The Experts below are selected from a list of 990 Experts worldwide ranked by ideXlab platform
Rose Khavari - One of the best experts on this subject based on the ideXlab platform.
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functional magnetic resonance imaging with concurrent Urodynamic Testing identifies brain structures involved in micturition cycle in patients with multiple sclerosis
The Journal of Urology, 2017Co-Authors: Rose Khavari, Sophie G Fletcher, Michael E Shy, Christof Karmonik, Timothy B BooneAbstract:Purpose: Neurogenic lower urinary tract dysfunction, which is common in patients with multiple sclerosis, has a significant impact on quality of life. In this study we sought to determine brain activity processes during the micturition cycle in female patients with multiple sclerosis and neurogenic lower urinary tract dysfunction.Materials and Methods: We report brain activity on functional magnetic resonance imaging and simultaneous Urodynamic Testing in 23 ambulatory female patients with multiple sclerosis. Individual functional magnetic resonance imaging activation maps at strong desire to void and at initiation of voiding were calculated and averaged at Montreal Neuroimaging Institute. Areas of significant activation were identified in these average maps. Subgroup analysis was performed in patients with elicitable neurogenic detrusor overactivity or detrusor-sphincter dyssynergia.Results: Group analysis of all patients at strong desire to void yielded areas of activation in regions associated with exe...
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functional magnetic resonance imaging during Urodynamic Testing identifies brain structures initiating micturition
The Journal of Urology, 2014Co-Authors: Michael E Shy, Sophie G Fletcher, Steve H Fung, Timothy B Boone, Christof Karmonik, Rose KhavariAbstract:Purpose Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction. Materials and Methods We screened 13 healthy premenopausal female volunteers using baseline clinic Urodynamics to document normal voiding parameters. We then recorded brain activity via functional magnetic resonance imaging and simultaneous Urodynamics, including the pressure flow voiding phase. After motion correction of functional magnetic resonance images we performed activation and connectivity analyses in 10 subjects. Results Group analysis revealed consistent activation areas, including regions for motor control (cerebellum, thalamus, caudate, lentiform nucleus, red nucleus, supplementary motor area and post-central gyrus), emotion (anterior/posterior cingulate gyrus and insula), executive function (left superior frontal gyrus) and a focal region in the pons. Connectivity analysis demonstrated strong interconnectivity of the pontine micturition center with many short-range and long-range cortical clusters. Conclusions Our study is one of the first reports of brain activation centers associated with micturition initiation in normal healthy females. Results show activation of a brain network consisting of regions for motor control, executive function and emotion processing. Further studies are planned to create and validate a model of brain activity during normal voiding in women.
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functional magnetic resonance imaging during Urodynamic Testing identifies brain structures initiating micturition
The Journal of Urology, 2014Co-Authors: Michael E Shy, Steve H Fung, Christof Karmonik, Timothy Oone, Sophie G Fletche, Rose KhavariAbstract:Purpose: Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction.Materials and Methods: We screened 13 healthy premenopausal female volunteers using baseline clinic Urodynamics to document normal voiding parameters. We then recorded brain activity via functional magnetic resonance imaging and simultaneous Urodynamics, including the pressure flow voiding phase. After motion correction of functional magnetic resonance images we performed activation and connectivity analyses in 10 subjects.Results: Group analysis revealed consistent...
Timothy B Boone - One of the best experts on this subject based on the ideXlab platform.
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functional magnetic resonance imaging with concurrent Urodynamic Testing identifies brain structures involved in micturition cycle in patients with multiple sclerosis
The Journal of Urology, 2017Co-Authors: Rose Khavari, Sophie G Fletcher, Michael E Shy, Christof Karmonik, Timothy B BooneAbstract:Purpose: Neurogenic lower urinary tract dysfunction, which is common in patients with multiple sclerosis, has a significant impact on quality of life. In this study we sought to determine brain activity processes during the micturition cycle in female patients with multiple sclerosis and neurogenic lower urinary tract dysfunction.Materials and Methods: We report brain activity on functional magnetic resonance imaging and simultaneous Urodynamic Testing in 23 ambulatory female patients with multiple sclerosis. Individual functional magnetic resonance imaging activation maps at strong desire to void and at initiation of voiding were calculated and averaged at Montreal Neuroimaging Institute. Areas of significant activation were identified in these average maps. Subgroup analysis was performed in patients with elicitable neurogenic detrusor overactivity or detrusor-sphincter dyssynergia.Results: Group analysis of all patients at strong desire to void yielded areas of activation in regions associated with exe...
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functional magnetic resonance imaging during Urodynamic Testing identifies brain structures initiating micturition
The Journal of Urology, 2014Co-Authors: Michael E Shy, Sophie G Fletcher, Steve H Fung, Timothy B Boone, Christof Karmonik, Rose KhavariAbstract:Purpose Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction. Materials and Methods We screened 13 healthy premenopausal female volunteers using baseline clinic Urodynamics to document normal voiding parameters. We then recorded brain activity via functional magnetic resonance imaging and simultaneous Urodynamics, including the pressure flow voiding phase. After motion correction of functional magnetic resonance images we performed activation and connectivity analyses in 10 subjects. Results Group analysis revealed consistent activation areas, including regions for motor control (cerebellum, thalamus, caudate, lentiform nucleus, red nucleus, supplementary motor area and post-central gyrus), emotion (anterior/posterior cingulate gyrus and insula), executive function (left superior frontal gyrus) and a focal region in the pons. Connectivity analysis demonstrated strong interconnectivity of the pontine micturition center with many short-range and long-range cortical clusters. Conclusions Our study is one of the first reports of brain activation centers associated with micturition initiation in normal healthy females. Results show activation of a brain network consisting of regions for motor control, executive function and emotion processing. Further studies are planned to create and validate a model of brain activity during normal voiding in women.
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video Urodynamic findings in men with the central cord syndrome
The Journal of Urology, 2000Co-Authors: Christopher P Smith, Stephen R Kraus, Kevin G Nickell, Timothy B BooneAbstract:Purpose: The central cord syndrome reportedly has a favorable prognosis and rehabilitation outcome. However, to our knowledge the status of the lower urinary tract in patients with the central cord syndrome is unclear. We report on 22 men with the central cord syndrome who were evaluated by video Urodynamics.Materials and Methods: From 1986 to the present we identified 22 men with a mean age of 51 years who had the central cord syndrome and were included in the Houston Veterans Affairs spinal cord registry. All patients underwent video Urodynamic evaluation a mean of 34.5 months after injury.Results: Video Urodynamic Testing for vesicourethral dysfunction was normal in 3 patients, while it showed bladder outlet obstruction secondary to benign prostatic hyperplasia in 2, detrusor areflexia in 4, external detrusor-sphincter dyssynergia in 11, detrusor hyperreflexia with a synergistic external urethral sphincter in 1 and detrusor hypocontractility in 1. Urinary tract infection recurred in 3 patients with ext...
Michael E Shy - One of the best experts on this subject based on the ideXlab platform.
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functional magnetic resonance imaging with concurrent Urodynamic Testing identifies brain structures involved in micturition cycle in patients with multiple sclerosis
The Journal of Urology, 2017Co-Authors: Rose Khavari, Sophie G Fletcher, Michael E Shy, Christof Karmonik, Timothy B BooneAbstract:Purpose: Neurogenic lower urinary tract dysfunction, which is common in patients with multiple sclerosis, has a significant impact on quality of life. In this study we sought to determine brain activity processes during the micturition cycle in female patients with multiple sclerosis and neurogenic lower urinary tract dysfunction.Materials and Methods: We report brain activity on functional magnetic resonance imaging and simultaneous Urodynamic Testing in 23 ambulatory female patients with multiple sclerosis. Individual functional magnetic resonance imaging activation maps at strong desire to void and at initiation of voiding were calculated and averaged at Montreal Neuroimaging Institute. Areas of significant activation were identified in these average maps. Subgroup analysis was performed in patients with elicitable neurogenic detrusor overactivity or detrusor-sphincter dyssynergia.Results: Group analysis of all patients at strong desire to void yielded areas of activation in regions associated with exe...
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functional magnetic resonance imaging during Urodynamic Testing identifies brain structures initiating micturition
The Journal of Urology, 2014Co-Authors: Michael E Shy, Sophie G Fletcher, Steve H Fung, Timothy B Boone, Christof Karmonik, Rose KhavariAbstract:Purpose Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction. Materials and Methods We screened 13 healthy premenopausal female volunteers using baseline clinic Urodynamics to document normal voiding parameters. We then recorded brain activity via functional magnetic resonance imaging and simultaneous Urodynamics, including the pressure flow voiding phase. After motion correction of functional magnetic resonance images we performed activation and connectivity analyses in 10 subjects. Results Group analysis revealed consistent activation areas, including regions for motor control (cerebellum, thalamus, caudate, lentiform nucleus, red nucleus, supplementary motor area and post-central gyrus), emotion (anterior/posterior cingulate gyrus and insula), executive function (left superior frontal gyrus) and a focal region in the pons. Connectivity analysis demonstrated strong interconnectivity of the pontine micturition center with many short-range and long-range cortical clusters. Conclusions Our study is one of the first reports of brain activation centers associated with micturition initiation in normal healthy females. Results show activation of a brain network consisting of regions for motor control, executive function and emotion processing. Further studies are planned to create and validate a model of brain activity during normal voiding in women.
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functional magnetic resonance imaging during Urodynamic Testing identifies brain structures initiating micturition
The Journal of Urology, 2014Co-Authors: Michael E Shy, Steve H Fung, Christof Karmonik, Timothy Oone, Sophie G Fletche, Rose KhavariAbstract:Purpose: Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction.Materials and Methods: We screened 13 healthy premenopausal female volunteers using baseline clinic Urodynamics to document normal voiding parameters. We then recorded brain activity via functional magnetic resonance imaging and simultaneous Urodynamics, including the pressure flow voiding phase. After motion correction of functional magnetic resonance images we performed activation and connectivity analyses in 10 subjects.Results: Group analysis revealed consistent...
Christof Karmonik - One of the best experts on this subject based on the ideXlab platform.
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functional magnetic resonance imaging with concurrent Urodynamic Testing identifies brain structures involved in micturition cycle in patients with multiple sclerosis
The Journal of Urology, 2017Co-Authors: Rose Khavari, Sophie G Fletcher, Michael E Shy, Christof Karmonik, Timothy B BooneAbstract:Purpose: Neurogenic lower urinary tract dysfunction, which is common in patients with multiple sclerosis, has a significant impact on quality of life. In this study we sought to determine brain activity processes during the micturition cycle in female patients with multiple sclerosis and neurogenic lower urinary tract dysfunction.Materials and Methods: We report brain activity on functional magnetic resonance imaging and simultaneous Urodynamic Testing in 23 ambulatory female patients with multiple sclerosis. Individual functional magnetic resonance imaging activation maps at strong desire to void and at initiation of voiding were calculated and averaged at Montreal Neuroimaging Institute. Areas of significant activation were identified in these average maps. Subgroup analysis was performed in patients with elicitable neurogenic detrusor overactivity or detrusor-sphincter dyssynergia.Results: Group analysis of all patients at strong desire to void yielded areas of activation in regions associated with exe...
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functional magnetic resonance imaging during Urodynamic Testing identifies brain structures initiating micturition
The Journal of Urology, 2014Co-Authors: Michael E Shy, Sophie G Fletcher, Steve H Fung, Timothy B Boone, Christof Karmonik, Rose KhavariAbstract:Purpose Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction. Materials and Methods We screened 13 healthy premenopausal female volunteers using baseline clinic Urodynamics to document normal voiding parameters. We then recorded brain activity via functional magnetic resonance imaging and simultaneous Urodynamics, including the pressure flow voiding phase. After motion correction of functional magnetic resonance images we performed activation and connectivity analyses in 10 subjects. Results Group analysis revealed consistent activation areas, including regions for motor control (cerebellum, thalamus, caudate, lentiform nucleus, red nucleus, supplementary motor area and post-central gyrus), emotion (anterior/posterior cingulate gyrus and insula), executive function (left superior frontal gyrus) and a focal region in the pons. Connectivity analysis demonstrated strong interconnectivity of the pontine micturition center with many short-range and long-range cortical clusters. Conclusions Our study is one of the first reports of brain activation centers associated with micturition initiation in normal healthy females. Results show activation of a brain network consisting of regions for motor control, executive function and emotion processing. Further studies are planned to create and validate a model of brain activity during normal voiding in women.
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functional magnetic resonance imaging during Urodynamic Testing identifies brain structures initiating micturition
The Journal of Urology, 2014Co-Authors: Michael E Shy, Steve H Fung, Christof Karmonik, Timothy Oone, Sophie G Fletche, Rose KhavariAbstract:Purpose: Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction.Materials and Methods: We screened 13 healthy premenopausal female volunteers using baseline clinic Urodynamics to document normal voiding parameters. We then recorded brain activity via functional magnetic resonance imaging and simultaneous Urodynamics, including the pressure flow voiding phase. After motion correction of functional magnetic resonance images we performed activation and connectivity analyses in 10 subjects.Results: Group analysis revealed consistent...
Neil M. Resnick - One of the best experts on this subject based on the ideXlab platform.
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brain mechanisms underlying urge incontinence and its response to pelvic floor muscle training
The Journal of Urology, 2015Co-Authors: Derek Griffiths, Stasa Tadic, Becky Clarkson, Neil M. ResnickAbstract:Purpose: Urge urinary incontinence is a major problem, especially in the elderly, and to our knowledge the underlying mechanisms of disease and therapy are unknown. We used biofeedback assisted pelvic floor muscle training and functional brain imaging (functional magnetic resonance imaging) to investigate cerebral mechanisms, aiming to improve the understanding of brain-bladder control and therapy.Materials and Methods: Before receiving biofeedback assisted pelvic floor muscle training functionally intact, older community dwelling women with urge urinary incontinence as well as normal controls underwent comprehensive clinical and bladder diary evaluation, Urodynamic Testing and brain functional magnetic resonance imaging. Evaluation was repeated after pelvic floor muscle training in those with urge urinary incontinence. Functional magnetic resonance imaging was done to determine the brain reaction to rapid bladder filling with urgency.Results: Of 65 subjects with urge urinary incontinence 28 responded to ...
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brain activity measured by functional magnetic resonance imaging is related to patient reported urgency urinary incontinence severity
The Journal of Urology, 2010Co-Authors: Stasa Tadic, Derek Griffiths, Werner Schaefer, Cathy I Cheng, Neil M. ResnickAbstract:Purpose: We investigated the relationship between experimental neuroimaging and self-reported urinary incontinence measures.Materials and Methods: We evaluated 14 functionally independent, community dwelling women older than 60 years with moderate to severe urgency urinary incontinence. All underwent detailed clinical assessment (3-day bladder diary, 24-hour pad test and quality of life assessment), Urodynamic Testing and functional brain scanning. Brain activity during reported urgency was assessed using a method that combines functional magnetic resonance imaging with simultaneous Urodynamic monitoring during repeat bladder filling/emptying cycles. We used the statistical parametric mapping program SPM2 (http://www.fil.ion.ucl.ac.uk/spm/spm2.html) to correlate brain activity with relevant clinical covariates, including the number of urgency incontinent episodes, amount of urine leakage and psychological burden as assessed by the Urge Impact Scale questionnaire.Results: Activity in rostral and subgenual ...
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Voiding cystourethrography findings in elderly women with urge incontinence.
The Journal of Urology, 2000Co-Authors: Julia R. Fielding, Jhemon H. Lee, Catherine E. Dubeau, Kelly H. Zou, Neil M. ResnickAbstract:Purpose:: We report voiding cystourethrography findings associated with urge incontinence in elderly women.Materials and Methods:: Two observers jointly reviewed voiding cystourethrograms of 50 cognitively intact and mobile elderly female participants in a drug trial for urge incontinence and 19 continent volunteers. Multichannel Urodynamic Testing was performed in all subjects. Bladder wall trabeculation and diverticula, cystocele and vesicoureteral reflux were noted. Maximal bladder capacity, post-void residual, and history of bladder suspension and hysterectomy were obtained from clinical records.Results:: Of the incontinent women 35 (70%) had trabeculation, which was mild in 30 (60%) and moderate in 5 (10%), and 41 (82%) had cystocele, which was mild in 23 (46%), moderate in 15 (30%) and severe in 3 (6%). Maximal bladder capacity ranged from less than 100 to more than 900 cc, and was greater than 500 in 37 incontinent women (74%). Of the continent women 16 (84%) had smooth bladders, 2 had mild (11%) a...