The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform
Carmine Sessa - One of the best experts on this subject based on the ideXlab platform.
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The Vascular connector, design of a new Device for sutureless Vascular anastomosis
Annals of Surgical Innovation and Research, 2014Co-Authors: Lulzim Vokrri, Xhavit Krasniqi, Arsim Qavdarbasha, Nexhmi Hyseni, Philippe Cinquin, Paolo Porcu, Carmine SessaAbstract:BACKGROUND: In recent years, several methods and new techniques have been studied and proposed for establishment of sutureless Vascular anastomoses, streaming use of sutureless Vascular surgery in the future. PRESENTATION OF THE HYPOTHESIS: The new Vascular connector (NVC) is a hypothetical design of a Vascular Device, proposed for creation and maintenance of sutureless Vascular anastomosis. Implication of NVC would introduce a new Device and technique in establishment of sutureless Vascular anastomosis in which surgical approach is minimized and so post-operation disorders. It would eliminate need for suture; shorten clampage and operation time, consequently reducing stress for both, the surgeon and the patient. It enables the creation of Vascular anastomosis fast, simple, safe, reliable, with satisfactory patency and stability of anastomosis. TESTING THE HYPOTHESIS: Efficacy of NVC needs to be evaluated in further studies, in order to be confirmed for clinical use. The effectiveness of NVC should be verified firstly in vitro and in vivo tests; and by animal experiments. The likelihood of its negative influence in thrombogenicity should be well evaluated. IMPLICATIONS OF THE HYPOTHESIS: Implication of the new Vascular connector (NVC) would be of interest to both patients and the surgeon due to the following main achievements: 1) enables the creation of Vascular anastomosis fast and simple, 2) significant shortening of clampage time of blood vessels and operation time-this assumption would be followed by reduced risk of operative and post-operative complications and length of hospital stay or admission to Intensive care unit, 3) safe and reliable, 4) compatible with any blood vessel and standard Vascular graft, 5) using the NVC we will reduce in minimum need for replaced blood volume, 6) reduces the cost of treatment. It is anticipated that the NVC would provide shorter operation time and least operative and post-operative complications in creation of sutureless Vascular anastomosis.
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The Vascular connector, design of a new Device for sutureless Vascular anastomosis
Annals of surgical innovation and research, 2014Co-Authors: Lulzim Vokrri, Xhavit Krasniqi, Arsim Qavdarbasha, Nexhmi Hyseni, Philippe Cinquin, Paolo Porcu, Carmine SessaAbstract:In recent years, several methods and new techniques have been studied and proposed for establishment of sutureless Vascular anastomoses, streaming use of sutureless Vascular surgery in the future. The new Vascular connector (NVC) is a hypothetical design of a Vascular Device, proposed for creation and maintenance of sutureless Vascular anastomosis. Implication of NVC would introduce a new Device and technique in establishment of sutureless Vascular anastomosis in which surgical approach is minimized and so post-operation disorders. It would eliminate need for suture; shorten clampage and operation time, consequently reducing stress for both, the surgeon and the patient. It enables the creation of Vascular anastomosis fast, simple, safe, reliable, with satisfactory patency and stability of anastomosis. Efficacy of NVC needs to be evaluated in further studies, in order to be confirmed for clinical use. The effectiveness of NVC should be verified firstly in vitro and in vivo tests; and by animal experiments. The likelihood of its negative influence in thrombogenicity should be well evaluated. Implication of the new Vascular connector (NVC) would be of interest to both patients and the surgeon due to the following main achievements: 1) enables the creation of Vascular anastomosis fast and simple, 2) significant shortening of clampage time of blood vessels and operation time-this assumption would be followed by reduced risk of operative and post-operative complications and length of hospital stay or admission to Intensive care unit, 3) safe and reliable, 4) compatible with any blood vessel and standard Vascular graft, 5) using the NVC we will reduce in minimum need for replaced blood volume, 6) reduces the cost of treatment. It is anticipated that the NVC would provide shorter operation time and least operative and post-operative complications in creation of sutureless Vascular anastomosis.
Lulzim Vokrri - One of the best experts on this subject based on the ideXlab platform.
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The Vascular connector, design of a new Device for sutureless Vascular anastomosis
Annals of Surgical Innovation and Research, 2014Co-Authors: Lulzim Vokrri, Xhavit Krasniqi, Arsim Qavdarbasha, Nexhmi Hyseni, Philippe Cinquin, Paolo Porcu, Carmine SessaAbstract:BACKGROUND: In recent years, several methods and new techniques have been studied and proposed for establishment of sutureless Vascular anastomoses, streaming use of sutureless Vascular surgery in the future. PRESENTATION OF THE HYPOTHESIS: The new Vascular connector (NVC) is a hypothetical design of a Vascular Device, proposed for creation and maintenance of sutureless Vascular anastomosis. Implication of NVC would introduce a new Device and technique in establishment of sutureless Vascular anastomosis in which surgical approach is minimized and so post-operation disorders. It would eliminate need for suture; shorten clampage and operation time, consequently reducing stress for both, the surgeon and the patient. It enables the creation of Vascular anastomosis fast, simple, safe, reliable, with satisfactory patency and stability of anastomosis. TESTING THE HYPOTHESIS: Efficacy of NVC needs to be evaluated in further studies, in order to be confirmed for clinical use. The effectiveness of NVC should be verified firstly in vitro and in vivo tests; and by animal experiments. The likelihood of its negative influence in thrombogenicity should be well evaluated. IMPLICATIONS OF THE HYPOTHESIS: Implication of the new Vascular connector (NVC) would be of interest to both patients and the surgeon due to the following main achievements: 1) enables the creation of Vascular anastomosis fast and simple, 2) significant shortening of clampage time of blood vessels and operation time-this assumption would be followed by reduced risk of operative and post-operative complications and length of hospital stay or admission to Intensive care unit, 3) safe and reliable, 4) compatible with any blood vessel and standard Vascular graft, 5) using the NVC we will reduce in minimum need for replaced blood volume, 6) reduces the cost of treatment. It is anticipated that the NVC would provide shorter operation time and least operative and post-operative complications in creation of sutureless Vascular anastomosis.
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The Vascular connector, design of a new Device for sutureless Vascular anastomosis
Annals of surgical innovation and research, 2014Co-Authors: Lulzim Vokrri, Xhavit Krasniqi, Arsim Qavdarbasha, Nexhmi Hyseni, Philippe Cinquin, Paolo Porcu, Carmine SessaAbstract:In recent years, several methods and new techniques have been studied and proposed for establishment of sutureless Vascular anastomoses, streaming use of sutureless Vascular surgery in the future. The new Vascular connector (NVC) is a hypothetical design of a Vascular Device, proposed for creation and maintenance of sutureless Vascular anastomosis. Implication of NVC would introduce a new Device and technique in establishment of sutureless Vascular anastomosis in which surgical approach is minimized and so post-operation disorders. It would eliminate need for suture; shorten clampage and operation time, consequently reducing stress for both, the surgeon and the patient. It enables the creation of Vascular anastomosis fast, simple, safe, reliable, with satisfactory patency and stability of anastomosis. Efficacy of NVC needs to be evaluated in further studies, in order to be confirmed for clinical use. The effectiveness of NVC should be verified firstly in vitro and in vivo tests; and by animal experiments. The likelihood of its negative influence in thrombogenicity should be well evaluated. Implication of the new Vascular connector (NVC) would be of interest to both patients and the surgeon due to the following main achievements: 1) enables the creation of Vascular anastomosis fast and simple, 2) significant shortening of clampage time of blood vessels and operation time-this assumption would be followed by reduced risk of operative and post-operative complications and length of hospital stay or admission to Intensive care unit, 3) safe and reliable, 4) compatible with any blood vessel and standard Vascular graft, 5) using the NVC we will reduce in minimum need for replaced blood volume, 6) reduces the cost of treatment. It is anticipated that the NVC would provide shorter operation time and least operative and post-operative complications in creation of sutureless Vascular anastomosis.
Peter A Lambert - One of the best experts on this subject based on the ideXlab platform.
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epidemiology clinical and laboratory characteristics of staphylococcus aureus bacteraemia in a university hospital in uk
Journal of Hospital Infection, 2007Co-Authors: I Das, N Oconnell, Peter A LambertAbstract:There has been a persistent increase in the number of meticillin-resistant Staphylococcus aureus (MRSA) and meticillin-susceptible Staphylococcus aureus (MSSA) bacteraemia in the UK. This prospective study included 147 episodes of S. aureus bacteraemia in 139 patients over a 14 month period, from 1 November 2001 to 31 December 2002. Eighty-seven (59%) episodes in 84 patients and 60 (41%) in 56 patients were due to MRSA and MSSA, respectively. An intra-Vascular Device (29, 33%) and a soft-tissue (15, 25%) source were the commonest identifiable foci for bacteraemia in the MRSA and MSSA groups, respectively. Attributable mortality in the MRSA group was higher than the MSSA group (33% vs 16%; P = 0.03) but there was no statistical difference for either attributable (P = 0.35) or crude (P = 0.39) mortality between the two groups, when adjusted for age, respiratory focus and inappropriate antibiotic therapy. A respiratory source (P = 0.02) and inappropriate antibiotic therapy (P = 0.02) were associated with attributable mortality in the MRSA group whereas advanced age was the only risk factor (P = 0.02) in the MSSA group. The present study shows that S. aureus bacteraemia continues to be a serious infection mostly affecting the elderly and emphasizes the need for improved strategy in the control and management of this condition. © 2006 The Hospital Infection Society.
Michel Wolff - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of cloxacillin versus cefazolin for methicillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): study protocol for a randomised, controlled, non-inferiority trial
BMJ Open, 2018Co-Authors: Charles Burdet, Paul Loubet, Vincent Le Moing, William Vindrios, Marina Esposito-farèse, Morgane Linard, Tristan Ferry, Laurent Massias, Pierre Tattevin, Michel WolffAbstract:Introduction Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia is a common and severe disease responsible for approximately 65,000 deaths every year in Europe. Intravenous anti-staphylococcal penicillins (ASP) such as cloxacillin are the current recommended antibiotics. However, increasing reports of toxicity and recurrent stock-outs of ASP prompted healthcare providers to seek for alternative antibiotic treatment. Based on retrospective studies, cefazolin, a 1st generation cephalosporin, is recommended in patients at risk of severe ASP-associated toxicity. We hypothesized that cefazolin has a non-inferior efficacy in comparison to cloxacillin, with a better safety profile for the treatment of MSSA bacteremia. Methods and analysis The CloCeBa trial is an open-label, randomized, controlled, non-inferiority trial conducted in academic centers throughout France. Eligible patients are adults with MSSA bacteremia without intra-Vascular Device or suspicion of central nervous system infection. Patients will be randomized (1:1) to receive either cloxacillin or cefazolin by the intravenous route, for the first 14 days of therapy. The evaluation criteria is a composite criteria of negative blood cultures at day 5, survival, absence of relapse, and clinical success at day 90 after randomization. Secondary evaluation criteria include both efficacy and safety assessments. Three ancillary studies are planned to describe the epidemiology of β-lactamase encoding genes, the ecological impact, and pharmacokinetic/pharmacodynamic parameters of cefazolin and cloxacillin. Including 300 patients will provide 80% power to demonstrate the non-inferiority of cefazolin over cloxacillin, assuming 85% success rate with cloxacillin and taking into account loss-to-follow-up, with a 0.12 non-inferiority margin and a one-sided type I error of 0.025. Ethics and dissemination This protocol received authorization from the ethics committee Sud-Est I on November, 13th 2017 (2017-87-PP). Results will be disseminated to the scientific community through congresses and publication in peer-reviewed journals. Trial registration This trial is registered on clinicaltrial.gov (NCT03248063) and on Eudract (2017-003967-36) databases.
Paolo Porcu - One of the best experts on this subject based on the ideXlab platform.
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The Vascular connector, design of a new Device for sutureless Vascular anastomosis
Annals of Surgical Innovation and Research, 2014Co-Authors: Lulzim Vokrri, Xhavit Krasniqi, Arsim Qavdarbasha, Nexhmi Hyseni, Philippe Cinquin, Paolo Porcu, Carmine SessaAbstract:BACKGROUND: In recent years, several methods and new techniques have been studied and proposed for establishment of sutureless Vascular anastomoses, streaming use of sutureless Vascular surgery in the future. PRESENTATION OF THE HYPOTHESIS: The new Vascular connector (NVC) is a hypothetical design of a Vascular Device, proposed for creation and maintenance of sutureless Vascular anastomosis. Implication of NVC would introduce a new Device and technique in establishment of sutureless Vascular anastomosis in which surgical approach is minimized and so post-operation disorders. It would eliminate need for suture; shorten clampage and operation time, consequently reducing stress for both, the surgeon and the patient. It enables the creation of Vascular anastomosis fast, simple, safe, reliable, with satisfactory patency and stability of anastomosis. TESTING THE HYPOTHESIS: Efficacy of NVC needs to be evaluated in further studies, in order to be confirmed for clinical use. The effectiveness of NVC should be verified firstly in vitro and in vivo tests; and by animal experiments. The likelihood of its negative influence in thrombogenicity should be well evaluated. IMPLICATIONS OF THE HYPOTHESIS: Implication of the new Vascular connector (NVC) would be of interest to both patients and the surgeon due to the following main achievements: 1) enables the creation of Vascular anastomosis fast and simple, 2) significant shortening of clampage time of blood vessels and operation time-this assumption would be followed by reduced risk of operative and post-operative complications and length of hospital stay or admission to Intensive care unit, 3) safe and reliable, 4) compatible with any blood vessel and standard Vascular graft, 5) using the NVC we will reduce in minimum need for replaced blood volume, 6) reduces the cost of treatment. It is anticipated that the NVC would provide shorter operation time and least operative and post-operative complications in creation of sutureless Vascular anastomosis.
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The Vascular connector, design of a new Device for sutureless Vascular anastomosis
Annals of surgical innovation and research, 2014Co-Authors: Lulzim Vokrri, Xhavit Krasniqi, Arsim Qavdarbasha, Nexhmi Hyseni, Philippe Cinquin, Paolo Porcu, Carmine SessaAbstract:In recent years, several methods and new techniques have been studied and proposed for establishment of sutureless Vascular anastomoses, streaming use of sutureless Vascular surgery in the future. The new Vascular connector (NVC) is a hypothetical design of a Vascular Device, proposed for creation and maintenance of sutureless Vascular anastomosis. Implication of NVC would introduce a new Device and technique in establishment of sutureless Vascular anastomosis in which surgical approach is minimized and so post-operation disorders. It would eliminate need for suture; shorten clampage and operation time, consequently reducing stress for both, the surgeon and the patient. It enables the creation of Vascular anastomosis fast, simple, safe, reliable, with satisfactory patency and stability of anastomosis. Efficacy of NVC needs to be evaluated in further studies, in order to be confirmed for clinical use. The effectiveness of NVC should be verified firstly in vitro and in vivo tests; and by animal experiments. The likelihood of its negative influence in thrombogenicity should be well evaluated. Implication of the new Vascular connector (NVC) would be of interest to both patients and the surgeon due to the following main achievements: 1) enables the creation of Vascular anastomosis fast and simple, 2) significant shortening of clampage time of blood vessels and operation time-this assumption would be followed by reduced risk of operative and post-operative complications and length of hospital stay or admission to Intensive care unit, 3) safe and reliable, 4) compatible with any blood vessel and standard Vascular graft, 5) using the NVC we will reduce in minimum need for replaced blood volume, 6) reduces the cost of treatment. It is anticipated that the NVC would provide shorter operation time and least operative and post-operative complications in creation of sutureless Vascular anastomosis.
