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James F. Bale - One of the best experts on this subject based on the ideXlab platform.
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mondini dysplasia and congenital cytomegalovirus infection
The Journal of Pediatrics, 1994Co-Authors: Nancy M Bauman, Linda Kirbykeyser, David B Wexler, Brian F Mccabe, Bruce J Gantz, Kenneth D. Dolan, James F. BaleAbstract:Abstract We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age. High-resolution temporal bone computed tomography (HRCT) revealed bilateral findings of a short, malformed cochlea lacking an interscalar septum, a short and wide internal auditory canal, and an enlarged vestibular aqueduct, features diagnostic of bilateral Mondini dysplasia. To determine the importance of this observation, we completed HRCT in five additional children between 7 months and 9 years of age who had evidence of symptomatic congenital cytomegalovirus infection. One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal Vestibule, and a large cochlear aqueduct. Of the remaining four children, hearing thresholds ranged from normal to profoundly decreased, but their HRCT scans were normal to visual inspection. When inner ear dimensions of these temporal bones were compared with norms established by Pappas and co-workers, however, seven of the eight ears had short cochleas and narrow lateral semicircular canals, and three ears had short or narrow Vestibules. These results indicate that congenital cytomegalovirus infection may cause anomalies or growth disturbances of the temporal bone. (J P EDIATR 1994;124:71-8)
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mondini dysplasia and congenital cytomegalovirus infection
The Journal of Pediatrics, 1994Co-Authors: Nancy M Bauman, Linda Kirbykeyser, David B Wexler, Brian F Mccabe, Bruce J Gantz, Kenneth D. Dolan, James F. BaleAbstract:Abstract We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age. High-resolution temporal bone computed tomography (HRCT) revealed bilateral findings of a short, malformed cochlea lacking an interscalar septum, a short and wide internal auditory canal, and an enlarged vestibular aqueduct, features diagnostic of bilateral Mondini dysplasia. To determine the importance of this observation, we completed HRCT in five additional children between 7 months and 9 years of age who had evidence of symptomatic congenital cytomegalovirus infection. One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal Vestibule, and a large cochlear aqueduct. Of the remaining four children, hearing thresholds ranged from normal to profoundly decreased, but their HRCT scans were normal to visual inspection. When inner ear dimensions of these temporal bones were compared with norms established by Pappas and co-workers, however, seven of the eight ears had short cochleas and narrow lateral semicircular canals, and three ears had short or narrow Vestibules. These results indicate that congenital cytomegalovirus infection may cause anomalies or growth disturbances of the temporal bone. (J P EDIATR 1994;124:71-8)
Lawrence M. Witmer - One of the best experts on this subject based on the ideXlab platform.
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Alternate airway models for Euoplocephalus tutus.
2018Co-Authors: Jason M. Bourke, Wm. Ruger Porter, Lawrence M. WitmerAbstract:(A) Dorsal view of the straightened airway (removal of nasal Vestibule curvature) and the original, ST-corrected airway. (B) Lateral view of skull of E. tutus (AMNH 5405) with basic airway in situ. A direct connection between the bony narial aperture and the CNP resulted in a loss of 80% of the original nasal Vestibule.
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Alternate airway models for Panoplosaurus mirus.
2018Co-Authors: Jason M. Bourke, Wm. Ruger Porter, Lawrence M. WitmerAbstract:(A) Dorsal view of the straightened airway (removal of nasal Vestibule curvature) and the original, ST-corrected airway. (B) Lateral view of skull of P. mirus (ROM 1215) with basic airway in situ. A direct connection between the bony narial aperture and the CNP in a loss of 55% of the original nasal Vestibule.
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Airflow comparison between the straightened airway and the ST airway in Panoplosaurus mirus (ROM 1215).
2018Co-Authors: Jason M. Bourke, Wm. Ruger Porter, Lawrence M. WitmerAbstract:(A) Dorsal view of the skull of P. mirus with left ST airway in situ. (B) Dorsal view of the straightened airway with flow lines in place. Airflow lines are color-coded for temperature (hotter colors = hotter temperatures). Inset: Magnified region of nasal Vestibule showing evenly spaced, straight flow lines. (C) Dorsal view of the ST airway under the low flow scenario. Vorticity is observable throughout the nasal Vestibule. Note: ST airway in C is not to scale with straightened airway B.
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Convoluted nasal passages function as efficient heat exchangers in ankylosaurs (Dinosauria: Ornithischia: Thyreophora).
'Public Library of Science (PLoS)', 2018Co-Authors: Jason M. Bourke, Wm. Ruger Porter, Lawrence M. WitmerAbstract:Convoluted nasal passages are an enigmatic hallmark of Ankylosauria. Previous research suggested that these convoluted nasal passages functioned as heat exchangers analogous to the respiratory turbinates of mammals and birds. We tested this hypothesis by performing a computational fluid dynamic analysis on the nasal passages of two ankylosaurs: Panoplosaurus mirus and Euoplocephalus tutus. Our models predicted that Panoplosaurus and Euoplocephalus would have required 833 and 1568 thermal calories, respectively, to warm a single breath of air by 20°C. Heat recovery during exhalation resulted in energy savings of 65% for Panoplosaurus and 84% for Euoplocephalus. Our results fell well within the range of values for heat and water savings observed in extant terrestrial amniotes. We further tested alternate airway reconstructions that removed nasal passage convolutions or reduced nasal Vestibule length. Our results revealed that the extensive elaboration observed in the nasal Vestibules of ankylosaurs was a viable alternative to respiratory turbinates with regards to air conditioning. Of the two dinosaurs tested, Euoplocephalus repeatedly exhibited a more efficient nasal passage than Panoplosaurus. We suggest that the higher heat loads associated with the larger body mass of Euoplocephalus necessitated these more efficient nasal passages. Our findings further indicate that the evolution of complicated airways in dinosaurs may have been driven by the thermal requirements of maintaining cerebral thermal homeostasis
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Endosseous labyrinth of the left inner ear of Spinophorosaurus nigerensis (GCP-CV-4229) reconstructed from CT scan; in lateral (A), caudal (B), and dorsal (D) views.
2012Co-Authors: Fabien Knoll, Lawrence M. Witmer, Francisco Ortega, Ryan C. Ridgely, Daniela Schwarz-wingsAbstract:Orientations were determined based on orientation of the labyrinth within the braincase and with the lateral semicircular canal placed horizontally. Abbreviations: C, cochlea ( = lagena); CRC, crus commune; CSC, caudal ( = posterior) semicircular canal; CSCA, ampulla of caudal semicircular canal; FP, fenestra perilymphatica ( = round window); FV, fenestra vestibuli ( = oval window); LSC, lateral ( = horizontal) semicircular canal; LSCA, ampulla of lateral semicircular canal; RSC, rostral ( = anterior) semicircular canal; RSCA, ampulla of rostral semicircular canal; VE, Vestibule of inner ear.
Nancy M Bauman - One of the best experts on this subject based on the ideXlab platform.
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mondini dysplasia and congenital cytomegalovirus infection
The Journal of Pediatrics, 1994Co-Authors: Nancy M Bauman, Linda Kirbykeyser, David B Wexler, Brian F Mccabe, Bruce J Gantz, Kenneth D. Dolan, James F. BaleAbstract:Abstract We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age. High-resolution temporal bone computed tomography (HRCT) revealed bilateral findings of a short, malformed cochlea lacking an interscalar septum, a short and wide internal auditory canal, and an enlarged vestibular aqueduct, features diagnostic of bilateral Mondini dysplasia. To determine the importance of this observation, we completed HRCT in five additional children between 7 months and 9 years of age who had evidence of symptomatic congenital cytomegalovirus infection. One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal Vestibule, and a large cochlear aqueduct. Of the remaining four children, hearing thresholds ranged from normal to profoundly decreased, but their HRCT scans were normal to visual inspection. When inner ear dimensions of these temporal bones were compared with norms established by Pappas and co-workers, however, seven of the eight ears had short cochleas and narrow lateral semicircular canals, and three ears had short or narrow Vestibules. These results indicate that congenital cytomegalovirus infection may cause anomalies or growth disturbances of the temporal bone. (J P EDIATR 1994;124:71-8)
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mondini dysplasia and congenital cytomegalovirus infection
The Journal of Pediatrics, 1994Co-Authors: Nancy M Bauman, Linda Kirbykeyser, David B Wexler, Brian F Mccabe, Bruce J Gantz, Kenneth D. Dolan, James F. BaleAbstract:Abstract We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age. High-resolution temporal bone computed tomography (HRCT) revealed bilateral findings of a short, malformed cochlea lacking an interscalar septum, a short and wide internal auditory canal, and an enlarged vestibular aqueduct, features diagnostic of bilateral Mondini dysplasia. To determine the importance of this observation, we completed HRCT in five additional children between 7 months and 9 years of age who had evidence of symptomatic congenital cytomegalovirus infection. One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal Vestibule, and a large cochlear aqueduct. Of the remaining four children, hearing thresholds ranged from normal to profoundly decreased, but their HRCT scans were normal to visual inspection. When inner ear dimensions of these temporal bones were compared with norms established by Pappas and co-workers, however, seven of the eight ears had short cochleas and narrow lateral semicircular canals, and three ears had short or narrow Vestibules. These results indicate that congenital cytomegalovirus infection may cause anomalies or growth disturbances of the temporal bone. (J P EDIATR 1994;124:71-8)
Kenneth D. Dolan - One of the best experts on this subject based on the ideXlab platform.
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mondini dysplasia and congenital cytomegalovirus infection
The Journal of Pediatrics, 1994Co-Authors: Nancy M Bauman, Linda Kirbykeyser, David B Wexler, Brian F Mccabe, Bruce J Gantz, Kenneth D. Dolan, James F. BaleAbstract:Abstract We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age. High-resolution temporal bone computed tomography (HRCT) revealed bilateral findings of a short, malformed cochlea lacking an interscalar septum, a short and wide internal auditory canal, and an enlarged vestibular aqueduct, features diagnostic of bilateral Mondini dysplasia. To determine the importance of this observation, we completed HRCT in five additional children between 7 months and 9 years of age who had evidence of symptomatic congenital cytomegalovirus infection. One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal Vestibule, and a large cochlear aqueduct. Of the remaining four children, hearing thresholds ranged from normal to profoundly decreased, but their HRCT scans were normal to visual inspection. When inner ear dimensions of these temporal bones were compared with norms established by Pappas and co-workers, however, seven of the eight ears had short cochleas and narrow lateral semicircular canals, and three ears had short or narrow Vestibules. These results indicate that congenital cytomegalovirus infection may cause anomalies or growth disturbances of the temporal bone. (J P EDIATR 1994;124:71-8)
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mondini dysplasia and congenital cytomegalovirus infection
The Journal of Pediatrics, 1994Co-Authors: Nancy M Bauman, Linda Kirbykeyser, David B Wexler, Brian F Mccabe, Bruce J Gantz, Kenneth D. Dolan, James F. BaleAbstract:Abstract We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age. High-resolution temporal bone computed tomography (HRCT) revealed bilateral findings of a short, malformed cochlea lacking an interscalar septum, a short and wide internal auditory canal, and an enlarged vestibular aqueduct, features diagnostic of bilateral Mondini dysplasia. To determine the importance of this observation, we completed HRCT in five additional children between 7 months and 9 years of age who had evidence of symptomatic congenital cytomegalovirus infection. One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal Vestibule, and a large cochlear aqueduct. Of the remaining four children, hearing thresholds ranged from normal to profoundly decreased, but their HRCT scans were normal to visual inspection. When inner ear dimensions of these temporal bones were compared with norms established by Pappas and co-workers, however, seven of the eight ears had short cochleas and narrow lateral semicircular canals, and three ears had short or narrow Vestibules. These results indicate that congenital cytomegalovirus infection may cause anomalies or growth disturbances of the temporal bone. (J P EDIATR 1994;124:71-8)
Brian F Mccabe - One of the best experts on this subject based on the ideXlab platform.
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mondini dysplasia and congenital cytomegalovirus infection
The Journal of Pediatrics, 1994Co-Authors: Nancy M Bauman, Linda Kirbykeyser, David B Wexler, Brian F Mccabe, Bruce J Gantz, Kenneth D. Dolan, James F. BaleAbstract:Abstract We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age. High-resolution temporal bone computed tomography (HRCT) revealed bilateral findings of a short, malformed cochlea lacking an interscalar septum, a short and wide internal auditory canal, and an enlarged vestibular aqueduct, features diagnostic of bilateral Mondini dysplasia. To determine the importance of this observation, we completed HRCT in five additional children between 7 months and 9 years of age who had evidence of symptomatic congenital cytomegalovirus infection. One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal Vestibule, and a large cochlear aqueduct. Of the remaining four children, hearing thresholds ranged from normal to profoundly decreased, but their HRCT scans were normal to visual inspection. When inner ear dimensions of these temporal bones were compared with norms established by Pappas and co-workers, however, seven of the eight ears had short cochleas and narrow lateral semicircular canals, and three ears had short or narrow Vestibules. These results indicate that congenital cytomegalovirus infection may cause anomalies or growth disturbances of the temporal bone. (J P EDIATR 1994;124:71-8)
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mondini dysplasia and congenital cytomegalovirus infection
The Journal of Pediatrics, 1994Co-Authors: Nancy M Bauman, Linda Kirbykeyser, David B Wexler, Brian F Mccabe, Bruce J Gantz, Kenneth D. Dolan, James F. BaleAbstract:Abstract We report a case of bilateral temporal bone anomalies in a child with symptomatic congenital cytomegalovirus infection and severe, bilateral sensorineural hearing loss identified at 3 months of age. High-resolution temporal bone computed tomography (HRCT) revealed bilateral findings of a short, malformed cochlea lacking an interscalar septum, a short and wide internal auditory canal, and an enlarged vestibular aqueduct, features diagnostic of bilateral Mondini dysplasia. To determine the importance of this observation, we completed HRCT in five additional children between 7 months and 9 years of age who had evidence of symptomatic congenital cytomegalovirus infection. One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal Vestibule, and a large cochlear aqueduct. Of the remaining four children, hearing thresholds ranged from normal to profoundly decreased, but their HRCT scans were normal to visual inspection. When inner ear dimensions of these temporal bones were compared with norms established by Pappas and co-workers, however, seven of the eight ears had short cochleas and narrow lateral semicircular canals, and three ears had short or narrow Vestibules. These results indicate that congenital cytomegalovirus infection may cause anomalies or growth disturbances of the temporal bone. (J P EDIATR 1994;124:71-8)
