The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform
Kumarasen Cooper - One of the best experts on this subject based on the ideXlab platform.
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palisading and Verocay Body prominent dermatofibrosarcoma protuberans a case report
Pathology Research and Practice, 2016Co-Authors: Shuanzeng Wei, Alain Dumas, Paul J Zhang, Kumarasen CooperAbstract:Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma with a tendency for local recurrence, which commonly presents as a slowly growing flesh-colored skin lesion without epidermal invasion but with intracutaneous and subcutaneous spread. Pathologically, the tumor generally presents with an infiltrating dermal mass containing closely packed fibroblasts arranged in a storiform pattern. Several uncommon growth patterns have been described, including sclerosing, atrophic, myxoid, pigmented, giant cell-rich, granular cell, herringbone pattern and palisading/Verocay Body-prominent forms. To our knowledge, only five cases of DFSP with nuclear palisading/Verocay Body formation have been reported in the literature, and no t(17:22) translocation study has been done on these cases. In this report we describe such a case with negative t(17:22) translocation.
Aurelio Ariza - One of the best experts on this subject based on the ideXlab platform.
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palisading and Verocay Body prominent dermatofibrosarcoma protuberans a report of three cases
Histopathology, 2000Co-Authors: R Llatjos, Maria Teresa Fernandezfigueras, C Diazcascajo, M Ribera, Aurelio ArizaAbstract:The aim of this report is to draw attention to nuclear palisading and Verocay Body formation as peculiar, previously undescribed histological findings in rare instances of dermatofibrosarcoma protuberans (DFSP). Methods and results: Three indurated, nodular or plaque skin lesions were diagnosed as DFSP on the basis of their storiform proliferation of spindle-shaped cells diffusely infiltrating the dermis and subcutaneous tissue. Sclerosing and giant cell areas were also identified. Unexpectedly, conspicuous nuclear palisading was also noted in all cases and Verocay Body formation was present in two. Immunostains were positive for CD34 and negative for S100 protein in every instance. Proliferating cells were seen to display fibroblast-like features by ultrastructural study of one case. Conclusions: DFSP may rarely show a schwannoid histological appearance as the result of nuclear palisading and even Verocay Body formation. In this setting, both the search for DFSP characteristic morphologic features and the performance of CD34 and S100 protein immunohistochemistry will facilitate the correct diagnosis.
Shuanzeng Wei - One of the best experts on this subject based on the ideXlab platform.
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palisading and Verocay Body prominent dermatofibrosarcoma protuberans a case report
Pathology Research and Practice, 2016Co-Authors: Shuanzeng Wei, Alain Dumas, Paul J Zhang, Kumarasen CooperAbstract:Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma with a tendency for local recurrence, which commonly presents as a slowly growing flesh-colored skin lesion without epidermal invasion but with intracutaneous and subcutaneous spread. Pathologically, the tumor generally presents with an infiltrating dermal mass containing closely packed fibroblasts arranged in a storiform pattern. Several uncommon growth patterns have been described, including sclerosing, atrophic, myxoid, pigmented, giant cell-rich, granular cell, herringbone pattern and palisading/Verocay Body-prominent forms. To our knowledge, only five cases of DFSP with nuclear palisading/Verocay Body formation have been reported in the literature, and no t(17:22) translocation study has been done on these cases. In this report we describe such a case with negative t(17:22) translocation.
Anat Stemmerrachamimov - One of the best experts on this subject based on the ideXlab platform.
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24 year old woman with an internal auditory canal mass
Brain Pathology, 2013Co-Authors: Facundo Las Heras, Robert L Martuza, Paul A Caruso, Sandra Rincon, Anat StemmerrachamimovAbstract:Benign peripheral nerve sheath tumors are divided into schwannomas, neurofibromas and perineuriomas. In recent years, tumors with hybrid features, composed of multiple, discrete areas of different histological types, were described. These tumors may represent a diagnostic challenge. A 24-year-old woman with multiple sclerosis was found to have a 1.3 cm TV × 0.7 cm AP T2 intermediate lesion within the left internal auditory canal. Gross examination revealed a tan-white, well circumscribed mass. Histologic examination demonstrated a well demarcated, cellular, solid neoplasm with a biphasic pattern. Most of the tumor was composed of spindle cells arranged in fascicles with focal Verocay Body formation and diffuse S100 positivity. A second, minor area showed concentric proliferation of neoplastic spindle cells around one or more axons. Tumor cells in this area were positive for perineurial markers, claudin-1 and Glut-1, and focally immunopositive for CD34.We present here a case of a benign peripheral nerve sheath tumor with histological and immunohistochemical features consistent with a dual pattern of differentiation of schwannoma and perineurioma, in the VIIIth cranial nerve. This is, to our knowledge, the first case of a hybrid perineurioma/schwannoma reported in a cranial nerve.
R Llatjos - One of the best experts on this subject based on the ideXlab platform.
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palisading and Verocay Body prominent dermatofibrosarcoma protuberans a report of three cases
Histopathology, 2000Co-Authors: R Llatjos, Maria Teresa Fernandezfigueras, C Diazcascajo, M Ribera, Aurelio ArizaAbstract:The aim of this report is to draw attention to nuclear palisading and Verocay Body formation as peculiar, previously undescribed histological findings in rare instances of dermatofibrosarcoma protuberans (DFSP). Methods and results: Three indurated, nodular or plaque skin lesions were diagnosed as DFSP on the basis of their storiform proliferation of spindle-shaped cells diffusely infiltrating the dermis and subcutaneous tissue. Sclerosing and giant cell areas were also identified. Unexpectedly, conspicuous nuclear palisading was also noted in all cases and Verocay Body formation was present in two. Immunostains were positive for CD34 and negative for S100 protein in every instance. Proliferating cells were seen to display fibroblast-like features by ultrastructural study of one case. Conclusions: DFSP may rarely show a schwannoid histological appearance as the result of nuclear palisading and even Verocay Body formation. In this setting, both the search for DFSP characteristic morphologic features and the performance of CD34 and S100 protein immunohistochemistry will facilitate the correct diagnosis.
