The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Yves Longtin - One of the best experts on this subject based on the ideXlab platform.
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impact of extended use and decontamination with Vaporized Hydrogen Peroxide on n95 respirator fit
American Journal of Infection Control, 2020Co-Authors: Anthony Lieu, Veronica Zanichelli, Rose Carmel Exantus, Yves LongtinAbstract:ABSTRACT Background To address the shortage of N95 respirators in the wake of the COVID19 pandemic, some organizations have recommended the decontamination of respirators using Vaporized Hydrogen Peroxide (VHP) sterilizer for up to 10 times. However, these recommendations are based on studies that did not take into account the extended use of respirators, which can degrade respirator fit. Methods We investigated the impact of extended use and decontamination with VHP on N95 Respirator Fit. We performed a prospective cohort study to determine the number of times respirators can be decontaminated before respirator fit test failure. The primary outcome was the overall number of cycles required for half of the respirators to fail (either mechanical failure or fit test failure). Results 36 participants completed 360 hours of respirator usage across 90 cycles. The median number of cycles completed by participants before respirator failure was 2. The overall number of cycles required for half of respirators to fail was 1, 3, 5 and 4 for the 3M 1860(S), 3M 1870+, Moldex 151X and ProGear 88020 respirators, respectively. Conclusion The combination of prolonged usage and VHP decontamination was associated with early failure. Decontamination and prolonged usage of respirators must be done cautiously.
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Impact of extended use and decontamination with Vaporized Hydrogen Peroxide on N95 respirator fit.
American journal of infection control, 2020Co-Authors: Anthony Lieu, Veronica Zanichelli, Rose Carmel Exantus, Yves LongtinAbstract:To address the shortage of N95 respirators in the wake of the COVID-19 pandemic, some organizations have recommended the decontamination of respirators using Vaporized Hydrogen Peroxide (VHP) sterilizer for up to 10 times. However, these recommendations are based on studies that did not take into account the extended use of respirators, which can degrade respirator fit. We investigated the impact of extended use and decontamination with VHP on N95 Respirator Fit. We performed a prospective cohort study to determine the number of times respirators can be decontaminated before respirator fit test failure. The primary outcome was the overall number of cycles required for half of the respirators to fail (either mechanical failure or fit test failure). Thirty-six participants completed 360 hours of respirator usage across 90 cycles. The median number of cycles completed by participants before respirator failure was 2. The overall number of cycles required for half of respirators to fail was 1, 3, 5, and 4 for the 3M 1860(S), 3M 1870+, Moldex 151X and ProGear 88020 respirators, respectively. The combination of prolonged usage and VHP decontamination was associated with early failure. Decontamination and prolonged usage of respirators must be done cautiously. Copyright © 2020 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
Lewis I. Schwartz - One of the best experts on this subject based on the ideXlab platform.
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decontamination of vx gd and hd on a surface using modified Vaporized Hydrogen Peroxide
Langmuir, 2007Co-Authors: George W. Wagner, Iain F Mcvey, David C. Sorrick, Lawrence R. Procell, Mark D. Brickhouse, Lewis I. SchwartzAbstract:Vaporized Hydrogen Peroxide (VHP) has proven efficacy for biological decontamination and is a common gaseous sterilant widely used by industry. Regarding chemical warfare agent decontamination, VHP is also effective against HD and VX, but not GD. Simple addition of ammonia gas to VHP affords reactivity toward GD, while maintaining efficacy for HD (and bioagents) and further enhancing efficacy for VX. Thus, modified VHP is a broad-spectrum CB decontaminant suitable for fumigant-type decontamination scenarios, i.e., building, aircraft, and vehicle interiors and sensitive equipment. Finally, as an interesting aside to the current study, commercial ammonia-containing cleaners are also shown to be effective surface decontaminants for GD, but not for VX or HD.
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Vaporized Hydrogen Peroxide (VHP) Decontamination of VX, GD, and HD
2003Co-Authors: George W. Wagner, Iain F Mcvey, David C. Sorrick, Lawrence R. Procell, Zoe A Hess, Mark D. Brickhouse, Lewis I. SchwartzAbstract:Abstract : Vaporized Hydrogen Peroxide (VHP) has been utilized for more than a decade to sterilize clean rooms and pharmaceutical processing equipment and, quite recently, to decontaminate anthrax-ridden buildings. VHP is also suitable for the decontamination of VX and HD, which readily converts these agents to ethyl methylphosphonic acid and bis(2-chloroethyl) sulfoxide, respectively. However, GD is quite stable in the presence of VHP. The simple addition of low-levels of ammonia gas renders VHP reactive towards GD, converting it pinacolyl methylphosphonic acid. Thus, with suitable activation via ammonia gas, VHP affords the broad-spectrum decontamination of VX, GD, and HD. Potential decontamination applications for this gaseous reactant system include: buildings, vehicle and aircraft interiors, and sensitive equipment.
Brandon Moore - One of the best experts on this subject based on the ideXlab platform.
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efficacy of Vaporized Hydrogen Peroxide for repeated sterilization of a single use single incision laparoscopic surgery port
Veterinary Surgery, 2019Co-Authors: Valery F Scharf, Brian Dent, Megan E Jacob, Brandon MooreAbstract:OBJECTIVE: To determine the ability of Vaporized Hydrogen Peroxide (VHP) to sterilize a single-use single-incision laparoscopic surgery port and its associated components after repeated simulated uses. STUDY DESIGN: Prospective in vitro experimental study. SAMPLE POPULATION: Six single-use single-incision laparoscopic surgery ports with associated cannulas and insufflation tubing. METHODS: Ports, cannulas, and tubing were subjected to 10 cycles of simulated use, bacterial inoculation with Staphylococcus pseudintermedius and Escherichia coli, decontamination and sterilization, and testing via culture based on their treatment group designation. Bacteriological scores were compared among the negative control, positive control, and 4 treated ports and components. RESULTS: There was no difference in bacteriological scores between treated ports, cannulas, and insufflation tubing and the negative control port and components. Bacteriological scores of ports and components undergoing 6-10 cycles were not significantly different from scores of ports and components undergoing 5 or fewer sterilization cycles. No difference was found in detection of bacteria from treated ports by biopsy of the foam versus sampling via wash. CONCLUSION: This study suggests that a single-use single-incision laparoscopic port and its associated components can be effectively sterilized after multiple simulated uses by using VHP. CLINICAL SIGNIFICANCE: Reuse of a single-use single-incision laparoscopic port is a safe and effective method of cost reduction in veterinary patients.
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Hydrogen Peroxide plasma sterilization of a waterproof, high‐definition video camera case for intraoperative imaging in veterinary surgery
Veterinary Surgery, 2018Co-Authors: Christopher A. Adin, Brandon Moore, Kenneth D. Royal, Megan E JacobAbstract:OBJECTIVE: To evaluate the safety and usability of a wearable, waterproof high-definition camera/case for acquisition of surgical images by sterile personnel. STUDY DESIGN: An in vitro study to test the efficacy of biodecontamination of camera cases. Usability for intraoperative image acquisition was assessed in clinical procedures. METHODS: Two waterproof GoPro Hero4 Silver camera cases were inoculated by immersion in media containing Staphylococcus pseudointermedius or Escherichia coli at ≥5.50E+07 colony forming units/mL. Cases were biodecontaminated by manual washing and Hydrogen Peroxide plasma sterilization. Cultures were obtained by swab and by immersion in enrichment broth before and after each contamination/decontamination cycle (n = 4). The cameras were then applied by a surgeon in clinical procedures by using either a headband or handheld mode and were assessed for usability according to 5 user characteristics. RESULTS: Cultures of all poststerilization swabs were negative. One of 8 cultures was positive in enrichment broth, consistent with a low level of contamination in 1 sample. Usability of the camera was considered poor in headband mode, with limited battery life, inability to control camera functions, and lack of zoom function affecting image quality. Handheld operation of the camera by the primary surgeon improved usability, allowing close-up still and video intraoperative image acquisition. CONCLUSION: Vaporized Hydrogen Peroxide sterilization of this camera case was considered effective for biodecontamination. Handheld operation improved usability for intraoperative image acquisition. CLINICAL SIGNIFICANCE: Vaporized Hydrogen Peroxide sterilization and thorough manual washing of a waterproof camera may provide cost effective intraoperative image acquisition for documentation purposes.
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Efficacy of Vaporized Hydrogen Peroxide for repeated sterilization of a single‐use single‐incision laparoscopic surgery port
Veterinary Surgery, 2018Co-Authors: Valery F Scharf, Brian Dent, Megan E Jacob, Brandon MooreAbstract:OBJECTIVE: To determine the ability of Vaporized Hydrogen Peroxide (VHP) to sterilize a single-use single-incision laparoscopic surgery port and its associated components after repeated simulated uses. STUDY DESIGN: Prospective in vitro experimental study. SAMPLE POPULATION: Six single-use single-incision laparoscopic surgery ports with associated cannulas and insufflation tubing. METHODS: Ports, cannulas, and tubing were subjected to 10 cycles of simulated use, bacterial inoculation with Staphylococcus pseudintermedius and Escherichia coli, decontamination and sterilization, and testing via culture based on their treatment group designation. Bacteriological scores were compared among the negative control, positive control, and 4 treated ports and components. RESULTS: There was no difference in bacteriological scores between treated ports, cannulas, and insufflation tubing and the negative control port and components. Bacteriological scores of ports and components undergoing 6-10 cycles were not significantly different from scores of ports and components undergoing 5 or fewer sterilization cycles. No difference was found in detection of bacteria from treated ports by biopsy of the foam versus sampling via wash. CONCLUSION: This study suggests that a single-use single-incision laparoscopic port and its associated components can be effectively sterilized after multiple simulated uses by using VHP. CLINICAL SIGNIFICANCE: Reuse of a single-use single-incision laparoscopic port is a safe and effective method of cost reduction in veterinary patients.
Ronald E Shaffer - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of five decontamination methods for filtering facepiece respirators
Annals of Occupational Hygiene, 2009Co-Authors: Dennis J. Viscusi, Michael S. Bergman, Benjamin C Eimer, Ronald E ShafferAbstract:Concerns have been raised regarding the availability of National Institute for Occupational Safety and Health (NIOSH)-certified N95 filtering facepiece respirators (FFRs) during an influenza pandemic. One possible strategy to mitigate a respirator shortage is to reuse FFRs following a biological decontamination process to render infectious material on the FFR inactive. However, little data exist on the effects of decontamination methods on respirator integrity and performance. This study evaluated five decontamination methods [ultraviolet germicidal irradiation (UVGI), ethylene oxide, Vaporized Hydrogen Peroxide (VHP), microwave oven irradiation, and bleach] using nine models of NIOSH-certified respirators (three models each of N95 FFRs, surgical N95 respirators, and P100 FFRs) to determine which methods should be considered for future research studies. Following treatment by each decontamination method, the FFRs were evaluated for changes in physical appearance, odor, and laboratory performance (filter aerosol penetration and filter airflow resistance). Additional experiments (dry heat laboratory oven exposures, off-gassing, and FFR hydrophobicity) were subsequently conducted to better understand material properties and possible health risks to the respirator user following decontamination. However, this study did not assess the efficiency of the decontamination methods to inactivate viable microorganisms. Microwave oven irradiation melted samples from two FFR models. The remainder of the FFR samples that had been decontaminated had expected levels of filter aerosol penetration and filter airflow resistance. The scent of bleach remained noticeable following overnight drying and low levels of chlorine gas were found to off-gas from bleach-decontaminated FFRs when rehydrated with deionized water. UVGI, ethylene oxide (EtO), and VHP were found to be the most promising decontamination methods; however, concerns remain about the throughput capabilities for EtO and VHP. Further research is needed before any specific decontamination methods can be recommended.
Anthony W Baffoebonnie - One of the best experts on this subject based on the ideXlab platform.
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n95 reprocessing by low temperature sterilization with 59 Vaporized Hydrogen Peroxide during the 2020 covid 19 pandemic
American Journal of Infection Control, 2020Co-Authors: Maimuna Jatta, Carolyn Kiefer, Harsh Patolia, Charbel Harb, Linsey C Marr, Anthony W BaffoebonnieAbstract:Structured Abstract Background Response to the COVID-19 pandemic by hospital systems has been strained by severe shortages in personal protective equipment (PPE), particularly N95 respirators. Recently, the Centers for Disease Control and Prevention endorsed decontamination strategies to prolong the lifespan of single use respirators. Battelle and Duke University have validated hospital protocols to decontaminate respirators using Vaporized Hydrogen Peroxide (VHP) at 30%-35% concentrations. To prolong our supply of respirators, we evaluated and implemented VHP decontamination at 59% Hydrogen Peroxide concentration while detailing the effects of this process on the filtration efficiency and quantitative fit of single-use respirators. This study may help other health systems develop local solutions to their N95 mask shortage during this COVID-19 pandemic. Methods N95 respirators (3M 8211 FF and 9210 FF) that were treated with 5 and 10 cycles of VHP by the V-PRO® maX Low Temperature Sterilization System were evaluated quantitatively for filtration efficiency as well as with quantitative fit testing per Occupational Safety and Health Administration standards. A decontamination protocol was concurrently implemented at our institution. This process involved depositing used masks, reprocessing, and re-distributing treated masks efficiently back to frontline providers. Furthermore, we implemented patient safety officers (PSO) on COVID-19/person under investigation (PUI) units to ensure optimized donning/doffing of respirators through frontline provider education. Results There were no statistically significant changes in mean filtration efficiency between the control and VHP-treated respirators. Furthermore, both treated and untreated respirators demonstrated fit factors above the minimum pass requirement. Conclusion We have successfully demonstrated that N95 respirator decontamination with VHP at 59% Hydrogen Peroxide can be safely utilized to decontaminate single-use N95 respirators without significant effects on filtration efficiency or quantitative fit testing. With the COVID-19 pandemic and N95 respirator shortage, health systems without access to commercial decontamination processes should investigate the viability of such a process in their facilities.
