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Charlotte A. Gaydos - One of the best experts on this subject based on the ideXlab platform.

  • Patterns of point-of-care test use among obstetricians and gynaecologists in the US
    Sexual Health, 2018
    Co-Authors: Anne Marie Rompalo, Neko M. Castleberry, Lea E. Widdice, Jay Schulkin, Charlotte A. Gaydos
    Abstract:

    Background Point-of-care tests (POCTs) for reproductive health conditions have existed for decades. Newer POCTs for sypHilis, HIV and trichomonas are currently available and easy to use. We surveyed practicing obstetricians and gynaecologists to determine current POCT use and perceived obstacles to use. Methods: Between June and August 2016, 1000 members of the American College of Obstetricians and Gynecologists were randomly selected and invited to complete a Qualtrics (222 West river Park Drive, Provo, Utah 84604, USA) survey; 600 of these were members of the Collaborative Ambulatory Research Network. Respondents who completed at least 60% of the survey were included in the analysis. Results: Of the 1000 selected members, 749 had valid emails and 288 (38%) of these participated in and completed the survey. Of the respondents, 70% were male with a mean of 18 years in practice. Detection of sexually transmissible infections (STIs) once or twice a week was reported by 30%, whereas 45% reported detecting STIs once or twice a month. POCTs used included pregnancy tests (83%), urine dipstick (83%), wet mount tests (79%) and the Vagina pH test (54.8%). Few used Gram stain (5%) and stat rapid plasma regain tests (4%). Relatively newer US Food and Drug Administration-approved POCTs were used less frequently, with 25% of respondents reporting using the Affirm VPIII (Becton, Dickinson and Company, 1 Becton Drive, Franklin Lakes, NJ 07471, USA) test use and only 10% using a rapid HIV test. The most common perceived barriers to testing were the amount of reimbursement received for performing the test (61.9%) and the payment coverage from the patient (61.3%). Conclusions: US obstetricians and gynaecologists rely on laboratory test results and traditional POCTs to diagnosis STIs. Future development and marketing of POCTs should consider not only ease and time of test performance, but also the cost of the tests to the practice and the patient, as well as reimbursement.

  • P4.14 Patterns of point of care test use among obstetricians and gynaecologists(OB-GYNS) in the u.s
    Sexually Transmitted Infections, 2017
    Co-Authors: Anne Marie Rompalo, Neko M. Castleberry, Lea E. Widdice, Charlotte A. Gaydos, Jay Schulkin
    Abstract:

    Introduction Point of care tests (POCTs) for sypHilis, HIV, and Trichomonas are currently available, easy-to-use and inexpensive. We surveyed practicing Ob-gyns to determine POCT current use and perceived barriers to use. Methods Between June and August 2016, 1000 members of the American College of Ob-gyns were randomly selected and invited to complete a Qualtrics survey: 600 were members of the Collaborative Ambulatory Research Network (CARN). Respondents completing at least 60% of the survey were included in analyses. Results 930 members had valid emails; 288 (31%) participated in and completed the survey. 70% were male. Average years in practice were 16 for males and 23 for females. 30% reported diagnosing STDs 1–2 times/week and 45% reported 1–2 times/month. POCTs used included pregnancy test (83%), urine dipstick (83%), wet mount test (79%) and the Vagina pH test (54.8%). Few used Gram stain (5%) and stat RPRs (4%). Newer POCTs were used less frequently with 20% reporting Affirm VPIII test use, and only 9% using a rapid HIV test. Most common barriers were the amount of reimbursement received for performing the test (61.9%) and the payment coverage from the patient (61.3%). Conclusion Ob-gyns in the U.S. rely on laboratory test results and older traditional POCTs to diagnosis STDs. Future development and marketing of POCTs should consider not only ease and time of test performance but also cost of tests to the practice and the patient, as well as reimbursement.

Katarzyna Małolepsza-jarmołowska - One of the best experts on this subject based on the ideXlab platform.

  • OF HYDROpHILIC GELS CONTAINING LACTIC ACID COMPLEX WITH CHITOSAN
    2020
    Co-Authors: Katarzyna Małolepsza-jarmołowska
    Abstract:

    The investigated preparations on methylcellulose base revealed good adhesion to the Vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of 24-hour action of the drug. Gels containing lactic acid complex with chitosan at 1 : 1 stoichiometric ratio is equivalent to regular pHysiological conditions of a Vagina. pH of gel at 2 : 1 stoichiometric composition ratio of lactic acid to chitosan remains below a pHysiological reaction and can be used in benign inflammatory condition. The value of pH of a gel is greatly influenced by the content of lactic acid in relation to chitosan and the type and concentration of a auxiliary substance.

  • Studies on gynaecological hydropHilic lactic acid preparations. Part 3: Effects of chitosan on the properties of methylcellulose gels.
    Die Pharmazie, 2000
    Co-Authors: Katarzyna Małolepsza-jarmołowska, Kubis Aa
    Abstract:

    : Methylcellulose gels comprising lactic acid, similarly to its water solutions, have pH values between 2.0 and 2.6, i.e. out of the pHysiological range. Addition of Chitosan enables preparation of gels with pH values from 2.2 to 4.9 similar to the natural Vagina pH range, 3.8-4.4. The absolute viscosity of the gels, ranging from 27 up to 700 mPa.s, depends on chemical composition and on excess of lactic acid used. Measurement of adhesion enabled the selection of gels which remain located at the point of application under simulated biopHarmaceutical conditions. The behavior of those preparations in the true environment of the Vagina needs to be verified in vivo.

Jay Schulkin - One of the best experts on this subject based on the ideXlab platform.

  • Patterns of point-of-care test use among obstetricians and gynaecologists in the US
    Sexual Health, 2018
    Co-Authors: Anne Marie Rompalo, Neko M. Castleberry, Lea E. Widdice, Jay Schulkin, Charlotte A. Gaydos
    Abstract:

    Background Point-of-care tests (POCTs) for reproductive health conditions have existed for decades. Newer POCTs for sypHilis, HIV and trichomonas are currently available and easy to use. We surveyed practicing obstetricians and gynaecologists to determine current POCT use and perceived obstacles to use. Methods: Between June and August 2016, 1000 members of the American College of Obstetricians and Gynecologists were randomly selected and invited to complete a Qualtrics (222 West river Park Drive, Provo, Utah 84604, USA) survey; 600 of these were members of the Collaborative Ambulatory Research Network. Respondents who completed at least 60% of the survey were included in the analysis. Results: Of the 1000 selected members, 749 had valid emails and 288 (38%) of these participated in and completed the survey. Of the respondents, 70% were male with a mean of 18 years in practice. Detection of sexually transmissible infections (STIs) once or twice a week was reported by 30%, whereas 45% reported detecting STIs once or twice a month. POCTs used included pregnancy tests (83%), urine dipstick (83%), wet mount tests (79%) and the Vagina pH test (54.8%). Few used Gram stain (5%) and stat rapid plasma regain tests (4%). Relatively newer US Food and Drug Administration-approved POCTs were used less frequently, with 25% of respondents reporting using the Affirm VPIII (Becton, Dickinson and Company, 1 Becton Drive, Franklin Lakes, NJ 07471, USA) test use and only 10% using a rapid HIV test. The most common perceived barriers to testing were the amount of reimbursement received for performing the test (61.9%) and the payment coverage from the patient (61.3%). Conclusions: US obstetricians and gynaecologists rely on laboratory test results and traditional POCTs to diagnosis STIs. Future development and marketing of POCTs should consider not only ease and time of test performance, but also the cost of the tests to the practice and the patient, as well as reimbursement.

  • P4.14 Patterns of point of care test use among obstetricians and gynaecologists(OB-GYNS) in the u.s
    Sexually Transmitted Infections, 2017
    Co-Authors: Anne Marie Rompalo, Neko M. Castleberry, Lea E. Widdice, Charlotte A. Gaydos, Jay Schulkin
    Abstract:

    Introduction Point of care tests (POCTs) for sypHilis, HIV, and Trichomonas are currently available, easy-to-use and inexpensive. We surveyed practicing Ob-gyns to determine POCT current use and perceived barriers to use. Methods Between June and August 2016, 1000 members of the American College of Ob-gyns were randomly selected and invited to complete a Qualtrics survey: 600 were members of the Collaborative Ambulatory Research Network (CARN). Respondents completing at least 60% of the survey were included in analyses. Results 930 members had valid emails; 288 (31%) participated in and completed the survey. 70% were male. Average years in practice were 16 for males and 23 for females. 30% reported diagnosing STDs 1–2 times/week and 45% reported 1–2 times/month. POCTs used included pregnancy test (83%), urine dipstick (83%), wet mount test (79%) and the Vagina pH test (54.8%). Few used Gram stain (5%) and stat RPRs (4%). Newer POCTs were used less frequently with 20% reporting Affirm VPIII test use, and only 9% using a rapid HIV test. Most common barriers were the amount of reimbursement received for performing the test (61.9%) and the payment coverage from the patient (61.3%). Conclusion Ob-gyns in the U.S. rely on laboratory test results and older traditional POCTs to diagnosis STDs. Future development and marketing of POCTs should consider not only ease and time of test performance but also cost of tests to the practice and the patient, as well as reimbursement.

Anne Marie Rompalo - One of the best experts on this subject based on the ideXlab platform.

  • Patterns of point-of-care test use among obstetricians and gynaecologists in the US
    Sexual Health, 2018
    Co-Authors: Anne Marie Rompalo, Neko M. Castleberry, Lea E. Widdice, Jay Schulkin, Charlotte A. Gaydos
    Abstract:

    Background Point-of-care tests (POCTs) for reproductive health conditions have existed for decades. Newer POCTs for sypHilis, HIV and trichomonas are currently available and easy to use. We surveyed practicing obstetricians and gynaecologists to determine current POCT use and perceived obstacles to use. Methods: Between June and August 2016, 1000 members of the American College of Obstetricians and Gynecologists were randomly selected and invited to complete a Qualtrics (222 West river Park Drive, Provo, Utah 84604, USA) survey; 600 of these were members of the Collaborative Ambulatory Research Network. Respondents who completed at least 60% of the survey were included in the analysis. Results: Of the 1000 selected members, 749 had valid emails and 288 (38%) of these participated in and completed the survey. Of the respondents, 70% were male with a mean of 18 years in practice. Detection of sexually transmissible infections (STIs) once or twice a week was reported by 30%, whereas 45% reported detecting STIs once or twice a month. POCTs used included pregnancy tests (83%), urine dipstick (83%), wet mount tests (79%) and the Vagina pH test (54.8%). Few used Gram stain (5%) and stat rapid plasma regain tests (4%). Relatively newer US Food and Drug Administration-approved POCTs were used less frequently, with 25% of respondents reporting using the Affirm VPIII (Becton, Dickinson and Company, 1 Becton Drive, Franklin Lakes, NJ 07471, USA) test use and only 10% using a rapid HIV test. The most common perceived barriers to testing were the amount of reimbursement received for performing the test (61.9%) and the payment coverage from the patient (61.3%). Conclusions: US obstetricians and gynaecologists rely on laboratory test results and traditional POCTs to diagnosis STIs. Future development and marketing of POCTs should consider not only ease and time of test performance, but also the cost of the tests to the practice and the patient, as well as reimbursement.

  • P4.14 Patterns of point of care test use among obstetricians and gynaecologists(OB-GYNS) in the u.s
    Sexually Transmitted Infections, 2017
    Co-Authors: Anne Marie Rompalo, Neko M. Castleberry, Lea E. Widdice, Charlotte A. Gaydos, Jay Schulkin
    Abstract:

    Introduction Point of care tests (POCTs) for sypHilis, HIV, and Trichomonas are currently available, easy-to-use and inexpensive. We surveyed practicing Ob-gyns to determine POCT current use and perceived barriers to use. Methods Between June and August 2016, 1000 members of the American College of Ob-gyns were randomly selected and invited to complete a Qualtrics survey: 600 were members of the Collaborative Ambulatory Research Network (CARN). Respondents completing at least 60% of the survey were included in analyses. Results 930 members had valid emails; 288 (31%) participated in and completed the survey. 70% were male. Average years in practice were 16 for males and 23 for females. 30% reported diagnosing STDs 1–2 times/week and 45% reported 1–2 times/month. POCTs used included pregnancy test (83%), urine dipstick (83%), wet mount test (79%) and the Vagina pH test (54.8%). Few used Gram stain (5%) and stat RPRs (4%). Newer POCTs were used less frequently with 20% reporting Affirm VPIII test use, and only 9% using a rapid HIV test. Most common barriers were the amount of reimbursement received for performing the test (61.9%) and the payment coverage from the patient (61.3%). Conclusion Ob-gyns in the U.S. rely on laboratory test results and older traditional POCTs to diagnosis STDs. Future development and marketing of POCTs should consider not only ease and time of test performance but also cost of tests to the practice and the patient, as well as reimbursement.

Richard A Cone - One of the best experts on this subject based on the ideXlab platform.

  • acid production by Vaginal flora in vitro is consistent with the rate and extent of Vaginal acidification
    Infection and Immunity, 1999
    Co-Authors: Elizabeth R Boskey, K M Telsch, Kevin J Whaley, Thomas R Moench, Richard A Cone
    Abstract:

    Perinatally, and between menarche and menopause, increased levels of estrogen cause large amounts of glycogen to be deposited in the Vaginal epithelium. During these times, the anaerobic metabolism of the glycogen, by the epithelial cells themselves and/or by Vaginal flora, causes the Vagina to become acidic (pH ∼4). This study was designed to test whether the characteristics of acid production by Vaginal flora in vitro can account for Vaginal acidity. Eight Vaginal Lactobacillus isolates from four species— L. gasseri , L. Vaginalis , L. crispatus , and L. jensenii —acidified their growth medium to an asymptotic pH (3.2 to 4.8) that matches the range seen in the Lactobacillus -dominated human Vagina (pH 3.6 to 4.5 in most women) (B. Andersch, L. Forssman, K. Lincoln, and P. Torstensson, Gynecol. Obstet. Investig. 21:19–25, 1986; L. Cohen, Br. J. Vener. Dis. 45:241–246, 1969; J. Paavonen, Scand. J. Infect. Dis. Suppl. 40:31–35, 1983; C. Tevi-Benissan, L. Belec, M. Levy, V. Schneider-Fauveau, A. Si Mohamed, M.-C. Hallouin, M. Matta, and G. Gresenguet, Clin. Diagn. Lab. Immunol. 4:367–374, 1997). During exponential growth, all of these Lactobacillus species acidified their growth medium at rates on the order of 10 6 protons/bacterium/s. Such rates, combined with an estimate of the total number of lactobacilli in the Vagina, suggest that Vaginal lactobacilli could reacidify the Vagina at the rate observed postcoitally following neutralization by the male ejaculate (W. H. Masters and V. E. Johnson, Human sexual response, p. 93, 1966). During bacterial vaginosis (BV), there is a loss of Vaginal acidity, and the Vaginal pH rises to >4.5. This correlates with a loss of lactobacilli and an overgrowth of diverse bacteria. Three BV-associated bacteria, Gardnerella Vaginalis , Prevotella bivia , and Peptostreptococcus anaerobius , acidified their growth medium to an asymptotic pH (4.7 to 6.0) consistent with the characteristic elevated Vaginal pH associated with BV. Together, these observations are consistent with Vaginal flora, rather than epithelial cells, playing a primary role in creating the acidity of the Vagina.