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Thomas Remer - One of the best experts on this subject based on the ideXlab platform.

  • Urine Volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children.
    Steroids, 2020
    Co-Authors: Stefan A. Wudy, Christiane Maser-gluth, Michaela F. Hartmann, Thomas Remer
    Abstract:

    Abstract Urine Volume should be considered as a confounder when using urinary free cortisol (UFF) and cortisone (UFE) to assess glucocorticoid (GC) status. We aimed to examine whether adrenal androgen (AA) metabolites may be also affected by Urine Volume in healthy children. To compare the flow dependence of GC and AA metabolites, specific GC metabolites were examined. In 24-h Urine samples of 120 (60 boys) healthy children (4–10 yr), steroid profiles were determined by GC–MS analysis, UFF and UFE by radioimmunoassay. To assess daily AA and GC secretion rates, 7 quantitatively most important AA (∑C19) and GC (∑C21) metabolites were summed. Sum of DHEA and its 16α-hydroxylated metabolites were denoted as DHEA&M. Association of Urine Volume with AA (∑C19, DHEA&M, DHEA, 16α-hydroxy-DHEA, 3β,16α,17β-androstenetriol) and GC (∑C21, UFF, UFE, 6β-hydroxycortisol, 20α-dihydrocortisol) were examined in linear regression models. Among the examined AA metabolites, 16α-hydroxy-DHEA ( β  = 0.56, p β  = 0.43, p  = 0.05) showed relatively strong association with Urine Volume. A trend was seen for ∑C19 ( β  = 0.23, p  = 0.08), but not for DHEA&M ( p  > 0.1). Regarding GC metabolites, Urine Volume showed a stronger association with cortisol's direct metabolites, i.e., cortisone, 6β-hydroxycortisol and 20α-dihydrocortisol ( β  = 0.4–0.6, p β  = 0.28, p

  • higher Urine Volume results in additional renal iodine loss
    Thyroid, 2010
    Co-Authors: Simone A Johner, Thomas Remer
    Abstract:

    Background: For some endocrine and nutritional biomarkers, for example, cortisol and vitamin B12, significant associations between 24-hour renal analyte excretion and the respective 24-hour Urine Volume (U-Vol) have been reported. Therefore, our objective was to investigate whether 24-hour U-Vol (a marker of fluid intake) is also a relevant influencing factor of absolute daily iodine excretion. Methods: Urinary iodine excretion rates were measured in repeatedly collected 24-hour Urine samples of (i) 9 healthy women participating in a controlled diet experiment with constant iodine intake and (ii) 204 healthy free-living adolescents (aged 13–18 years) who performed the respective Urine collection during 2003–2008. Associations between U-Vol (L) and renal iodine excretion (μg/24 h) were investigated cross sectionally (multiple linear regression model, PROC GLM) and longitudinally (repeated-measures regression models, PROC MIXED). The major iodine sources in the adolescent's diet (iodized salt, milk, fish, e...

  • Urine Volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children.
    Steroids, 2010
    Co-Authors: Stefan A. Wudy, Christiane Maser-gluth, Michaela F. Hartmann, Thomas Remer
    Abstract:

    Urine Volume should be considered as a confounder when using urinary free cortisol (UFF) and cortisone (UFE) to assess glucocorticoid (GC) status. We aimed to examine whether adrenal androgen (AA) metabolites may be also affected by Urine Volume in healthy children. To compare the flow dependence of GC and AA metabolites, specific GC metabolites were examined. In 24-h Urine samples of 120 (60 boys) healthy children (4-10 yr), steroid profiles were determined by GC-MS analysis, UFF and UFE by radioimmunoassay. To assess daily AA and GC secretion rates, 7 quantitatively most important AA (∑C19) and GC (∑C21) metabolites were summed. Sum of DHEA and its 16α-hydroxylated metabolites were denoted as DHEA&M. Association of Urine Volume with AA (∑C19, DHEA&M, DHEA, 16α-hydroxy-DHEA, 3β,16α,17β-androstenetriol) and GC (∑C21, UFF, UFE, 6β-hydroxycortisol, 20α-dihydrocortisol) were examined in linear regression models. Among the examined AA metabolites, 16α-hydroxy-DHEA (β=0.56, p0.1). Regarding GC metabolites, Urine Volume showed a stronger association with cortisol's direct metabolites, i.e., cortisone, 6β-hydroxycortisol and 20α-dihydrocortisol (β=0.4-0.6, p

  • Urinary free cortisone, but not cortisol, is associated with Urine Volume in severe obesity.
    Steroids, 2009
    Co-Authors: Karsten Müssig, Thomas Remer, Andreas Fritsche, Hans-ulrich Häring, Christiane Maser-gluth
    Abstract:

    BACKGROUND: High Urine Volume enhances urinary free cortisol (UFF) and cortisone (UFE) excretion rates in normal-weight adults and children. Renal excretion rates of glucocorticoids (GC) and their metabolites are frequently altered in obesity. The aim of the present study was to investigate whether UFF and UFE excretion is also affected by Urine Volume in severely obese subjects. EXPERIMENTAL: In 24-h Urine samples of 59 extremely obese subjects (mean BMI 45.3+/-8.9 kg/m(2)) and 20 healthy lean subjects (BMI 22.1+/-1.8 kg/m(2)), UFF and UFE, tetrahydrocortisol (THF), 5alpha-tetrahydrocortisol (5alpha-THF), and tetrahydrocortisone (THE) were quantified by RIA. The sum of THF, 5alpha-THF, and THE (GC3), the three major GC metabolites, reflects daily cortisol secretion. 11beta-Hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity was assessed by the ratio UFE/UFF. Daily GC excretion rates were corrected for Urine creatinine and adjusted for gender and body weight. RESULTS: In extremely obese subjects, Urine Volume was significantly associated with creatinine-corrected UFE and 11beta-HSD2 activity after adjustment for gender and BMI (r=0.47, p=0.0002 and r=0.31, p=0.02, respectively). However, Urine Volume was not associated with creatinine-corrected UFF and GC3 (p=0.4 and p=0.6, respectively). In lean controls, Urine Volume was significantly associated with creatinine-corrected UFE and UFF (r=0.58, p=0.01 and r=0.55, p=0.02, respectively), whereas Urine Volume was not associated with 11beta-HSD2 activity after appropriate adjustment (p=0.3). CONCLUSIONS: In severe obesity, in contrast to normal weight, renal excretion of UFE, but not of UFF is affected by fluid intake. This discrepancy may be due to the increased renal 11beta-HSD2 activity in obesity.

  • daily urinary free cortisol and cortisone excretion is associated with Urine Volume in healthy children
    Steroids, 2008
    Co-Authors: Christiane Masergluth, Thomas Remer
    Abstract:

    Abstract Background In experimental studies, a high fluid intake and a corresponding high Urine Volume have been shown to increase renal excretion rates of urinary free cortisol (UFF) and cortisone (UFE) in adults. We aimed to examine whether 24-h UFF and UFE excretion rates are also affected by Urine Volume in children. Methods In 24-h Urine samples of 100 pre-pubertal and 100 pubertal healthy children UFF, UFE, tetrahydrocortisol (THF), 5α-tetrahydrocortisol (5α-THF), and tetrahydrocortisone (THE) were quantified by RIA. The sum of THF, 5α-THF, and THE, the 3 primarily glucuronidated tetrahydrometabolites (GC3), reflects daily cortisol secretion. Associations of Urine Volume with outcome variables UFF, UFE, and GC3 were examined in both developmental groups using multiple regression models adjusted for sex, body weight and height. Results Significant positive associations were observed between 24-h Urine Volume and UFF and UFE in both groups with the highest explained variation for UFE [partial R 2  = 0.11 in pre-pubertal group ( P R 2  = 0.15 in pubertal group ( P Conclusion Urinary 24-h excretion rates of UFF and UFE but not of the marker of glucocorticoid secretion are affected by daily Urine Volume in healthy free-living children. For a specific assessment of associations of UFF and UFE with (patho)physiologically relevant factors, Urine Volume should be considered as a confounder.

Karsten Müssig - One of the best experts on this subject based on the ideXlab platform.

  • association between urinary catecholamine excretion and Urine Volume
    Hormone and Metabolic Research, 2019
    Co-Authors: Michael Haap, Friedemann Blaschka, Annika Hoyer, Rainer Lehmann, Karsten Müssig
    Abstract:

    Several confounders must be considered in the evaluation of urinary catecholamine excretion. However, literature is contradictory about potential confounders. The aim of the present study was to assess correlations between catecholamine excretion and anthropometric or clinical parameters with special attention to Urine Volume. A total of 967 24-h urinary catecholamine measurements were performed in 593 patients for diagnostic purposes. The indication for Urine examination was suspicion of secondary hypertension, phaeochromocytoma, or paraganglioma. From the patients examined, 57% were females and 43% were males. The patients’ age ranged between 15 and 87 years with a median [Q1; Q3] of 51 [39; 62] years. Seventy-eight percent of the patients suffered from hypertension. Seventy percent of patients took one or more antihypertensive drugs. The most commonly used drugs were ACE inhibitors (43%), while α-blockers (15%) were the least used drugs. Urinary excretion was between 500 and 11 950 ml/24 h with a median of 2200 [1600; 2685] ml/24 h. The median body mass index (BMI) was 26.7 [24.0; 30.4] kg/m2. The excretion of all catecholamines was greater in men than in women (all p

  • Urinary free cortisone, but not cortisol, is associated with Urine Volume in severe obesity.
    Steroids, 2009
    Co-Authors: Karsten Müssig, Thomas Remer, Andreas Fritsche, Hans-ulrich Häring, Christiane Maser-gluth
    Abstract:

    BACKGROUND: High Urine Volume enhances urinary free cortisol (UFF) and cortisone (UFE) excretion rates in normal-weight adults and children. Renal excretion rates of glucocorticoids (GC) and their metabolites are frequently altered in obesity. The aim of the present study was to investigate whether UFF and UFE excretion is also affected by Urine Volume in severely obese subjects. EXPERIMENTAL: In 24-h Urine samples of 59 extremely obese subjects (mean BMI 45.3+/-8.9 kg/m(2)) and 20 healthy lean subjects (BMI 22.1+/-1.8 kg/m(2)), UFF and UFE, tetrahydrocortisol (THF), 5alpha-tetrahydrocortisol (5alpha-THF), and tetrahydrocortisone (THE) were quantified by RIA. The sum of THF, 5alpha-THF, and THE (GC3), the three major GC metabolites, reflects daily cortisol secretion. 11beta-Hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity was assessed by the ratio UFE/UFF. Daily GC excretion rates were corrected for Urine creatinine and adjusted for gender and body weight. RESULTS: In extremely obese subjects, Urine Volume was significantly associated with creatinine-corrected UFE and 11beta-HSD2 activity after adjustment for gender and BMI (r=0.47, p=0.0002 and r=0.31, p=0.02, respectively). However, Urine Volume was not associated with creatinine-corrected UFF and GC3 (p=0.4 and p=0.6, respectively). In lean controls, Urine Volume was significantly associated with creatinine-corrected UFE and UFF (r=0.58, p=0.01 and r=0.55, p=0.02, respectively), whereas Urine Volume was not associated with 11beta-HSD2 activity after appropriate adjustment (p=0.3). CONCLUSIONS: In severe obesity, in contrast to normal weight, renal excretion of UFE, but not of UFF is affected by fluid intake. This discrepancy may be due to the increased renal 11beta-HSD2 activity in obesity.

Danny Lovatsis - One of the best experts on this subject based on the ideXlab platform.

  • do subjective symptoms of obstructive voiding correlate with post void residual Urine Volume in women
    International Urogynecology Journal, 2005
    Co-Authors: Mesfer Alshahrani, Danny Lovatsis
    Abstract:

    The objective was to determine if symptoms of obstructive voiding correlate with post-void residual Urine Volume measured by catheterization. A cross-sectional study of 134 consecutive women referred to a tertiary urogynecology clinic was performed. Subjects were interviewed regarding three types of obstructive voiding symptoms: a sensation of incomplete emptying, straining to void, and slow Urine stream. Post-void residual Urine Volume was measured by catheterization as the gold standard. Data for each symptom were analyzed using Cohen’s kappa test, sensitivity, specificity, likelihood ratios for a positive of negative test, and positive and negative predictive values. A total of 11 out of 134 patients (8%) had a post-void residual Volume greater than 100 ml. Of these 11, 1 had symptoms of incomplete emptying (9%), 1 had symptoms of straining to void (9%), and 2 had symptoms of slow Urine stream (18%). Sensitivity, specificity, likelihood ratio for a positive symptom, likelihood ratio for a negative symptom, positive predictive value, negative predictive value, and Cohen’s kappa, respectively, were 9%, 80%, 0.47, 1.13, 4%, 91%, and 0.05 for the symptom of incomplete emptying, 9%, 91%, 1.12, 1.0, 8%, 92%, and 0.01 for straining to void, and 18%, 89%, 1.6, 0.92, 13%, 92%, and 0.07 for the symptom of slow Urine stream. It was concluded that symptoms of obstructive voiding do not correlate with measured post-void Urine Volume. In clinically important situations, these symptoms cannot substitute for measurement of post-void residual Urine Volume.

Th. Junginger - One of the best experts on this subject based on the ideXlab platform.

  • Evaluation of residual Urine Volume by ultrasound for detection of urinary bladder dysfunction after surgical therapy of rectal cancer
    Chirurg, 2005
    Co-Authors: Thomas Borschitz, Werner Kneist, Th. Junginger
    Abstract:

    INTRODUCTION: Despite total mesorectal excision and protection of the pelvic autonomous nerve system, dysfunctions of the urinary bladder are often observed after surgical therapy for rectal cancer. In this prospective study, the frequency of urinary bladder malfunctions was assessed by measuring residual Urine Volume using transcutaneous ultrasound before and after surgery. PATIENTS AND METHODS: Seventy-five patients with rectal cancer were analyzed for Urine Volume retained before and after surgical therapy. The tumors were localized in the lower third of the rectum for 31 patients, in the middle for 30, and in the upper third for 14. RESULTS: An increase in retained Urine of more than 100 ml was found in 12 patients (15%), and neurogenic bladder was diagnosed in two (3%). In female patients, urinary bladder malfunctions were significantly less frequent and severe. CONCLUSIONS: The percutaneous assessment of Urine Volume retained in the bladder is suited for determining urinary bladder malfunctions after surgery. This method can serve to assess the quality of surgical treatment for rectal cancer. A standardized definition of relevant urinary bladder malfunctions is required.

  • residual Urine Volume after total mesorectal excision an indicator of pelvic autonomic nerve preservation results of a case control study
    Colorectal Disease, 2004
    Co-Authors: Werner Kneist, Th. Junginger
    Abstract:

    Objective  The rate of bladder dysfunctions after total mesorectal excision (TME) for rectal cancer can be decreased by bilateral pelvic autonomic nerve preservation (PANP). However, it is not clear yet, how often partial nerve impairment may lead to bladder dysfunction. It was the aim of a case-control study, to examine the residual Urine Volume in patients before and after TME with and without complete PANP, in order to clarify, whether this parameter allows conclusions on the quality of PANP. Patients and methods  Regarding bladder function, a case group (n = 26) without complete PANP was compared with a control group (n = 26) with complete identification and nerve preservation according to standadized intra-operative documentation. Twenty-six match pairs were established, identical regarding gender, wall infiltration depth, tumour site, operation procedure and operation extent. Rates of neoadjuvant therapy, R0-classification, anastomotic leakage, wound and urinary tract infection were equally distributed for both the case- and control group (P > 0.05). Residual Urine Volume was pre- and post-operatively determined by sonography. Results  Pre-operatively, residual Urine Volumes differed neither between the pairs nor between both groups with and without nerve preservation. In the case group with incomplete PANP there was a difference between pre- and post-operative residual Urine Volume (median; quartil: 2.5 ml; 0.0–32.5 ml vs 130 ml; 0.0–317 ml; P = 0.001). In the control group there was no difference (median; quartile: 0.0 ml; 0.0–20 ml vs 15.5 ml; 0.0–62.0 ml; P = 0.07). The difference between the postoperatively measured Volumes of the case and control group were significant (P = 0.001). With residual Urine Volume = 100 ml, the risk of incomplete PANP was 14 times higher (odds ratio). Conclusions  Residual Urine Volume is an indicator of the completeness of PANP during TME. It should be determined pre- and post-operatively, and besides the recording of the neurogenic bladder, serve as a quality control.

Michael Haap - One of the best experts on this subject based on the ideXlab platform.

  • association between urinary catecholamine excretion and Urine Volume
    Hormone and Metabolic Research, 2019
    Co-Authors: Michael Haap, Friedemann Blaschka, Annika Hoyer, Rainer Lehmann, Karsten Müssig
    Abstract:

    Several confounders must be considered in the evaluation of urinary catecholamine excretion. However, literature is contradictory about potential confounders. The aim of the present study was to assess correlations between catecholamine excretion and anthropometric or clinical parameters with special attention to Urine Volume. A total of 967 24-h urinary catecholamine measurements were performed in 593 patients for diagnostic purposes. The indication for Urine examination was suspicion of secondary hypertension, phaeochromocytoma, or paraganglioma. From the patients examined, 57% were females and 43% were males. The patients’ age ranged between 15 and 87 years with a median [Q1; Q3] of 51 [39; 62] years. Seventy-eight percent of the patients suffered from hypertension. Seventy percent of patients took one or more antihypertensive drugs. The most commonly used drugs were ACE inhibitors (43%), while α-blockers (15%) were the least used drugs. Urinary excretion was between 500 and 11 950 ml/24 h with a median of 2200 [1600; 2685] ml/24 h. The median body mass index (BMI) was 26.7 [24.0; 30.4] kg/m2. The excretion of all catecholamines was greater in men than in women (all p