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Keiichiro Kawata - One of the best experts on this subject based on the ideXlab platform.
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postpartum plasma pgf metabolite profile in cows with dystocia and or retained placenta and effect of fenprostalene on Uterine Involution and reproductive performance
Journal of Veterinary Medical Science, 1997Co-Authors: Toshihiko Nakao, Masaharu Moriyoshi, Absy Gamal, Takeshi Osawa, Ken Nakada, Keiichiro KawataAbstract:Objectives of this study were to show postpartum plasma PGF2α metabolite (PGFM) profile, to clarify whether endogenous PGF2α plays a certain role in the Uterine Involution in cows with dystocia and/or retained placenta, and to examine the effects of fenprostalene, a long-acting PGF2α analog, on the Uterine Involution and reproductive performance of the cows with abnormal puerperium. A group of 27 cows with dystocia and/or retained placenta showed a massive release of PGF2α after parturition as indicated by a rise of plasma concentrations of PGFM, significantly higher than 33 cows with normal puerperium. The duration of the elevated plasma PGFM concentrations in the cows with abnormal puerperium was shorter than that of the normal cows. In cows with normal puerperium, those showing relatively longer duration of elevated plasma PGFM levels needed a shorter period for postpartum Uterine Involution than the cows showing a shorter duration of the PGFM elevation (P<0.01), while no such relationship was observed in cows with abnormal puerperium. In field trials, an administration of an exogenous PGF2α, fenprostalene, at 7 to 10 days (78 cows) or 14 to 28 days postpartum (74 cows) was found to be effective in facilitating Uterine Involution and resumption of ovarian cyclicity, and improved reproductive performance. It may be concluded that a large amount of PGF2α is released for a relatively shorter period in cows after dystocia and/or retained placenta and the elevation of PGFM is not responsible for the Uterine Involution. The administration of the exogenous PGF2α was shown to be effective at improving the postpartum reproductive performance of cows with abnormal puerperium.
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Postpartum Plasma PGF Metabolite Profile in Cows with Dystocia and/or Retained Placenta, and Effect of Fenprostalene on Uterine Involution and Reproductive Performance
The Journal of veterinary medical science, 1997Co-Authors: Toshihiko Nakao, Masaharu Moriyoshi, Absy Gamal, Takeshi Osawa, Ken Nakada, Keiichiro KawataAbstract:Objectives of this study were to show postpartum plasma PGF2α metabolite (PGFM) profile, to clarify whether endogenous PGF2α plays a certain role in the Uterine Involution in cows with dystocia and/or retained placenta, and to examine the effects of fenprostalene, a long-acting PGF2α analog, on the Uterine Involution and reproductive performance of the cows with abnormal puerperium. A group of 27 cows with dystocia and/or retained placenta showed a massive release of PGF2α after parturition as indicated by a rise of plasma concentrations of PGFM, significantly higher than 33 cows with normal puerperium. The duration of the elevated plasma PGFM concentrations in the cows with abnormal puerperium was shorter than that of the normal cows. In cows with normal puerperium, those showing relatively longer duration of elevated plasma PGFM levels needed a shorter period for postpartum Uterine Involution than the cows showing a shorter duration of the PGFM elevation (P
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factors in the resumption of ovarian activity and Uterine Involution in postpartum dairy cows
Animal Reproduction Science, 1995Co-Authors: Eldin A Zain, Toshihiko Nakao, Masaharu Moriyoshi, Keiichiro Kawata, Abdel M Raouf, Y MoritsuAbstract:As a step toward clarifying intricate relationships among the factors responsible for delay of postpartum ovarian cyclicity and Uterine Involution in high-producing dairy cows, we analyzed the clinical, production, and environmental findings derived from 72 Holstein—Friesian dams in one dairy herd for 13 consecutive months. The interval from calving to resumption of ovarian activity ranged from 13 to 64 days, the average being 25 ± 13 days SD. Variation in the number of days between calving and first ovulation was largely accounted for by the factors included in the investigative model (r2=0.75, P<0.001), as shown by covariance analysis. The greatest effect on resumed ovulation was, by far, that of the daily level of total digestible nutrients (TDN) at resumption of the postpartum ovarian activity (P<0.001), although the puerperal condition was also shown to play a significant role (P<0.05) on the resumption of ovulation. Dams without puerperal complications ovulated markedly earlier (at 22 days) than those encountering puerperal complications (≥ 31 days). The greatest influences on the Uterine Involution were puerperal condition (P<0.001) and parity (P<0.01), followed by season of calving (P<0.05). Age at calving, daily 4% fat corrected milk yield, daily TDN and crude protein levels had no significant bearing on Involution. The puerperal condition had the most noticeably widespread influence in governing both ovarian activity and Uterine Involution in postpartum cows, while a level of TDN intake played an important role in the resumption of ovarian activity.
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Therapeutic effects of moxibustion on delayed Uterine Involution in postpartum dairy cows.
The Journal of veterinary medical science, 1993Co-Authors: Kiyoshi Korematsu, Eisyu Takagi, Takashi Kawabe, Toshihiko Nakao, Masaharu Moriyoshi, Keiichiro KawataAbstract:Moxibustion on 12 specific points (Keiketsu in Japanese) was applied for treatment of delayed Uterine Involution in 16 cows that were diagnosed on the basis of rectal palpation and vaginoscopic examination 21 to 35 days after parturition. The treatment was continued for three consecutive days. Other 32 cows with the delayed Uterine Involution were either injected intramuscularly with 25 mg PGF2 alpha (17 cows) or infused in utero with 500 mg ampicillin (15 cows). The Uterine Involution following the treatment was monitored by rectal palpation and vaginoscopic examination. Milk samples were collected three times weekly and used for milk progesterone assay to monitor the ovarian function. No significant difference was observed in the Uterine Involution among the groups treated with moxibustion, PGF2 alpha or ampicillin. Percentages of cows with abnormal cervical mucus and bacterial isolation from cervical swab decreased remarkably in all groups during 4 weeks after treatment. Forty-six percent of cows with delayed Uterine Involution was diagnosed as having inactive ovaries. Percentage of cows that responded with ovulation and corpus luteum formation after moxibustion was 67 percent, slightly higher than those in cows treated with PGF2 alpha or ampicillin. Reproductive performance after the moxibustion was well-comparable to those after PGF2 alpha or ampicillin treatment. Result indicates that the moxibustion could be used as the alternative to PGF2 alpha and antibiotics for treating delayed Uterine Involution in cows.
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Therapeutic Effects of the Moxibustion on Delayed Uterine Involution in Postpartum Dairy Cows
1992Co-Authors: Kiyoshi Korematsu, Takashi Kawabe, Toshihiko Nakao, Eisyuu Takagi, Keiichiro KawataAbstract:A calving interval of 12 months has been considered to be a goal of reproductive management of dairy cows. Delay of postpartum Uterine Involution and ovarian resumption of them results in extension of calving intervals and hence, causes major economical loss. It is therefore,very important to carry out reproductive check and to give proper treatment to cows with delayed reproductive recovery. For the treatment delayed Uterine Involution, some antibiotics have been infused in utero with indistinct effect1,2,3. Recently, administration of PGF2a or it's analog has been provided to to be more effective on the postpartum Uterine losses than the antibiotics treatment4,5.Preventive effect of GriRH on cows with endometritis following retained placenta in resumption of ovarian cycle has also been reported6. The acupancuture and the moxibustion therapy has been known to facilitate Uterine contraction and ovarian function in cattle7,8,9. These methods have some advantages over the administrations. The treatments have neither side effect or drug residue, and easy to accomplish and economial. This paper reports therapeutic effects of the moxibustion on cows with delayed Uterine Involution.
Marlene Sickinger - One of the best experts on this subject based on the ideXlab platform.
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Association of bovine Uterine Involution disturbances with serum neuropeptide concentrations.
Veterinary world, 2020Co-Authors: Aida Abultdinova, Isatay Jakupov, Joachim Roth, Klaus Failing, Axel Wehrend, Marlene SickingerAbstract:Puerperal diseases influence fertility and should be diagnosed as soon as possible. This study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin (IL)1β in the early diagnosis of Uterine Involution disturbances. Blood serum samples of 86 dairy cows from six different farms were harvested within the first 20 days after calving from cows with Uterine Involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP, and IL-1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with Uterine disease. SP concentrations increased significantly within 20 days after calving (p<0.04) with no significant difference observed between the groups. Moreover, no significant differences were found between VIP and log IL-1β. Results showed that none of the examined serum parameters seems suitable as indicator of Uterine Involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded. Further research is needed as regards the establishment of normative values concerning this parameter. Copyright: © Abultdinova, et al.
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association of bovine Uterine Involution disturbances with serum neuropeptide concentrations
Veterinary World, 2020Co-Authors: Aida Abultdinova, Isatay Jakupov, Joachim Roth, Klaus Failing, Axel Wehrend, Marlene SickingerAbstract:Background and Aim Puerperal diseases influence fertility and should be diagnosed as soon as possible. This study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin (IL)1β in the early diagnosis of Uterine Involution disturbances. Materials and Methods Blood serum samples of 86 dairy cows from six different farms were harvested within the first 20 days after calving from cows with Uterine Involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP, and IL-1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with Uterine disease. Results SP concentrations increased significantly within 20 days after calving (p<0.04) with no significant difference observed between the groups. Moreover, no significant differences were found between VIP and log IL-1β. Conclusion Results showed that none of the examined serum parameters seems suitable as indicator of Uterine Involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded. Further research is needed as regards the establishment of normative values concerning this parameter.
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Association of bovine Uterine Involution disturbances with serum neuropeptide concentrations
2019Co-Authors: Aida Abultdinova, Isatay Jakupov, Joachim Roth, Klaus Failing, Axel Wehrend, Marlene SickingerAbstract:Abstract Background: Puerperal diseases influence fertility and should be diagnosed as soon as possible. The present study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP) and IL‑1β in the early diagnosis of Uterine Involution disturbances. Blood serum samples of 86 dairy cows from 6 different farms were harvested within the first 20 days after calving from cows with Uterine Involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP and IL‑1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with Uterine disease. Results: SP-concentrations increased significantly within 20 days after calving (P < 0.04) with no significant difference between the groups. No significant differences could be shown for VIP and logIL-1β. Conclusion: None of the examined serum parameters seems suitable as indicator of Uterine Involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded though. Further research is needed with regard to the establishment of normative values concerning this parameter.
Donny Kristanto Mulyantoro - One of the best experts on this subject based on the ideXlab platform.
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EFFECT OF COMBINATION OF OXYTOCIN MASSAGE AND HYPNOBREASTFEEDING ON Uterine Involution AND PROLACTIN LEVELS IN POSTPARTUM MOTHERS
Belitung Nursing Journal, 2017Co-Authors: Yuni Nor Aini, Hadi Hadi, Sri Rahayu, Noor Pramono, Donny Kristanto MulyantoroAbstract:Background: The absence of contractions after childbirth can lead to a slow-running Uterine Involution process. Thus, the effort to maintain and accelerate the process is needed. Oxytocin massage and hypnobreastfeeding are considered as an alternative treatment, but the effect of the combination of the two treatments have not yet been examined.Objective: To examine the effect of combination of oxytocin massage and hypnobreastfeeding on Uterine Involution and prolactin levels in post partum.Methods: A Quasy experimental study with pretest posttest control group design. a total of 40 respondents were recruited using simple random sampling, with 20 respondents assigned in the treatment and control group. Metline and ELISA methods were used to measure Uterine Involution prolactin levels. Paired t-test and independent t-test were used to analyze the data.Results: There was a significant decrease of Uterine Involution in the experiment group and control group after intervention with p-value 0.000 (<0.05), and it can be seen that the Uterine Involution in the experiment group (6.05) was faster than uterin Involution in the control group (7.00). Findings also showed that the prolactin level in the experiment group (273.53) was higher than the prolactin level in the control group (209.37).Conclusion: There was statistically significant effect of the combination of oxytocin massage and hypnobreastfeeding on the Uterine Involution and prolactin level in postpartum mothers in the General Hospital of Semarang. It is expected that the combination of oxytocin massage and hypnobreastfeeding can be used as consideration and references in providing postpartum midwifery care.
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EFFECT OF COMBINATION OF OXYTOCIN MASSAGE AND HYPNOBREASTFEEDING ON Uterine Involution AND PROLACTIN LEVELS IN POSTPARTUM MOTHERS
Belitung Raya Publisher, 2017Co-Authors: Yuni Nor Aini, Sri Rahayu, Noor Pramono, Donny Kristanto MulyantoroAbstract:Background: The absence of contractions after childbirth can lead to a slow-running Uterine Involution process. Thus, the effort to maintain and accelerate the process is needed. Oxytocin massage and hypnobreastfeeding are considered as an alternative treatment, but the effect of the combination of the two treatments have not yet been examined. Objective: To examine the effect of combination of oxytocin massage and hypnobreastfeeding on Uterine Involution and prolactin levels in post partum. Methods: A Quasy experimental study with pretest posttest control group design. a total of 40 respondents were recruited using simple random sampling, with 20 respondents assigned in the treatment and control group. Metline and ELISA methods were used to measure Uterine Involution prolactin levels. Paired t-test and independent t-test were used to analyze the data. Results: There was a significant decrease of Uterine Involution in the experiment group and control group after intervention with p-value 0.000 (
Toshihiko Nakao - One of the best experts on this subject based on the ideXlab platform.
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postpartum plasma pgf metabolite profile in cows with dystocia and or retained placenta and effect of fenprostalene on Uterine Involution and reproductive performance
Journal of Veterinary Medical Science, 1997Co-Authors: Toshihiko Nakao, Masaharu Moriyoshi, Absy Gamal, Takeshi Osawa, Ken Nakada, Keiichiro KawataAbstract:Objectives of this study were to show postpartum plasma PGF2α metabolite (PGFM) profile, to clarify whether endogenous PGF2α plays a certain role in the Uterine Involution in cows with dystocia and/or retained placenta, and to examine the effects of fenprostalene, a long-acting PGF2α analog, on the Uterine Involution and reproductive performance of the cows with abnormal puerperium. A group of 27 cows with dystocia and/or retained placenta showed a massive release of PGF2α after parturition as indicated by a rise of plasma concentrations of PGFM, significantly higher than 33 cows with normal puerperium. The duration of the elevated plasma PGFM concentrations in the cows with abnormal puerperium was shorter than that of the normal cows. In cows with normal puerperium, those showing relatively longer duration of elevated plasma PGFM levels needed a shorter period for postpartum Uterine Involution than the cows showing a shorter duration of the PGFM elevation (P<0.01), while no such relationship was observed in cows with abnormal puerperium. In field trials, an administration of an exogenous PGF2α, fenprostalene, at 7 to 10 days (78 cows) or 14 to 28 days postpartum (74 cows) was found to be effective in facilitating Uterine Involution and resumption of ovarian cyclicity, and improved reproductive performance. It may be concluded that a large amount of PGF2α is released for a relatively shorter period in cows after dystocia and/or retained placenta and the elevation of PGFM is not responsible for the Uterine Involution. The administration of the exogenous PGF2α was shown to be effective at improving the postpartum reproductive performance of cows with abnormal puerperium.
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Postpartum Plasma PGF Metabolite Profile in Cows with Dystocia and/or Retained Placenta, and Effect of Fenprostalene on Uterine Involution and Reproductive Performance
The Journal of veterinary medical science, 1997Co-Authors: Toshihiko Nakao, Masaharu Moriyoshi, Absy Gamal, Takeshi Osawa, Ken Nakada, Keiichiro KawataAbstract:Objectives of this study were to show postpartum plasma PGF2α metabolite (PGFM) profile, to clarify whether endogenous PGF2α plays a certain role in the Uterine Involution in cows with dystocia and/or retained placenta, and to examine the effects of fenprostalene, a long-acting PGF2α analog, on the Uterine Involution and reproductive performance of the cows with abnormal puerperium. A group of 27 cows with dystocia and/or retained placenta showed a massive release of PGF2α after parturition as indicated by a rise of plasma concentrations of PGFM, significantly higher than 33 cows with normal puerperium. The duration of the elevated plasma PGFM concentrations in the cows with abnormal puerperium was shorter than that of the normal cows. In cows with normal puerperium, those showing relatively longer duration of elevated plasma PGFM levels needed a shorter period for postpartum Uterine Involution than the cows showing a shorter duration of the PGFM elevation (P
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factors in the resumption of ovarian activity and Uterine Involution in postpartum dairy cows
Animal Reproduction Science, 1995Co-Authors: Eldin A Zain, Toshihiko Nakao, Masaharu Moriyoshi, Keiichiro Kawata, Abdel M Raouf, Y MoritsuAbstract:As a step toward clarifying intricate relationships among the factors responsible for delay of postpartum ovarian cyclicity and Uterine Involution in high-producing dairy cows, we analyzed the clinical, production, and environmental findings derived from 72 Holstein—Friesian dams in one dairy herd for 13 consecutive months. The interval from calving to resumption of ovarian activity ranged from 13 to 64 days, the average being 25 ± 13 days SD. Variation in the number of days between calving and first ovulation was largely accounted for by the factors included in the investigative model (r2=0.75, P<0.001), as shown by covariance analysis. The greatest effect on resumed ovulation was, by far, that of the daily level of total digestible nutrients (TDN) at resumption of the postpartum ovarian activity (P<0.001), although the puerperal condition was also shown to play a significant role (P<0.05) on the resumption of ovulation. Dams without puerperal complications ovulated markedly earlier (at 22 days) than those encountering puerperal complications (≥ 31 days). The greatest influences on the Uterine Involution were puerperal condition (P<0.001) and parity (P<0.01), followed by season of calving (P<0.05). Age at calving, daily 4% fat corrected milk yield, daily TDN and crude protein levels had no significant bearing on Involution. The puerperal condition had the most noticeably widespread influence in governing both ovarian activity and Uterine Involution in postpartum cows, while a level of TDN intake played an important role in the resumption of ovarian activity.
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Therapeutic effects of moxibustion on delayed Uterine Involution in postpartum dairy cows.
The Journal of veterinary medical science, 1993Co-Authors: Kiyoshi Korematsu, Eisyu Takagi, Takashi Kawabe, Toshihiko Nakao, Masaharu Moriyoshi, Keiichiro KawataAbstract:Moxibustion on 12 specific points (Keiketsu in Japanese) was applied for treatment of delayed Uterine Involution in 16 cows that were diagnosed on the basis of rectal palpation and vaginoscopic examination 21 to 35 days after parturition. The treatment was continued for three consecutive days. Other 32 cows with the delayed Uterine Involution were either injected intramuscularly with 25 mg PGF2 alpha (17 cows) or infused in utero with 500 mg ampicillin (15 cows). The Uterine Involution following the treatment was monitored by rectal palpation and vaginoscopic examination. Milk samples were collected three times weekly and used for milk progesterone assay to monitor the ovarian function. No significant difference was observed in the Uterine Involution among the groups treated with moxibustion, PGF2 alpha or ampicillin. Percentages of cows with abnormal cervical mucus and bacterial isolation from cervical swab decreased remarkably in all groups during 4 weeks after treatment. Forty-six percent of cows with delayed Uterine Involution was diagnosed as having inactive ovaries. Percentage of cows that responded with ovulation and corpus luteum formation after moxibustion was 67 percent, slightly higher than those in cows treated with PGF2 alpha or ampicillin. Reproductive performance after the moxibustion was well-comparable to those after PGF2 alpha or ampicillin treatment. Result indicates that the moxibustion could be used as the alternative to PGF2 alpha and antibiotics for treating delayed Uterine Involution in cows.
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Therapeutic Effects of the Moxibustion on Delayed Uterine Involution in Postpartum Dairy Cows
1992Co-Authors: Kiyoshi Korematsu, Takashi Kawabe, Toshihiko Nakao, Eisyuu Takagi, Keiichiro KawataAbstract:A calving interval of 12 months has been considered to be a goal of reproductive management of dairy cows. Delay of postpartum Uterine Involution and ovarian resumption of them results in extension of calving intervals and hence, causes major economical loss. It is therefore,very important to carry out reproductive check and to give proper treatment to cows with delayed reproductive recovery. For the treatment delayed Uterine Involution, some antibiotics have been infused in utero with indistinct effect1,2,3. Recently, administration of PGF2a or it's analog has been provided to to be more effective on the postpartum Uterine losses than the antibiotics treatment4,5.Preventive effect of GriRH on cows with endometritis following retained placenta in resumption of ovarian cycle has also been reported6. The acupancuture and the moxibustion therapy has been known to facilitate Uterine contraction and ovarian function in cattle7,8,9. These methods have some advantages over the administrations. The treatments have neither side effect or drug residue, and easy to accomplish and economial. This paper reports therapeutic effects of the moxibustion on cows with delayed Uterine Involution.
Aida Abultdinova - One of the best experts on this subject based on the ideXlab platform.
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Association of bovine Uterine Involution disturbances with serum neuropeptide concentrations.
Veterinary world, 2020Co-Authors: Aida Abultdinova, Isatay Jakupov, Joachim Roth, Klaus Failing, Axel Wehrend, Marlene SickingerAbstract:Puerperal diseases influence fertility and should be diagnosed as soon as possible. This study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin (IL)1β in the early diagnosis of Uterine Involution disturbances. Blood serum samples of 86 dairy cows from six different farms were harvested within the first 20 days after calving from cows with Uterine Involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP, and IL-1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with Uterine disease. SP concentrations increased significantly within 20 days after calving (p<0.04) with no significant difference observed between the groups. Moreover, no significant differences were found between VIP and log IL-1β. Results showed that none of the examined serum parameters seems suitable as indicator of Uterine Involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded. Further research is needed as regards the establishment of normative values concerning this parameter. Copyright: © Abultdinova, et al.
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association of bovine Uterine Involution disturbances with serum neuropeptide concentrations
Veterinary World, 2020Co-Authors: Aida Abultdinova, Isatay Jakupov, Joachim Roth, Klaus Failing, Axel Wehrend, Marlene SickingerAbstract:Background and Aim Puerperal diseases influence fertility and should be diagnosed as soon as possible. This study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin (IL)1β in the early diagnosis of Uterine Involution disturbances. Materials and Methods Blood serum samples of 86 dairy cows from six different farms were harvested within the first 20 days after calving from cows with Uterine Involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP, and IL-1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with Uterine disease. Results SP concentrations increased significantly within 20 days after calving (p<0.04) with no significant difference observed between the groups. Moreover, no significant differences were found between VIP and log IL-1β. Conclusion Results showed that none of the examined serum parameters seems suitable as indicator of Uterine Involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded. Further research is needed as regards the establishment of normative values concerning this parameter.
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Association of bovine Uterine Involution disturbances with serum neuropeptide concentrations
2019Co-Authors: Aida Abultdinova, Isatay Jakupov, Joachim Roth, Klaus Failing, Axel Wehrend, Marlene SickingerAbstract:Abstract Background: Puerperal diseases influence fertility and should be diagnosed as soon as possible. The present study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP) and IL‑1β in the early diagnosis of Uterine Involution disturbances. Blood serum samples of 86 dairy cows from 6 different farms were harvested within the first 20 days after calving from cows with Uterine Involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP and IL‑1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with Uterine disease. Results: SP-concentrations increased significantly within 20 days after calving (P < 0.04) with no significant difference between the groups. No significant differences could be shown for VIP and logIL-1β. Conclusion: None of the examined serum parameters seems suitable as indicator of Uterine Involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded though. Further research is needed with regard to the establishment of normative values concerning this parameter.
