Vitamin D Metabolism

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Marie A Caudill - One of the best experts on this subject based on the ideXlab platform.

  • placental Vitamin D Metabolism anD its associations with circulating Vitamin D metabolites in pregnant women
    The American Journal of Clinical Nutrition, 2017
    Co-Authors: Heyjun Park, Madeleine R Wood, Olga V Malysheva, Sara Jones, Saurabh Mehta, Patsy M Brannon, Marie A Caudill
    Abstract:

    BackgrounD: Little is known about placental Vitamin D Metabolism anD its impact on maternal circulating Vitamin D concentrations in humans. Objective: This stuDy sought to aDvance the current unDerstanDing of placental Vitamin D Metabolism anD its role in moDulating maternal circulating Vitamin D metabolites During pregnancy. Design: NesteD within a feeDing stuDy, 24 healthy pregnant women (26–29 wk of gestation) consumeD a single amount of Vitamin D (511 IU/D from Diet anD a cholecalciferol supplement) for 10 wk. Concentrations of placental anD blooD Vitamin D metabolites anD placental messenger RNA (mRNA) abunDance of Vitamin D metabolic pathway components were quantifieD. In aDDition, cultureD human trophoblasts were incubateD with 13C-cholecalciferol to examine the intracellular generation anD secretion of Vitamin D metabolites along with the regulation of target genes. Results: In placental tissue, 25-hyDroxyVitamin D3 [25(OH)D3] was strongly correlateD (r = 0.83, P < 0.001) with 24,25-DihyDroxyVitamin D3. Moreover, these placental metabolites were strongly correlateD (r ≤ 0.85, P ≤ 0.04) with their respective metabolites in maternal circulation. Positive associations (P ≤ 0.045) were also observeD between placental mRNA abunDance of Vitamin D metabolic components anD circulating Vitamin D metabolites [i.e., LDL-relateD protein 2 (LRP2, also known as megalin) with 25(OH)D3 anD the C3 epimer of 25(OH)D3 [3-epi-25(OH)D3]; cubilin (CUBN) with 25(OH)D3; 25-hyDroxylase (CYP2R1) with 3-epi-25(OH)D3; 24-hyDroxylase (CYP24A1) with 25(OH)D3, 3-epi-25(OH)D3, anD 1,25-DihyDroxyVitamin D3 [1,25(OH)2D3]; anD 1α-hyDroxylase [(CYP27B1) with 3-epi-25(OH)D3 anD 1,25(OH)2D3]. Notably, in vitro experiments with trophoblasts showeD increaseD proDuction anD secretion of 25(OH)D3 anD higher CYP24A1 gene transcript abunDance in response to cholecalciferol treatment. Conclusions: The numerous associations of many of the placental biomarkers of Vitamin D Metabolism with circulating Vitamin D metabolites among pregnant women [incluDing a CYP27B1–associateD increase in 1,25(OH)2D3] anD the eviDence of trophoblast proDuction anD secretion of Vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in moDulating the Vitamin D metabolite profile in maternal circulation in human pregnancy. This trial was registereD at clinicaltrials.gov as {"type":"clinical-trial","attrs":{"text":"NCT03051867","term_iD":"NCT03051867"}}NCT03051867.

Daniel A Enquobahrie - One of the best experts on this subject based on the ideXlab platform.

Raymond Hupperts - One of the best experts on this subject based on the ideXlab platform.

  • fok i Vitamin D receptor gene polymorphism rs10735810 anD Vitamin D Metabolism in multiple sclerosis
    Journal of Neuroimmunology, 2009
    Co-Authors: Joost Smolders, Jan Damoiseaux, Paul P C A Menheere, Jan Willem Cohen Tervaert, Raymond Hupperts
    Abstract:

    Abstract Multiple sclerosis (MS) has been associateD with low levels of 25-hyDroxyVitamin D (25(OH)D). Several genetic polymorphisms of the Vitamin D receptor gene (VDRG), of whom Fok-I (rs10735810) has functional consequences for receptor protein structure anD the immune system, have been stuDieD in relation to MS with variable results. The purpose of our stuDy was to assess an association of the Fok-I VDRG polymorphism with MS, anD to further unravel the interaction of this polymorphism with Vitamin D Metabolism. Therefore, we genotypeD 212 MS patients anD 289 healthy controls for the Fok-I polymorphism anD DetermineD levels of the Vitamin D metabolites 25(OH)D anD 1,25(OH) 2 D. No association of the Fok-I VDRG polymorphism with MS was founD. The F-allele was associateD with lower winter anD summer serum 25(OH)D levels in our MS patients, anD with lower 25(OH)D levels in healthy controls. Remarkably, the F-allele corresponDeD with higher 1,25(OH) 2 D levels in MS patients. In all groups, carriers of the F-allele haD higher 1,25(OH) 2 D/ 25(OH)D-ratios compareD to their f-allele counterparts. In conclusion, we DemonstrateD the importance of the Fok-I VDRG polymorphism for Vitamin D Metabolism. This shoulD be taken into account in association anD ultimately intervention stuDies on Vitamin D anD MS.

Heyjun Park - One of the best experts on this subject based on the ideXlab platform.

  • placental Vitamin D Metabolism anD its associations with circulating Vitamin D metabolites in pregnant women
    The American Journal of Clinical Nutrition, 2017
    Co-Authors: Heyjun Park, Madeleine R Wood, Olga V Malysheva, Sara Jones, Saurabh Mehta, Patsy M Brannon, Marie A Caudill
    Abstract:

    BackgrounD: Little is known about placental Vitamin D Metabolism anD its impact on maternal circulating Vitamin D concentrations in humans. Objective: This stuDy sought to aDvance the current unDerstanDing of placental Vitamin D Metabolism anD its role in moDulating maternal circulating Vitamin D metabolites During pregnancy. Design: NesteD within a feeDing stuDy, 24 healthy pregnant women (26–29 wk of gestation) consumeD a single amount of Vitamin D (511 IU/D from Diet anD a cholecalciferol supplement) for 10 wk. Concentrations of placental anD blooD Vitamin D metabolites anD placental messenger RNA (mRNA) abunDance of Vitamin D metabolic pathway components were quantifieD. In aDDition, cultureD human trophoblasts were incubateD with 13C-cholecalciferol to examine the intracellular generation anD secretion of Vitamin D metabolites along with the regulation of target genes. Results: In placental tissue, 25-hyDroxyVitamin D3 [25(OH)D3] was strongly correlateD (r = 0.83, P < 0.001) with 24,25-DihyDroxyVitamin D3. Moreover, these placental metabolites were strongly correlateD (r ≤ 0.85, P ≤ 0.04) with their respective metabolites in maternal circulation. Positive associations (P ≤ 0.045) were also observeD between placental mRNA abunDance of Vitamin D metabolic components anD circulating Vitamin D metabolites [i.e., LDL-relateD protein 2 (LRP2, also known as megalin) with 25(OH)D3 anD the C3 epimer of 25(OH)D3 [3-epi-25(OH)D3]; cubilin (CUBN) with 25(OH)D3; 25-hyDroxylase (CYP2R1) with 3-epi-25(OH)D3; 24-hyDroxylase (CYP24A1) with 25(OH)D3, 3-epi-25(OH)D3, anD 1,25-DihyDroxyVitamin D3 [1,25(OH)2D3]; anD 1α-hyDroxylase [(CYP27B1) with 3-epi-25(OH)D3 anD 1,25(OH)2D3]. Notably, in vitro experiments with trophoblasts showeD increaseD proDuction anD secretion of 25(OH)D3 anD higher CYP24A1 gene transcript abunDance in response to cholecalciferol treatment. Conclusions: The numerous associations of many of the placental biomarkers of Vitamin D Metabolism with circulating Vitamin D metabolites among pregnant women [incluDing a CYP27B1–associateD increase in 1,25(OH)2D3] anD the eviDence of trophoblast proDuction anD secretion of Vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in moDulating the Vitamin D metabolite profile in maternal circulation in human pregnancy. This trial was registereD at clinicaltrials.gov as {"type":"clinical-trial","attrs":{"text":"NCT03051867","term_iD":"NCT03051867"}}NCT03051867.

Tsegaselassie Workalemahu - One of the best experts on this subject based on the ideXlab platform.

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