The Experts below are selected from a list of 367062 Experts worldwide ranked by ideXlab platform
Emily P Chang - One of the best experts on this subject based on the ideXlab platform.
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analysis of Aldehydes in excipients used in liquid semi solid formulations by gas chromatography negative chemical ionization mass spectrometry
Journal of Chromatography A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Abstract Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC–MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1–C8 aliphatic Aldehydes in LFC excipients at sub-μg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
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Analysis of Aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography–negative chemical ionization mass spectrometry
Journal of Chromatography A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Abstract Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC–MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1–C8 aliphatic Aldehydes in LFC excipients at sub-μg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
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Analysis of Aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography-negative chemical ionization mass spectrometry.
Journal of chromatography. A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC-MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1-C8 aliphatic Aldehydes in LFC excipients at sub-microg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
Yoshinori Asakawa - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of terpene Aldehydes by Euglena gracilis Z
Phytochemistry, 2001Co-Authors: Yoshiaki Noma, Hironobu Takahashi, Yoshinori AsakawaAbstract:Abstract Biotransformation of seven classes of monoterpene Aldehydes, namely myrtenal, l - and dl -perillaldehyde, 1-phellandral, citral as α,β-unsaturated terpene Aldehydes and trans - and cis -1,2-dihydroperillaldehyde and d -, l - and dl -citronellal and an aromatic aldehyde, cumin aldehyde, was carried out by Euglena gracilis Z cultured photoheterotropically. Euglena gracilis Z reduced saturated and unsaturated terpene Aldehydes to corresponding terpene alcohols. The double bond of the resulting α,β-unsaturated terpene alcohols was further hydrogenated to form the corresponding saturated terpene alcohols. A small amount of terpenic acids was also formed.
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Biotransformation of terpene Aldehydes, aromatic Aldehydes and related compounds by Dunaliella tertiolecta
Phytochemistry, 1992Co-Authors: Yoshiaki Noma, Etsuko Akehi, Naoko Miki, Yoshinori AsakawaAbstract:Abstract Biotransformation of seven classes of monoterpene Aldehydes and 21 classes of aromatic Aldehydes and related compounds was carried out by Dunaliella tertiolecta cultured autophototrophically. The phytoflagellate reduced all saturated and unsaturated terpene Aldehydes and most of aromatic and related Aldehydes to corresponding primary alcohols. However, monosubstituted aromatic Aldehydes such as salicyl aldehyde, p -hydroxy- and o -nitrobenzAldehydes and disubstituted aromatic Aldehydes such as 2-hydroxy-5-methoxybenzaldehyde, vanillin and ethyl vanillin were difficult to transform or not transformed. On the other hand, the CC double bond of the resulting α,β-unsaturated alcohols in the cases of cinnamyl alcohol and 2-methylcinnamyl alcohol was hydrogenated to the corresponding saturated alcohols.
Zhong Li - One of the best experts on this subject based on the ideXlab platform.
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analysis of Aldehydes in excipients used in liquid semi solid formulations by gas chromatography negative chemical ionization mass spectrometry
Journal of Chromatography A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Abstract Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC–MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1–C8 aliphatic Aldehydes in LFC excipients at sub-μg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
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Analysis of Aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography–negative chemical ionization mass spectrometry
Journal of Chromatography A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Abstract Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC–MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1–C8 aliphatic Aldehydes in LFC excipients at sub-μg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
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Analysis of Aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography-negative chemical ionization mass spectrometry.
Journal of chromatography. A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC-MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1-C8 aliphatic Aldehydes in LFC excipients at sub-microg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
Yoshiaki Noma - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of terpene Aldehydes by Euglena gracilis Z
Phytochemistry, 2001Co-Authors: Yoshiaki Noma, Hironobu Takahashi, Yoshinori AsakawaAbstract:Abstract Biotransformation of seven classes of monoterpene Aldehydes, namely myrtenal, l - and dl -perillaldehyde, 1-phellandral, citral as α,β-unsaturated terpene Aldehydes and trans - and cis -1,2-dihydroperillaldehyde and d -, l - and dl -citronellal and an aromatic aldehyde, cumin aldehyde, was carried out by Euglena gracilis Z cultured photoheterotropically. Euglena gracilis Z reduced saturated and unsaturated terpene Aldehydes to corresponding terpene alcohols. The double bond of the resulting α,β-unsaturated terpene alcohols was further hydrogenated to form the corresponding saturated terpene alcohols. A small amount of terpenic acids was also formed.
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Biotransformation of terpene Aldehydes, aromatic Aldehydes and related compounds by Dunaliella tertiolecta
Phytochemistry, 1992Co-Authors: Yoshiaki Noma, Etsuko Akehi, Naoko Miki, Yoshinori AsakawaAbstract:Abstract Biotransformation of seven classes of monoterpene Aldehydes and 21 classes of aromatic Aldehydes and related compounds was carried out by Dunaliella tertiolecta cultured autophototrophically. The phytoflagellate reduced all saturated and unsaturated terpene Aldehydes and most of aromatic and related Aldehydes to corresponding primary alcohols. However, monosubstituted aromatic Aldehydes such as salicyl aldehyde, p -hydroxy- and o -nitrobenzAldehydes and disubstituted aromatic Aldehydes such as 2-hydroxy-5-methoxybenzaldehyde, vanillin and ethyl vanillin were difficult to transform or not transformed. On the other hand, the CC double bond of the resulting α,β-unsaturated alcohols in the cases of cinnamyl alcohol and 2-methylcinnamyl alcohol was hydrogenated to the corresponding saturated alcohols.
Brian M Kozlowski - One of the best experts on this subject based on the ideXlab platform.
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analysis of Aldehydes in excipients used in liquid semi solid formulations by gas chromatography negative chemical ionization mass spectrometry
Journal of Chromatography A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Abstract Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC–MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1–C8 aliphatic Aldehydes in LFC excipients at sub-μg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
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Analysis of Aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography–negative chemical ionization mass spectrometry
Journal of Chromatography A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Abstract Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC–MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1–C8 aliphatic Aldehydes in LFC excipients at sub-μg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
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Analysis of Aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography-negative chemical ionization mass spectrometry.
Journal of chromatography. A, 2007Co-Authors: Zhong Li, Brian M Kozlowski, Emily P ChangAbstract:Monitoring of low-molecular-weight aldehyde levels in excipients used in liquid/semi-solid based capsule (LFC) dosage forms plays a critical role in the development of these pharmaceutical products. A simple, sensitive and specific method based on gas chromatography coupled with mass spectrometry (GC-MS) utilizing an Rtx-5MS capillary column was developed and validated for the detection and quantification of C1-C8 aliphatic Aldehydes in LFC excipients at sub-microg/g levels. The proposed procedure is based on the derivatization of Aldehydes in 10:1 (v/v) acetonitrile:water with O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA), followed by direct GC analysis of aldehyde-PFBHA-oxime derivatives with negative chemical ionization (NCI) MS detection. The method developed was successfully applied to the analysis of short chain Aldehydes in 30 typical LFC excipients. An example case study on the formation and growth of Aldehydes in these excipients under accelerated storage conditions is also reported.
