The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform
Domenico Rubello - One of the best experts on this subject based on the ideXlab platform.
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18F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac Endocarditis
European journal of nuclear medicine and molecular imaging, 2013Co-Authors: Rachele Bonfiglioli, Cristina Nanni, Joshua James Morigi, Maddalena Graziosi, Filippo Trapani, Michele Bartoletti, Fabio Tumietto, Valentina Ambrosini, Alice Ferretti, Domenico RubelloAbstract:Purpose Acute infective Endocarditis is a potentially life-threatening disease. Its outcome strongly depends on systemic embolization and extracardiac infections. When present, these conditions usually lead to a more aggressive therapeutic approach. However, the diagnosis of peripheral septic embolism is very challenging. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT has proven to be accurate for the detection of inflammatory diseases and occult infections. The aim of this study was to assess the added value of 18F-FDG PET/CT in the detection of extracardiac embolisms in the evaluation of patients with suspected Valvular Endocarditis (VE).
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18 F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac Endocarditis
European journal of nuclear medicine and molecular imaging, 2013Co-Authors: Rachele Bonfiglioli, Cristina Nanni, Joshua James Morigi, Maddalena Graziosi, Filippo Trapani, Michele Bartoletti, Fabio Tumietto, Valentina Ambrosini, Alice Ferretti, Domenico RubelloAbstract:Purpose Acute infective Endocarditis is a potentially life-threatening disease. Its outcome strongly depends on systemic embolization and extracardiac infections. When present, these conditions usually lead to a more aggressive therapeutic approach. However, the diagnosis of peripheral septic embolism is very challenging. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT has proven to be accurate for the detection of inflammatory diseases and occult infections. The aim of this study was to assess the added value of 18F-FDG PET/CT in the detection of extracardiac embolisms in the evaluation of patients with suspected Valvular Endocarditis (VE).
Andre Ferland - One of the best experts on this subject based on the ideXlab platform.
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Another Whipple’s triad? Pericardial, myocardial and Valvular disease in an unusual case presentation from a Canadian perspective
BMC Cardiovascular Disorders, 2019Co-Authors: Christina S. Thornton, Yinong Wang, Martin Köebel, Kathryn Bernard, Tamara Burdz, Andrew Maitland, Jose G. Ferraz, Paul L. Beck, Andre FerlandAbstract:Background Whipple’s disease is a clinically relevant multi-system disorder that is often undiagnosed given its elusive nature. We present an atypical case of Whipple’s disease involving pan-Valvular Endocarditis and constrictive pericarditis, requiring cardiac intervention. A literature review was also performed assessing the prevalence of atypical cases of Whipple’s disease. Case presentation A previously healthy 56-year-old male presented with a four-year history of congestive heart failure with weight loss and fatigue. Notably, he had absent gastrointestinal symptoms. He went on to develop pan-Valvular Endocarditis and constrictive pericarditis requiring urgent cardiac surgery. A clinical diagnosis of Whipple’s disease was suspected, prompting duodenal biopsy sampling which was unremarkable, Subsequently, Tropheryma whipplei was identified by 16S rDNA PCR on the cardiac Valvular tissue. He underwent prolonged antibiotic therapy with recovery of symptoms. Conclusions Our study reports the first known case of Whipple’s disease involving pan-Valvular Endocarditis and constrictive pericarditis. A literature review also highlights this presentation of atypical Whipple’s with limited gastrointestinal manifestations. Duodenal involvement was limited and the gold standard of biopsy was not contributory. We also highlight the Canadian epidemiology of the disease from 2012 to 2016 with an approximate 4% prevalence rate amongst submitted samples. Routine investigations for Whipple’s disease, including duodenal biopsy, in this case may have missed the diagnosis. A high degree of suspicion was critical for diagnosis of unusual manifestations of Whipple’s disease.
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Another Whipple’s triad? Pericardial, myocardial and Valvular disease in an unusual case presentation from a Canadian perspective
BMC cardiovascular disorders, 2019Co-Authors: Christina S. Thornton, Yinong Wang, Martin Köebel, Kathryn Bernard, Tamara Burdz, Andrew Maitland, Jose G. Ferraz, Paul L. Beck, Andre FerlandAbstract:Background Whipple’s disease is a clinically relevant multi-system disorder that is often undiagnosed given its elusive nature. We present an atypical case of Whipple’s disease involving pan-Valvular Endocarditis and constrictive pericarditis, requiring cardiac intervention. A literature review was also performed assessing the prevalence of atypical cases of Whipple’s disease.
Magne Bisgaard - One of the best experts on this subject based on the ideXlab platform.
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observations on the incidence and aetiology of Valvular Endocarditis in broiler breeders and detection of a newly described taxon of pasteurellaceae avibacterium endocarditidis
Avian Pathology, 2010Co-Authors: Magne Bisgaard, Jens Peter Christensen, Anders Miki Bojesen, Henrik ChristensenAbstract:A total of 122 dead broiler breeders randomly selected from a flock showing normal production parameters and covering the age from 44 to 61 weeks were subjected to a comprehensive routine post-mortem examination including examination for lesions of Endocarditis. Forty-two hens (34%) showed Valvular Endocarditis caused by Avibacterium endocarditidis (43%), Enterococcus faecalis (31%), Staphylococcus aureus (5%) and Streptococcus pluranimalium (5%), while growth was not obtained from 17% with the methods used for isolation. Gross lesions associated with the different bacterial pathogens did not allow separation according to pathogens involved. Port of entry and pathogenesis associated with the high prevalence of Valvular Endocarditis remained speculative. The present findings demonstrated the newly described species of Pasteurellaceae, Avibacterium endocarditidis associated with Endocarditis in chickens and confirm previous observations on the prevalence of Endocarditis in chickens, partly explaining the sl...
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Association of Streptococcus pluranimalium with Valvular Endocarditis and septicaemia in adult broiler parents
Avian Pathology, 2009Co-Authors: Lars Hedegaard, M S Chadfield, Henrik Christensen, Jens Peter Christensen, Magne BisgaardAbstract:The genus Streptococcus consists of more than 60 species, but only Streptococcus equi subspecies zooepidemicus, Streptococcus gallolyticus ssp. gallolyticus, Streptococcus gallinaceus, Streptococcus dysgalactiae, Streptococcus mutans and Streptococcus suis have been isolated from poultry. During investigations of the aetiology of increased mortality in broiler parent stock at the end of production, pure cultures of streptococcal-like organisms that could not be classified among these six species were obtained from 24 cases of septicaemia or Valvular Endocarditis and septicaemia. Phenotypic characterization using the API20 STREP kit identified the isolates as Aerococcus viridans (10), Aerococcus urinae (2), Leuconostoc species (4), Streptococcus salivarius (2), Streptococcus bovis II 3 (1), Enterococcus avium (3), Enterococcus faecium (1) or Gemella morbillorum (1). However, this identification was misleading as subsequent genetic investigations using pulse field gel electrophoresis and sequencing of 16S r...
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Association of Streptococcus pluranimalium with Valvular Endocarditis and septicaemia in adult broiler parents
Avian Pathology, 2009Co-Authors: Lars Hedegaard, M S Chadfield, Henrik Christensen, Jens Peter Christensen, Magne BisgaardAbstract:The genus Streptococcus consists of more than 60 species, but only Streptococcus equi subspecies zooepidemicus, Streptococcus gallolyticus ssp. gallolyticus, Streptococcus gallinaceus, Streptococcus dysgalactiae, Streptococcus mutans and Streptococcus suis have been isolated from poultry. During investigations of the aetiology of increased mortality in broiler parent stock at the end of production, pure cultures of streptococcal-like organisms that could not be classified among these six species were obtained from 24 cases of septicaemia or Valvular Endocarditis and septicaemia. Phenotypic characterization using the API20 STREP kit identified the isolates as Aerococcus viridans (10), Aerococcus urinae (2), Leuconostoc species (4), Streptococcus salivarius (2), Streptococcus bovis II 3 (1), Enterococcus avium (3), Enterococcus faecium (1) or Gemella morbillorum (1). However, this identification was misleading as subsequent genetic investigations using pulse field gel electrophoresis and sequencing of 16S r...
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Association of Streptococcus pluranimalium with Valvular Endocarditis and septicaemia in adult broiler parents
Avian Pathology, 2009Co-Authors: Lise Hedegaard, M S Chadfield, Henrik Christensen, Jens Peter Christensen, Magne BisgaardAbstract:The genus Streptococcus consists of more than 60 species, but only S. equi subspecies zooepidemicus, S. gallolyticus ssp. gallolyticus, S. gallinaceus, S. dysgalactiae, S. mutans and S. suis have been isolated from poultry. During investigations of the aetiology of increased mortality in broiler parent stock at the end of production, pure cultures of streptococcal-like organisms that could not be classified among these six species were obtained from 24 cases of septicaemia or Valvular Endocarditis and septicaemia. Phenotypic characterization using the API20 STREP kit identified the isolates as Aerococcus viridans (10), Aerococcus urinae (2), Leuconostoc species (4), S. salivarius (2), S. bovis II 3 (1), Enterococcus avium (3), E. faecium (1) or Gemella morbillorum (1). However, this identification was misleading as subsequent genetic investigations using pulse field gel electrophoresis and sequencing of 16S rRNA genes showed that 19 isolates were classified as S. pluranimalium, while the remaining isolates were E. avium (3), E. faecium (1) or Lactobacillus species (1). Misidentification by API20 STREP was related to the database provided by the manufacturer, as the phenotypic characteristics could identify these organisms as S. pluranimalium. The isolates of S. pluranimalium belonged to at least three different clones as determined by pulsed field gel electrophoresis of SmaI digested genomic DNA. The capacity that these isolates had to colonise the Valvular endothelium was suggested by the occurrence of Valvular Endocarditis in 12 of 19 cases. Demonstration of the same clone in all four houses on a farm suggested the pathogenic potential of this organism.
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Association of Streptococcus pluranimalium with Valvular Endocarditis and septicaemia in adult broiler parents
Avian pathology : journal of the W.V.P.A, 2009Co-Authors: Lars Hedegaard, M S Chadfield, Henrik Christensen, Jens Peter Christensen, Magne BisgaardAbstract:The genus Streptococcus consists of more than 60 species, but only Streptococcus equi subspecies zooepidemicus, Streptococcus gallolyticus ssp. gallolyticus, Streptococcus gallinaceus, Streptococcus dysgalactiae, Streptococcus mutans and Streptococcus suis have been isolated from poultry. During investigations of the aetiology of increased mortality in broiler parent stock at the end of production, pure cultures of streptococcal-like organisms that could not be classified among these six species were obtained from 24 cases of septicaemia or Valvular Endocarditis and septicaemia. Phenotypic characterization using the API20 STREP kit identified the isolates as Aerococcus viridans (10), Aerococcus urinae (2), Leuconostoc species (4), Streptococcus salivarius (2), Streptococcus bovis II 3 (1), Enterococcus avium (3), Enterococcus faecium (1) or Gemella morbillorum (1). However, this identification was misleading as subsequent genetic investigations using pulse field gel electrophoresis and sequencing of 16S rRNA genes showed that 19 isolates were classified as Streptococcus pluranimalium, while the remaining isolates were E. avium (3), E. faecium (1) or Lactobacillus species (1). Misidentification by API20 STREP was related to the database provided by the manufacturer, as the phenotypic characteristics could identify these organisms as S. pluranimalium. The isolates of S. pluranimalium belonged to at least three different clones as determined by pulsed field gel electrophoresis of SmaI-digested genomic DNA. The capacity that these isolates had to colonize the Valvular endothelium was suggested by the occurrence of Valvular Endocarditis in 12 of 19 cases. Demonstration of the same clone in all four houses on a farm suggested the pathogenic potential of this organism.
Rachele Bonfiglioli - One of the best experts on this subject based on the ideXlab platform.
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18F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac Endocarditis
European journal of nuclear medicine and molecular imaging, 2013Co-Authors: Rachele Bonfiglioli, Cristina Nanni, Joshua James Morigi, Maddalena Graziosi, Filippo Trapani, Michele Bartoletti, Fabio Tumietto, Valentina Ambrosini, Alice Ferretti, Domenico RubelloAbstract:Purpose Acute infective Endocarditis is a potentially life-threatening disease. Its outcome strongly depends on systemic embolization and extracardiac infections. When present, these conditions usually lead to a more aggressive therapeutic approach. However, the diagnosis of peripheral septic embolism is very challenging. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT has proven to be accurate for the detection of inflammatory diseases and occult infections. The aim of this study was to assess the added value of 18F-FDG PET/CT in the detection of extracardiac embolisms in the evaluation of patients with suspected Valvular Endocarditis (VE).
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18 F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac Endocarditis
European journal of nuclear medicine and molecular imaging, 2013Co-Authors: Rachele Bonfiglioli, Cristina Nanni, Joshua James Morigi, Maddalena Graziosi, Filippo Trapani, Michele Bartoletti, Fabio Tumietto, Valentina Ambrosini, Alice Ferretti, Domenico RubelloAbstract:Purpose Acute infective Endocarditis is a potentially life-threatening disease. Its outcome strongly depends on systemic embolization and extracardiac infections. When present, these conditions usually lead to a more aggressive therapeutic approach. However, the diagnosis of peripheral septic embolism is very challenging. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT has proven to be accurate for the detection of inflammatory diseases and occult infections. The aim of this study was to assess the added value of 18F-FDG PET/CT in the detection of extracardiac embolisms in the evaluation of patients with suspected Valvular Endocarditis (VE).
Henrik Christensen - One of the best experts on this subject based on the ideXlab platform.
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observations on the incidence and aetiology of Valvular Endocarditis in broiler breeders and detection of a newly described taxon of pasteurellaceae avibacterium endocarditidis
Avian Pathology, 2010Co-Authors: Magne Bisgaard, Jens Peter Christensen, Anders Miki Bojesen, Henrik ChristensenAbstract:A total of 122 dead broiler breeders randomly selected from a flock showing normal production parameters and covering the age from 44 to 61 weeks were subjected to a comprehensive routine post-mortem examination including examination for lesions of Endocarditis. Forty-two hens (34%) showed Valvular Endocarditis caused by Avibacterium endocarditidis (43%), Enterococcus faecalis (31%), Staphylococcus aureus (5%) and Streptococcus pluranimalium (5%), while growth was not obtained from 17% with the methods used for isolation. Gross lesions associated with the different bacterial pathogens did not allow separation according to pathogens involved. Port of entry and pathogenesis associated with the high prevalence of Valvular Endocarditis remained speculative. The present findings demonstrated the newly described species of Pasteurellaceae, Avibacterium endocarditidis associated with Endocarditis in chickens and confirm previous observations on the prevalence of Endocarditis in chickens, partly explaining the sl...
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Association of Streptococcus pluranimalium with Valvular Endocarditis and septicaemia in adult broiler parents
Avian Pathology, 2009Co-Authors: Lars Hedegaard, M S Chadfield, Henrik Christensen, Jens Peter Christensen, Magne BisgaardAbstract:The genus Streptococcus consists of more than 60 species, but only Streptococcus equi subspecies zooepidemicus, Streptococcus gallolyticus ssp. gallolyticus, Streptococcus gallinaceus, Streptococcus dysgalactiae, Streptococcus mutans and Streptococcus suis have been isolated from poultry. During investigations of the aetiology of increased mortality in broiler parent stock at the end of production, pure cultures of streptococcal-like organisms that could not be classified among these six species were obtained from 24 cases of septicaemia or Valvular Endocarditis and septicaemia. Phenotypic characterization using the API20 STREP kit identified the isolates as Aerococcus viridans (10), Aerococcus urinae (2), Leuconostoc species (4), Streptococcus salivarius (2), Streptococcus bovis II 3 (1), Enterococcus avium (3), Enterococcus faecium (1) or Gemella morbillorum (1). However, this identification was misleading as subsequent genetic investigations using pulse field gel electrophoresis and sequencing of 16S r...
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Association of Streptococcus pluranimalium with Valvular Endocarditis and septicaemia in adult broiler parents
Avian Pathology, 2009Co-Authors: Lars Hedegaard, M S Chadfield, Henrik Christensen, Jens Peter Christensen, Magne BisgaardAbstract:The genus Streptococcus consists of more than 60 species, but only Streptococcus equi subspecies zooepidemicus, Streptococcus gallolyticus ssp. gallolyticus, Streptococcus gallinaceus, Streptococcus dysgalactiae, Streptococcus mutans and Streptococcus suis have been isolated from poultry. During investigations of the aetiology of increased mortality in broiler parent stock at the end of production, pure cultures of streptococcal-like organisms that could not be classified among these six species were obtained from 24 cases of septicaemia or Valvular Endocarditis and septicaemia. Phenotypic characterization using the API20 STREP kit identified the isolates as Aerococcus viridans (10), Aerococcus urinae (2), Leuconostoc species (4), Streptococcus salivarius (2), Streptococcus bovis II 3 (1), Enterococcus avium (3), Enterococcus faecium (1) or Gemella morbillorum (1). However, this identification was misleading as subsequent genetic investigations using pulse field gel electrophoresis and sequencing of 16S r...
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Association of Streptococcus pluranimalium with Valvular Endocarditis and septicaemia in adult broiler parents
Avian Pathology, 2009Co-Authors: Lise Hedegaard, M S Chadfield, Henrik Christensen, Jens Peter Christensen, Magne BisgaardAbstract:The genus Streptococcus consists of more than 60 species, but only S. equi subspecies zooepidemicus, S. gallolyticus ssp. gallolyticus, S. gallinaceus, S. dysgalactiae, S. mutans and S. suis have been isolated from poultry. During investigations of the aetiology of increased mortality in broiler parent stock at the end of production, pure cultures of streptococcal-like organisms that could not be classified among these six species were obtained from 24 cases of septicaemia or Valvular Endocarditis and septicaemia. Phenotypic characterization using the API20 STREP kit identified the isolates as Aerococcus viridans (10), Aerococcus urinae (2), Leuconostoc species (4), S. salivarius (2), S. bovis II 3 (1), Enterococcus avium (3), E. faecium (1) or Gemella morbillorum (1). However, this identification was misleading as subsequent genetic investigations using pulse field gel electrophoresis and sequencing of 16S rRNA genes showed that 19 isolates were classified as S. pluranimalium, while the remaining isolates were E. avium (3), E. faecium (1) or Lactobacillus species (1). Misidentification by API20 STREP was related to the database provided by the manufacturer, as the phenotypic characteristics could identify these organisms as S. pluranimalium. The isolates of S. pluranimalium belonged to at least three different clones as determined by pulsed field gel electrophoresis of SmaI digested genomic DNA. The capacity that these isolates had to colonise the Valvular endothelium was suggested by the occurrence of Valvular Endocarditis in 12 of 19 cases. Demonstration of the same clone in all four houses on a farm suggested the pathogenic potential of this organism.
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Association of Streptococcus pluranimalium with Valvular Endocarditis and septicaemia in adult broiler parents
Avian pathology : journal of the W.V.P.A, 2009Co-Authors: Lars Hedegaard, M S Chadfield, Henrik Christensen, Jens Peter Christensen, Magne BisgaardAbstract:The genus Streptococcus consists of more than 60 species, but only Streptococcus equi subspecies zooepidemicus, Streptococcus gallolyticus ssp. gallolyticus, Streptococcus gallinaceus, Streptococcus dysgalactiae, Streptococcus mutans and Streptococcus suis have been isolated from poultry. During investigations of the aetiology of increased mortality in broiler parent stock at the end of production, pure cultures of streptococcal-like organisms that could not be classified among these six species were obtained from 24 cases of septicaemia or Valvular Endocarditis and septicaemia. Phenotypic characterization using the API20 STREP kit identified the isolates as Aerococcus viridans (10), Aerococcus urinae (2), Leuconostoc species (4), Streptococcus salivarius (2), Streptococcus bovis II 3 (1), Enterococcus avium (3), Enterococcus faecium (1) or Gemella morbillorum (1). However, this identification was misleading as subsequent genetic investigations using pulse field gel electrophoresis and sequencing of 16S rRNA genes showed that 19 isolates were classified as Streptococcus pluranimalium, while the remaining isolates were E. avium (3), E. faecium (1) or Lactobacillus species (1). Misidentification by API20 STREP was related to the database provided by the manufacturer, as the phenotypic characteristics could identify these organisms as S. pluranimalium. The isolates of S. pluranimalium belonged to at least three different clones as determined by pulsed field gel electrophoresis of SmaI-digested genomic DNA. The capacity that these isolates had to colonize the Valvular endothelium was suggested by the occurrence of Valvular Endocarditis in 12 of 19 cases. Demonstration of the same clone in all four houses on a farm suggested the pathogenic potential of this organism.
