The Experts below are selected from a list of 8370 Experts worldwide ranked by ideXlab platform
Cui Xuel - One of the best experts on this subject based on the ideXlab platform.
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Diagnosis value of human epididymis protein 4 in patients with gynecological pelvic lesions
Labmedicine, 2012Co-Authors: Cui XuelAbstract:Objective To investigate the clinical value of human epididymis protein 4(HE4)on diagnosing gynecological pelvic lesions.Methods The HE4 and carbohydrate antigen 125(CA125) levels in sera from 133 patients with gynecological pelvic lesions(ovarian cancer: 7 cases,intrauterine tumor: 40 cases,benign ovarian Disease: 34 cases and benign Uterus Disease: 52 cases)and 43 healthy women(as the control group)were determined by enzyme-linked immunosorbent assay(ELISA) and chemiluminescence immunoassay,respectively.The patients were classified according to the postoperative pathology results.The control group′s ±2s was as the normal reference range,and the HE4 and CA125 levels were used to evaluate the sensitivity and specificity on diagnosing gynecological pelvic malignant lesions.Results The threshold values of serum HE4 and CA125 in the control group were 55.86 pmoL/L and 35 kU/L respectively.The levels of serum HE4 and CA125 had no statistical significance in the patients with benign ovarian Disease,benign Uterus Disease and the control group(P0.05),and the levels of serum HE4 and CA125 in patients with ovarian cancer were significantly higher than the normal reference range and those in patients with intrauterine tumor,benign ovarian Disease,benign Uterus Disease and the control group(P0.01).The levels of serum HE4 in patients with intrauterine tumor were significantly higher than the normal reference range and those in patients with benign ovarian Disease,benign Uterus Disease and the control group(P0.05).However,the levels of serum CA125 had no significant difference in the 4 groups(P0.05).The levels of serum HE4 and CA125 had positive correlation[coefficient of correlation(r)=0.467 and 0.380,P0.05]in the patients with ovarian cancer and intrauterine tumor,but there was no correlation among the other 3 groups.The positive rates of HE4 and CA125 in patients with ovarian cancer,intrauterine tumor,benign ovarian Disease,benign Uterus Disease and the control group were 100.00%,71.43%;37.50%,30.00%;14.70%,11.76%;19.23%,32.69% and 2.32%,2.32% respectively.The sensitivities of HE4 and CA125 to ovarian cancr were 100.00% and 71.43%,the specificities were 82.35% and 85.29%,the positive predictive values were 53.85% and 50.00%,and the negative predictive values were 100.00% and 93.50%.The area under the receiver operating characteristic(ROC) curve(AUC)of HE4 was bigger than that of CA125 in patients with ovarian cancer(P0.01).Merging the ovarian cancer group and the intrauterine tumor group as pelvic malignant lesion group,the diagnostic sensitivities of HE4,CA125 and HE4+CA125 were 46.80%,36.17% and 54.41%,the specificities were 82.60%,75.58% and 47.22%,the positive predictive values were 59.50%,44.74% and 49.33%,and the negative predictive values were 74.00%,68.42% and 52.31%.Conclusions Besides the serum level of HE4 is helpful in the diagnosis of ovarian cancer and intrauterine tumor,the levels of HE4 will increase in a part of benign gynecological pelvic lesion.
Du Jing - One of the best experts on this subject based on the ideXlab platform.
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Value of human serum levels of human epididymis protein 4 in patients with gynecological pelvic lesions
Medical Journal of West China, 2012Co-Authors: Du JingAbstract:Objective To investigate the value of human epididymis secretory protein 4(HE4) diagnosis of patients with Gynecological Pelvic Lesions.Methods An Enzyme-linked immunosorbent assay(ELISA) Was used to detect the level of serum HE4.patients were divided into the following foure groups and evaluate the sensitivity,specificity and other diagnostic indicators according to their postoperative pathology results.Results The average value of serum HE4 in the healthy control group was 32.52±11.67 pmol/L,and in ovarian cancer group was 463.05±365.81 pmoL/L(100%),in benign ovarian Disease group was 40.55±18.88 pmoL/L(17.65%),in Uterus malignant tumor group was 59.47±40.78 pmoL/L(37.5%),in benign Uterus Disease group was 42.74±18.33 pmoL/L(19.23%).The sensitivity and the specificity and the positive predictive value and the negative predictive value of HE4 to detection gynecological pelvic neoplasms were 46.8%and 82.6% and 59.5% and 74.0% respectively.Conclusion Human Serum level of HE4 can is helpful in the diagnosis of ovarian cancer and Uterus malignant tumor,but Serum level of HE4 can were higher than that healthy Reference values with a part of benign gynecological pelvic Disease.
Dong Rui-feng - One of the best experts on this subject based on the ideXlab platform.
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Clinical Analysis of 242 Postmenopausal Uterine Bleeding
Hebei Medicine, 2003Co-Authors: Dong Rui-fengAbstract:Objective: To investigate the causes of postmenopausal vagina bleeding and the value of dilation and curettage. Methods: A retrospective analysis was done on 242 cases of postmenopausal uterine bleeding in our hospital of obstetrics and gynecology from July 1992 to February 1999. Results: The first reason of uterine bleeding was atrophied endometrium, it was found in 33.4% of patients. The second reason was functional uterine bleeding (28.51%), the third reason was endometritis(19.83%), the forth reason was malignant tumor(7.44%),the fifth reason was Uterus Disease include polypus of endometrium and leiomyoma in uteri (6.61). Conclusions: Benign lesions had been detected in most of the patients with postmenopausal vagina bleeding .The probability of cancer underlying cause increased with longer duration of menopause. The first method of diagnostic eudiometrical Disease is dilation and curettage.
Zhang Ping - One of the best experts on this subject based on the ideXlab platform.
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Differential diagnostic value of combined detection of serum HE4 and CA125 in patients with endometrial carcinoma from benign Uterus tumor
China Oncology, 2012Co-Authors: Zhang PingAbstract:Background and purpose:To date,there is no good marker for screening or Disease monitoring of endometrial carcinoma.The present study aimed to investigate the significance of human epididymis protein 4(HE4) as a tumor marker combined with CA125 in diagnosis of endometrial carcinoma patients.Methods:Serum levels of HE4 and CA125 were examined in 80 patients with endometrial carcinoma.Twenty-seven patients with benign Uterus Disease were used as controls.Results:Serum levels of HE4 in endometrial carcinoma group were significantly higher than those in the benign Uterus Disease group(92.32±7.60 pmol/L vs 58.88±3.01 pmol/L,P0.0001),while the difference of these CA125 levels have no statistical meaning(30.05±5.24 U/mL vs 34.32±8.16 U/mL,P0.05).The receiver operating characteristic area under the curve(ROC-AUC) were 0.731,0.503 and 0.758,the sensitivity were 32.5%,10% and 33.8% when the specificity was 95% in HE4 alone,CA125 alone and HE4+CA125 combined detection in endometrial cancer group.Conclusion:HE4 is an ideal tumor marker and it has certain values in accessory diagnosis and differential diagnosis of endometrial cancer.The clinical value can be improved by combined detection of HE4 and CA125.
Xu Lei - One of the best experts on this subject based on the ideXlab platform.
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Improved Transvaginal Hysterectomy:A Clinical Analysis of 108 Cases
China Modern Doctor, 2010Co-Authors: Xu LeiAbstract:Objective To evaluate the clinical value of improved transvaginal hysterectomy for no-prolapse Uterus.Methods All 108 cases of no-prolapse Uterus Disease treated by improved transvaginal hysterectomy from Dec.2007 to Oct 2009 were analyzed as study group,and 100 cases were treated by transabdominal hysterectomy as control group.The operative time,blood loss,exhaust time,action time of getting up of bed and mean postoperative hospital stay of both groups were observed.Results The operating time was(63.00±35.28)min,the blood loss was(93.00±50.18)mL,the action time of getting up of bed was(24.2±9.08)h,the exhaust time was(28.16±11.72)h,and the mean postoperative hospital stay was(5.50±1.50)days in the study group,and those of the control group were(92.35±26.43)min,(132.35±56.33)mL,(36.25±12.12)h,(34.12±13.68)h,and(7.40±2.60)d,with a significant difference between the two groups(P0.01).Conclusion Transvaginal hysterectomy for no-prolapse Uterus Disease has remarkable advantages of less blood loss,reduced operating time,quicker recovery,less pain and no abdominal scar,and it is a safe and adopted operation.
