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V. Ivanova - One of the best experts on this subject based on the ideXlab platform.
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Comparison of the phytotoxic effects of usnic acid on cultures of free-living alga Scenedesmus quadricauda and aposymbiotically grown lichen photobiont Trebouxia erici.
Journal of chemical ecology, 2010Co-Authors: Martin Bačkor, Miriam Bačkorová, Katarína Klemová, V. IvanovaAbstract:The phytotoxic effects of the lichen secondary metabolite—usnic acid on cultures of free living alga—Scenedesmus quadricauda (UTEX 76) and aposymbiotically grown lichen photobiont Trebouxia erici (UTEX 911) were assessed. We found a relatively strong inhibition effect of usnic acid on the growth of alga Scenedesmus, accompanied by an increase of cell size, an alteration of assimilation pigment composition, followed by strong degradation of chlorophyll a, a decrease of chlorophyll a fluorescence, and an increase of reactive oxygen species in the cells. The content of soluble proteins remained a stable parameter. Phytotoxicity of usnic acid on cultures of Trebouxia photobiont was significantly lower. Usnic acid in lichens may act as an allochemical that controls the division of photobiont cells, thereby regulating the balance between the photobiont and mycobiont forming thallus. Higher tolerance to usnic acid in Trebouxia cultures may be an adaptation resulting from the long term co-evolution of these algae with fungi that produce secondary metabolites.
Christopher P Crum - One of the best experts on this subject based on the ideXlab platform.
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serous tubal intraepithelial carcinoma and the dominant ovarian mass clues to serous tumor origin
The American Journal of Surgical Pathology, 2009Co-Authors: Michael H Roh, David Kindelberger, Christopher P CrumAbstract:Pelvic serous cancer is a diverse disease, and the assignment of primary site -- ovarian, tubal, or peritoneal -- is often problematic. Recent studies indicate that a proportion of these tumors arise from the distal fallopian tube, originating as serous tubal intraepithelial carcinoma (STIC). This study examined the relationship of 2 parameters for assigning origin -- endosalpingeal involvement and dominant ovarian mass -- in the context of STIC. Endometrioid carcinomas served as a reference. Eighty-seven consecutive pelvic serous cancers in which the tubes and ovaries were completely examined (SEE-FIM protocol) were analyzed. The presence of a dominant ovarian mass (DOM+), involvement of the fimbrial mucosa (FIM+), and STIC were correlated. In addition, tumor categories were compared with respect to PAX8, p73, p53, and p16 immunohistochemistry. Of the 27 DOM+ cases, 13 (48%) were FIM+ and a STIC was present in 3 (11%). Of the 60 DOM(-) cases, 48 (78%) were FIM+ and 28 (45%) harbored a STIC. In 92% of all cases, tumor distribution was extensive with bilateral ovarian and extraovarian peritoneal involvement. All tumor categories were immunophenotypically similar. In contrast, DOM+, FIM+, and STIC were found in 81%, 19%, and 0% of ovarian endometrioid carcinomas. In conclusion, there is a significant inverse relationship between DOM+ and STIC (P=0.001), indicating both parameters are of value in grouping pelvic serous carcinomas more likely to be ovarian [DOM+/FIM(-)] versus fimbrial [DOM(-)/STIC], and ovarian or peritoneal surface (DOM-/FIM-) in origin. Nevertheless, the shared immunophenotype suggests a common cell of origin for all categories, irrespective of site.
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serous tubal intraepithelial carcinoma its potential role in primary peritoneal serous carcinoma and serous cancer prevention
Journal of Clinical Oncology, 2008Co-Authors: Joseph W Carlson, David Kindelberger, Alexander Miron, Elke A Jarboe, Mana M Parast, Michelle S Hirsch, Yonghee Lee, Michael G Muto, Christopher P CrumAbstract:Purpose A diagnosis of primary peritoneal serous carcinoma (PPSC) requires exclusion of a source in other reproductive organs. Serous tubal intraepithelial carcinoma (STIC; stage 0) has been described in asymptomatic women with BRCA mutations and linked to a serous cancer precursor in the fimbria. This study examined the frequency of STIC in PPSC and its clinical outcome in BRCA-positive women. Patients and Methods Presence or absence of STIC was recorded in consecutive cases meeting the 2001 WHO criteria for PPSC, including 26 patients with nonuniform sampling of the fallopian tubes (group 1) and 19 patients with complete tubal examination (group 2; sectioning and extensively examining the fimbriated end, or SEE-FIM protocol). In selected cases, STIC or its putative precursor and the peritoneal tumor were analyzed for p53 mutations (exons 1 to 11). Outcome of STIC was ascertained by literature review. Result Thirteen (50%) of 26 PPSCs in group 1 involved the endosalpinx, with nine STICs (35%). Fifteen (7...
Anna Yemelyanova - One of the best experts on this subject based on the ideXlab platform.
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Additional file 2: Figure S2. of Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma
2017Co-Authors: Rosie Jiang, Tian Li Wang, Anna Yemelyanova, Deyin Xing, Ravi Anchoori, Jun Hamazaki, Shigeo Murata, Jeffrey Seidman, Richard RodenAbstract:PPIB positive control pictures for STIC. Matched FT, STIC, and HGSC samples as well as TMA HGSCs were probed for housekeeping mRNA, PPIB, by RNA-CISH to assess RNA integrity. (TIFF 9327 kb
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primary peritoneal high grade serous carcinoma is very likely metastatic from serous tubal intraepithelial carcinoma assessing the new paradigm of ovarian and pelvic serous carcinogenesis and its implications for screening for ovarian cancer
Gynecologic Oncology, 2011Co-Authors: Jeffrey D Seidman, Po Zhao, Anna YemelyanovaAbstract:Abstract Objective Primary peritoneal high-grade serous carcinoma is thought to arise from the peritoneum, but recent data suggest that the fallopian tube may be an occult source of many of these tumors. This study was performed to evaluate this hypothesis in an unselected series of cases. Methods Fallopian tubes from 51 consecutive cases meeting the GOG criteria for primary peritoneal high-grade serous carcinoma, FIGO stages II–IV, were analyzed. Results Serous tubal intraepithelial carcinoma (STIC) was identified in 19 patients (37%). When the fimbriae were examined, STIC was identified in 46%, and when all tubal tissue was examined, 56%. STIC was confined to the fimbriae in 53%, involved fimbriae and nonfimbrial mucosa in 20%, and was confined to nonfimbrial mucosa in 20%. Patients with STIC were significantly older than those without STIC (75years vs. 67years, respectively; p =0.007). Patients with STIC were significantly more likely to have FIGO stage IV disease as compared to those without STIC (42% vs. 12.5%, respectively; p =0.037). Conclusions At least half the cases of primary peritoneal high-grade serous carcinoma are associated with intraepithelial carcinoma of the fallopian tube, usually involving the fimbriae. These findings support the view that, like "primary ovarian carcinoma," what has been traditionally classified as "primary peritoneal carcinoma" is probably derived from occult high-grade serous carcinoma in the fallopian tube. These findings have important implications for ultrasound screening trials for ovarian cancer which are based on the assumption that an enlarged ovary is a very early manifestation of disease.
Martin Bačkor - One of the best experts on this subject based on the ideXlab platform.
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Comparison of the phytotoxic effects of usnic acid on cultures of free-living alga Scenedesmus quadricauda and aposymbiotically grown lichen photobiont Trebouxia erici.
Journal of chemical ecology, 2010Co-Authors: Martin Bačkor, Miriam Bačkorová, Katarína Klemová, V. IvanovaAbstract:The phytotoxic effects of the lichen secondary metabolite—usnic acid on cultures of free living alga—Scenedesmus quadricauda (UTEX 76) and aposymbiotically grown lichen photobiont Trebouxia erici (UTEX 911) were assessed. We found a relatively strong inhibition effect of usnic acid on the growth of alga Scenedesmus, accompanied by an increase of cell size, an alteration of assimilation pigment composition, followed by strong degradation of chlorophyll a, a decrease of chlorophyll a fluorescence, and an increase of reactive oxygen species in the cells. The content of soluble proteins remained a stable parameter. Phytotoxicity of usnic acid on cultures of Trebouxia photobiont was significantly lower. Usnic acid in lichens may act as an allochemical that controls the division of photobiont cells, thereby regulating the balance between the photobiont and mycobiont forming thallus. Higher tolerance to usnic acid in Trebouxia cultures may be an adaptation resulting from the long term co-evolution of these algae with fungi that produce secondary metabolites.
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Usnic acid and copper toxicity in aposymbiotically grown lichen photobiont Trebouxia erici
Symbiosis, 2006Co-Authors: Jana Bud’ová, Martin Bačkor, Miriam Bačkorová, J. ŽidzikAbstract:Effects of copper and usnic acid on the lichen photobiont Trebouxia erici were assessed in order to determine whether usnic acid detoxifies copper. Copper and usnic acid were phytotoxic: each inhibited growth, decreased viability and chlorophyll a fluorescence, and altered assimilation pigments of lichen algae. Although usnic acid and increased copper were not synergistic, usnic acid did not significantly protect photobionts from negative physiological effects of copper.
Olaya, Ruth E. - One of the best experts on this subject based on the ideXlab platform.
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Pruebas regionales para una variedad promisoria de pimentón evaluando varias dosis de n.
Universidad Nacional de Colombia Sede Palmira, 1995Co-Authors: Madero Edgar, Olaya, Ruth E.Abstract:En la Universidad Nacional de Colombia en Palmira, Valle del Cauca, se realizó un experimento en dos suelos (isohipertérmico fino/franco fino Haplustol Vértico e isohipertérmico muy fino/ franco fino Epiaquert Ustico), tratados con seis dosis de úrea (O a 250 kg N ha-1) para crear 12 "ambientes" con el fin de evaluar la adaptabilidad de la línea promisoria 003 de pimentón, del Programa de Mejoramiento Genético y Producción de Semillas de esta Facultad, mediante la metodología de Eberhart y Russell (1966). En un clima favorable, la línea demostró adaptabilidad a todos los ambientes y sus rendimientos relativos y cantidad de frutos por planta fueron bastante altos: 417 g y 4.95 unidades respectivamente; su respuesta a los incrementos en la dosis de N. fue producir más cosecha sin incrementar la altura y la dosis 250 Kg N ha-1 fue la mas económica. Para producir 400 g/planta se registró la siguiente extracción de nutrientes: 73 kg ha- N, 12 P, 57 K, 27 Ca, 12 Mg, 4 Na, 495 g ha-1Fe, 181 Mn, 36 Cu, 181 Zn y 5 B.At the National University of Colombia in Palmira, Valle del Cauca, was carried out an experiment to evaluate in 12 "environments" (two soils: an isohiperthermic fine/fine loam Vertic Haplustoll and an isohiperthermic very fine/fine loam Ustic Epiaquert, and six urea doses from 0 to 250 kg N ha-1) the adaptability of a 003 new pepper Capsicum annuum cultivar bred by a Genetic Program of this Faculty, using Eberhart and Russell's methodology (1966). Under a favorable weather the cultivar showed adaptability lo all environments and had a relatively high yield: 417 g/plant and 4.95 fruits/plant; the more soil N-doses the more its harvest with a stable height, and the best economic N-dose was 250 kg N ha-l. To produce 400 g/plant the 003 cultivar extracted 73 kg ha-1 N, 12 P, 57 K, 27 Ca, 12 Mg, 4 Na, 495g ha-1 Fe, 181 Mn, 36 Cu, 181 Zn and 5B
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Regional tests for a new pepper cultivar (Capsicum annuum) appraising six nitrogen doses Pruebas regionales para una variedad promisoria de pimentón evaluando varias dosis de N.
Universidad Nacional de Colombia, 1995Co-Authors: Madero Edgar, Olaya, Ruth E.Abstract:<p>At the National University of Colombia in Palmira, Valle del Cauca, was carried out an experiment to evaluate in 12 "environments" (two soils: an isohiperthermic fine/fine loam Vertic Haplustoll and an isohiperthermic very fine/fine loam Ustic Epiaquert, and six urea doses from 0 to 250 kg N ha-1) the adaptability of a 003 new pepper Capsicum annuum cultivar bred by a Genetic Program of this Faculty, using Eberhart and Russell's methodology (1966). Under a favorable weather the cultivar showed adaptability lo all environments and had a relatively high yield: 417 g/plant and 4.95 fruits/plant; the more soil N-doses the more its harvest with a stable height, and the best economic N-dose was 250 kg N ha-l. To produce 400 g/plant the 003 cultivar extracted 73 kg ha-1 N, 12 P, 57 K, 27 Ca, 12 Mg, 4 Na, 495g ha-1 Fe, 181 Mn, 36 Cu, 181 Zn and 5B.</p><p>En la Universidad Nacional de Colombia en Palmira, Valle del Cauca, se realizó un experimento en dos suelos (isohipertérmico fino/franco fino Haplustol Vértico e isohipertérmico muy fino/ franco fino Epiaquert Ustico), tratados con seis dosis de úrea (O a 250 kg N ha<sup>-1</sup>) para crear 12 "ambientes" con el fin de evaluar la adaptabilidad de la línea promisoria 003 de pimentón, del Programa de Mejoramiento Genético y Producción de Semillas de esta Facultad, mediante la metodología de Eberhart y Russell (1966). En un clima favorable, la línea demostró adaptabilidad a todos los ambientes y sus rendimientos relativos y cantidad de frutos por planta fueron bastante altos: 417 g y 4.95 unidades respectivamente; su respuesta a los incrementos en la dosis de N. fue producir más cosecha sin incrementar la altura y la dosis 250 Kg N ha<sup>-1</sup> fue la mas económica. Para producir 400 g/planta se registró la siguiente extracción de nutrientes: 73 kg ha- N, 12 P, 57 K, 27 Ca, 12 Mg, 4 Na, 495 g ha<sup>-1</sup>Fe, 181 Mn, 36 Cu, 181 Zn y 5 B.</p>
