The Experts below are selected from a list of 17781 Experts worldwide ranked by ideXlab platform
Shifang Ding - One of the best experts on this subject based on the ideXlab platform.
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a case of human Viral Encephalitis caused by pseudorabies virus infection in china
Frontiers in Neurology, 2019Co-Authors: Hongna Yang, Han Liu, Hui Han, Hao Wang, Yi Cui, Shifang DingAbstract:We report a human case of Viral Encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in the bilateral basal ganglia, bilateral occipital lobe, bilateral limbic lobe, and left thalamic. Next-generation sequencing (NGS) confirmed the presence of PRV in cerebral spinal fluid (CSF). Regular polymerase chain reaction (PCR) was applied to confirm the presence of PRV in the CSF and blood. In addition, serological (immunological) tests were used to further validate the presence of PRV in the peripheral blood. This case suggested that it was possible for PRV to result in human central nervous system (CNS) infection, and it is necessary for people to increase awareness of self-protection when contacting animals.
Tom Solomon - One of the best experts on this subject based on the ideXlab platform.
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herpes simplex virus Encephalitis in pregnancy a case report and review of reported patients in the literature
BMC Research Notes, 2015Co-Authors: Katherine Dodd, Benedict Michael, Besa Ziso, Bode Williams, Ray Borrow, Anita Krishnan, Tom SolomonAbstract:Herpes simplex virus (HSV) Encephalitis is the most common sporadic cause of Encephalitis with significant morbidity and mortality that is drastically reduced by early antiViral treatment. We report a 37 year old woman, 33 weeks pregnant, who presented with seizures due to proven HSV-1 Encephalitis, and who had had a previous episode of probable Viral Encephalitis aged 14 years. She was successfully treated with aciclovir on both occasions and, in the latter, went on to deliver a healthy infant. This case is compared with 17 cases of HSV Encephalitis in pregnancy in the literature identifying a predominance in the late 2nd and 3rd trimesters, perhaps in part due to immunological changes in pregnancy. The clinical presentation is also compared with non-pregnant patients with HSV Encephalitis in the largest prospective UK and European studies. We also present practical advice on management from recent national guidelines. When pregnant women present with new seizures, headache, impaired consciousness or altered behaviour urgent investigation is required to identify common diagnoses, such as eclampsia, venous sinus thrombosis and metabolic disturbances. Nevertheless, Viral Encephalitis is a very treatable cause of this presentation with potentially serious complications if missed, and may be more common in latter stages of pregnancy. Encephalitis should not be discounted if the patient is afebrile, has a normal Glasgow coma score, or the cerebrospinal fluid white cell count is only slightly elevated, as these features are well recognised in Viral Encephalitis.
Hongna Yang - One of the best experts on this subject based on the ideXlab platform.
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a case of human Viral Encephalitis caused by pseudorabies virus infection in china
Frontiers in Neurology, 2019Co-Authors: Hongna Yang, Han Liu, Hui Han, Hao Wang, Yi Cui, Shifang DingAbstract:We report a human case of Viral Encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in the bilateral basal ganglia, bilateral occipital lobe, bilateral limbic lobe, and left thalamic. Next-generation sequencing (NGS) confirmed the presence of PRV in cerebral spinal fluid (CSF). Regular polymerase chain reaction (PCR) was applied to confirm the presence of PRV in the CSF and blood. In addition, serological (immunological) tests were used to further validate the presence of PRV in the peripheral blood. This case suggested that it was possible for PRV to result in human central nervous system (CNS) infection, and it is necessary for people to increase awareness of self-protection when contacting animals.
Suzanne Cotter - One of the best experts on this subject based on the ideXlab platform.
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underreporting of Viral Encephalitis and Viral meningitis ireland 2005 2008
Emerging Infectious Diseases, 2013Co-Authors: Tara A Kelly, Piaras Olorcain, Joanne Moran, Patricia Garvey, Paul Mckeown, Jeff Connell, Suzanne CotterAbstract:Viral Encephalitis (VE) and Viral meningitis (VM) have been notifiable infectious diseases under surveillance in the Republic of Ireland since 1981. Laboratories have reported confirmed cases by detection of Viral nucleic acid in cerebrospinal fluid since 2004. To determine the prevalence of these diseases in Ireland during 2005-2008, we analyzed 3 data sources: Hospital In-patient Enquiry data (from hospitalized following patients discharge) accessed through Health Intelligence Ireland, laboratory confirmations from the National Virus Reference Laboratory, and events from the Computerised Infectious Disease Reporting surveillance system. We found that the national surveillance system underestimates the incidence of these diseases in Ireland with a 10-fold higher VE hospitalization rate and 3-fold higher VM hospitalization rate than the reporting rate. Herpesviruses were responsible for most specified VE and enteroviruses for most specified VM from all 3 sources. Recommendations from this study have been implemented to improve the surveillance of these diseases in Ireland.
Kunling Shen - One of the best experts on this subject based on the ideXlab platform.
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etiology and prognosis of acute Viral Encephalitis and meningitis in chinese children a multicentre prospective study
BMC Infectious Diseases, 2017Co-Authors: Zhengde Xie, Gang Liu, Zongbo Chen, Yong Yang, Jing Chen, Guo Zheng, Kunling ShenAbstract:In China, there were few studies about the pathogens of acute Viral Encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute Viral Encephalitis and meningitis in Chinese children. This was a multicentre prospective study. Two hundred and sixty one Viral Encephalitis patients and 285 Viral meningitis patients were enrolled. The mean age of Viral Encephalitis and meningitis were 5.88 ± 3.60 years and 6.39 ± 3.57 years, respectively. Real-time reverse transcription PCR and multiplex PCR were used to detect human enteroviruses and herpes viruses in cerebrospinal fluid (CSF) of patients with Encephalitis or meningitis. The enzyme-linked immune absorbent assay (ELISA) was used for detecting IgM antibody against Japanese Encephalitis virus (JEV) in CSF and against mumps virus, tick-borne Encephalitis virus (TBEV), dengue virus and rubella virus in acute serum. The clinical and outcome data were collected during patients’ hospitalization. The etiology of Viral Encephalitis was confirmed in 52.5% patients. The primary pathogen was human enteroviruses (27.7%) in Viral Encephalitis. The incidence of sequelae and the fatality rate of Viral Encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The etiology of Viral meningitis was identified in 42.8% cases. The leading pathogen was also human enteroviruses (37.7%) in Viral meningitis. The prognosis of Viral meningitis was favorable with only 0.7% patients had neurological sequelae. Human enteroviruses were the leading cause both in acute Viral Encephalitis and Viral meningitis in children. The incidence of sequelae and fatality rate of Viral Encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The prognosis of Viral meningitis was favorable compared to Viral Encephalitis.
