The Experts below are selected from a list of 1863 Experts worldwide ranked by ideXlab platform
M Divya - One of the best experts on this subject based on the ideXlab platform.
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spindle cell sarcoma of Vagina a case report
Journal of Evolution of medical and Dental Sciences, 2013Co-Authors: R Sankareswari, K Geetha, S Van, M DivyaAbstract:Malignant Tumors of Vagina are rare accounting for 1 to 4 % of all genital malignancies. Rarest of rare is spindle cell sarcoma of Vagina having a very poor prognosis. 47yrs old, regularly menstruating woman, completed family, presented with hard painful ulcerated swelling near the Vaginal introitus and lower Vaginal wall of 4 months duration. On examination, 2x4cms sized ulcerated growth with excavated base, covered with necrotic material, present in the left antero-lateral lower end of Vagina, inner to hymenal ring which was tender, hard, indurated, infiltrating, fixed to base and did not bleed to touch. Another nodule of size 1x1cm tender, hard, fixed and necrotic was present below the external urethral meatus. HPE revealed Amelanotic malignant melanoma of Vagina. Immunohistochemistry revealed Spindle cell sarcoma of Vagina. Tumor board recommended neo-adjuvant chemotherapy and radiotherapy (CT + EBRT). Of the recommended 50Gy, she completed 46Gy in 23days and 1 course of chemotherapy (VAC). On review after 9 months, the lesion disappeared clinically and she was advised to complete the treatment. Inspite of radio and chemotherapy secondaries to lungs and brain could not be prevented and the patient expired 20 months after the final
R Sankareswari - One of the best experts on this subject based on the ideXlab platform.
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spindle cell sarcoma of Vagina a case report
Journal of Evolution of medical and Dental Sciences, 2013Co-Authors: R Sankareswari, K Geetha, S Van, M DivyaAbstract:Malignant Tumors of Vagina are rare accounting for 1 to 4 % of all genital malignancies. Rarest of rare is spindle cell sarcoma of Vagina having a very poor prognosis. 47yrs old, regularly menstruating woman, completed family, presented with hard painful ulcerated swelling near the Vaginal introitus and lower Vaginal wall of 4 months duration. On examination, 2x4cms sized ulcerated growth with excavated base, covered with necrotic material, present in the left antero-lateral lower end of Vagina, inner to hymenal ring which was tender, hard, indurated, infiltrating, fixed to base and did not bleed to touch. Another nodule of size 1x1cm tender, hard, fixed and necrotic was present below the external urethral meatus. HPE revealed Amelanotic malignant melanoma of Vagina. Immunohistochemistry revealed Spindle cell sarcoma of Vagina. Tumor board recommended neo-adjuvant chemotherapy and radiotherapy (CT + EBRT). Of the recommended 50Gy, she completed 46Gy in 23days and 1 course of chemotherapy (VAC). On review after 9 months, the lesion disappeared clinically and she was advised to complete the treatment. Inspite of radio and chemotherapy secondaries to lungs and brain could not be prevented and the patient expired 20 months after the final
K Geetha - One of the best experts on this subject based on the ideXlab platform.
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spindle cell sarcoma of Vagina a case report
Journal of Evolution of medical and Dental Sciences, 2013Co-Authors: R Sankareswari, K Geetha, S Van, M DivyaAbstract:Malignant Tumors of Vagina are rare accounting for 1 to 4 % of all genital malignancies. Rarest of rare is spindle cell sarcoma of Vagina having a very poor prognosis. 47yrs old, regularly menstruating woman, completed family, presented with hard painful ulcerated swelling near the Vaginal introitus and lower Vaginal wall of 4 months duration. On examination, 2x4cms sized ulcerated growth with excavated base, covered with necrotic material, present in the left antero-lateral lower end of Vagina, inner to hymenal ring which was tender, hard, indurated, infiltrating, fixed to base and did not bleed to touch. Another nodule of size 1x1cm tender, hard, fixed and necrotic was present below the external urethral meatus. HPE revealed Amelanotic malignant melanoma of Vagina. Immunohistochemistry revealed Spindle cell sarcoma of Vagina. Tumor board recommended neo-adjuvant chemotherapy and radiotherapy (CT + EBRT). Of the recommended 50Gy, she completed 46Gy in 23days and 1 course of chemotherapy (VAC). On review after 9 months, the lesion disappeared clinically and she was advised to complete the treatment. Inspite of radio and chemotherapy secondaries to lungs and brain could not be prevented and the patient expired 20 months after the final
S Van - One of the best experts on this subject based on the ideXlab platform.
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spindle cell sarcoma of Vagina a case report
Journal of Evolution of medical and Dental Sciences, 2013Co-Authors: R Sankareswari, K Geetha, S Van, M DivyaAbstract:Malignant Tumors of Vagina are rare accounting for 1 to 4 % of all genital malignancies. Rarest of rare is spindle cell sarcoma of Vagina having a very poor prognosis. 47yrs old, regularly menstruating woman, completed family, presented with hard painful ulcerated swelling near the Vaginal introitus and lower Vaginal wall of 4 months duration. On examination, 2x4cms sized ulcerated growth with excavated base, covered with necrotic material, present in the left antero-lateral lower end of Vagina, inner to hymenal ring which was tender, hard, indurated, infiltrating, fixed to base and did not bleed to touch. Another nodule of size 1x1cm tender, hard, fixed and necrotic was present below the external urethral meatus. HPE revealed Amelanotic malignant melanoma of Vagina. Immunohistochemistry revealed Spindle cell sarcoma of Vagina. Tumor board recommended neo-adjuvant chemotherapy and radiotherapy (CT + EBRT). Of the recommended 50Gy, she completed 46Gy in 23days and 1 course of chemotherapy (VAC). On review after 9 months, the lesion disappeared clinically and she was advised to complete the treatment. Inspite of radio and chemotherapy secondaries to lungs and brain could not be prevented and the patient expired 20 months after the final
Marisa R Nucci - One of the best experts on this subject based on the ideXlab platform.
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perivascular epithelioid cell neoplasm pecoma of the gynecologic tract clinicopathologic and immunohistochemical characterization of 16 cases
The American Journal of Surgical Pathology, 2014Co-Authors: John K Schoolmeester, Brooke E Howitt, Michelle S Hirsch, Bradley J Quade, Marisa R NucciAbstract:Perivascular epithelioid cell Tumor (PEComa) belongs to a family of Tumors characterized by coexpression of melanocytic and muscle markers. Recent studies have shown that sporadic and tuberous sclerosis complex-associated PEComa may respond to mTOR inhibitors underscoring the importance of recognizing this Tumor. However, its occurrence in the gynecologic tract continues to be disputed owing to its common misclassification as other types of uterine sarcoma and its controversial relationship with epithelioid smooth muscle Tumors. To more fully characterize PEComa of the female genital tract, 16 cases of gynecologic PEComa were identified (1990 to 2012) and formed the basis of this study. Each case was analyzed for conventional morphologic and immunohistochemical characteristics established for PEComa of extrauterine sites; clinical outcome data were obtained for all cases. The 16 patients were aged 28 to 60 (mean 49; median 50) years, and 1 had a history of tuberous sclerosis complex. Thirteen cases were primary of the uterus, 2 of the adnexa, and 1 of the Vagina. Tumor size ranged from 0.3 to 25.0 (mean 8.7) cm. Three patients died of disease, 6 were alive with disease, and 7 were alive without evidence of disease at last follow-up (1 mo to 13 y follow-up; mean 26 mo). All patients with an adverse outcome met established criteria for malignancy as proposed for extrauterine sites (ie, 2 or more features present: size ≥5 cm, high-grade nuclear features, infiltration, necrosis, lymphovascular invasion, or a mitotic rate ≥1/50 high-power fields). Of the melanocytic markers, HMB45 was most commonly expressed (16/16 positive, 100%), followed by microphthalmia transcription factor (11/12 positive, 92%), MelanA (14/16 positive, 88%), and S100 protein (2/10 positive, 20%). Of the smooth muscle markers, desmin was most commonly expressed (15/15 cases, 100%), followed by SMA (14/15 cases, 93%) and h-caldesmon (11/12 cases, 92%). TFE3 immunopositivity was identified in 5 of 13 cases; however, 3 tested cases were negative for a TFE3 rearrangement by fluorescence in situ hybridization. Current criteria for malignancy appear to be valid in the female genital tract, although modified criteria, as described herein, may be more specific. Awareness of the characteristic features of PEComa is important to help distinguish it from epithelioid smooth muscle Tumors and other mimics as PEComa may respond to unique chemotherapeutic regimens.
