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W. Wuttke - One of the best experts on this subject based on the ideXlab platform.
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Der Stellenwert des Mönchspfeffers (Vitex Agnus-Castus) in der gynäkologischen Endokrinologie
2011Co-Authors: W. Wuttke, H. Jarry, D. Seidlová-wuttke, Natalya ArtymukAbstract:The status of chaste tree ( Vitex Agnus-Castus) in gynaecological endocrinology Extracts of the dried fruits of the chaste tree ( Vitex Agnus-Castus, VAC) contain dopaminergic compounds which are inhibitory to pituitary prolactin release. The development of premenstrual mastalgia as well as of fibrocystic breast changes involves an action of prolactin. Hence, treatment with VAC is helpful to prevent these mammary gland symptoms. Prolactin is also involved in the function of the corpus luteum and patients with a latent hyperprolactinemia often suffer from a corpus luteum insufficiency where treatment with VAC extracts may also be helpful to improve fertility.
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Vitex Agnus Castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation.
Phytotherapy Research, 2008Co-Authors: Stephan Sehmisch, W. Wuttke, D. Seidlová-wuttke, J. Boeckhoff, J. Wille, T. Rack, M. Tezval, K. M. Stuermer, Ewa Klara StuermerAbstract:Osteoporosis research undertaken in males is rare and there are only a few therapeutic options. Phytoestrogens might be a safe alternative for prophylaxis. Sixty 3-month-old male rats were orchidectomized and divided into five groups. The groups either received soy-free food (C), estradiol (E), testosterone (T) or Vitex Agnus Castus in different concentrations (AC high/AC low) for 12 weeks. The tibia metaphysis was tested biomechanically and histomorphometrically. The AC high group reached 87% of the biomechanical values of the estradiol group and was significantly superior to the control group. Testosterone supplementation resulted in poor biomechanical properties. The cortical bone parameters of the AC group were similar to the control group, while supplementation with estradiol and testosterone demonstrated a reduction of cortical bone. The AC high group reached 88.4% of trabecular bone area, 80.7% of trabecular number and 66.9% of the number of trabecular nodes compared with estradiol supplementation. Vitex Agnus Castus demonstrated osteoprotective effects in males. It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT. Testosterone supplementation has positive effects on trabecular bone, which are concurrently counteracted by the loss of cortical bone.
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Extrakte aus Mönchspfeffer (Vitex Agnus Castus)
Gynäkologische Endokrinologie, 2008Co-Authors: W. Wuttke, H. Jarry, D. Seidlová-wuttke, T. Devyatchenko, O. Pogodin, S.a. LevenetsAbstract:Vitex Agnus Castus extracts contain dopaminergic compounds which, chemically speaking, belong to the diterpenes. They have mild D_2 receptor agonistic properties that are able to inhibit latent hyperprolactinemia. Latent hyperprolactinemia may be the cause of premenstrual mastodynia and corpus luteum defects. Similar results were obtained with synthetic dopaminergic drugs; however, these drugs have severe side effects, whereas no adverse effects were observed under treatment with Vitex Agnus Castus extracts. Extrakte aus Vitex Agnus Castus enthalten dopaminerge Verbindungen, die chemisch zu den Diterpenen gehören. Sie besitzen leichte D_2-Rezeptor-agonistische Eigenschaften, die eine latente überschießende Prolaktinsekretion inhibieren können. Eine latente Hyperprolaktinämie kann die Ursache für eine prämenstruelle Mastodynie und für eine Corpus-luteum-Insuffizienz sein. Ähnliche Ergebnisse wurden mit synthetischen dopaminergen Medikamenten erzielt, die allerdings schwerwiegende Nebenwirkungen haben. Unter der Behandlung mit Extrakten aus Vitex Agnus Castus dagegen wurden keinerlei unerwünschte Wirkungen beobachtet.
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Extrakte aus Mönchspfeffer (Vitex Agnus Castus)
Gynäkologische Endokrinologie, 2008Co-Authors: W. Wuttke, H. Jarry, D. Seidlová-wuttke, T. Devyatchenko, O. Pogodin, S.a. LevenetsAbstract:Extrakte aus Vitex Agnus Castus enthalten dopaminerge Verbindungen, die chemisch zu den Diterpenen gehoren. Sie besitzen leichte D2-Rezeptor-agonistische Eigenschaften, die eine latente uberschiesende Prolaktinsekretion inhibieren konnen. Eine latente Hyperprolaktinamie kann die Ursache fur eine pramenstruelle Mastodynie und fur eine Corpus-luteum-Insuffizienz sein. Ahnliche Ergebnisse wurden mit synthetischen dopaminergen Medikamenten erzielt, die allerdings schwerwiegende Nebenwirkungen haben. Unter der Behandlung mit Extrakten aus Vitex Agnus Castus dagegen wurden keinerlei unerwunschte Wirkungen beobachtet.
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Chaste tree (Vitex Agnus-Castus) – Pharmacology and clinical indications
Phytomedicine, 2004Co-Authors: W. Wuttke, H. Jarry, V. Christoffel, B. Spengler, D. Seidlová-wuttkeAbstract:Extracts of the fruits of chaste tree (Vitex Agnus Castus = AC) are widely used to treat premenstrual symptoms. Double-blind placebo-controlled studies indicate that one of the most common premenstrual symptoms, i.e. premenstrual mastodynia (mastalgia) is beneficially influenced by an AC extract. In addition, numerous less rigidly controlled studies indicate that AC extracts have also beneficial effects on other psychic and somatic symptoms of the PMS. Premenstrual mastodynia is most likely due to a latent hyperprolactinemia, i.e. patients release more than physiologic amounts of prolactin in response to stressful situations and during deep sleep phases which appear to stimulate the mammary gland. Premenstrually this unphysiological prolactin release is so high that the serum prolactin levels often approach heights which are misinterpreted as prolactinomas. Since AC extracts were shown to have beneficial effects on premenstrual mastodynia serum prolactin levels in such patients were also studied in one double-blind, placebo-controlled clinical study. Serum prolactin levels were indeed reduced in the patients treated with the extract. The search for the prolactin-suppressive principle(s) yielded a number of compounds with dopaminergic properties: they bound to recombinant DA2-receptor protein and suppressed prolactin release from cultivated lactotrophs as well as in animal experiments. The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects. They were almost identical in their prolactin-suppressive properties than dopamine itself. Hence, it is concluded that dopaminergic compounds present in Vitex Agnus Castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome.
Dana Seidlovawuttke - One of the best experts on this subject based on the ideXlab platform.
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chaste tree Vitex Agnus Castus pharmacology and clinical indications
Phytomedicine, 2003Co-Authors: W. Wuttke, H. Jarry, V. Christoffel, B. Spengler, Dana SeidlovawuttkeAbstract:Extracts of the fruits of chaste tree (Vitex Agnus Castus = AC) are widely used to treat premenstrual symptoms. Double-blind placebo-controlled studies indicate that one of the most common premenstrual symptoms, i.e. premenstrual mastodynia (mastalgia) is beneficially influenced by an AC extract. In addition, numerous less rigidly controlled studies indicate that AC extracts have also beneficial effects on other psychic and somatic symptoms of the PMS. Premenstrual mastodynia is most likely due to a latent hyperprolactinemia, i.e. patients release more than physiologic amounts of prolactin in response to stressful situations and during deep sleep phases which appear to stimulate the mammary gland. Premenstrually this unphysiological prolactin release is so high that the serum prolactin levels often approach heights which are misinterpreted as prolactinomas. Since AC extracts were shown to have beneficial effects on premenstrual mastodynia serum prolactin levels in such patients were also studied in one double-blind, placebo-controlled clinical study. Serum prolactin levels were indeed reduced in the patients treated with the extract. The search for the prolactin-suppressive principle(s) yielded a number of compounds with dopaminergic properties: they bound to recombinant DA2-receptor protein and suppressed prolactin release from cultivated lactotrophs as well as in animal experiments. The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects. They were almost identical in their prolactin-suppressive properties than dopamine itself. Hence, it is concluded that dopaminergic compounds present in Vitex Agnus Castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome.
F S Revazova - One of the best experts on this subject based on the ideXlab platform.
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Vitex Agnus Castus successful treatment of moderate to severe premenstrual syndrome
Maturitas, 2006Co-Authors: V N Prilepskaya, A V Ledina, A V Tagiyeva, F S RevazovaAbstract:Objectives: To assess efficacy and tolerability of a special extract of Vitex Agnus Castus (VAC, BNO 1095) in the treatment of women suffering from premenstrual syndrome (PMS) with moderate to severe complaints. Methods: Prospective, open, non-comparative, monocentre study. After a run-in phase lasting three cycles, eligible patients were treated for up to three cycles with VAC extract. Efficacy was assessed using a PMS-Diary (primarily) and the PMTS score. Results: One hundred and twenty-one patients were enrolled, 118 provided efficacy data (full analysis set), and 109 completed the treatment phase. The severity of the PMS symptoms consistently decreased during treatment, on average from 22.8 score points during the baseline cycle to 10.2 during the third cycle. The mean decrease was 12.6 score points (95% CI: 10.9-14.4, p<0.0001, Student's t-test). Response to treatment was found in 67.8% of the women during the third treatment cycle (95% CI: 58.6-77.0). Results for the PMTS were similar with a decrease on average from 22.5 to 11.0 score points, i.e. mean change -11.4 (95% CI: 10.1-12.8, p<0.0001). Conclusion: Vitex Agnus Castus extract BNO 1095 is effective and well tolerated in the treatment of moderate to severe PMS.
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Vitex Agnus Castus: Successful treatment of moderate to severe premenstrual syndrome
Maturitas, 2006Co-Authors: V N Prilepskaya, A V Ledina, A V Tagiyeva, F S RevazovaAbstract:Objectives: To assess efficacy and tolerability of a special extract of Vitex Agnus Castus (VAC, BNO 1095) in the treatment of women suffering from premenstrual syndrome (PMS) with moderate to severe complaints. Methods: Prospective, open, non-comparative, monocentre study. After a run-in phase lasting three cycles, eligible patients were treated for up to three cycles with VAC extract. Efficacy was assessed using a PMS-Diary (primarily) and the PMTS score. Results: One hundred and twenty-one patients were enrolled, 118 provided efficacy data (full analysis set), and 109 completed the treatment phase. The severity of the PMS symptoms consistently decreased during treatment, on average from 22.8 score points during the baseline cycle to 10.2 during the third cycle. The mean decrease was 12.6 score points (95% CI: 10.9-14.4, p
Chlodwig Franz - One of the best experts on this subject based on the ideXlab platform.
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essential oil composition of Vitex Agnus Castus comparison of accessions and different plant organs
Flavour and Fragrance Journal, 2005Co-Authors: Johannes Novak, Leopold Draxler, Irina Göhler, Chlodwig FranzAbstract:Leaves, immature and mature fruits of seven different accessions of chaste tree (Vitex Agnus-Castus L., Verbenaceae), cultivated at one location, were analysed for their essential oil composition. The main compounds of the essential oil were 1,8-cineole, sabinene, α-pinene, β-phellandrene and α-terpinyl acetate, trans-β-farnesene and bicyclogermacrene. Although the same compounds were present in all plant organs, the leaves differed from the fruits in the concentrations of all compounds except α-terpinyl acetate and manoyl-oxide. The compositions of immature and mature fruits were equal. Two distinct chemotypes (an α-pinene chemotype and an α-terpinyl acetate chemotype) could be identified in Vitex Agnus-Castus. Both chemotypes occurred between as well within accessions. The differences between the accessions were based mainly on the occurrence of these chemotypes in accessions and the frequency of their occurrence within accessions. Copyright © 2004 John Wiley & Sons, Ltd.
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Essential oil composition of Vitex Agnus‐Castus —comparison of accessions and different plant organs
Flavour and Fragrance Journal, 2004Co-Authors: Johannes Novak, Leopold Draxler, Irina Göhler, Chlodwig FranzAbstract:Leaves, immature and mature fruits of seven different accessions of chaste tree (Vitex Agnus-Castus L., Verbenaceae), cultivated at one location, were analysed for their essential oil composition. The main compounds of the essential oil were 1,8-cineole, sabinene, α-pinene, β-phellandrene and α-terpinyl acetate, trans-β-farnesene and bicyclogermacrene. Although the same compounds were present in all plant organs, the leaves differed from the fruits in the concentrations of all compounds except α-terpinyl acetate and manoyl-oxide. The compositions of immature and mature fruits were equal. Two distinct chemotypes (an α-pinene chemotype and an α-terpinyl acetate chemotype) could be identified in Vitex Agnus-Castus. Both chemotypes occurred between as well within accessions. The differences between the accessions were based mainly on the occurrence of these chemotypes in accessions and the frequency of their occurrence within accessions. Copyright © 2004 John Wiley & Sons, Ltd.
H. Jarry - One of the best experts on this subject based on the ideXlab platform.
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Der Stellenwert des Mönchspfeffers (Vitex Agnus-Castus) in der gynäkologischen Endokrinologie
2011Co-Authors: W. Wuttke, H. Jarry, D. Seidlová-wuttke, Natalya ArtymukAbstract:The status of chaste tree ( Vitex Agnus-Castus) in gynaecological endocrinology Extracts of the dried fruits of the chaste tree ( Vitex Agnus-Castus, VAC) contain dopaminergic compounds which are inhibitory to pituitary prolactin release. The development of premenstrual mastalgia as well as of fibrocystic breast changes involves an action of prolactin. Hence, treatment with VAC is helpful to prevent these mammary gland symptoms. Prolactin is also involved in the function of the corpus luteum and patients with a latent hyperprolactinemia often suffer from a corpus luteum insufficiency where treatment with VAC extracts may also be helpful to improve fertility.
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Extrakte aus Mönchspfeffer (Vitex Agnus Castus)
Gynäkologische Endokrinologie, 2008Co-Authors: W. Wuttke, H. Jarry, D. Seidlová-wuttke, T. Devyatchenko, O. Pogodin, S.a. LevenetsAbstract:Vitex Agnus Castus extracts contain dopaminergic compounds which, chemically speaking, belong to the diterpenes. They have mild D_2 receptor agonistic properties that are able to inhibit latent hyperprolactinemia. Latent hyperprolactinemia may be the cause of premenstrual mastodynia and corpus luteum defects. Similar results were obtained with synthetic dopaminergic drugs; however, these drugs have severe side effects, whereas no adverse effects were observed under treatment with Vitex Agnus Castus extracts. Extrakte aus Vitex Agnus Castus enthalten dopaminerge Verbindungen, die chemisch zu den Diterpenen gehören. Sie besitzen leichte D_2-Rezeptor-agonistische Eigenschaften, die eine latente überschießende Prolaktinsekretion inhibieren können. Eine latente Hyperprolaktinämie kann die Ursache für eine prämenstruelle Mastodynie und für eine Corpus-luteum-Insuffizienz sein. Ähnliche Ergebnisse wurden mit synthetischen dopaminergen Medikamenten erzielt, die allerdings schwerwiegende Nebenwirkungen haben. Unter der Behandlung mit Extrakten aus Vitex Agnus Castus dagegen wurden keinerlei unerwünschte Wirkungen beobachtet.
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Extrakte aus Mönchspfeffer (Vitex Agnus Castus)
Gynäkologische Endokrinologie, 2008Co-Authors: W. Wuttke, H. Jarry, D. Seidlová-wuttke, T. Devyatchenko, O. Pogodin, S.a. LevenetsAbstract:Extrakte aus Vitex Agnus Castus enthalten dopaminerge Verbindungen, die chemisch zu den Diterpenen gehoren. Sie besitzen leichte D2-Rezeptor-agonistische Eigenschaften, die eine latente uberschiesende Prolaktinsekretion inhibieren konnen. Eine latente Hyperprolaktinamie kann die Ursache fur eine pramenstruelle Mastodynie und fur eine Corpus-luteum-Insuffizienz sein. Ahnliche Ergebnisse wurden mit synthetischen dopaminergen Medikamenten erzielt, die allerdings schwerwiegende Nebenwirkungen haben. Unter der Behandlung mit Extrakten aus Vitex Agnus Castus dagegen wurden keinerlei unerwunschte Wirkungen beobachtet.
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Chaste tree (Vitex Agnus-Castus) – Pharmacology and clinical indications
Phytomedicine, 2004Co-Authors: W. Wuttke, H. Jarry, V. Christoffel, B. Spengler, D. Seidlová-wuttkeAbstract:Extracts of the fruits of chaste tree (Vitex Agnus Castus = AC) are widely used to treat premenstrual symptoms. Double-blind placebo-controlled studies indicate that one of the most common premenstrual symptoms, i.e. premenstrual mastodynia (mastalgia) is beneficially influenced by an AC extract. In addition, numerous less rigidly controlled studies indicate that AC extracts have also beneficial effects on other psychic and somatic symptoms of the PMS. Premenstrual mastodynia is most likely due to a latent hyperprolactinemia, i.e. patients release more than physiologic amounts of prolactin in response to stressful situations and during deep sleep phases which appear to stimulate the mammary gland. Premenstrually this unphysiological prolactin release is so high that the serum prolactin levels often approach heights which are misinterpreted as prolactinomas. Since AC extracts were shown to have beneficial effects on premenstrual mastodynia serum prolactin levels in such patients were also studied in one double-blind, placebo-controlled clinical study. Serum prolactin levels were indeed reduced in the patients treated with the extract. The search for the prolactin-suppressive principle(s) yielded a number of compounds with dopaminergic properties: they bound to recombinant DA2-receptor protein and suppressed prolactin release from cultivated lactotrophs as well as in animal experiments. The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects. They were almost identical in their prolactin-suppressive properties than dopamine itself. Hence, it is concluded that dopaminergic compounds present in Vitex Agnus Castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome.
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Evidence for estrogen receptor beta-selective activity of Vitex Agnus-Castus and isolated flavones.
Planta Medica, 2003Co-Authors: H. Jarry, W. Wuttke, Barbara Spengler, Andrea Porzel, J. Schmidt, Volker ChristoffelAbstract:Recent cell culture experiments indicated that extracts of Vitex Agnus-Castus (VAC) may contain yet unidentified phytoestrogens. Estrogenic actions are mediated via estrogen receptors (ER). To investigate whether VAC compounds bind to the currently known isoforms ERalpha or ERss, ligand binding assays (LBA) were performed. Subtype specific ER-LBA revealed a binding of VAC to ERss only. To isolate the ERss-selective compounds, the extract was fractionated by bio-guidance. The flavonoid apigenin was isolated and identified as the most active ERss-selective phytoestrogen in VAC. Other isolated compounds were Vitexin and penduletin. These data demonstrate that the phytoestrogens in VAC are ERss-selective.
