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Peter F.j. Schulte - One of the best experts on this subject based on the ideXlab platform.
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The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis.
American Journal of Obstetrics and Gynecology, 2017Co-Authors: Saskia Verkaik, Astrid M. Kamperman, Roos Van Westrhenen, Peter F.j. SchulteAbstract:Background Premenstrual syndrome is characterized by the cyclic occurrence of physical, behavioral and psychological symptoms during the luteal phase of the menstrual cycle disappearing within a few days of the onset of menstruation. Generally symptoms are mild, but 5–8% of women suffer from severe PMS. Apart from conventional drugs, like serotonin reuptake inhibitors and oral contraceptives, complementary and alternative medicines such as Vitex agnus castus are used by many women experiencing PMS. Objective Our objective was to determine the efficacy, tolerability, and acceptability of Vitex agnus castus preparations for treatment of premenstrual syndrome. Study Design All journals in the Ovid software from inception through January 2016 were searched, including the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and PsycINFO. Gray literature was searched by Google Scholar and manufacturers of Vitex agnus castus preparations were contacted for information about unpublished trials. We included randomized controlled trials with Vitex agnus castus in women with premenstrual syndrome and/or premenstrual dysphoric disorder with a minimal duration of 2 menstrual cycles. The eligibility of the manuscripts was assessed by 2 reviewers independently. The data abstracted included characteristics of the study design, characteristics of the patient population, intervention details, type of comparator, method of diagnosis, and outcome measures. We adhered to the PRISMA guidelines. Results We found 17 randomized controlled trials of Vitex agnus castus in the treatment of premenstrual syndrome. Fourteen of these could be included in the quantitative analysis. Thirteen of 14 studies with placebo, dietary supplements, or herbal preparations as controls reported positive effects of Vitex agnus castus on total premenstrual syndrome symptoms. Unfortunately most of the trials are associated with a high risk of bias. The pooled effect of Vitex agnus castus in placebo-controlled trials was large (Hedges g, –1.21; 95% confidence interval, –1.53 to –0.88), but heterogeneity was extremely high (I 2 , 91%). We were unable to single out factors that could explain this heterogeneity satisfactorily. The funnel plot and Egger tests suggest the presence of publication bias. Conclusion Although meta-analysis shows a large pooled effect of Vitex agnus castus in placebo-controlled trials, the high risk of bias, high heterogeneity, and risk of publication bias of the included studies preclude a definitive conclusion. The pooled treatment effects should be viewed as merely explorative and, at best, overestimating the real treatment effect of Vitex agnus castus for premenstrual syndrome symptoms. There is a clear need for high-quality trials of appropriate size examining the effect of standardized extracts of Vitex agnus castus in comparison to placebo, selective serotonin reuptake inhibitors, and oral contraceptives to establish relative efficacy.
Badri Prasad Shaw - One of the best experts on this subject based on the ideXlab platform.
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preliminary studies on anti inflammatory activity of zingber officinale rosc Vitex negundo linn and tinospora cordifolia willid miers in albino rats
Indian Journal of Pharmacology, 1999Co-Authors: U Jana, Rabindra Nath Chattopadhyay, Badri Prasad ShawAbstract:Objectives: To study the anti-inflammatory effect of Zingiber officinale, Vitex negundo and Tinospora cordifolia on carrageenin induced hind paw oedema and cotton pellet granuloma in rats. Methods: Hind paw oedema was produced by subplanter injection of carrageenin and paw volume was measured plethysmometrically at '0' and '3' hours intervals after injection. Cotton pellet granuloma was produced by implantation of 50(1mg sterile cotton in each axilla under ether anaesthesia. The animals were treated with Zingiber officinale, Vitex negundo, Tinospora cordifolia and the standard drugs acetylsalicylic acid and phenylbutazone. Results: Zingiber officinale, Vitex negundo and Tinospora cordifolia produced significant anti-inflammatory effect in both acute and subacute models of inflammation. In acute inflammation, effect of Tinospora cordifolia was more than acetylsalicylic acid. In subacute inflammation, the results of these drugs were less than phenylbutazone. Conclusion: Zingiber officinale, Vitex negundo and Tinospora cordifolia possess anti-inflammatory effects in both acute and subacute inflammation.
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PRELIMINARY STUDIES ON ANTI – INFLAMMATORY ACTIVITY OF ZINGBER OFFICINALE ROSC, Vitex NEGUNDO LINN AND TINOSPORA CORDIFOLIA (WILLID) MIERS IN ALBINO RATS
Indian Journal of Pharmacology, 1999Co-Authors: U Jana, Rabindra Nath Chattopadhyay, Badri Prasad ShawAbstract:Objectives: To study the anti-inflammatory effect of Zingiber officinale, Vitex negundo and Tinospora cordifolia on carrageenin induced hind paw oedema and cotton pellet granuloma in rats. Methods: Hind paw oedema was produced by subplanter injection of carrageenin and paw volume was measured plethysmometrically at '0' and '3' hours intervals after injection. Cotton pellet granuloma was produced by implantation of 50(1mg sterile cotton in each axilla under ether anaesthesia. The animals were treated with Zingiber officinale, Vitex negundo, Tinospora cordifolia and the standard drugs acetylsalicylic acid and phenylbutazone. Results: Zingiber officinale, Vitex negundo and Tinospora cordifolia produced significant anti-inflammatory effect in both acute and subacute models of inflammation. In acute inflammation, effect of Tinospora cordifolia was more than acetylsalicylic acid. In subacute inflammation, the results of these drugs were less than phenylbutazone. Conclusion: Zingiber officinale, Vitex negundo and Tinospora cordifolia possess anti-inflammatory effects in both acute and subacute inflammation.
Kerry M. Bone - One of the best experts on this subject based on the ideXlab platform.
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Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.
Planta medica, 2012Co-Authors: M. Diana Van Die, Henry G. Burger, Helena J. Teede, Kerry M. BoneAbstract:Vitex agnus-castus L. (chaste tree; chasteberry) is a popular herbal treatment, predominantly used for a range of female reproductive conditions in Anglo-American and European practice. The objective of this systematic review was to evaluate the evidence for the efficacy and safety of Vitex extracts from randomised, controlled trials investigating womenʼs health. Eight databases were searched using Latin and common names for Vitex and phytotherapeutic preparations of the herb as a sole agent, together with filters for randomised, controlled trials or clinical trials. Methodological quality was assessed according to the Cochrane risk of bias and Jadad scales, as well as the proposed elaboration of CONSORT for reporting trials on herbal interventions. Thirteen randomised, controlled trials were identified and twelve are included in this review, of which eight investigated premenstrual syndrome, two premenstrual dysphoric disorder, and two latent hyperprolactinaemia. For premenstrual syndrome, seven of eight trials found Vitex extracts to be superior to placebo (5 of 6 studies), pyridoxine (1), and magnesium oxide (1). In premenstrual dysphoric disorder, one study reported Vitex to be equivalent to fluoxetine, while in the other, fluoxetine outperformed Vitex. In latent hyperprolactinaemia, one trial reported it to be superior to placebo for reducing TRH-stimulated prolactin secretion, normalising a shortened luteal phase, increasing mid-luteal progesterone and 17β-oestradiol levels, while the other found Vitex comparable to bromocriptine for reducing serum prolactin levels and ameliorating cyclic mastalgia. Adverse events with Vitex were mild and generally infrequent. The methodological quality of the included studies varied, but was generally moderate-to-high. Limitations include small sample sizes in some studies, heterogeneity of conditions being treated, and a range of reference treatments. Despite some methodological limitations, the results from randomised, controlled trials to date suggest benefits for Vitex extracts in the treatment of premenstrual syndrome, premenstrual dysphoric disorder and latent hyperprolactinaemia. Further research is recommended, and greater transparency in reporting for future trials.
Sinjumol Thomas - One of the best experts on this subject based on the ideXlab platform.
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Anatomical Studies on Vitex Leucoxylon and Vitex Negundo (Verbenaceae)
International Journal of Research, 2014Co-Authors: Silvy Mathew, S. John Britto, Sinjumol ThomasAbstract:Plants have served as a source of medicine to man for several decades now and still remain a source for vast potent bioactive molecules for the treatment of ailments. The anatomical and physiological features of plants may provide valuable characters and character states in assessing homology and elucidating phylogenetic relationships among plants. Anatomical features of vegetative as well as reproductive organs have been studied and the results of such research have found application in systematics, particularly for resolving controversial taxonomic problems. Vitex species possesses numerous biological activities proved by many experimental studies. One of the ancient uses of Vitex negundo Linn. documented in ayurveda is to provide mental peace. The leaf extract of Vitex negundo are generally used as preservation in storage of grain to protect the pulses against insects. Vitex leucoxylon Linn. is used as folkloric medicine in India for the treatment of cancer. The stem of Vitex negundo consists of wide parenchymatous pith, Chlorenchymatous hypodermis and TLS showing the multiseriate rays. Vitex leucoxylon TLS shows biseriate and uniseriate rays with intervessel pits.
Suchada Sukrong - One of the best experts on this subject based on the ideXlab platform.
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Molecular analysis of Vitex species using candidate DNA barcoding and PCR-RFLP of the matK gene for authentication of Vitex glabrata.
Natural product communications, 2013Co-Authors: Waranyoo Phoolcharoen, Suchada SukrongAbstract:Several species of the Vitex genus, family Lamiaceae, are used in folk medicine for a variety of remedies. V. glabrata is unique among Vitex species because its main effect is sexual enhancement. However, crude drugs derived from different Vitex species might not be easily distinguishable, which could lead to their misidentification and misuse. Therefore, the accurate authentication of V. glabrata is critical for its effective medicinal use. In this study, the matK gene and the psbA-trnH intergenic spacer candidate DNA barcodes were sequenced and analyzed to identify five different Vitex species that are medicinally used in Thailand: V. negundo, V. trifolia, V. rotundifolia, V. limonifolia, and V. glabrata. Each region was successfully amplified from the leaves of the five species using a single set of primers, and the sequences determined. The size difference in PCR products of psbA-trnH and PCR restriction fragment length polymorphism (PCR-RFLP) of the matK gene sequences were used to differentiate V. glabrata from other Vitex species. These results indicate both the matK gene and the psbA-trnH intergenic spacer as candidate DNA barcodes of Vitex species and suggest that the difference of psbA-trnH PCR products and PCR-RFLP analysis based on the matK gene are effective for the authentication of V. glabrata.
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Molecular authentication of Thai medicinal plant, Vitex glabrata, by PCR-RFLP
Planta Medica, 2011Co-Authors: Waranyoo Phoolcharoen, N Ruangrungsri, Suchada SukrongAbstract:Several species in Vitex, a genus in the family Labiatae, are medicinal plants used in folk remedy in many countries with different effects. Vitex glabrata R. Br. is used as anthelmintic, wound healing and sexual enhancer, which are different from the uses of other Vitex species. These effects are related to the presence of ecdysteroids in the plant (1) since it has high amount of 20-hydroxyecdysone (2). Crude drugs of many Vitex species have similar appearance, which lead to confusion and misuse. Therefore, an accurate authentication of V. glabrata is essential for medicinal purpose. In this study, PCR-restriction fragment length polymorphism (PCR-RFLP) based on the chloroplast maturase K (matK) gene analysis was applied to identify V. glabrata from other Vitex species commonly found in Thailand. Among five Vitex species, a distinctive site recognize by a restriction enzyme HindIII in V. glabrata was found. A pair of new primers, Vt1110matKF and Vt1516matKR, was designed based on the sequence of V. glabrata to amplify a smaller fragment of 407 bp in length from genomic DNAs of the leaves of these five species. Only the PCR product of V. glabrata could be digested with HindIII into two fragments of 324 bp and 83 bp while the other species remained undigested. This result suggests that PCR-RFLP analysis is an effective and accurate method for authentication of V. glabrata. Acknowledgement: the Faculty of Pharmaceutical Sciences Research Funds, Faculty of Sciences, Chulalongkorn University, Thailand References: 1. Bathori M, Pongracz Z (2005) Curr Med 12:153–172. 2. Werawattanametin K (1986)J Nat Prod 9(2):365–366
