The Experts below are selected from a list of 32094 Experts worldwide ranked by ideXlab platform
Francois Busquet - One of the best experts on this subject based on the ideXlab platform.
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consensus report on the future of animal free systemic toxicity testing
ALTEX-Alternatives to Animal Experimentation, 2008Co-Authors: Marcel Leist, Nina Hasiwa, Tilman Gocht, Alan M. Goldberg, Mardas Daneshian, Ian Kimber, Harvey J. Clewell, Costanza Rovida, Francois BusquetAbstract:Since March 2013, animal use for cosmetics testing for the European market has been banned. This requires a renewed view on risk assessment in this field. However, in other fields as well, traditional animal experimentation does not always satisfy requirements in safety testing, as the need for human-relevant information is ever increasing. A general strategy for animal-free test approaches was outlined by the US National Research Council’s Vision Document for Toxicity Testing in the 21st Century in 2007. It is now possible to provide a more defined roadmap on how to implement this Vision for the four principal areas of systemic toxicity evaluation: repeat dose organ toxicity, carcinogenicity, reproductive toxicity and allergy induction (skin sensitization), as well as for the evaluation of toxicant metabolism (toxicokinetics) (Fig. 1). CAAT-Europe assembled experts from Europe, America and Asia to design a scientific roadmap for future risk assessment approaches and the outcome was then further discussed and refined in two consensus meetings with over 200 stakeholders. The key recommendations include: focusing on improving existing methods rather than favoring de novo design; combining hazard testing with toxicokinetics predictions; developing integrated test strategies; incorporating new high content endpoints to classical assays; evolving test validation procedures; promoting collaboration and data-sharing of different industrial sectors; integrating new disciplines, such as systems biology and high throughput screening; and involving regulators early on in the test development process. A focus on data quality, combined with increased attention to the scientific background of a test method, will be important drivers. Information from each test system should be mapped along adverse outcome pathways. Finally, quantitative information on all factors and key events will be fed into systems biology models that allow a probabilistic risk assessment with flexible adaptation to exposure scenarios and individual risk factors.
Van Vliet E - One of the best experts on this subject based on the ideXlab platform.
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current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century
ALTEX-Alternatives to Animal Experimentation, 2011Co-Authors: Van Vliet EAbstract:The National Academy of Sciences publication, Toxicity Testing in the 21st Century: A Vision and a Strategy, proposes a paradigm shift in toxicology from current animal-based testing towards the application of emerging technologies, i.e., assays based on human cells or non-mammalian models, high throughput testing, omics approaches, systems biology, and computational modeling. These technologies should be used to identify how chemicals interact with cellular response networks and alter them to toxicity pathways. According to the authors, such a new paradigm would provide a better scientific understanding and more adequate data to predict the adverse effects of chemicals on human health. As expected from a Vision Document, the report enthusiastically and optimistically describes a radical transformation of toxicology from current practices to a new approach. Several toxicologists have commented on the report, and although they generally confirm the importance of the Vision, they pose critical questions regarding its feasibility. Unlike the theoretical concepts, which are carefully described, many practical aspects of how to establish the Vision are less well defined. Today's technologies provide great opportunities, although many challenges remain regarding their development, implementation, and validation to adequately assess human health effects. To bring the enVisioned toxicology closer to concrete implementation, it is important to identify the current knowledge gaps in the Vision and develop solutions. The goal of this review is to evaluate the technologies proposed as to their maturation to transform toxicity testing in the 21st century. This paper will provide an overview of the current standing by defining advantages, limitations, and developmental needs. In doing so, I do not intend to point out obstacles but, rather, to focus on current opportunities to advance toxicity testing for human risk assessment.
Marcel Leist - One of the best experts on this subject based on the ideXlab platform.
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consensus report on the future of animal free systemic toxicity testing
ALTEX-Alternatives to Animal Experimentation, 2008Co-Authors: Marcel Leist, Nina Hasiwa, Tilman Gocht, Alan M. Goldberg, Mardas Daneshian, Ian Kimber, Harvey J. Clewell, Costanza Rovida, Francois BusquetAbstract:Since March 2013, animal use for cosmetics testing for the European market has been banned. This requires a renewed view on risk assessment in this field. However, in other fields as well, traditional animal experimentation does not always satisfy requirements in safety testing, as the need for human-relevant information is ever increasing. A general strategy for animal-free test approaches was outlined by the US National Research Council’s Vision Document for Toxicity Testing in the 21st Century in 2007. It is now possible to provide a more defined roadmap on how to implement this Vision for the four principal areas of systemic toxicity evaluation: repeat dose organ toxicity, carcinogenicity, reproductive toxicity and allergy induction (skin sensitization), as well as for the evaluation of toxicant metabolism (toxicokinetics) (Fig. 1). CAAT-Europe assembled experts from Europe, America and Asia to design a scientific roadmap for future risk assessment approaches and the outcome was then further discussed and refined in two consensus meetings with over 200 stakeholders. The key recommendations include: focusing on improving existing methods rather than favoring de novo design; combining hazard testing with toxicokinetics predictions; developing integrated test strategies; incorporating new high content endpoints to classical assays; evolving test validation procedures; promoting collaboration and data-sharing of different industrial sectors; integrating new disciplines, such as systems biology and high throughput screening; and involving regulators early on in the test development process. A focus on data quality, combined with increased attention to the scientific background of a test method, will be important drivers. Information from each test system should be mapped along adverse outcome pathways. Finally, quantitative information on all factors and key events will be fed into systems biology models that allow a probabilistic risk assessment with flexible adaptation to exposure scenarios and individual risk factors.
Rao Farman Ali - One of the best experts on this subject based on the ideXlab platform.
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Vision Document department of education district anantnag
Social Science Research Network, 2010Co-Authors: Rao Farman AliAbstract:Vision is defined as desired or intended future state of an organization or enterprise or department in terms of its fundamental objective and/or strategic direction. Vision is a long term view, sometimes describing how the parent organization or department would like the world in which it operates to be. For example a charity working with the poor might have a Vision statement which read "A world without poverty".The Vision helps in developing strategic planning and guides in shaping the programs and activities which will contribute to the accomplishment of desired future state of affairs in the given area to which the Vision pertains.During the recent past state and central governments have been seriously unveiling various programs, schemes and steps to ensure the universalization of education throughout the country. Extraordinary measures are being taken to handle various challenges like teaching methodologies, infrastructure, recruitment of qualified teachers, planning and linking the village school system with community for grassroots level monitoring and superVision of a village school. ProVision of quality Elementary Education to all children up to the age of 14 years prompted education planners to design and implement an effective education Vision plan to achieve the goal of Universalisation of Elementary Education within a given time frame and through a definite route and strategy.As a result of various consultations facilitated under the EU, DFID and Save the Children supported programme in district Anantnag, the officials of department of education and the project staff of JKYT have decided to work together to develop Education Vision plan at district level. One of the gaps which have been figured out as a result of various internal meetings and forums is there is absence of an overall Vision in the area of education not only in Jammu and Kashmir but perhaps in entire country. With the result of these, Anantnag will be leading in the area of developing an education specific Vision and strategy. Once agreed and adopted by the department, this Vision will become a guiding Document for shaping the future programs in education in the district Anantnag and will go long way in improving the state of education in the district. With the publication of this Document, Anantnag will be setting an example in looking at the education sector in terms of long term planning which will cascade in annual and perspective planning of education in the district. The Vision envisages in bringing positive changes through educational system. There is no second thought among the policy makers and general public that investment in education is the only way forward for overcoming various challenges human societies face from across the globe. Education helps in polishing human resources and helps in securing a better tomorrow for one and all irrespective of the caste, color, language, sex and religion.Major objectives of developing this Vision Document have been following;i) To generate a common perspective, among diverse stakeholders, for the holistic development of the Educational System in the district especially in the domain of Quality Education.ii) To work out a strategy for the optimal and balanced utilization of the available resources.iii) To bring the socially excluded sections in the fold of educational system through formulating a need based plan on an individual basis.iv) To enhance the role of community in the sense that it instills the wisdom of ownership among them.
Nina Hasiwa - One of the best experts on this subject based on the ideXlab platform.
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consensus report on the future of animal free systemic toxicity testing
ALTEX-Alternatives to Animal Experimentation, 2008Co-Authors: Marcel Leist, Nina Hasiwa, Tilman Gocht, Alan M. Goldberg, Mardas Daneshian, Ian Kimber, Harvey J. Clewell, Costanza Rovida, Francois BusquetAbstract:Since March 2013, animal use for cosmetics testing for the European market has been banned. This requires a renewed view on risk assessment in this field. However, in other fields as well, traditional animal experimentation does not always satisfy requirements in safety testing, as the need for human-relevant information is ever increasing. A general strategy for animal-free test approaches was outlined by the US National Research Council’s Vision Document for Toxicity Testing in the 21st Century in 2007. It is now possible to provide a more defined roadmap on how to implement this Vision for the four principal areas of systemic toxicity evaluation: repeat dose organ toxicity, carcinogenicity, reproductive toxicity and allergy induction (skin sensitization), as well as for the evaluation of toxicant metabolism (toxicokinetics) (Fig. 1). CAAT-Europe assembled experts from Europe, America and Asia to design a scientific roadmap for future risk assessment approaches and the outcome was then further discussed and refined in two consensus meetings with over 200 stakeholders. The key recommendations include: focusing on improving existing methods rather than favoring de novo design; combining hazard testing with toxicokinetics predictions; developing integrated test strategies; incorporating new high content endpoints to classical assays; evolving test validation procedures; promoting collaboration and data-sharing of different industrial sectors; integrating new disciplines, such as systems biology and high throughput screening; and involving regulators early on in the test development process. A focus on data quality, combined with increased attention to the scientific background of a test method, will be important drivers. Information from each test system should be mapped along adverse outcome pathways. Finally, quantitative information on all factors and key events will be fed into systems biology models that allow a probabilistic risk assessment with flexible adaptation to exposure scenarios and individual risk factors.
