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Katsumi Shibata - One of the best experts on this subject based on the ideXlab platform.
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Urinary excretion levels of Water-Soluble Vitamins in pregnant and lactating women in Japan.
Journal of Nutritional Science and Vitaminology, 2020Co-Authors: Katsumi Shibata, Tsutomu Fukuwatari, Satoshi Sasaki, Mitsue Sano, Kahoru Suzuki, Chiaki Hiratsuka, Asami Aoki, Chiharu NagaiAbstract:Summary Recent studies have shown that the urinary excretion levels of Water-Soluble Vitamins can be used as biomarkers for the nutritional status of these Vitamins. To determine changes in the urinary excretion levels of Water-Soluble Vitamins during pregnant and lactating stages, we surveyed and compared levels of nine Water-Soluble Vitamins in control (non-pregnant and non-lactating women), pregnant and lactating women. Control women (n537), women in the 2nd (16–27 wk, n524) and 3rd trimester of pregnancy (over 28 wk, n532), and early- (0–5 mo, n554) and late-stage lactating (6–11 mo, n549) women took part in the survey. The mean age of subjects was ~30 y, and mean height was ~160 cm. A single 24-h urine sample was collected 1 d after the completion of a validated, self-administered comprehensive diet history questionnaire to measure Water-Soluble Vitamins or metabolites. The average intake of each Water-Soluble Vitamin was ~ the estimated average requirement value and adequate intake for the Japanese Dietary Reference Intakes in all life stages, except for Vitamin B6 and folate intakes during pregnancy. No change was observed in the urinary excretion levels of Vitamin B2, Vitamin B6, Vitamin B12, biotin or Vitamin C among stages. Urine nicotinamide and folate levels were higher in pregnant women than in control women. Urine excretion level of Vitamin B1 decreased during lactation and that of pantothenic acid decreased during pregnancy and lactation. These results provide valuable information for setting the Dietary Reference Intakes of Water-Soluble Vitamins for pregnant and lactating women.
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Urinary Water-Soluble Vitamins as Potential Nutritional Biomarkers to Assess Their Intakes
Journal of Nutrition and Food Sciences, 2020Co-Authors: Tsutomu Fukuwatari, Katsumi ShibataAbstract:To determine micronutrient intake by dietary assessment is difficult because of high variations in habitual micronutrient intake. A nutritional biomarker can be an indicator of nutritional status with respect to intake or metabolism of dietary constituents. Recent validation studies have developed the urinary compounds as nutritional biomarkers to estimate nutrient intakes, and urinary nitrogen and sodium have been well established as nutritional biomarkers. Recent studies have conducted to establish urinary Water-Soluble Vitamins as nutritional biomarkers to assess their intakes, and made the following findings to contribute to the establishment and effective use of urinary Water-Soluble Vitamins as potential nutritional biomarkers. Only urinary Vitamin B12 content reflects urine volume but not its intake. Eight of nine Water-Soluble Vitamin levels in 24-hr urine increase in dose-dependent-manner, and are strongly correlated with Vitamin intakes. Each urinary Water-Soluble Vitamin level, except for Vitamin B12, is positively correlated with the mean intake over the recent 2-4 days in free-living children, young and elderly. These findings suggest that urinary Water-Soluble Vitamins can be used as nutritional biomarkers to assess their mean intakes in groups. Based on previous findings, the reference values for urinary Water-Soluble Vitamins are proposed to show adequate nutritional status.
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Relationship Between Urinary Concentrations of Nine Water-Soluble Vitamins and their Vitamin Intakes in Japanese Adult Males.
Nutrition and metabolic insights, 2014Co-Authors: Katsumi Shibata, Junko Hirose, Tsutomu FukuwatariAbstract:Excess Water-Soluble Vitamins are thought to be eliminated in the urine. We have reported a strong relationship between Water-Soluble Vitamin intake and urinary excretion in females. The relationship, however, is not well understood in males. In the present experiment, 10 Japanese male subjects were given a standard Japanese diet for the first week. The subjects remained on the same diet, and a synthesized Water-Soluble Vitamin mixture containing one time the Dietary Reference Intakes (DRIs) for Japanese was given for the second week, three times the DRIs for the third week, and six times the DRIs for the fourth week. Twenty-four-hour urine samples were collected each week. Urinary excretion levels for seven of the nine Water-Soluble Vitamin levels, excluding Vitamin B12 and folate, increased linearly and sharply in a dose-dependent manner. These results suggest that measuring urinary Water-Soluble Vitamins can be good nutritional markers for assessing Vitamin intakes in humans.
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Values for evaluating the nutritional status of Water-Soluble Vitamins in humans
Journal of Integrated OMICS, 2013Co-Authors: Katsumi ShibataAbstract:Previously, we clarified that the amount of urinary excretion of Water-Soluble Vitamins closely reflects the surplus amount of Water-Soluble Vitamins in the body stores of rats and humans. We tried to set a tentative amount of urinary excretion of eight Water-Soluble Vitamins of nine Water-Soluble Vitamins (except Vitamin B 12 ) for maintaining health based on experiments in healthy young females administered a semi-chemically defined diet according to Japanese Dietary Reference Intakes and related data. We proposed a tentative value for the amount of urinary excretion of Water-Soluble Vitamins for maintaining health. The values were: 200–2000 nmol/d for Vitamin B 1 ; 200–2000 nmol/d for Vitamin B 2 ; 2–15 µ mol/d for 4-pyridoxic acid (a catabolite of Vitamin B 6 ); 50–300 µ mol/d for the sum of the nicotinamide catabolites N 1 -methylnicotinamide, N 1 -methyl-2-pyridone-5-carboxamide, and N 1 -methyl-4-pyridone-3-carboxamide; 10–30 µ mol/d for pantothenic acid; 15–100 nmol/d for folate; 50–200 nmol/d for biotin; and 100–2000 µ mol/d for Vitamin C. By using these values, we attempted to evaluate the nutritional status of Water-Soluble Vitamins for 709 young Japanese females. The percentage within the tentative value of urinary excretion of Water-Soluble Vitamin for maintaining health was 73.6% for Vitamin B 1 , 63.5% for Vitamin B 2 , 90.0% for Vitamin B 6 , 85.6% for niacin, 58.1% for folate, 85.6% for pantothenic acid, 70.2% for biotin, and 65.4% for Vitamin C. The percentage beyond the lower limit of detection was 22.4% for Vitamin B 1 , 31.3% for Vitamin B 2 , 6.2% for Vitamin B 6 , 14.0% for niacin, 40.9% for folate, 12.4% for pantothenic acid, 26.2% for biotin, and 33.0% for Vitamin C. The percentage over the upper limit of detection was 4.1% for Vitamin B 1 , 5.2% for Vitamin B 2 , 3.8% for Vitamin B 6 , 0.4% for niacin, 1.0% for folate, 2.0% for pantothenic acid, 3.6% for biotin, and 1.6% for Vitamin C. Nutritional assessment using urinary excretion amounts of Water-Soluble Vitamins is persuasive, and leads to the transformation of habitual dietary intakes.
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Twenty-four-hour urinary Water-Soluble Vitamin levels correlate with their intakes in free-living Japanese schoolchildren
Public Health Nutrition, 2010Co-Authors: Tomiko Tsuji, Tsutomu Fukuwatari, Satoshi Sasaki, Katsumi ShibataAbstract:OBJECTIVE: To examine the association between 24 h urinary Water-Soluble Vitamin levels and their intakes in free-living Japanese schoolchildren. DESIGN: All foods consumed for four consecutive days were recorded accurately by a weighed food record. A single 24 h urine sample was collected on the fourth day, and the urinary levels of Water-Soluble Vitamins were measured. SETTING: An elementary school in Inazawa City, Japan. SUBJECTS: A total of 114 healthy, free-living, Japanese elementary-school children aged 10-12 years. RESULTS: The urinary level of each Water-Soluble Vitamin was correlated positively to its mean intake in the past 2-4 d (Vitamin B1: r = 0·42, P < 0·001; Vitamin B2: r = 0·43, P < 0·001; Vitamin B6: r = 0·49, P < 0·001; niacin: r = 0·32, P < 0·001; niacin equivalents: r = 0·32, P < 0·001; pantothenic acid: r = 0·32, P < 0·001; folic acid: r = 0·27, P < 0·01; Vitamin C: r = 0·39, P < 0.001), except for Vitamin B12 (r = 0·10, P = NS). Estimated mean intakes of Water-Soluble Vitamins calculated using urinary levels and recovery rates were 97-102 % of their 3 d mean intake, except for Vitamin B12 (79 %). CONCLUSIONS: The results show that urinary levels of Water-Soluble Vitamins, except for Vitamin B12, reflected their recent intakes in free-living Japanese schoolchildren and could be used as a potential biomarker to estimate mean Vitamin intake.
Raci Ekinci - One of the best experts on this subject based on the ideXlab platform.
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the effect of fermentation and drying on the water soluble Vitamin content of tarhana a traditional turkish cereal food
Food Chemistry, 2005Co-Authors: Raci EkinciAbstract:Tarhana is a popular and widely consumed traditional Turkish fermented wheat-flour-yoghurt mixture. The effects of fermentation (30 °C for 4 days) and drying (50, 60 and 70 °C) on the contents of several Water-Soluble Vitamins (ascorbic acid, niacin, pantothenic acid (Vitamin B5), pyridoxine (Vitamin B6), thiamine (Vitamin B1), folic acid and riboflavin (Vitamin B2)) in tarhana, a traditional Turkish cereal food, have been studied. The contents of Water-Soluble Vitamins was analyzed by HPLC. Statistical analysis of the data showed that a 4-day fermentation and drying had a significant effect (p<0.05) on the contents of Water-Soluble Vitamins of tarhana. The fermentation resulted in significant increases of riboflavin, niacin, pantothenic acid, ascorbic acid and folic acid contents of the samples, but no significant differences, with thiamine and pyridoxine. Highest losses of the Water-Soluble Vitamins were at 70 °C for the 35 h drying period.
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The effect of fermentation and drying on the Water-Soluble Vitamin content of tarhana, a traditional Turkish cereal food
Food Chemistry, 2005Co-Authors: Raci EkinciAbstract:Tarhana is a popular and widely consumed traditional Turkish fermented wheat-flour-yoghurt mixture. The effects of fermentation (30 °C for 4 days) and drying (50, 60 and 70 °C) on the contents of several Water-Soluble Vitamins (ascorbic acid, niacin, pantothenic acid (Vitamin B5), pyridoxine (Vitamin B6), thiamine (Vitamin B1), folic acid and riboflavin (Vitamin B2)) in tarhana, a traditional Turkish cereal food, have been studied. The contents of Water-Soluble Vitamins was analyzed by HPLC. Statistical analysis of the data showed that a 4-day fermentation and drying had a significant effect (p
Tsutomu Fukuwatari - One of the best experts on this subject based on the ideXlab platform.
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Urinary excretion levels of Water-Soluble Vitamins in pregnant and lactating women in Japan.
Journal of Nutritional Science and Vitaminology, 2020Co-Authors: Katsumi Shibata, Tsutomu Fukuwatari, Satoshi Sasaki, Mitsue Sano, Kahoru Suzuki, Chiaki Hiratsuka, Asami Aoki, Chiharu NagaiAbstract:Summary Recent studies have shown that the urinary excretion levels of Water-Soluble Vitamins can be used as biomarkers for the nutritional status of these Vitamins. To determine changes in the urinary excretion levels of Water-Soluble Vitamins during pregnant and lactating stages, we surveyed and compared levels of nine Water-Soluble Vitamins in control (non-pregnant and non-lactating women), pregnant and lactating women. Control women (n537), women in the 2nd (16–27 wk, n524) and 3rd trimester of pregnancy (over 28 wk, n532), and early- (0–5 mo, n554) and late-stage lactating (6–11 mo, n549) women took part in the survey. The mean age of subjects was ~30 y, and mean height was ~160 cm. A single 24-h urine sample was collected 1 d after the completion of a validated, self-administered comprehensive diet history questionnaire to measure Water-Soluble Vitamins or metabolites. The average intake of each Water-Soluble Vitamin was ~ the estimated average requirement value and adequate intake for the Japanese Dietary Reference Intakes in all life stages, except for Vitamin B6 and folate intakes during pregnancy. No change was observed in the urinary excretion levels of Vitamin B2, Vitamin B6, Vitamin B12, biotin or Vitamin C among stages. Urine nicotinamide and folate levels were higher in pregnant women than in control women. Urine excretion level of Vitamin B1 decreased during lactation and that of pantothenic acid decreased during pregnancy and lactation. These results provide valuable information for setting the Dietary Reference Intakes of Water-Soluble Vitamins for pregnant and lactating women.
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Urinary Water-Soluble Vitamins as Potential Nutritional Biomarkers to Assess Their Intakes
Journal of Nutrition and Food Sciences, 2020Co-Authors: Tsutomu Fukuwatari, Katsumi ShibataAbstract:To determine micronutrient intake by dietary assessment is difficult because of high variations in habitual micronutrient intake. A nutritional biomarker can be an indicator of nutritional status with respect to intake or metabolism of dietary constituents. Recent validation studies have developed the urinary compounds as nutritional biomarkers to estimate nutrient intakes, and urinary nitrogen and sodium have been well established as nutritional biomarkers. Recent studies have conducted to establish urinary Water-Soluble Vitamins as nutritional biomarkers to assess their intakes, and made the following findings to contribute to the establishment and effective use of urinary Water-Soluble Vitamins as potential nutritional biomarkers. Only urinary Vitamin B12 content reflects urine volume but not its intake. Eight of nine Water-Soluble Vitamin levels in 24-hr urine increase in dose-dependent-manner, and are strongly correlated with Vitamin intakes. Each urinary Water-Soluble Vitamin level, except for Vitamin B12, is positively correlated with the mean intake over the recent 2-4 days in free-living children, young and elderly. These findings suggest that urinary Water-Soluble Vitamins can be used as nutritional biomarkers to assess their mean intakes in groups. Based on previous findings, the reference values for urinary Water-Soluble Vitamins are proposed to show adequate nutritional status.
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Relationship Between Urinary Concentrations of Nine Water-Soluble Vitamins and their Vitamin Intakes in Japanese Adult Males.
Nutrition and metabolic insights, 2014Co-Authors: Katsumi Shibata, Junko Hirose, Tsutomu FukuwatariAbstract:Excess Water-Soluble Vitamins are thought to be eliminated in the urine. We have reported a strong relationship between Water-Soluble Vitamin intake and urinary excretion in females. The relationship, however, is not well understood in males. In the present experiment, 10 Japanese male subjects were given a standard Japanese diet for the first week. The subjects remained on the same diet, and a synthesized Water-Soluble Vitamin mixture containing one time the Dietary Reference Intakes (DRIs) for Japanese was given for the second week, three times the DRIs for the third week, and six times the DRIs for the fourth week. Twenty-four-hour urine samples were collected each week. Urinary excretion levels for seven of the nine Water-Soluble Vitamin levels, excluding Vitamin B12 and folate, increased linearly and sharply in a dose-dependent manner. These results suggest that measuring urinary Water-Soluble Vitamins can be good nutritional markers for assessing Vitamin intakes in humans.
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Twenty-four-hour urinary Water-Soluble Vitamin levels correlate with their intakes in free-living Japanese schoolchildren
Public Health Nutrition, 2010Co-Authors: Tomiko Tsuji, Tsutomu Fukuwatari, Satoshi Sasaki, Katsumi ShibataAbstract:OBJECTIVE: To examine the association between 24 h urinary Water-Soluble Vitamin levels and their intakes in free-living Japanese schoolchildren. DESIGN: All foods consumed for four consecutive days were recorded accurately by a weighed food record. A single 24 h urine sample was collected on the fourth day, and the urinary levels of Water-Soluble Vitamins were measured. SETTING: An elementary school in Inazawa City, Japan. SUBJECTS: A total of 114 healthy, free-living, Japanese elementary-school children aged 10-12 years. RESULTS: The urinary level of each Water-Soluble Vitamin was correlated positively to its mean intake in the past 2-4 d (Vitamin B1: r = 0·42, P < 0·001; Vitamin B2: r = 0·43, P < 0·001; Vitamin B6: r = 0·49, P < 0·001; niacin: r = 0·32, P < 0·001; niacin equivalents: r = 0·32, P < 0·001; pantothenic acid: r = 0·32, P < 0·001; folic acid: r = 0·27, P < 0·01; Vitamin C: r = 0·39, P < 0.001), except for Vitamin B12 (r = 0·10, P = NS). Estimated mean intakes of Water-Soluble Vitamins calculated using urinary levels and recovery rates were 97-102 % of their 3 d mean intake, except for Vitamin B12 (79 %). CONCLUSIONS: The results show that urinary levels of Water-Soluble Vitamins, except for Vitamin B12, reflected their recent intakes in free-living Japanese schoolchildren and could be used as a potential biomarker to estimate mean Vitamin intake.
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Twenty-four-hour urinary Water-Soluble Vitamin levels correlate with their intakes in free-living Japanese university students.
European Journal of Clinical Nutrition, 2010Co-Authors: Tomiko Tsuji, Tsutomu Fukuwatari, Satoshi Sasaki, Katsumi ShibataAbstract:We examined the association between 24-h urinary excretion of Water-Soluble Vitamin levels and their intakes in free-living Japanese university students. The design used was cross-sectional study. A total of 216 healthy, free-living male and female Japanese university students aged 18–27 years voluntarily participated in this study, of which 156 students were eligible for this assessment. All foods consumed for 4 consecutive days were recorded accurately by a weighed food record method. A 24-h urine sample was collected on the fourth day, and the urinary levels of Water-Soluble Vitamins were measured. Each urinary Water-Soluble Vitamin level, except for Vitamin B12, was correlated positively with its mean intake in the recent 2–4 days (Vitamin B1: r=0.42, P
Francesco Visioli - One of the best experts on this subject based on the ideXlab platform.
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the water soluble Vitamin e analogue trolox protects against ischaemia reperfusion damage in vitro and ex vivo a comparison with Vitamin e
Pharmacological Research, 2002Co-Authors: Vadim F Sagach, Monica Scrosati, Jeanette Fielding, Giuseppe Rossoni, Claudio Galli, Francesco VisioliAbstract:Abstract We investigated the activities, both in vitro and ex vivo, of the Water-Soluble Vitamin analogue Trolox in a model of isolated heart ischaemia–reperfusion and we compared them with those of α -tocopherol. Isolated rat hearts were perfused with Krebs–Henseleit solution. For in vitro experiments, the hearts were perfused with Trolox (20 μ mol l −1 ) and were subsequently subjected to 20 min of global ischaemia and 40 min of post-ischaemic reperfusion. For ex vivo experiments, either Trolox or α -tocopherol (10 mg kg −1 ) were administered by gastric gavage 60 min before excision of the heart. Various parameters of cardiac function were evaluated and oxidative damage was assessed by TBARS production. Trolox significantly enhanced cardiac recovery after ischaemia/reperfusion, both when it was perfused in vitro and after its oral administration. Vitamin E also favourably affected cardiac recovery but did so less effectively than Trolox. Further, the production of TBARS was significantly inhibited by Trolox, suggesting that its beneficial effects are due to its antioxidant activities. In conclusion, perfusion of isolated rat hearts with low concentrations of the Water-Soluble Vitamin E analogue Trolox effectively enhances cardiac recovery after a 20 min ischaemic period and decreases reperfusion-induced oxidative damage. Interestingly, Trolox retains its activities after oral administration. Vitamin E, when administered per os , also increases functional recovery but does so less potently than Trolox. These differential effects are likely due to the scavenging, by Trolox, of reactive oxygen species generated in the water phase.
Satoshi Sasaki - One of the best experts on this subject based on the ideXlab platform.
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Urinary excretion levels of Water-Soluble Vitamins in pregnant and lactating women in Japan.
Journal of Nutritional Science and Vitaminology, 2020Co-Authors: Katsumi Shibata, Tsutomu Fukuwatari, Satoshi Sasaki, Mitsue Sano, Kahoru Suzuki, Chiaki Hiratsuka, Asami Aoki, Chiharu NagaiAbstract:Summary Recent studies have shown that the urinary excretion levels of Water-Soluble Vitamins can be used as biomarkers for the nutritional status of these Vitamins. To determine changes in the urinary excretion levels of Water-Soluble Vitamins during pregnant and lactating stages, we surveyed and compared levels of nine Water-Soluble Vitamins in control (non-pregnant and non-lactating women), pregnant and lactating women. Control women (n537), women in the 2nd (16–27 wk, n524) and 3rd trimester of pregnancy (over 28 wk, n532), and early- (0–5 mo, n554) and late-stage lactating (6–11 mo, n549) women took part in the survey. The mean age of subjects was ~30 y, and mean height was ~160 cm. A single 24-h urine sample was collected 1 d after the completion of a validated, self-administered comprehensive diet history questionnaire to measure Water-Soluble Vitamins or metabolites. The average intake of each Water-Soluble Vitamin was ~ the estimated average requirement value and adequate intake for the Japanese Dietary Reference Intakes in all life stages, except for Vitamin B6 and folate intakes during pregnancy. No change was observed in the urinary excretion levels of Vitamin B2, Vitamin B6, Vitamin B12, biotin or Vitamin C among stages. Urine nicotinamide and folate levels were higher in pregnant women than in control women. Urine excretion level of Vitamin B1 decreased during lactation and that of pantothenic acid decreased during pregnancy and lactation. These results provide valuable information for setting the Dietary Reference Intakes of Water-Soluble Vitamins for pregnant and lactating women.
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Twenty-four-hour urinary Water-Soluble Vitamin levels correlate with their intakes in free-living Japanese schoolchildren
Public Health Nutrition, 2010Co-Authors: Tomiko Tsuji, Tsutomu Fukuwatari, Satoshi Sasaki, Katsumi ShibataAbstract:OBJECTIVE: To examine the association between 24 h urinary Water-Soluble Vitamin levels and their intakes in free-living Japanese schoolchildren. DESIGN: All foods consumed for four consecutive days were recorded accurately by a weighed food record. A single 24 h urine sample was collected on the fourth day, and the urinary levels of Water-Soluble Vitamins were measured. SETTING: An elementary school in Inazawa City, Japan. SUBJECTS: A total of 114 healthy, free-living, Japanese elementary-school children aged 10-12 years. RESULTS: The urinary level of each Water-Soluble Vitamin was correlated positively to its mean intake in the past 2-4 d (Vitamin B1: r = 0·42, P < 0·001; Vitamin B2: r = 0·43, P < 0·001; Vitamin B6: r = 0·49, P < 0·001; niacin: r = 0·32, P < 0·001; niacin equivalents: r = 0·32, P < 0·001; pantothenic acid: r = 0·32, P < 0·001; folic acid: r = 0·27, P < 0·01; Vitamin C: r = 0·39, P < 0.001), except for Vitamin B12 (r = 0·10, P = NS). Estimated mean intakes of Water-Soluble Vitamins calculated using urinary levels and recovery rates were 97-102 % of their 3 d mean intake, except for Vitamin B12 (79 %). CONCLUSIONS: The results show that urinary levels of Water-Soluble Vitamins, except for Vitamin B12, reflected their recent intakes in free-living Japanese schoolchildren and could be used as a potential biomarker to estimate mean Vitamin intake.
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Twenty-four-hour urinary Water-Soluble Vitamin levels correlate with their intakes in free-living Japanese university students.
European Journal of Clinical Nutrition, 2010Co-Authors: Tomiko Tsuji, Tsutomu Fukuwatari, Satoshi Sasaki, Katsumi ShibataAbstract:We examined the association between 24-h urinary excretion of Water-Soluble Vitamin levels and their intakes in free-living Japanese university students. The design used was cross-sectional study. A total of 216 healthy, free-living male and female Japanese university students aged 18–27 years voluntarily participated in this study, of which 156 students were eligible for this assessment. All foods consumed for 4 consecutive days were recorded accurately by a weighed food record method. A 24-h urine sample was collected on the fourth day, and the urinary levels of Water-Soluble Vitamins were measured. Each urinary Water-Soluble Vitamin level, except for Vitamin B12, was correlated positively with its mean intake in the recent 2–4 days (Vitamin B1: r=0.42, P
