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Su-yun Lyu - One of the best experts on this subject based on the ideXlab platform.
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The antimutagenic effect of mistletoe lectin (Viscum Album L. var. coloratum agglutinin).
Phytotherapy research : PTR, 2011Co-Authors: Chang-eui Hong, Su-yun LyuAbstract:A galactose- and N-acetyl-D-galactosamine-specific lectin (Viscum Album L. var. coloratum agglutinin, VCA), which is known for its anticancer activity, was isolated from mistletoe. In this study, we investigated the antimutagenic potentials of VCA by using the pre-incubation method of the Ames test (Salmonella typhimurium TA98 and TA100) in the presence or absence of S9 mixture. Viscum Album L. var. coloratum agglutinin was assessed for its antimutagenic properties against the mutagens 2-aminoanthracene (2AA) and furylfuramide (AF-2) for strain TA98, and sodium azide (NaN3) and 2-aminoanthracene (2AA) for strain TA100. The concentrations used for this test compound were 100, 200 and 400 µg per plate. Viscum Album L. var. coloratum agglutinin showed moderate, but not negligible, protective effects regarding the antimutagenic properties against the direct-acting mutagens NaN3 and AF-2. Furthermore, VCA was more effective in preventing the mutagenicity of the indirect-acting mutagen 2-AA (in the presence of S9) when tested with both TA98 and TA100. In conclusion, this report has shown broad ranging antimutagenic effects of VCA to numerous mutagens in TA98 and TA100 Salmonella typhimurium strains. Although the data presented here cannot be applied in vivo, they can support other antimutagenic and anticarcinogenic findings for VCA. Copyright © 2011 John Wiley & Sons, Ltd.
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Antitumor Activities of Extract of Viscum Album var. coloratum Modified with Viscum Album var. coloratum Agglutinin
Natural product sciences, 2002Co-Authors: Su-yun Lyu, Jee-young Rhim, You-sun Moon, Seung-hee Jung, Kyue-yim Lee, Won-bong ParkAbstract:The mistletoe lectins are major active components in the extract of European mistletoe (Viscum Album L) that have been widely used in adjuvant chemotherapy of cancer. This study was performed to investigate the antitumor activity of extract of Korean mistletoe (Viscum Album var. coloratum) modified with Korean mistletoe lectin (Viscum Album var. coloratum agglutinin, VCA). Compared with the results of VCA, survival rate was increased and experimental lung metastasis was reduced by treatment of modified extract (VCM). In addition, the treatment of VCM reduced angiogenesis and VCA-induced toxicity measured by a CAM assay. And VCM inhibited proliferation and induced apoptosis in vitro in tumor cells originated from tissues which are possible to apply topically without surgery. Taken together, the antitumor activities of VCM-treated group outperformed the activities of the VCA-treated group.
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Comparative study of Korean (Viscum Album var. coloratum) and European mistletoes (Viscum Album).
Archives of pharmacal research, 2000Co-Authors: Su-yun Lyu, Sun Myo Park, Bo Yun Choung, Won-bong ParkAbstract:A lectin (agglutinin, VCA) from Korean mistletoe (Viscum Album L.coloratum) was isolated by affinity chromatograpy on a asialofetuin-Sepharose 4B. The molecular weights of A-and B-chains of VCA were differenf from those of VAAS. The VCA recognized the antibody of VAAs in the Western blot analysis and ELLA system. We also investigated the synergistic effects of the components in mistletoe by dividing the extract into different molecular weight fractions.
Fatma Ergun - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of the hypoglycemic effect and antioxidant activity of three Viscum Album subspecies (European mistletoe) in streptozotocin-diabetic rats
Journal of Ethnopharmacology, 2005Co-Authors: Didem Deliorman Orhan, Fatma Ergun, Mustafa Aslan, Nilüfer Sendogdu, Erdem YesiladaAbstract:The acute hypoglycaemic effect of water and ethanolic extracts of three Viscum Album subspecies, ssp. Album, ssp. austriacum, ssp. abietis, were investigated in normoglycaemic and streptozotozocin-induced diabetic rats. Blood glucose level was measured according to glucose oxidase method. The antioxidant activity of these extracts was also studied in the liver, kidney and heart tissues of streptozotocin-induced diabetic rats after subacute administration. In order to determine antioxidant activity of extracts, tissue MDA and GSH levels were measured by using spectrophotometric methods. All results were compared with the diabetic control groups. The findings obtained in the experiments demonstrated that European mistletoe (Viscum Album L.) subspecies possess potent antihyperglycaemic and antioxidant activity depending on host plant.
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Evaluation of Antimycobacterial Activity of Viscum Album Subspecies
Pharmaceutical Biology, 2001Co-Authors: D. Deliorman, Fatma Ergun, Bilge Sener, Prasit PalittapongarnpimAbstract:Continuing our investigations to search for antimycobacterial drugs from Turkish plants, the results of samples prepared from Viscum Album L. subspecies growing in Turkey are presented in this paper.
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A new acyclic monoterpene glucoside from Viscum Album ssp. Album.
Fitoterapia, 2001Co-Authors: Didem Deliorman, Ihsan Calis, Fatma ErgunAbstract:Abstract 2,6-Dimethylocta-2,7-diene-1,6-diol 6-O-[6′-O-β- d -apiofuranosyl]-β- d -glucopyranoside (1) was isolated from Viscum Album ssp. Album.
Won-bong Park - One of the best experts on this subject based on the ideXlab platform.
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Antitumor Activities of Extract of Viscum Album var. coloratum Modified with Viscum Album var. coloratum Agglutinin
Natural product sciences, 2002Co-Authors: Su-yun Lyu, Jee-young Rhim, You-sun Moon, Seung-hee Jung, Kyue-yim Lee, Won-bong ParkAbstract:The mistletoe lectins are major active components in the extract of European mistletoe (Viscum Album L) that have been widely used in adjuvant chemotherapy of cancer. This study was performed to investigate the antitumor activity of extract of Korean mistletoe (Viscum Album var. coloratum) modified with Korean mistletoe lectin (Viscum Album var. coloratum agglutinin, VCA). Compared with the results of VCA, survival rate was increased and experimental lung metastasis was reduced by treatment of modified extract (VCM). In addition, the treatment of VCM reduced angiogenesis and VCA-induced toxicity measured by a CAM assay. And VCM inhibited proliferation and induced apoptosis in vitro in tumor cells originated from tissues which are possible to apply topically without surgery. Taken together, the antitumor activities of VCM-treated group outperformed the activities of the VCA-treated group.
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Comparative study of Korean (Viscum Album var. coloratum) and European mistletoes (Viscum Album).
Archives of pharmacal research, 2000Co-Authors: Su-yun Lyu, Sun Myo Park, Bo Yun Choung, Won-bong ParkAbstract:A lectin (agglutinin, VCA) from Korean mistletoe (Viscum Album L.coloratum) was isolated by affinity chromatograpy on a asialofetuin-Sepharose 4B. The molecular weights of A-and B-chains of VCA were differenf from those of VAAS. The VCA recognized the antibody of VAAs in the Western blot analysis and ELLA system. We also investigated the synergistic effects of the components in mistletoe by dividing the extract into different molecular weight fractions.
Chang-eui Hong - One of the best experts on this subject based on the ideXlab platform.
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The antimutagenic effect of mistletoe lectin (Viscum Album L. var. coloratum agglutinin).
Phytotherapy research : PTR, 2011Co-Authors: Chang-eui Hong, Su-yun LyuAbstract:A galactose- and N-acetyl-D-galactosamine-specific lectin (Viscum Album L. var. coloratum agglutinin, VCA), which is known for its anticancer activity, was isolated from mistletoe. In this study, we investigated the antimutagenic potentials of VCA by using the pre-incubation method of the Ames test (Salmonella typhimurium TA98 and TA100) in the presence or absence of S9 mixture. Viscum Album L. var. coloratum agglutinin was assessed for its antimutagenic properties against the mutagens 2-aminoanthracene (2AA) and furylfuramide (AF-2) for strain TA98, and sodium azide (NaN3) and 2-aminoanthracene (2AA) for strain TA100. The concentrations used for this test compound were 100, 200 and 400 µg per plate. Viscum Album L. var. coloratum agglutinin showed moderate, but not negligible, protective effects regarding the antimutagenic properties against the direct-acting mutagens NaN3 and AF-2. Furthermore, VCA was more effective in preventing the mutagenicity of the indirect-acting mutagen 2-AA (in the presence of S9) when tested with both TA98 and TA100. In conclusion, this report has shown broad ranging antimutagenic effects of VCA to numerous mutagens in TA98 and TA100 Salmonella typhimurium strains. Although the data presented here cannot be applied in vivo, they can support other antimutagenic and anticarcinogenic findings for VCA. Copyright © 2011 John Wiley & Sons, Ltd.
Nazli Arda - One of the best experts on this subject based on the ideXlab platform.
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Antioxidant activity of Viscum Album ssp. Album.
Fitoterapia, 2006Co-Authors: Evren Onay-uçar, Ali Karagöz, Nazli ArdaAbstract:Methanolic extracts of Viscum Album ssp. Album (mistletoe) grown on different host trees were investigated for their potential antioxidant activity. Scavenging activity was tested by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and the inhibitory effect on lipid peroxidation was examined by ferric thiocyanate and thiobarbituric acid methods. The extract from mistletoe grown on lime tree in summer showed the highest activity. It was found that antioxidant capacity of the plant differed according to the harvesting time as well as the host tree.
