Gravity in patients with polyuria and diabetes mellitus to detect diabetes insipidus.

Bertram L Kasiske - One of the best experts on this subject based on the ideXlab platform.

  • use of Urine Specific Gravity to improve screening for albuminuria
    Kidney International, 1997
    Co-Authors: Richard R Moore, Cheryl A Hiratadulas, Bertram L Kasiske
    Abstract:

    Use of Urine Specific Gravity to improve screening for albuminuria. The albumin to creatinine ratio (ACR) can be used to measure Urine albumin excretion rates, but is inconvenient and expensive. More rapid and less expensive screening methods estimate only albumin concentration and are subject to errors caused by variation in Urine volume. We examined whether Urine Specific Gravity could be used in place of Urine creatinine to correct albumin concentration for differences in Urine volume in 50 patients. Urine Specific Gravity accurately estimated Urine creatinine concentration ( r = 0.79, P r = 0.98, P r = 0.95, P

  • use of Urine Specific Gravity to improve screening for albuminuria
    The Renal Association. Meeting, 1997
    Co-Authors: Richard R Moore, Cheryl A Hiratadulas, Bertram L Kasiske
    Abstract:

    The albumin to creatinine ratio (ACR) can be used to measure Urine albumin excretion rates, but is inconvenient and expensive. More rapid and less expensive screening methods estimate only albumin concentration and are subject to errors caused by variation in Urine volume. We examined whether Urine Specific Gravity could be used in place of Urine creatinine to correct albumin concentration for differences in Urine volume in 50 patients. Urine Specific Gravity accurately estimated Urine creatinine concentration (r = 0.79, P < 0.001). The albumin estimated-creatinine ratio (ACestR) in a random spot Urine sample correlated with Urine albumin excretion measured in a 24-hour Urine collection (r = 0.98, P < 0.001), as did the ACR (r = 0.95, P < 0.001). For determining microalbuminuria, the sensitivity (0.88) and Specificity (0.93) of the ACestR were similar to those of ACR (0.89 and 0.93, respectively). Unfortunately, the sensitivity (0.63) of the Micral-Test was relatively poor, and was only slightly improved by correcting for Urine Specific Gravity (0.69) in this small sample of patients. Nevertheless, these results suggest that as rapid methods for measuring Urine albumin concentration improve, combining them with Urine Specific Gravity might produce a less expensive and more convenient alternative to the ACR.

Casey Burton - One of the best experts on this subject based on the ideXlab platform.

  • a rebuttal to a comment to normalization of urinary pteridines by Urine Specific Gravity for early cancer detection clin chim acta 435 2014 42 47
    Clinica Chimica Acta, 2015
    Co-Authors: Casey Burton
    Abstract:

    Abstract We really appreciate the comments from Drs. Reibnegger and Fuchs regarding our recent publication “Normalization of urinary pteridines by Urine Specific Gravity for early cancer detection [Clin. Chim. Acta 435 (2014) 42–47]”. In their letter, Drs. Reibnegger and Fuchs identify several potential concerns regarding our recent publication [1] that evaluated the normalization performance of Urine Specific Gravity (USG) and urinary creatinine with respect to the diagnostic properties of selected pteridines in discerning aggressive and benign breast cancers. Their letter not only provides unique insights that are both relevant and helpful to many researchers engaging in similar studies, but also provides a wonderful opportunity for us to address these potential concerns that may also be shared by other readers. We addressed all of the comments by Drs. Reibnegger and Fuchs in this letter.

  • normalization of urinary pteridines by Urine Specific Gravity for early cancer detection
    Clinica Chimica Acta, 2014
    Co-Authors: Casey Burton
    Abstract:

    Abstract Background Urinary biomarkers, such as pteridines, require normalization with respect to an individual's hydration status and time since last urination. Conventional creatinine-based corrections are affected by a multitude of patient factors whereas Urine Specific Gravity (USG) is a bulk specimen property that may better resist those same factors. We examined the performance of traditional creatinine adjustments relative to USG to six urinary pteridines in aggressive and benign breast cancers. Methods 6-Biopterin, neopterin, pterin, 6-hydroxymethylpterin, isoxanthopterin, xanthopterin, and creatinine were analyzed in 50 Urine specimens with a previously developed liquid chromatography–tandem mass spectrometry technique. Creatinine and USG performance were evaluated with non-parametric Mann–Whitney hypothesis testing. Results USG and creatinine were moderately correlated (r = 0.857) with deviations occurring in dilute and concentrated specimens. In 48 aggressive and benign breast cancers, normalization by USG significantly outperformed creatinine adjustments which marginally outperformed uncorrected pteridines in predicting pathological status. In addition, isoxanthopterin and xanthopterin were significantly higher in pathological specimens when normalized by USG. Conclusion USG, as a bulk property, can provide better performance over creatinine-based normalizations for urinary pteridines in cancer detection applications.

Ersin Akarsu - One of the best experts on this subject based on the ideXlab platform.

  • the value of Urine Specific Gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus Urine Specific Gravity in differential diagnosis
    Journal of General Internal Medicine, 2006
    Co-Authors: Ersin Akarsu, Hakan Buyukhatipoglu, Sebnem Aktaran, Ramazan Geyik
    Abstract:

    When a patient with diabetes mellitus presents with worsening polyuria and polydipsia, what is a sensible, cost-effective approach? We report the unique coincidence of type 2 diabetes mellitus and diabetes insipidus. A 46-year-old woman with poorly controlled type 2 diabetes complained of polyuria with a daily output of 5 L. Although urinalysis demonstrated significant glucosuria, diabetes insipidus was suspected owing to a low Urine Specific Gravity (1.008). The low Specific Gravity persisted during a water deprivation test. Ultimately, diabetes insipidus was confirmed when Urine Specific Gravity and Urine osmolality normalized following desmopressin administration. This case emphasizes the importance of accurately interpreting the Urine Specific Gravity in patients with polyuria and diabetes mellitus to detect diabetes insipidus.

  • the value of Urine Specific Gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus
    Journal of General Internal Medicine, 2006
    Co-Authors: Ersin Akarsu, Hakan Buyukhatipoglu, Sebnem Aktaran, Ramazan Geyik
    Abstract:

    When a patient with diabetes mellitus presents with worsening polyuria and polydipsia, what is a sensible, cost-effective approach? We report the unique coincidence of type 2 diabetes mellitus and diabetes insipidus. A 46-year-old woman with poorly controlled type 2 diabetes complained of polyuria with a daily output of 5 L. Although urinalysis demonstrated significant glucosuria, diabetes insipidus was suspected owing to a low Urine Specific Gravity (1.008). The low Specific Gravity persisted during a water deprivation test. Ultimately, diabetes insipidus was confirmed when Urine Specific Gravity and Urine osmolaity normalized following desmopressin administration. This case emphasizes the importance of accurately interpreting the Urine Specific Gravity in patients with polyuria and diabetes mellitus to detect diabetes insipidus.

Richard R Moore - One of the best experts on this subject based on the ideXlab platform.

  • use of Urine Specific Gravity to improve screening for albuminuria
    Kidney International, 1997
    Co-Authors: Richard R Moore, Cheryl A Hiratadulas, Bertram L Kasiske
    Abstract:

    Use of Urine Specific Gravity to improve screening for albuminuria. The albumin to creatinine ratio (ACR) can be used to measure Urine albumin excretion rates, but is inconvenient and expensive. More rapid and less expensive screening methods estimate only albumin concentration and are subject to errors caused by variation in Urine volume. We examined whether Urine Specific Gravity could be used in place of Urine creatinine to correct albumin concentration for differences in Urine volume in 50 patients. Urine Specific Gravity accurately estimated Urine creatinine concentration ( r = 0.79, P r = 0.98, P r = 0.95, P

  • use of Urine Specific Gravity to improve screening for albuminuria
    The Renal Association. Meeting, 1997
    Co-Authors: Richard R Moore, Cheryl A Hiratadulas, Bertram L Kasiske
    Abstract:

    The albumin to creatinine ratio (ACR) can be used to measure Urine albumin excretion rates, but is inconvenient and expensive. More rapid and less expensive screening methods estimate only albumin concentration and are subject to errors caused by variation in Urine volume. We examined whether Urine Specific Gravity could be used in place of Urine creatinine to correct albumin concentration for differences in Urine volume in 50 patients. Urine Specific Gravity accurately estimated Urine creatinine concentration (r = 0.79, P < 0.001). The albumin estimated-creatinine ratio (ACestR) in a random spot Urine sample correlated with Urine albumin excretion measured in a 24-hour Urine collection (r = 0.98, P < 0.001), as did the ACR (r = 0.95, P < 0.001). For determining microalbuminuria, the sensitivity (0.88) and Specificity (0.93) of the ACestR were similar to those of ACR (0.89 and 0.93, respectively). Unfortunately, the sensitivity (0.63) of the Micral-Test was relatively poor, and was only slightly improved by correcting for Urine Specific Gravity (0.69) in this small sample of patients. Nevertheless, these results suggest that as rapid methods for measuring Urine albumin concentration improve, combining them with Urine Specific Gravity might produce a less expensive and more convenient alternative to the ACR.