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Marianne Dieterich - One of the best experts on this subject based on the ideXlab platform.

  • clinical implications of head shaking nystagmus in central and peripheral Vestibular Disorders is perverted head shaking nystagmus specific for central Vestibular pathology
    European Journal of Neurology, 2020
    Co-Authors: Taeho Yang, Juhyung Lee, Jinju Kang, Ji Soo Kim, Marianne Dieterich
    Abstract:

    BACKGROUND AND PURPOSE The patterns of head-shaking nystagmus (HSN) aid in differentiation between central and peripheral Vestibular Disorders, and perverted HSN (pHSN) has been considered a central sign. The aim was to determine the characteristics of HSN in a large number of patients with either peripheral or central Vestibular Disorders in a dizziness clinic of a university hospital. METHODS The medical records of 7544 dizzy patients were reviewed during a year and 822 patients with a clinical diagnosis of Vestibular Disorders were recruited. The findings of spontaneous nystagmus (SN) and HSN in these patients were compared with those of healthy controls (n = 48). RESULTS A total of 217 of the 822 patients (26.4%) were classified as having a central Vestibular Disorder, whilst 397 (48.3%) had a peripheral Vestibular Disorder. In the peripheral Vestibular Disorder group, SN was observed in 14.1% and HSN in 40.8%, amongst whom 24.1% were the pHSN form. In the central group, SN was observed in 17.5% and HSN in 24.0% of whom 57.7% was pHSN. HSN was more frequently observed in the peripheral Vestibular Disorder group than in the central group (40.8% vs. 24.0%, P < 0.01). However, the proportion of pHSN was significantly increased in the central group compared to the peripheral Vestibular patient group (57.7% vs. 24.1%, P < 0.01). CONCLUSIONS Since pHSN is not specific for central Vestibular Disorders, other clinical features should be considered in pursuing a central lesion in patients with pHSN.

  • p34 i slipped did it slip my mind cognitive deficits in patients with a peripheral Vestibular Disorder
    Clinical Neurophysiology, 2015
    Co-Authors: Pauline Popp, Melanie Wulff, Marianne Dieterich
    Abstract:

    Introduction So far, studies in animals as well as humans gave evidence that damage to the peripheral Vestibular system leads deficits in spatial memory and navigation by neuronal changes in the hippocampus (atrophy) and a general reorganization of the Vestibular cortex network (Brandt et al., 2005; Eulenburg et al., 2010). Pathology of the peripheral-Vestibular endorgan causes a range of cognitive deficits, not only spatial, but also non-spatial, like object recognition memory (Zheng et al., 2009; Andersson et al., 2003). Patients with a chronic bilateral Vestibular failure (BVF) complain to troubled in their abilities to sustain attention. Until now, only few studies have used complex cognitive tasks to examine this empirically. Aim of this study was to test patients with chronic unilateral Vestibular failure (UVF) and BVF systematically in a series of attentionale tests and analyze which domains are especially affected. Methods All patients underwent a neurological examination and detailed Vestibular testing and were diagnosed on-site. Eight patients with UVF (4 female, mean age 59years, 2 lesions left-sided) and 16 BVF (8 female, mean age 59) executed the TAP Alertness and Visual Scanning, the TVA whole and partial report, the Stroop Test (ST) and the Digit Span Test (DST).The Wechsler Memory Test (MWT) and the Mini Mental Status Test (MMST) were used additionally to exclude negative influences on performance due to other cognitive impairments. Standard values exist for all tests (except TVA) and the deviation from the population average was calculated accordingly, using a One-sample T -Test. A T -value or PR-value below 43 was considered pathological (Zimmermann and Fimm, 2009). Results MMST and MWT were within a normal range in all patients. The ST and the DST showed no anomaly, however the variance was high. There was a mild effect in the TAP Alertness and in the TAP Visual Scanning performance in BVF patients. Their reaction times were slightly decelerated. In the TVA test attentionale selectivity was strongly affected in UVF patients, their attention was shifted to one side, which did not correlate with the lesion side. In both patient groups, the information processing speed and the short term memory capacity were reduced. Conclusion We found a set of cognitive tasks affected by the peripheral deficits, i.e. short term memory, processing speed of information, and especially in UVF attentionale selectivity. These cognitive deficits might be explained by pathways from the Vestibular nuclei to the limbic system, the neocortex and other areas that are likely linked to non-spatial memory, such as the perirhinal cortex (Liu et al., 2004). Accordingly, the Vestibular afferents appear to be necessary for many cognitive operations. This rearrangement after damage probably, includes some cognitive compromises. Forward-looking, more complex behavioral tests have to be developed and combined with functional to increase the understanding of how the Vestibular system is involved in cognitive tasks and how Vestibular damage can impair cognitive function. Acknowledgements Supported by the Graduate School of Neuroscience, the GRK, the German Federal Ministry of Education and Research (BMBF: IFB), and the German Foundation for Neurology (DSN).

  • who is at risk for ongoing dizziness and psychological strain after a Vestibular Disorder
    Neuroscience, 2009
    Co-Authors: C Best, Marianne Dieterich, Regine Tschan, Annegret Eckhardthenn
    Abstract:

    Patients with Vestibular vertigo syndromes often suffer from anxiety and depression, whereas patients with psychiatric Disorders often experience subjective unsteadiness, dizziness, or vertigo. Thus, it has been hypothesized that the Vestibular system may be interlinked with the emotion processing systems. The aim of the current study was to evaluate this hypothesis by correlating Vestibular and psychiatric symptoms with the course of the disease over 1 year. This interdisciplinary, prospective, longitudinal study included a total of 68 patients with acute Vestibular vertigo syndromes. Four subgroups of patients with benign paroxysmal positioning vertigo (BPPV, n=19), acute Vestibular neuritis (VN, n=14), Vestibular migraine (VM, n=27), or Meniere's disease (MD, n=8) were compared. All patients underwent neurological and neuro-otological examinations and filled out standardized self-report inventories including the Vertigo Symptom Scale (VSS), the Vertigo Handicap Questionnaire (VHQ) and the Symptom Checklist 90R (GSI, SCL-90R) at five different times (T0-T4) in the course of 1 year. VM patients experienced significantly more "vertigo and related symptoms" (VSS-VER), "somatic anxiety and autonomic arousal" (VSS-AA), and "vertigo induced handicap" (VHQ) than all other patients (P<0.001-P=0.006). Patients with a positive history of psychiatric Disorders had significantly more emotional distress (GSI, SCL-90R), regardless of the specific phenomenology of the four diagnostic subgroups. Finally, fluctuations of Vestibular excitability correlated positively with the extent of subjectively perceived vertigo. VM patients are significantly more handicapped by vertigo and related symptoms. They show significantly elevated fluctuations of Vestibular excitability, which correlate with the (subjective) severity of vertigo symptoms.

  • spatial neglect a Vestibular Disorder
    Brain, 2006
    Co-Authors: Hans-otto Karnath, Marianne Dieterich
    Abstract:

    The phenomenon of spatial neglect after right brain damage greatly helps our understanding of the normal mechanisms of directing and maintaining spatial attention, of spatial orientation, and the characteristics of neural representation of space. The intriguing symptom is a spontaneous orientation bias towards the right leading to neglect of objects or persons on the left. Interestingly, we observe similar symptoms namely a spontaneous bias of eyes and head along the horizontal dimension of space in patients with unilateral Vestibular dysfunction. Further similarities concern anatomical findings. Both spatial neglect and Vestibular processing at cortical level show dominance in the right hemisphere and involve common brain areas. Lesion studies in human and monkey, electrical and transcranial magnetic stimulation, as well as functional imaging results have revealed the superior temporal cortex, insula and the temporo-parietal junction to be substantial parts of the multisensory (Vestibular) system as well as to be affected in spatial neglect. We argue that these structures are not strictly 'Vestibular' but rather have a multimodal character representing a significant site for the neural transformation of converging Vestibular, auditory, neck proprioceptive and visual input into higher order spatial representations. Neurons of these regions provide us with redundant information about the position and motion of our body in space. They seem to play an essential role in adjusting body position relative to external space. This view may initiate further development of those strategies to treat spatial neglect that use routes to rehabilitation based on specific manipulations of sensory input feeding into this system.

Hiroshi Yamashita - One of the best experts on this subject based on the ideXlab platform.

  • a novel treatment for Vestibular Disorder with fglm nh2 plus sssr
    Neuroscience Letters, 2012
    Co-Authors: Hideki Toyota, Hiroaki Shimogori, Kazuma Sugahara, Hiroshi Yamashita
    Abstract:

    Topical FGLM-NH(2) (Phenylalanine-Glycine-Leucine-Methionine-Amide) plus SSSR (Serine-Serine-Serine-Arginine) facilitates recovery from Vestibular Disorders induced by (±)-α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) in guinea pigs and might offer a treatment strategy for patients with peripheral Vestibular Disorders. The tetrapeptide FGLM-NH(2) derived from substance P (SP) can be used to treat corneal Disorders when combined with SSSR, which is a tetrapeptide derived from insulin-like growth factor-1 (IGF-1). We examined the influence of FGLM-NH(2) plus SSSR when locally applied to the unilateral inner ear of guinea pigs with Vestibular Disorder induced by AMPA. A total of 18 Hartley white guinea pigs were assigned to groups receiving either FGLM-NH(2) plus SSSR, artificial perilymph, or no treatment at all. A hole was drilled adjacent to the round window, with AMPA then infused into the hole in order to induce the Vestibular Disorder. Thereafter, FGLM-NH(2) plus SSSR or artificial perilymph was delivered via an osmotic pump that was inserted into the hole. Sinusoidal rotation tests were used for observing spontaneous nystagmus and for measurements of the vestibulo-ocular reflexes (VOR). Two animals from each group were immunohistochemically examined at 24h after the treatment. Spontaneous nystagmus decreased immediately after FGLM-NH(2) plus SSSR infusion. The recovery of the VOR gains was statistically faster than that seen in the control group at 3 and 7 days after treatment. Immunohistochemical examination revealed that many synaptic ribbons, which are markers of the synapse, were stained in the FGLM-NH(2) plus SSSR group compared with the untreated group. Topical application of FGLM-NH(2) plus SSSR accelerates functional recovery from AMPA-induced Vestibular Disorders by facilitating synaptic regeneration in guinea pigs.

  • peripheral Vestibular Disorder induced by α amino 3 hydroxy 5 methyl isoxazole 4 propionic acid ampa
    Neuroscience Letters, 2004
    Co-Authors: Hiroaki Shimogori, Hiroshi Yamashita
    Abstract:

    An intracochlear infusion of (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) was done in guinea pigs with a syringe pump and peripheral Vestibular Disorder was induced. Spontaneous nystagmus toward the intact side reached a peak 9 h after the infusion and disappeared within 18 h. As a control, artificial perilymph was infused and animals had no nystagmus. The nystagmus frequency was decreased by simultaneous infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in a dose-dependent manner. In the animals treated with AMPA or AMPA + CNQX, caloric tests performed 1 week after treatment revealed a partial dysfunction of Vestibular periphery. These results indicate that the nystagmus observed is induced by AMPA via AMPA receptors and that AMPA-induced Vestibular Disorder is partial. This animal model may be a candidate for pharmacological study of inner ear diseases induced by glutamate excitotoxicity.

  • rapid correction of Vestibular imbalance by intracochlear administration of atp in a guinea pig model of unilateral peripheral Vestibular Disorder
    Neuroscience Letters, 2001
    Co-Authors: Hiroaki Shimogori, Hiroshi Yamashita
    Abstract:

    Abstract The effect of inner ear administration of adenosine triphosphate (ATP) on Vestibular function was investigated in guinea pigs with Vestibular Disorder. The right lateral semicircular canal was cut surgically. Animals were then treated with saline, 5 mM ATP, 50 mM ATP, or 50 mM ATP+10 mM pyridoxal-phosphate-6-azophenyl-2′, 4′-disulfonic acid (PPADS), a P2X receptor antagonist, administered directly into the scala tympani by osmotic pump. Before treatment, and at 3, 5 and 7 days after treatment, trapezoid rotation tests were performed on all animals, and the post-rotatory nystagmus (PRN) ratio (number of nystagmus beats after counterclockwise rotation/number of nystagmus beats after clockwise rotation) was calculated and compared between groups. The PRN ratio was statistically greater at 5 days after treatment in the 50 mM ATP group than in the saline group. A statistical difference was also observed in animals treated with 50 mM ATP+10 mM PPADS. Our results indicate that ATP plays an important role in the Vestibular periphery to correct Vestibular imbalance and that this action may not occur via P2X receptors.

  • evaluation of Vestibular function in animal models with partial peripheral Vestibular Disorder
    Equilibrium Research, 2001
    Co-Authors: Hiroaki Shimogori, Osamu Horiike, Takuo Ikeda, Hiroshi Yamashita
    Abstract:

    In this study we used the trapezoid rotation test to evaluate Vestibular function in normal guinea pigs or guinea pigs with peripheral Vestibular Disorder. Post-rotatory nystagmus (PRN) was recorded on videotape under dark conditions with an infrared charge-coupled device camera. The analysis was performed using the pubic domain NIH Image program, and the horizontal and vertical components were calculated automatically. The mean value of maximum slow phase velocity (MSPV) in the normal guinea pigs and guinea pigs with Vestibular Disorder was 37.288±9.423 degree/sec and 9.786±2.758 degree/sec respectively. There was a significant correlation between the PRN number and MSPV.We consider that this system makes it possible to evaluate Vestibular function in animal models easily and inexpensively.

  • efficacy of intracochlear administration of betamethasone on peripheral Vestibular Disorder in the guinea pig
    Neuroscience Letters, 2000
    Co-Authors: Hiroaki Shimogori, Hiroshi Yamashita
    Abstract:

    We evaluated the effect of steroid hormone on Vestibular function in a guinea pig of peripheral Vestibular Disorder. The right lateral semicircular canal was surgically damaged, and after surgery, animals were treated with 0.1 mg/ml of betamethasone in saline, 1 mg/ml of betamethasone in saline, or saline only, which was administrated directly into the scala tympani by osmotic pump. Rotation tests were performed, and the post-rotatory nystagmus (PRN) ratio (PRN number after counterclockwise rotation/PRN number after clockwise rotation) was calculated. The PRN ratio was recovered to normal at 5 days after treatment in the betamethasone administrated groups, but it did not recover to normal until 14 days after treatment in the saline administrated group. Results indicate that in the Vestibular periphery steroid hormones may play an important role in recover of Vestibular function.

Eiji Kajii - One of the best experts on this subject based on the ideXlab platform.

  • association between smoking and the peripheral Vestibular Disorder a retrospective cohort study
    Scientific Reports, 2017
    Co-Authors: Masaoki Wada, Taro Takeshima, Yosikazu Nakamura, Shoichiro Nagasaka, Toyomi Kamesaki, Eiji Kajii, Kazuhiko Kotani
    Abstract:

    Common inner ear diseases include peripheral Vestibular Disorder (PVD) and hearing impairment. The association between smoking and peripheral Vestibular Disorder (PVD) is unclear. We examined associations between smoking and new PVD events. In this retrospective study, we consecutively enrolled 393 participants aged ≥20 years [mean age 65.3 years; males 133 (33.8%)] treated for hypertension, dyslipidaemia, or diabetes mellitus at a primary care clinic between November 2011 and March 2013. Participants were categorized as ever-smokers (including current and past -smokers; divided per <30 and ≥30 pack-years), and never-smokers. New PVD events were reported over a 1-year follow-up period. Hazard ratios (HR) for new onset PVD were estimated using the Cox proportional hazard regression model. Compared to never-smokers, the adjusted HR was 2.22 for ever-smokers and 2.70 for all ever-smokers with ≥30 pack-years among all 393 participants. Among male participants, compared to never-smokers, the adjusted HR was 4.41 for ever-smokers with ≥30 pack-years. A smoking history of ≥30 pack-years was strongly associated with the risk of new onset PVD in males but not, females. This study may assist patients with smoking cessation for the prevention of new PVD events among males.

  • carotid plaque is a new risk factor for peripheral Vestibular Disorder a retrospective cohort study
    Medicine, 2016
    Co-Authors: Masaoki Wada, Taro Takeshima, Yosikazu Nakamura, Shoichiro Nagasaka, Toyomi Kamesaki, Eiji Kajii
    Abstract:

    Many chronic diseases are associated with dizziness or vertigo, as is peripheral Vestibular Disorder (PVD). Although carotid plaque development is linked to atherosclerosis, it is unclear whether such plaques can lead to the development of PVD. We therefore conducted this study to investigate the presence of an association between carotid plaque and new PVD events.In this retrospective study, we consecutively enrolled 393 patients ≥20 years old who had been treated for chronic diseases such as hypertension, dyslipidemia, and diabetes mellitus for ≥6 months at a primary care clinic (Oki Clinic, Japan) between November 2011 and March 2013. Carotid plaque presence was measured with high-resolution ultrasonography for all patients. During a 1-year follow-up period, an otorhinolaryngologist diagnosed and reported any new PVD events (the main end point). Hazard ratios (HRs) and 95% confidence intervals (CIs) for new PVD occurrence were estimated using the Cox proportional hazard regression model.The mean age of the participants was 65.5 years; 33.8% were men, and 12.7%, 82.4%, and 93.1% had diabetes mellitus, hypertension, and dyslipidemia, respectively. There were 76 new PVD events; patients with carotid plaque had a greater risk of such events (crude HR: 3.25; 95% CI: 1.62-6.52) compared to those without carotid plaque. This risk was even higher after adjusting for traditional risk factors for atherosclerosis (adjusted HR: 4.41; 95% CI: 1.75-11.14).Carotid plaques are associated with an increased risk of new PVD events.

Masaoki Wada - One of the best experts on this subject based on the ideXlab platform.

  • association between smoking and the peripheral Vestibular Disorder a retrospective cohort study
    Scientific Reports, 2017
    Co-Authors: Masaoki Wada, Taro Takeshima, Yosikazu Nakamura, Shoichiro Nagasaka, Toyomi Kamesaki, Eiji Kajii, Kazuhiko Kotani
    Abstract:

    Common inner ear diseases include peripheral Vestibular Disorder (PVD) and hearing impairment. The association between smoking and peripheral Vestibular Disorder (PVD) is unclear. We examined associations between smoking and new PVD events. In this retrospective study, we consecutively enrolled 393 participants aged ≥20 years [mean age 65.3 years; males 133 (33.8%)] treated for hypertension, dyslipidaemia, or diabetes mellitus at a primary care clinic between November 2011 and March 2013. Participants were categorized as ever-smokers (including current and past -smokers; divided per <30 and ≥30 pack-years), and never-smokers. New PVD events were reported over a 1-year follow-up period. Hazard ratios (HR) for new onset PVD were estimated using the Cox proportional hazard regression model. Compared to never-smokers, the adjusted HR was 2.22 for ever-smokers and 2.70 for all ever-smokers with ≥30 pack-years among all 393 participants. Among male participants, compared to never-smokers, the adjusted HR was 4.41 for ever-smokers with ≥30 pack-years. A smoking history of ≥30 pack-years was strongly associated with the risk of new onset PVD in males but not, females. This study may assist patients with smoking cessation for the prevention of new PVD events among males.

  • carotid plaque is a new risk factor for peripheral Vestibular Disorder a retrospective cohort study
    Medicine, 2016
    Co-Authors: Masaoki Wada, Taro Takeshima, Yosikazu Nakamura, Shoichiro Nagasaka, Toyomi Kamesaki, Eiji Kajii
    Abstract:

    Many chronic diseases are associated with dizziness or vertigo, as is peripheral Vestibular Disorder (PVD). Although carotid plaque development is linked to atherosclerosis, it is unclear whether such plaques can lead to the development of PVD. We therefore conducted this study to investigate the presence of an association between carotid plaque and new PVD events.In this retrospective study, we consecutively enrolled 393 patients ≥20 years old who had been treated for chronic diseases such as hypertension, dyslipidemia, and diabetes mellitus for ≥6 months at a primary care clinic (Oki Clinic, Japan) between November 2011 and March 2013. Carotid plaque presence was measured with high-resolution ultrasonography for all patients. During a 1-year follow-up period, an otorhinolaryngologist diagnosed and reported any new PVD events (the main end point). Hazard ratios (HRs) and 95% confidence intervals (CIs) for new PVD occurrence were estimated using the Cox proportional hazard regression model.The mean age of the participants was 65.5 years; 33.8% were men, and 12.7%, 82.4%, and 93.1% had diabetes mellitus, hypertension, and dyslipidemia, respectively. There were 76 new PVD events; patients with carotid plaque had a greater risk of such events (crude HR: 3.25; 95% CI: 1.62-6.52) compared to those without carotid plaque. This risk was even higher after adjusting for traditional risk factors for atherosclerosis (adjusted HR: 4.41; 95% CI: 1.75-11.14).Carotid plaques are associated with an increased risk of new PVD events.

Adolfo M. Bronstein - One of the best experts on this subject based on the ideXlab platform.

  • diagnostic criteria for persistent postural perceptual dizziness pppd consensus document of the committee for the classification of Vestibular Disorders of the barany society
    Journal of Vestibular Research-equilibrium & Orientation, 2017
    Co-Authors: Jeffrey P Staab, Annegret Eckhardthenn, Arata Horii, Rolf G Jacob, Michael Strupp, Thomas Brandt, Adolfo M. Bronstein
    Abstract:

    This paper presents diagnostic criteria for persistent postural-perceptual dizziness (PPPD) to be included in the International Classification of Vestibular Disorders (ICVD). The term PPPD is new, but the Disorder is not. Its diagnostic criteria were derived by expert consensus from an exhaustive review of 30 years of research on phobic postural vertigo, space-motion discomfort, visual vertigo, and chronic subjective dizziness. PPPD manifests with one or more symptoms of dizziness, unsteadiness, or non-spinning vertigo that are present on most days for three months or more and are exacerbated by upright posture, active or passive movement, and exposure to moving or complex visual stimuli. PPPD may be precipitated by conditions that disrupt balance or cause vertigo, unsteadiness, or dizziness, including peripheral or central Vestibular Disorders, other medical illnesses, or psychological distress. PPPD may be present alone or co-exist with other conditions. Possible subtypes await future identification and validation. The pathophysiologic processes underlying PPPD are not fully known. Emerging research suggests that it may arise from functional changes in postural control mechanisms, multi-sensory information processing, or cortical integration of spatial orientation and threat assessment. Thus, PPPD is classified as a chronic functional Vestibular Disorder. It is not a structural or psychiatric condition.

  • accessing escalators a central Vestibular Disorder after posterior fossa tumor removal
    Journal of Child Neurology, 2012
    Co-Authors: Hilary A Archer, Rosalyn Davies, M E Faldon, Adolfo M. Bronstein
    Abstract:

    About 20% of childhood tumors originate within the central nervous system. Progress in assessment and treatment of these lesions has led to improved survival rates. We describe a patient with a posterior fossa ependymoma who despite a remarkable recovery following treatment has been frustrated by difficulty in using escalators. Such symptom selectivity is explained by specific vertical visuomotor and high-frequency Vestibular deficits disrupting the execution of this complex motor act.

  • Interference between postural control and mental task performance in patients with Vestibular Disorder and healthy controls.
    Journal of neurology neurosurgery and psychiatry, 2001
    Co-Authors: Lucy Yardley, Mark Gardner, Adolfo M. Bronstein, Rosalyn Davies, David Buckwell, Linda M. Luxon
    Abstract:

    Objectives—To determine whether inter- ference between postural control and mental task performance in patients with balance system impairment and healthy subjects is due to general capacity limita- tions, motor control interference, compe- tition for spatial processing resources, or a combination of these. Method—Postural stability was assessed in 48 patients with Vestibular Disorder and 24 healthy controls while they were stand- ing with eyes closed on (a) a stable and (b) a moving platform. Mental task perform- ance was measured by accuracy and reac- tion time on mental tasks, comprising high and low load, spatial and non-spatial tasks. Interference between balancing and performing mental tasks was assessed by comparing baseline (single task) levels of sway and mental task performance with levels while concurrently balancing and carrying out mental tasks. Results—As the balancing task increased in diYculty, reaction times on both low load mental tasks grew progressively longer and accuracy on both high load tasks declined in patients and controls. Postural sway was essentially unaVected by mental activity in patients and con- trols. Conclusions—It is unlikely that dual task interference between balancing and men- tal activity is due to competition for spatial processing resources, as levels of interference were similar in patients with Vestibular Disorder and healthy controls, and were also similar for spatial and non- spatial tasks. Moreover, the finding that accuracy declined on the high load tasks when balancing cannot be attributed to motor control interference, as no motor control processing is involved in main- taining accuracy of responses. Therefore, interference between mental activity and postural control can be attributed princi- pally to general capacity limitations, and is hence proportional to the attentional demands of both tasks. (J Neurol Neurosurg Psychiatry 2001;71:48-52)

  • dissociation between the perception of body verticality and the visual vertical in acute peripheral Vestibular Disorder in humans
    Neuroscience Letters, 1997
    Co-Authors: Adolfo M. Bronstein, Dimitri Anastasopoulos, Thomas Haslwanter, M Fetter, J Dichgans
    Abstract:

    Estimates of the subjective visual and postural vertical were obtained from five patients with acute peripheral Vestibular lesions and 20 normal subjects. The visual vertical was assessed by asking the subjects to align a target line to earth vertical by means of remote control. Postural vertical judgments were obtained by exposing them to rotational displacements in the roll plane while sitting on a motor-driven chair and requiring them to align their body to vertical using a joystick control. While the patients showed strong deviations of the visual vertical towards the lesion side, their postural vertical judgments remained veridical. We conclude that the above perceptions are not processed identically and that the participating sensory systems are differently weighted during these tasks.