The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
C. V. Asokan - One of the best experts on this subject based on the ideXlab platform.
-
A facile method for the synthesis of nicotinonitriles from ketones via a one-pot chloromethyleneiminium salt mediated three-component Reaction
Tetrahedron Letters, 2007Co-Authors: C. V. Asokan, Ajith Dain Thomas, E. R. Anabha, Ann Maria Jose, Kallidanthiyil Chellappan Lethesh, M. Prasanth, K. U. KrishanrajAbstract:Abstract Simple enolizable ketones such as acetophenones and benzalacetones were treated with malononitrile under Vilsmeier–Haack Reaction conditions to afford 2-chloronicotinonitriles. The Reaction proceeds via a one-pot chloromethyleneiminium salt mediated three-component Reaction followed by sequential cyclization and aromatization under Vilsmeier–Haack Reaction conditions.
-
Vilsmeier–Haack Reactions of carbonyl compounds: synthesis of substituted pyrones and pyridines
Tetrahedron, 2004Co-Authors: Ajith Dain Thomas, Josemin, C. V. AsokanAbstract:Abstract Vilsmeier–Haack Reaction of substituted phenylacetones leads to the formation of conjugated iminium salts which on aqueous basic work up afford 3-formyl-4-pyrones and on ammonium acetate-induced cyclization afford 5-aryl-4-chloronicotinaldehydes in good yields.
-
Reactions of 1-aryl-2-propanones with chloromethyleneiminium salt
Tetrahedron Letters, 1997Co-Authors: Josemin, K.n. Nirmala, C. V. AsokanAbstract:Abstract A synthesis of 3-formyl-4-pyrones by Vilsmeier-Haack Reaction of substituted benzyl methyl ketones has been reported. The Reaction of benzyl ethyl ketone with chloromethyleneiminium salt gave corresponding 4-pyrone while phenoxy acetone gave N,N-dimethylamino substituted pentadienaldehyde.
-
The Vilsmeier Reaction on dithioketals: A facile method for the stereoselective synthesis of β-alkylthioethylenic aldehydes
Tetrahedron Letters, 1994Co-Authors: C. V. Asokan, Annie MathewsAbstract:Abstract An expedient and general method for the synthesis of β-alkylthioethylenic aldehydes from dithioketals under Vilsmeier-Haack Reaction conditions is described.
Marcus Bollyn - One of the best experts on this subject based on the ideXlab platform.
-
thermal hazards of the Vilsmeier Haack Reaction on n n dimethylaniline
Organic Process Research & Development, 2005Co-Authors: Marcus BollynAbstract:From literature data and a preliminary calorimetric study it is clear that the Vilsmeier−Haack Reaction poses specific thermal hazards as both the Vilsmeier−Haack intermediate (1) in N,N-dimethylformamide (2) and the Reaction mixture with N,N-dimethylaniline (3) are thermally unstable and can generate high and fast temperature and pressures rises when heated. Therefore alternatives were investigated for their thermal hazards. The stability of Vilsmeier intermediates generated from a series of other formamides was investigated. In principle the Vilsmeier intermediate could be generated and converted in situ, thus avoiding large amounts of an unstable intermediate in the process vessel and yielding the same Reaction mixture. This concept could also be applied to the other formamides studied, and this option was also included in the investigation.
-
Thermal Hazards of the Vilsmeier−Haack Reaction on N,N-Dimethylaniline
Organic Process Research & Development, 2005Co-Authors: Marcus BollynAbstract:From literature data and a preliminary calorimetric study it is clear that the Vilsmeier−Haack Reaction poses specific thermal hazards as both the Vilsmeier−Haack intermediate (1) in N,N-dimethylformamide (2) and the Reaction mixture with N,N-dimethylaniline (3) are thermally unstable and can generate high and fast temperature and pressures rises when heated. Therefore alternatives were investigated for their thermal hazards. The stability of Vilsmeier intermediates generated from a series of other formamides was investigated. In principle the Vilsmeier intermediate could be generated and converted in situ, thus avoiding large amounts of an unstable intermediate in the process vessel and yielding the same Reaction mixture. This concept could also be applied to the other formamides studied, and this option was also included in the investigation.
Mmakwena M. Mmonwa - One of the best experts on this subject based on the ideXlab platform.
-
Vilsmeier–Haack Reaction of 7-acetyl-2-arylindoles: a convenient method for the synthesis of 6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-1,5-dicarbaldehydes
Organic & biomolecular chemistry, 2019Co-Authors: Malose J. Mphahlele, Mmakwena M. MmonwaAbstract:A simple and efficient method for the one-pot synthesis of novel 6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-1,5-dicarbaldehydes via the Vilsmeier–Haack Reaction of the corresponding 7-acetyl-2-arylindoles has been developed. The mechanism of this Reaction is envisaged to involve initial C-3 formylation and subsequent diformylation at the acetyl group with the excess Vilsmeier–Haack reagent followed by heteroannulation of the six-membered ring with concomitant extrusion of dimethylamine to afford the 1,2,5,8-tetrasubstituted pyrroloquinolinones. The highlight of this method is the construction of carbon–carbon and carbon–nitrogen bonds in a single-pot operation to afford polycarbo-substituted pyrroloquinolinones.
-
Vilsmeier Haack Reaction of 7 acetyl 2 arylindoles a convenient method for the synthesis of 6 oxo 6h pyrrolo 3 2 1 ij quinoline 1 5 dicarbaldehydes
Organic and Biomolecular Chemistry, 2019Co-Authors: Malose J. Mphahlele, Mmakwena M. MmonwaAbstract:A simple and efficient method for the one-pot synthesis of novel 6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-1,5-dicarbaldehydes via the Vilsmeier–Haack Reaction of the corresponding 7-acetyl-2-arylindoles has been developed. The mechanism of this Reaction is envisaged to involve initial C-3 formylation and subsequent diformylation at the acetyl group with the excess Vilsmeier–Haack reagent followed by heteroannulation of the six-membered ring with concomitant extrusion of dimethylamine to afford the 1,2,5,8-tetrasubstituted pyrroloquinolinones. The highlight of this method is the construction of carbon–carbon and carbon–nitrogen bonds in a single-pot operation to afford polycarbo-substituted pyrroloquinolinones.
Palathurai Subramaniam Mohan - One of the best experts on this subject based on the ideXlab platform.
-
A Novel Approach to 12-Chloro-3-thio-4H-quino[3,2-e][1,3]diazocines via Vilsmeier—Haack Reaction
ChemInform, 2007Co-Authors: R. Nandha Kumar, Thangaraj Suresh, T. Dhanabal, Palathurai Subramaniam MohanAbstract:The Vilsmeier Haack Reaction on 4-hydroxyquinaldines lead to potential intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-l-yl)quinolines. The intermediate is further utilized to prepare quino[3,2-e][1,3]diazocines on treatment with thiourea. The structures of the new compounds are determined by the analytical and spectroscopic data.
-
A novel approach to 12-chloro-3-thio-4H-quino [3,2-e][1,3]diazocines via Vilsmeier Haack Reaction
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, 2007Co-Authors: R. Nandha Kumar, Thangaraj Suresh, T. Dhanabal, Palathurai Subramaniam MohanAbstract:The Vilsmeier Haack Reaction on 4-hydroxyquinaldines lead to potential intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-l-yl)quinolines. The intermediate is further utilized to prepare quino[3,2-e][1,3]diazocines on treatment with thiourea. The structures of the new compounds are determined by the analytical and spectroscopic data.
-
Vilsmeier—Haack Reaction on Quinaldines.
ChemInform, 2003Co-Authors: R. Nandha Kumar, Thangaraj Suresh, Palathurai Subramaniam MohanAbstract:The study of the Vilsmeicr-Haack Reaction on 4-hydroxyquinaldines resulted with the preparation of rarely existing 4-chloro-3-formyl-2(vinyl-1-ol)-quinolines.
-
Vilsmeier-Haack Reaction on quinaldines
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, 2003Co-Authors: R. Nandha Kumar, Thangaraj Suresh, Palathurai Subramaniam MohanAbstract:The study of the Vilsmeicr-Haack Reaction on 4-hydroxyquinaldines resulted with the preparation of rarely existing 4-chloro-3-formyl-2(vinyl-1-ol)-quinolines.
Malose J. Mphahlele - One of the best experts on this subject based on the ideXlab platform.
-
Vilsmeier–Haack Reaction of 7-acetyl-2-arylindoles: a convenient method for the synthesis of 6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-1,5-dicarbaldehydes
Organic & biomolecular chemistry, 2019Co-Authors: Malose J. Mphahlele, Mmakwena M. MmonwaAbstract:A simple and efficient method for the one-pot synthesis of novel 6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-1,5-dicarbaldehydes via the Vilsmeier–Haack Reaction of the corresponding 7-acetyl-2-arylindoles has been developed. The mechanism of this Reaction is envisaged to involve initial C-3 formylation and subsequent diformylation at the acetyl group with the excess Vilsmeier–Haack reagent followed by heteroannulation of the six-membered ring with concomitant extrusion of dimethylamine to afford the 1,2,5,8-tetrasubstituted pyrroloquinolinones. The highlight of this method is the construction of carbon–carbon and carbon–nitrogen bonds in a single-pot operation to afford polycarbo-substituted pyrroloquinolinones.
-
Vilsmeier Haack Reaction of 7 acetyl 2 arylindoles a convenient method for the synthesis of 6 oxo 6h pyrrolo 3 2 1 ij quinoline 1 5 dicarbaldehydes
Organic and Biomolecular Chemistry, 2019Co-Authors: Malose J. Mphahlele, Mmakwena M. MmonwaAbstract:A simple and efficient method for the one-pot synthesis of novel 6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-1,5-dicarbaldehydes via the Vilsmeier–Haack Reaction of the corresponding 7-acetyl-2-arylindoles has been developed. The mechanism of this Reaction is envisaged to involve initial C-3 formylation and subsequent diformylation at the acetyl group with the excess Vilsmeier–Haack reagent followed by heteroannulation of the six-membered ring with concomitant extrusion of dimethylamine to afford the 1,2,5,8-tetrasubstituted pyrroloquinolinones. The highlight of this method is the construction of carbon–carbon and carbon–nitrogen bonds in a single-pot operation to afford polycarbo-substituted pyrroloquinolinones.