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M. Kirchgessner - One of the best experts on this subject based on the ideXlab platform.
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Über die Vitamin‐B6‐Versorgung wachsender Schweine
Zeitschrift für Tierphysiologie Tierernährung und Futtermittelkunde, 2009Co-Authors: H. Friesecke, M. KirchgessnerAbstract:Zusammenfassung Um die Vitamin-B6-Versorgung wachsender Schweine bei Verfutterung verschiedener Mastrationen zu untersuchen, bestimmten wir in einer Anzahl Futtermittel den Vitamin-B6-Gehalt. Dabei ergab sich, das der minimale Vitamin-B6-Gehalt immer gedeckt sein durfte. Schweinemastfertigfutter bzw. Futterrationen mit Mais, Milocorn und Muhlennachprodukten als Sattfutter sichern zumeist optimale Vitamin-B6-Zufuhr. Suboptimale Vitamin-B6-Versorgung ist jedoch vor allem dann moglich, wenn neben Fischmehl oder Eiweiskonzentrat ein Sattfutter aus Gerste mit oder ohne Beimischung von Tapiokamehl verwendet wird.
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Effects of Vitamin B6 supplementation in rats during lactation on Vitamin B6 concentration and transaminase activities in the offspring.
Archiv fur Tierernahrung, 2000Co-Authors: Dora A. Roth-maier, Susanne I. Kettler, J. Benedikt, M. KirchgessnerAbstract:The aim of the present investigation was to study the effect of a varying maternal Vitamin B6 supplementation during lactation period on Vitamin B6 levels in blood, liver and total body, and on the activity of two transaminase enzymes in the offspring. Therefore, eighty female Sprague-Dawley rats were fed a semi-synthetic diet (0.2 mg Vitamin B6 per kg) which was supplemented during gravidity with 5 mg Vitamin B6 per kg diet. During the following lactation period the rats were assigned to one of 10 Vitamin B6 treatment groups (supplementation of 0, 3, 6, 9, 12, 15, 18, 36, 360, 3600 mg Vitamin B6 per kg diet). At day 14 of lactation the pubs of all dams were decapitated and blood, liver, and carcass were used for analysis of Vitamin B6 concentration, activities of two transaminases, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in plasma, erythrocytes, and liver, and of haematological parameters. While the liver and total body wet weights as well as the haematological parameters (red blood cells, haemoglobin concentration, hematocrit, middle corpuscular cell volume, middle corpuscular haemoglobin, middle corpuscular haemoglobin concentration) did not differ within the experimental groups, the present data clearly show that in blood, liver and total body of the offspring exists a slight dose-response relationship between the maternal dietary Vitamin B6 supplementation and the Vitamin B6 concentration. Concerning the activities of the transaminases a dietary supplementation above 3 mg Vitamin B6 per kg diet had no influence on the AST and ALT activities in offspring plasma. In the erythrocytes no statistical significant influence of the Vitamin B6 supplementation during lactation on the activities of AST and ALT was found. The activities of ALT and AST in liver were not consistently altered by the Vitamin B6 supplementation of the dams during lactation. In conclusion these results indicate that a minimal maternal dietary Vitamin B6 supply of 3.1 mg per kg diet is necessary with regard to health and development of their offspring. But not all of the analysed parameters as the liver and total body weights, the activities of AST and ALT in the erythrocytes, and the haematological parameters were influenced by a deficient maternal dietary Vitamin B6 supply.
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Zum einfluss von weizenkleie‐ und grünmehlzulagen auf den Vitamin‐B6‐ stoffwechsel von sauen mit suboptimaler Vitamin‐B6‐versorgung
Archiv fur Tierernahrung, 1997Co-Authors: Dora A. Roth-maier, M. KirchgessnerAbstract:The aim of these investigations was to examine the influence of "natural fibrous feedstuffs" as wheat bran and alfalfa meal on criteria of Vitamin B6 metabolism of adult sows subjected to a low Vitamin B6 supply. Two experiments were conducted in two periods with 12 sows (180 kg BW) and 3 groups each. The supplements were in the first experiment 0 g, 225 g and 675 g wheat bran, and in the second experiment 0 g, 575 g and 1150 g alfalfa meal to a compound feed, low in Vitamin B6 content. The criteria were fecal and urinary Vitamin B6 concentration and excretion, Vitamin B6 concentration in blood, hematological criteria, activity of aspartate aminotransferase in erythrocytes (EAST) and xanthurenic acid excretion in the tryptophan load test. Vitamin B6 concentration in feces amounted 10-12 micrograms/g DM and was neither influenced by quality or amount of the fibrous products. Vitamin B6 excretion was increased by each supplement and 60-70% of Vitamin B6 was excreted via feces. Fecal Vitamin B6 excretion was enlarged linearly by increasing fibrous supplementation. Bacterially fermentable substrates from wheat bran induced a higher bacterial Vitamin B6 synthesis compared to cellulose.
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Effect of feeding various dietary Vitamin B6 concentrations during gestation and lactation on Vitamin B6 level in liver and carcass of rat dams.
Archiv fur Tierernahrung, 1996Co-Authors: Dora A. Roth-maier, J. Benedikt, Gabriele I. Stangl, M. KirchgessnerAbstract:The present investigation was designed to determine the Vitamin B6 concentration in liver and carcass of rat dams fed various dietary Vitamin B6 levels during gestation and lactation. Therefore, gravid female rats received 0.6, 3, 6, 18 or 180 mg Vitamin B6 per kg diet. After parturition each group was divided into 2 groups of 8 dams each, which received then a diet with 3, respectively 6 mg/kg Vitamin B6 during lactation. At the end of the experiment at day 14 of lactation weight gain and food consumption as well as liver and carcass weights did not differ within the groups. The present data clearly show that both in liver and carcass of lactating rats, there exists only a slight dose-response-relationship between the dietary Vitamin B6 intake and the Vitamin B6 concentration in body tissue. Moreover, liver reflects the various Vitamin B6 supplies during gestation and lactation somewhat better than carcass. The distribution of the Vitamins did not differ among the groups and was therefore independent of the Vitamin B6 supply. The present findings, especially regarding the liver, elucidate, that an adequate Vitamin B6 supply during lactation can not compensate for a lack of Vitamin B6 during gestation and vice versa a high dose of Vitamin B6 during gestation did not completely protect against a suboptimal Vitamin B6 during lactation.
Ebba Nexo - One of the best experts on this subject based on the ideXlab platform.
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Vitamin B6 Level Is Associated with Symptoms of Depression
Psychotherapy and Psychosomatics, 2004Co-Authors: Anne-mette Hvas, Svend Juul, Per Bech, Ebba NexoAbstract:Background: A low level of Vitamin B6 might theoretically cause depression as Vitamin B6 is a cofactor in the tryptophan-serotonin pathway. In the present stud
Lorenzo Galluzzi - One of the best experts on this subject based on the ideXlab platform.
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prognostic impact of Vitamin B6 metabolism in lung cancer
Cell Reports, 2012Co-Authors: Lorenzo Galluzzi, Ilio Vitale, Laura Senovilla, Ken A OlaussenAbstract:Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified Vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo. By aggravating a bioenergetic catastrophe that involves the depletion of intracellular glutathione, Vitamin B6 exacerbates cisplatin-mediated DNA damage, thus sensitizing a large panel of cancer cell lines to apoptosis. Moreover, Vitamin B6 sensitizes cancer cells to apoptosis induction by distinct types of physical and chemical stress, including multiple chemotherapeutics. This effect requires pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of Vitamin B6. In line with a general role of Vitamin B6 in stress responses, low PDXK expression levels were found to be associated with poor disease outcome in two independent cohorts of patients with NSCLC. These results indicate that PDXK expression levels constitute a biomarker for risk stratification among patients with NSCLC.
Anne-mette Hvas - One of the best experts on this subject based on the ideXlab platform.
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Vitamin B6 Level Is Associated with Symptoms of Depression
Psychotherapy and Psychosomatics, 2004Co-Authors: Anne-mette Hvas, Svend Juul, Per Bech, Ebba NexoAbstract:Background: A low level of Vitamin B6 might theoretically cause depression as Vitamin B6 is a cofactor in the tryptophan-serotonin pathway. In the present stud
E. R. Smith - One of the best experts on this subject based on the ideXlab platform.
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Vitamin B6 levels in premenstrual syndrome
Journal of Psychosomatic Obstetrics & Gynecology, 1991Co-Authors: C. J. Chuong, E. B. Dawson, E. R. SmithAbstract:To determine whether changes in peripheral Vitamin B6 levels are associated with symptoms of premenstrual syndrome (PMS), ten PMS patients and ten controls were studied. They gave blood at 2- or 3-day intervals through three menstrual cycles. The Vitamin B6 was measured by fluorometry after the serum was heated with semicarbazide, and luteinizing hormone (LH) was measured by radioimmunoassay. In the controls, Vitamin B6 values were 15.3 ± 3.0 μg/dl (mean ± SEM) during the luteal phase, and 14.2 ± 3.0 μg/dl during the follicular phase. No significant changes were noted between the two values. In the patients, the values were 14.7 ± 1.9 μg/dl during the luteal phase which was not significantly different from 15.4 ± 3.3 μg/dl during the follicular phase. No significant changes were noted between the controls and the patients in either the luteal or the follicular phase. Although it remains possible that Vitamin B6 deficiency may exist in a subgroup of PMS patients, its deficiency was not demonstrated by peri...
